Highly Concentrated Autologous Platelet-Rich Plasma Restores Foveal Anatomy in Lamellar Macular Hole Surgery

Abstract Background Lamellar macular holes (LMHs) are an entity of a progressive disease in which the efficacy of the therapy of choice, vitrectomy, seems to be reduced. It is unknown whether highly concentrated autologous platelet-rich plasma (PRP) is of value in the therapy of LMHs. The purpose of this study was to gauge the potential of highly concentrated PRP to restore foveal anatomy in LMH surgery. Patients and Methods In this interventional case series, eight eyes of eight patients with progressive LMH were included. All patients underwent a 23-gauge pars plana vitrectomy with induction of a posterior vitreous detachment and peeling of tractive epiretinal membranes whenever present. Under air tamponade, 0.1 mL of highly concentrated autologous PRP was applied. Subsequently, a gas or air tamponade was performed. All patients were instructed to rest in the supine position for the first 1 to 2 postoperative hours. Best-corrected visual acuity (BCVA) testing, microperimetry, spectral-domain optical coherence tomography (SD-OCT) and fundus photography were performed prior to and 3 months after surgery. Results SD-OCT showed closure of the macular defect with restoration of a normal foveal configuration in all (8 of 8) patients 3 months postoperatively. BCVA improved significantly, from 0.28 ± 0.08 to 0.12 ± 0.14 logMAR (Wilcoxon: p = 0.03). Microperimetry remained unchanged (24.13 ± 1.96 vs. 23.7 ± 1.54 dB; p = 0.46). No clinically significant intra- or postoperative complications were observed. Conclusion The use of highly concentrated PRP enables excellent anatomical and functional outcomes in the surgical therapy of LMH. Further prospective comparative trials are warranted to compare this promising technique with existing surgical strategies.

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Improving morphological outcome in lamellar macular hole surgery by using highly concentrated autologous platelet-rich plasma

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-021-05486-5 ◽

2021 ◽

Author(s):

Felix Hagenau ◽

Nikolaus Luft ◽

Matthias Nobl ◽

Denise Vogt ◽

Julian E. Klaas ◽

...

Keyword(s):

Visual Acuity ◽

Macular Hole ◽

Platelet Rich Plasma ◽

Fundus Photography ◽

Lamellar Macular Hole ◽

Epiretinal Membranes ◽

Corrected Visual Acuity ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet ◽

Best Corrected Visual Acuity

Abstract Purpose To evaluate the use of highly concentrated autologous platelet-rich plasma (PRP) in lamellar macular hole (LMH) surgery with regard to function and morphology. Methods We included 12 eyes of 12 patients with progressive LMH in this interventional case series. After 23/25-gauge pars plana vitrectomy, 0.1ml highly concentrated autologous platelet-rich plasma was applied under air tamponade. Induction of posterior vitreous detachment and peeling of tractive epiretinal membranes were performed whenever present. Phacovitrectomy was undertaken in cases of phakic lens status. Postoperatively, all patients were instructed to rest in a supine position for the first two postoperative hours. Best-corrected visual acuity (BCVA) testing, microperimetry, spectral-domain optical coherence tomography (SD-OCT), and fundus photography were carried out preoperatively and 6 months postoperatively. Results Foveal configuration was restored in 10 of 12 patients (83.3%) at 6 months postoperatively. Two patients who had not undergone ILM peeling showed a recurring defect at 6-month follow-up. Best-corrected visual acuity improved significantly from 0.29 ± 0.08 to 0.14 ± 0.13 logMAR (Wilcoxon: p=0.028). Microperimetry remained unchanged (23.38 ± 2.53 preoperatively; 23.0 ± 2.49 dB postoperatively; p=0.67). No patient experienced vision loss after surgery, and no significant intra- or postoperative complications occurred. Conclusion The application of PRP in the surgical therapy of LMH results in good morphological and functional outcomes. Additional peeling of the ILM seems to be mandatory when using PRP to prevent the recurrence of LMH. Strict postoperative supine positioning for 2 h avoids PRP dislocation. Larger sample sizes are needed to confirm the results.

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Successful Management of Treatment-Resistant Alopecia Areata with Platelet Rich Plasma: A Case Series

Serbian Journal of Dermatology and Venerology ◽

10.2478/sjdv-2019-0007 ◽

2019 ◽

Vol 11 (2) ◽

pp. 50-52

Author(s):

Sanjeewani Fonseka ◽

Y.M.D.M Bandara ◽

Brabaharan Subhani

Keyword(s):

Alopecia Areata ◽

Platelet Rich Plasma ◽

Case Reports ◽

Immunosuppressive Agents ◽

Case Series ◽

Treatment Resistant ◽

Successful Management ◽

Autologous Platelet Rich Plasma ◽

Dermal Injection ◽

Autologous Platelet

Abstract Introduction. Alopecia areata (AA) is an autoimmune disease-causing non-scarring alopecia. It is usually treated with immunosuppressive agents, to which some patients fail to respond adequately. Material and Methods. Three patients with AA refractory to standard therapy were treated with intra-dermal injection of autologous platelet rich plasma (PRP) every four weeks. Results. All three patients showed remarkable improvement after multiple sessions of PRP treatment. Conclusion. Autologous PRP is safe and effective in treatment-resistant forms of AA demonstrated in many case reports; therefore it deserves further study with randomized, placebo-controlled trials.

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Bisphosphonate-related osteonecrosis of the jaws—an initial case series report of treatment combining marginal bone resection and autologous platelet-rich plasma

International Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.ijom.2011.07.152 ◽

2011 ◽

Vol 40 (10) ◽

pp. 1071

Author(s):

M. Curi ◽

C.L. Cardoso ◽

D.H. Koga ◽

C. Zardetto

Keyword(s):

Platelet Rich Plasma ◽

Case Series ◽

Bone Resection ◽

Osteonecrosis Of The Jaws ◽

Case Series Report ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet ◽

Series Report

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Bisphosphonate-Related Osteonecrosis of the Jaws–An Initial Case Series Report of Treatment Combining Partial Bone Resection and Autologous Platelet-Rich Plasma

Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.joms.2011.02.078 ◽

2011 ◽

Vol 69 (9) ◽

pp. 2465-2472 ◽

Cited By ~ 54

Author(s):

Marcos Martins Curi ◽

Giuliano Saraceni Issa Cossolin ◽

Daniel Henrique Koga ◽

Cristina Zardetto ◽

Silmara Christianini ◽

...

Keyword(s):

Platelet Rich Plasma ◽

Case Series ◽

Bone Resection ◽

Osteonecrosis Of The Jaws ◽

Case Series Report ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet ◽

Series Report

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The use of autologous platelet-rich plasma in the treatment of intractable skin ulcer: A case series

Open Journal of Regenerative Medicine ◽

10.4236/ojrm.2012.13005 ◽

2012 ◽

Vol 01 (03) ◽

pp. 29-32 ◽

Cited By ~ 5

Author(s):

Natsuko Kakudo ◽

Satoshi Kushida ◽

Tsunetaka Ogura ◽

Tomoya Hara ◽

Kenji Suzuki ◽

...

Keyword(s):

Platelet Rich Plasma ◽

Case Series ◽

Skin Ulcer ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet

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Effect of autologous platelet-rich plasma in the promotion of healing of chronic ulcers

International Surgery Journal ◽

10.18203/2349-2902.isj20175484 ◽

2017 ◽

Vol 5 (1) ◽

pp. 15 ◽

Cited By ~ 3

Author(s):

Mohamed M. Raslan ◽

Nader M. Milad ◽

Ahmed Abd AlAziz

Keyword(s):

Platelet Rich Plasma ◽

Case Series ◽

Cost Effective ◽

Complete Healing ◽

Major Advance ◽

Average Decrease ◽

Chronic Ulcers ◽

Autologous Platelet Rich Plasma ◽

The Mean ◽

Autologous Platelet

Background: Chronic ulcers are a big health problem worldwide. Having a great impact at personal, social and professional levels. The use of autologous Platelet Rich Plasma (PRP) is a major advance in the treatment of these ulcers as an easy and cost-effective method. Platelets provide numerous growth factors enhancing tissue healing. The aim of this study was to evaluate the safety and efficacy of autologous platelet-rich plasma as a treatment of chronic non-healing ulcers.Methods: Autologous PRP was prepared from whole blood by centrifugation and activated by 10% calcium chloride. Twenty-Four (24) patients with non-healing ulcers of different etiologies, whom they met our inclusion criteria, were treated with PRP injected every two weeks locally into their wounds until healing. The ulcer dimensions were measured every week. The follow-up period was 12 weeks after healing.Results: The mean age of the study population 41±21 years. Complete healing was achieved in all patients. The mean rate of healing (average decrease in ulcer dimensions) was 0.48 cm/week. The rate of healing was greater at the week following injection. The mean time for healing was 6.11 weeks.Conclusions: Author witnessed the useful effects of PRP application on enhancing wound healing. The results from our case series showed that PRP is a safe and effective treatment for the promotion of healing chronic ulcers. Further research and controlled, randomized prospective clinical trials on larger patient population are important to validate our results.

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Case series of patients with chronic foot ulcers treated with autologous platelet-rich plasma

The Journal of Dermatology ◽

10.1111/1346-8138.12777 ◽

2015 ◽

Vol 42 (3) ◽

pp. 288-295 ◽

Cited By ~ 9

Author(s):

Rie R. Yotsu ◽

Shotaro Hagiwara ◽

Hitoshi Okochi ◽

Takeshi Tamaki

Keyword(s):

Platelet Rich Plasma ◽

Case Series ◽

Foot Ulcers ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet

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CONTAMINATED PROBLEMATIC SKIN WOUNDS IN DIABETIC PATIENTS TREATED WITH AUTOLOGOUS PLATELET-RICH PLASMA (PRP): A case series study

Journal of IMAB - Annual Proceeding (Scientific Papers) ◽

10.5272/jimab.2016221.1067 ◽

2016 ◽

Vol 22 (1) ◽

pp. 1067-1071 ◽

Cited By ~ 2

Author(s):

Tsvetan Sokolov ◽

◽

Boyan Valentinov ◽

Jordan Andonov ◽

Sevdalin Angelov ◽

...

Keyword(s):

Platelet Rich Plasma ◽

Case Series ◽

Diabetic Patients ◽

Skin Wounds ◽

Case Series Study ◽

Autologous Platelet Rich Plasma ◽

Series Study ◽

Autologous Platelet

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Glenoid Labral Tear: follow up case series on ultrasound guided autologous platelet rich plasma in conjunction with a progressive rehabilitation program

F1000Research ◽

10.12688/f1000research.1-68.v1 ◽

2012 ◽

Vol 1 ◽

pp. 68 ◽

Cited By ~ 3

Author(s):

Robert Vander Kraats ◽

Arockia Doss

Keyword(s):

Glenohumeral Joint ◽

Platelet Rich Plasma ◽

Case Series ◽

Rehabilitation Program ◽

Labral Tear ◽

Work Activities ◽

Labral Tears ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet

Background: Labral tears commonly occur in both the general and sporting population, often leading to significant pain and dysfunction. Patients often engage in progressive rehabilitative programs, and surgical intervention may be required in severe cases. Autologous platelet rich plasma (PRP) injections have been growing in popularity in musculoskeletal medicine as an alternative to corticosteroid injections. This paper looks at the effectiveness of PRP injections in glenoid labral lesions.Methods: The clinical and radiological findings are presented for two patients who have been treated with autologous PRP into the glenohumeral joint adjacent to the labral tear, in conjunction with a progressive rehabilitative program. Follow up occurred at 18 months and 13 months, respectively.Results: Both subjects tolerated the PRP injection well with no adverse effects, and were compliant with their rehabilitative programs. On initial presentation, pain on the visual analogue scale (VAS) was 7/10 and 6/10 and at follow up it was reported as 0/10. Both subjects have now returned to normal sporting and work activities.Conclusions: The findings from this case series suggest that PRP in conjunction with appropriate rehabilitation can assist in the clinical recovery of glenoid labral tears. Further research is required with greater sample numbers and improved methodological parameters.

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