Evaluation of Beta Cell Dysfunction by Mixed Meal Tolerance Test and Oral L-arginine in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

2009 ◽  
Vol 117 (10) ◽  
pp. 573-576 ◽  
Author(s):  
M. Ozbek ◽  
M. Erdogan ◽  
M. Karadeniz ◽  
S. Cetinkalp ◽  
A. G. Ozgen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Tolerance Test ◽  
Beta Cell Dysfunction ◽  
Newly Diagnosed ◽  
Mixed Meal ◽  
Meal Tolerance Test ◽  
Cell Dysfunction ◽  
Mixed Meal Tolerance Test

scholarly journals Evaluation of second phase insulin secretion with simple surrogates derived from the mixed meal tolerance test in patients with type 2 diabetes

2013 ◽  
Vol 60 (9) ◽  
pp. 1077-1084 ◽  
Author(s):  
Wei-Cheng Lian ◽  
Jiunn-Diann Lin ◽  
Jin-Biou Chang ◽  
Chun-Hsien Hsu ◽  
Chun Pei ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Tolerance Test ◽  
Second Phase ◽  
Mixed Meal ◽  
Meal Tolerance Test ◽  
Mixed Meal Tolerance Test

scholarly journals Comparison of consumption behavior and appetite sensations among patients with type 2 diabetes mellitus after bariatric surgery

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3090 ◽  
Author(s):  
Chun Yeh ◽  
Hsien-Hao Huang ◽  
Shu-Chun Chen ◽  
Tung-Fang Chen ◽  
Kong-Han Ser ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Tolerance Test ◽  
Mixed Meal ◽  
C Peptide ◽  
Meal Tolerance Test ◽  
Mixed Meal Tolerance Test ◽  
One Year ◽  
Desire To Eat

Background The promising postsurgical weight loss and remission of type 2 diabetes (T2D) from bariatric surgery can be attributed to modified eating physiology after surgical procedures. We sought to investigate the changes in the parameters of consumption behaviors and appetite sensations induced by a mixed meal tolerance test, and to correlate these alterations with age, body mass index, C-peptide levels, and duration of T2D 1 year after bariatric surgery. Methods A total of 16 obese patients with T2D who underwent mini-gastric bypass (GB) and 16 patients who underwent sleeve gastrectomy (SG) were enrolled in this study and evaluated using a mixed meal tolerance test one year after surgery. A visual analogue scale was used for scoring appetite sensation at different time points. The area under the curve (AUC) and the incremental or decremental AUC (ΔAUC) were compared between the two groups. Results One year after surgery, a decreasing trend in the consumption time was observed in the GB group compared to the SG group, while the duration of T2D before surgery was negatively correlated with the post-operative consumed time in those after GB. Patients who underwent GB had significantly higher fasting scores for fullness and desire to eat, higher AUC0′–180′ of scores for desire to eat, as well as more effective post-meal suppression of hunger and desire to eat compared with those undergoing SG one year after surgery. Post-operative C-peptide levels were negatively correlated with ΔAUC0′–180′ for hunger and ΔAUC0′–180′ for desire to eat in the GB group, while negatively correlated with ΔAUC0′–180′ for fullness in the SG group. Discussion Patients with T2D after either GB or SG exhibit distinct nutrient-induced consumption behaviors and appetite sensations post-operatively, which may account for the differential effects on weight loss and glycemic control after different surgery.

scholarly journals Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242360
Author(s):  
Morgan Obura ◽  
Joline W. J. Beulens ◽  
Roderick Slieker ◽  
Anitra D. M. Koopman ◽  
Trynke Hoekstra ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Tolerance Test ◽  
Diabetes Research ◽  
Mixed Meal ◽  
Meal Tolerance Test ◽  
Metabolic Traits ◽  
Direct Study ◽  
Mixed Meal Tolerance Test ◽  
Glucose Curve

Aim Subclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine the association between subgroups based on their glucose curves during a five-point mixed-meal tolerance test (MMT) and metabolic traits at baseline and glycaemic deterioration in individuals with T2D. Methods The study included 787 individuals with newly diagnosed T2D from the Diabetes Research on Patient Stratification (IMI-DIRECT) Study. Latent class trajectory analysis (LCTA) was used to identify distinct glucose curve subgroups during a five-point MMT. Using general linear models, these subgroups were associated with metabolic traits at baseline and after 18 months of follow up, adjusted for potential confounders. Results At baseline, we identified three glucose curve subgroups, labelled in order of increasing glucose peak levels as subgroup 1–3. Individuals in subgroup 2 and 3 were more likely to have higher levels of HbA1c, triglycerides and BMI at baseline, compared to those in subgroup 1. At 18 months (n = 651), the beta coefficients (95% CI) for change in HbA1c (mmol/mol) increased across subgroups with 0.37 (-0.18–1.92) for subgroup 2 and 1.88 (-0.08–3.85) for subgroup 3, relative to subgroup 1. The same trend was observed for change in levels of triglycerides and fasting glucose. Conclusions Different glycaemic profiles with different metabolic traits and different degrees of subsequent glycaemic deterioration can be identified using data from a frequently sampled mixed-meal tolerance test in individuals with T2D. Subgroups with the highest peaks had greater metabolic risk.

The Arg121Trp variant in PAX4 gene is associated with beta-cell dysfunction in Japanese subjects with type 2 diabetes mellitus

Metabolism ◽  
2006 ◽  
Vol 55 (2) ◽  
pp. 213-216 ◽  
Author(s):  
Yoshiharu Tokuyama ◽  
Kana Matsui ◽  
Toshiharu Ishizuka ◽  
Toru Egashira ◽  
Azuma Kanatsuka
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Beta Cell ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction ◽  
Japanese Subjects
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