A new model of synergistic effects of alcohol and high-fat diet on hepatic injury

2010 ◽  
Vol 48 (01) ◽  
Author(s):  
E Gäbele ◽  
K Dostert ◽  
C Dorn ◽  
C Hellerbrand
Keyword(s):  
High Fat Diet ◽  
Hepatic Injury ◽  
Synergistic Effects ◽  
High Fat ◽  
New Model

scholarly journals High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis

2020 ◽  
Vol 319 (5) ◽  
pp. G626-G635
Author(s):  
Xue Chen ◽  
George K. Acquaah-Mensah ◽  
Krista L. Denning ◽  
Jonathan M. Peterson ◽  
Kesheng Wang ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Lipid Droplets ◽  
Liver Inflammation ◽  
High Fat ◽  
New Model

PPARα is upregulated in cyp2a5−/− mice, but HFD-induced steatosis is still deteriorated. PPARα abrogation makes cyp2a5−/− mice more sensitive to HFD-induced steatosis, liver inflammation, and fibrosis, suggesting that PPARα upregulation in cyp2a5−/− mice is a compensation response. HFD-induced liver inflammation, fibrosis, and nitrotyrosine formation in pparα−/−/cyp2a5−/− mice are all within clusters of lipid droplets, and lipid droplets are all within CYP2E1-positive area.

Selenium-enriched Bifidobacterium longum protected alcohol and high fat diet induced hepatic injury in mice

2020 ◽  
Vol 18 (3) ◽  
pp. 169-177
Author(s):  
Hong-Wei YI ◽  
Xiao-Xiao ZHU ◽  
Xiao-Li HUANG ◽  
Yu-Zhu LAI ◽  
Yue TANG
Keyword(s):  
High Fat Diet ◽  
Hepatic Injury ◽  
Bifidobacterium Longum ◽  
High Fat

scholarly journals The Characterization of High-Fat Diet and Multiple Low-Dose Streptozotocin Induced Type 2 Diabetes Rat Model

2008 ◽  
Vol 2008 ◽  
pp. 1-9 ◽  
Author(s):  
Ming Zhang ◽  
Xiao-Yan Lv ◽  
Jing Li ◽  
Zhi-Gang Xu ◽  
Li Chen
Keyword(s):  
Type 2 Diabetes ◽  
Animal Model ◽  
High Fat Diet ◽  
Low Dose ◽  
Tolerance Test ◽  
Male Rats ◽  
High Fat ◽  
New Model ◽  
Injection Group

Aim. Based on the previously established method, we developed a better and stable animal model of type 2 diabetes mellitus by high-fat diet combined with multiple low-dose STZ injections. Meanwhile, this new model was used to evaluate the antidiabetic effect of berberine.Method. Wistar male rats fed with regular chow for 4 weeks received vehicle (control groups), rats fed with high-fat diet for 4 weeks received different amounts of STZ once or twice by intraperitoneal injection (diabetic model groups), and diabetic rats were treated with berberine (100 mg/kg, berberine treatment group). Intraperitoneal glucose tolerance test and insulin tolerance test were carried out. Moreover, fasting blood glucose, fasting insulin, total cholesterol, and triglyceride were measured to evaluate the dynamic blood sugar and lipid metabolism.Result. The highest successful rate (100%) was observed in rats treated with a single injection of 45 mg/kg STZ, but the plasma insulin level of this particular group was significantly decreased, and ISI has no difference compared to control group. The successful rate of 30 mg/kg STZ twice injection group was significantly high (85%) and the rats in this group presented a typical characteristic of T2DM as insulin resistance, hyperglycemia, and blood lipid disorder. All these symptoms observed in the 30 mg/kg STZ twice injection group were recovered by the treatment of berberine.Conclusion. Together, these results indicated that high-fat diet combined with multiple low doses of STZ (30 mg/kg at weekly intervals for 2 weeks) proved to be a better way for developing a stable animal model of type 2 diabetes, and this new model may be suitable for pharmaceutical screening.

High-fat diet stimulates the gut pathogenic microbiota and maintains hepatic injury in antibiotic-treated rats

2018 ◽  
Vol 64 (1) ◽  
pp. 103 ◽  
Author(s):  
Sooad Al-Daihan ◽  
Abir Ben Bacha ◽  
Abeer M Al-Dbass ◽  
Mona Awad Alonazi ◽  
Ramesa Shafi Bhat
Keyword(s):  
High Fat Diet ◽  
Hepatic Injury ◽  
High Fat

scholarly journals Metabolaid® Combination of Lemon Verbena and Hibiscus Flower Extract Prevents High-Fat Diet-Induced Obesity through AMP-Activated Protein Kinase Activation

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1204 ◽  
Author(s):  
Young-Sil Lee ◽  
Won-Kyung Yang ◽  
Hwa Kim ◽  
Bokkee Min ◽  
Nuria Caturla ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Synergistic Effects ◽  
Liver Weight ◽  
Acid Oxidation ◽  
High Fat ◽  
Related Factors ◽  
Lippia Citriodora ◽  
Glucose Levels ◽  
Treatment Of Obesity ◽  
Lemon Verbena

Lemon verbena (Lippia citriodora) has been used as a food spice, cosmetic, and in traditional medicine formulations to treat asthma and diabetes in South America and Southern Europe. Hibiscus flower (Hibiscus sabdariffa L.) is used in traditional Chinese medicine in the form of a tea to treat hypertension and inflammation. In the present study, we examined the synergistic effects of a formula of Metabolaid® (MetA), a combination of lemon verbena and hibiscus-flower extracts, on obesity and its complications in high-fat-diet (HFD)-induced obese mice. The results showed that MetA decreased body weight, white adipose tissue (WAT), and liver weight. Additionally, serum and hepatic lipid profiles, glucose levels, glucose tolerance, and cold-induced thermogenesis were significantly improved. Appetite-regulating hormones adiponectin and leptin were significantly increased and decreased, respectively, while the inflammatory-related factors tumor necrosis factor (TNF)-α and interleukin (IL)-6 were downregulated by MetA. Adipogenesis-activating gene expression was decreased, while increased thermogenesis-inducing genes were upregulated in the WAT, correlating with increased phosphorylation of AMPK and fatty-acid oxidation in the liver. Taken together, these results suggest that MetA decreased obesity and its complications in HFD mice. Therefore, this formula may be a candidate for the prevention and treatment of obesity and its complications.

Synergistic effects of the capsaicinoid nonivamide and rosuvastatin on obesity‐related endothelial dysfunction in rat fed a high‐fat diet

2019 ◽  
Vol 33 (7) ◽  
pp. 1815-1826 ◽  
Author(s):  
Sivanan Sivasinprasasn ◽  
Naruemon Wikan ◽  
Jiraporn Tocharus ◽  
Rungusa Pantan ◽  
Waraluck Chaichompoo ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
High Fat Diet ◽  
Synergistic Effects ◽  
High Fat
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