p8 is a novel intracellular mediator of pancreatic beta cell protection that preserves insulin secretory function during inflammatory stress in vivo

2013 ◽  
Vol 8 (S 01) ◽  
Author(s):  
AE Mehana ◽  
I Pilz ◽  
B Dufner ◽  
C Jäger ◽  
S Sojka ◽  
...  
Keyword(s):  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Secretory Function ◽  
Cell Protection ◽  
Inflammatory Stress ◽  
Beta Cell Protection

scholarly journals Pancreatic beta cell protection/regeneration with phytotherapy

2015 ◽  
Vol 51 (1) ◽  
pp. 1-16 ◽  
Author(s):  
Azar Hosseini ◽  
Reza Shafiee-Nick ◽  
Ahmad Ghorbani
Keyword(s):  
Beta Cell ◽  
Late Onset ◽  
Pancreatic Beta Cell ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Cell Protection ◽  
Cell Degeneration ◽  
Number Of Patients ◽  
Insulin Dependent ◽  
Beta Cell Protection

Although currently available drugs are useful in controlling early onset complications of diabetes, serious late onset complications appear in a large number of patients. Considering the physiopathology of diabetes, preventing beta cell degeneration and stimulating the endogenous regeneration of islets will be essential approaches for the treatment of insulin-dependent diabetes mellitus. The current review focused on phytochemicals, the antidiabetic effect of which has been proved by pancreatic beta cell protection/regeneration. Among the hundreds of plants that have been investigated for diabetes, a small fraction has shown the regenerative property and was described in this paper. Processes of pancreatic beta cell degeneration and regeneration were described. Also, the proposed mechanisms for the protective/regenerative effects of such phytochemicals and their potential side effects were discussed.

scholarly journals Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes

2020 ◽  
Vol 2 (9) ◽  
pp. 934-945 ◽  
Author(s):  
Erica P. Cai ◽  
Yuki Ishikawa ◽  
Wei Zhang ◽  
Nayara C. Leite ◽  
Jian Li ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Cell Protection ◽  
Crispr Screen ◽  
Beta Cell Protection ◽  
Genome Scale

42-OR: Hub Cells Orchestrate 3-Dimensional Pancreatic Beta-Cell Ca2+ Dynamics In Vivo

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 42-OR
Author(s):  
VICTORIA SALEM ◽  
LUIS F. DELGADILLO SILVA ◽  
KINGA SUBA ◽  
ALDARA MARTIN ALONSO ◽  
WHEI-CHANG KIM ◽  
...  
Keyword(s):  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
3 Dimensional

scholarly journals Peroxisome proliferator-activated receptor α-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity

FEBS Journal ◽  
2007 ◽  
Vol 274 (23) ◽  
pp. 6094-6105 ◽  
Author(s):  
Karine Hellemans ◽  
Karen Kerckhofs ◽  
Jean-Claude Hannaert ◽  
Geert Martens ◽  
Paul Van Veldhoven ◽  
...  
Keyword(s):  
Beta Cell ◽  
Retinoid X Receptor ◽  
Peroxisome Proliferator ◽  
Cell Protection ◽  
Peroxisome Proliferator Activated Receptor ◽  
Receptor Agonists ◽  
Beta Cell Protection

scholarly journals Vasopressin receptors in islets enhance glucose tolerance, pancreatic beta-cell secretory function, proliferation and survival

Biochimie ◽  
2019 ◽  
Vol 158 ◽  
pp. 191-198 ◽  
Author(s):  
Shruti Mohan ◽  
R. Charlotte Moffett ◽  
Keith G. Thomas ◽  
Nigel Irwin ◽  
Peter R. Flatt
Keyword(s):  
Glucose Tolerance ◽  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Secretory Function ◽  
Vasopressin Receptors
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