Vermistatin Derivatives with α-Glucosidase Inhibitory Activity from the Mangrove Endophytic Fungus Penicillium sp. HN29-3B1

Two new diphenyl ethers (1 and 2) and four new phenolic bisabolane sesquiterpenoids (3–6), together with five known related derivatives, were isolated from the culture of the endophytic fungus Aspergillus flavus QQSG-3 obtained from a fresh branch of Kandelia obobata, which was collected from Huizhou city in the province of Guangdong, China. The structures of compounds 1–6 were determined by analyzing NMR and HRESIMS data. The absolute configurations of 5 and 6 were assigned by comparing their experimental ECD spectra with those reported for similar compounds in the literature. All isolates were evaluated for their α-glucosidase inhibitory activity, of which compounds 3, 5, 10, and 11 showed strong inhibitory effects with IC50 values in the range of 1.5–4.5 μM.

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Secondary Metabolites with α-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus Talaromyces sp. CY-3

Marine Drugs ◽

10.3390/md19090492 ◽

2021 ◽

Vol 19 (9) ◽

pp. 492

Author(s):

Wencong Yang ◽

Qi Tan ◽

Yihao Yin ◽

Yan Chen ◽

Yi Zhang ◽

...

Keyword(s):

Secondary Metabolites ◽

13C Nmr ◽

Inhibitory Activity ◽

Endophytic Fungus ◽

Spectroscopic Data ◽

Positive Control ◽

Mangrove Endophytic Fungus ◽

Chemical Hydrolysis ◽

Ic50 Value ◽

New Compounds

Eight new compounds, including two sambutoxin derivatives (1–2), two highly oxygenated cyclopentenones (7–8), four highly oxygenated cyclohexenones (9–12), together with four known sambutoxin derivatives (3–6), were isolated from semimangrove endophytic fungus Talaromyces sp. CY-3, under the guidance of molecular networking. The structures of new isolates were elucidated by analysis of detailed spectroscopic data, ECD spectra, chemical hydrolysis, 13C NMR calculation, and DP4+ analysis. In bioassays, compounds 1–5 displayed better α-glucosidase inhibitory activity than the positive control 1-deoxynojirimycin (IC50 = 80.8 ± 0.3 μM), and the IC50 value was in the range of 12.6 ± 0.9 to 57.3 ± 1.3 μM.

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Polyketide Derivatives, Guhypoxylonols A–D from a Mangrove Endophytic Fungus Aspergillus sp. GXNU-Y45 That Inhibit Nitric Oxide Production

Marine Drugs ◽

10.3390/md20010005 ◽

2021 ◽

Vol 20 (1) ◽

pp. 5

Author(s):

Xiaoya Qin ◽

Jiguo Huang ◽

Dexiong Zhou ◽

Wenxiu Zhang ◽

Yanjun Zhang ◽

...

Keyword(s):

Nitric Oxide ◽

Inhibitory Activity ◽

Endophytic Fungus ◽

Spectroscopic Data ◽

Inflammatory Activity ◽

Nitric Oxide Production ◽

Oxide Production ◽

Mangrove Endophytic Fungus ◽

Ic50 Values ◽

Aspergillus Sp

Four undescribed compounds, guhypoxylonols A (1), B (2), C (3), and D (4), were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-Y45, together with seven previously reported metabolites. The structures of 1–4 were elucidated based on analysis of HRESIMS and NMR spectroscopic data. The absolute configurations of the stereogenic carbons in 1–3 were established through a combination of spectroscopic data and electronic circular dichroism (ECD). Compounds 1–11 were evaluated for their anti-inflammatory activity. Compounds 1, 3, 4, and 6 showed an inhibitory activity against the production of nitric oxide (NO), with the IC50 values of 14.42 ± 0.11, 18.03 ± 0.14, 16.66 ± 0.21, and 21.05 ± 0.13 μM, respectively.

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Secondary Metabolites from the Mangrove Endophytic Fungus Penicillium sp. (SBE-8)

Natural Product Communications ◽

10.1177/1934578x0900401108 ◽

2009 ◽

Vol 4 (11) ◽

pp. 1934578X0900401 ◽

Cited By ~ 1

Author(s):

Zhiyong Guo ◽

Fan Cheng ◽

Kun Zou ◽

Junzhi Wang ◽

Zhigang She ◽

...

Keyword(s):

Secondary Metabolites ◽

Cell Lines ◽

Endophytic Fungus ◽

Spectroscopic Methods ◽

Penicillium Sp ◽

Mtt Method ◽

Mangrove Endophytic Fungus

A new metabolite, 7-hydroxyjanthinone (1), was isolated from the mangrove endophytic fungus Penicillium sp. (SBE-8), together with two known compounds, janthinone (2) and citrinin (3). The structures of these compounds were identified by spectroscopic methods. Compounds 1 and 2 showed no cytotoxicity against KB and KBv cell lines when tested by the MTT method, but compound 3 was weakly active.

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