A Short Contemporary History of Disseminated Intravascular Coagulation

2014 ◽  
Vol 40 (08) ◽  
pp. 874-880 ◽  
Author(s):  
Tom van der Poll ◽  
Marcel Levi
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Contemporary History ◽  
Intravascular Coagulation ◽  
History Of

scholarly journals Disseminated Intravascular Coagulation and Malignancy: A Case Report and Literature Review

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Sumit Sohal ◽  
Akhilesh Thakur ◽  
Aleena Zia ◽  
Mina Sous ◽  
Daniela Trelles
Keyword(s):  
Atrial Fibrillation ◽  
Pulmonary Embolism ◽  
Cardiac Arrest ◽  
Disseminated Intravascular Coagulation ◽  
Limb Ischemia ◽  
Symptomatic Treatment ◽  
Malignant Cells ◽  
Intravascular Coagulation ◽  
Fluid Analysis ◽  
History Of

Disseminated Intravascular Coagulation (DIC) is a disorder of coagulation which is commonly seen as a complication of infections, traumas, obstetric diseases, and cancers especially hematological and rarely solid cancers. DIC may rarely be the presenting feature of an undiagnosed malignancy. It may present in the form of different phenotypes which makes its diagnosis difficult and leads to high mortality. The treatment comprises supportive, symptomatic treatment and removal of the underlying source. Here, we present a patient with history of being on warfarin for atrial fibrillation and other comorbidities who presented with elevated INR of 6.3 and increasing dyspnea on exertion. Over the course of her stay, her platelet counts started dropping with a concurrent decrease in fibrinogen levels. She eventually developed pulmonary embolism, followed by stroke and limb ischemia, which was indicative of the thrombotic phenotype of DIC. Her pleural fluid analysis showed huge burden of malignant cells in glandular pattern suggestive of adenocarcinoma and was started on heparin drip. However, the patient had cardiac arrest and expired on the same day of diagnosis.

scholarly journals Disseminated intravascular coagulation in an under-recognised zoonotic infection

2017 ◽  
Vol 16 (3) ◽  
pp. 138-141
Author(s):  
Sarah Lawrence ◽  
◽  
Andrew Claxton ◽  
Mark Holland ◽  
Jack Hodd ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Disseminated Intravascular Coagulation ◽  
Platelet Transfusion ◽  
Purpura Fulminans ◽  
Blood Cultures ◽  
Organ Support ◽  
Zoonotic Infection ◽  
Intravascular Coagulation ◽  
Prompt Treatment ◽  
History Of

A 51 year old man presented with severe sepsis, disseminated intravascular coagulation (DIC) and multiorgan dysfunction after a 24 hour history of diarrhoea and malaise. Despite fluid resuscitation and receiving a platelet transfusion, freshfrozen plasma and intravenous broad-spectrum antibiotics, he remained anuric with a worsening metabolic acidosis. He was transferred to critical care for organ support including renal replacement therapy. He subsequently developed purpura fulminans. Blood cultures were positive for Captocytophaga carnimorsis, a gram-negative canine zoonosis that is an underdiagnosed cause of severe sepsis, for which DIC at presentation is characteristic. Treatment is with penicillins and fluoroquinolones. Identification of risk factors for unusual organisms and recognition of DIC allowing prompt treatment is critical for the acute physician.

Disseminated Intravascular Coagulation With Trauma: Treatment With Exchange Transfusion

PEDIATRICS ◽  
1979 ◽  
Vol 63 (2) ◽  
pp. 337-339
Author(s):  
Ashok P. Sarnaik ◽  
Kenneth D. Stringer ◽  
Patrick F. Jewell ◽  
Sharada A. Sarnaik ◽  
Y. Ravindranath
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Exchange Transfusion ◽  
Hypovolemic Shock ◽  
Volume Overload ◽  
Trauma Treatment ◽  
Severe Bleeding ◽  
Clotting Factors ◽  
Traumatic Injuries ◽  
Intravascular Coagulation ◽  
History Of

Disseminated intravascular coagulation (DIC) may complicate hypovolemic shock secondary to trauma.1 Treatment with heparin in such cases is contraindicated because of the risk of bleeding at the site of trauma. Replacement therapy with clotting factors and platelets alone may be inadequate2 or result in volume overload in the presence of compromised renal function. We describe here a patient with multiple intraabdominal traumatic injuries whose severe bleeding diathesis secondary to DIC was successfully treated with exchange transfusion. CASE REPORT A 10-month-old black boy weighing 10 kg was brought to Children's Hospital of Michigan, Detroit with a history of grunting for three hours and "not feeling well" for three weeks.

Severe Acquired Protein C Deficiency in Purpura Fulminans Associated With Disseminated Intravascular Coagulation: Treatment With Protein C Concentrate

PEDIATRICS ◽  
1993 ◽  
Vol 91 (2) ◽  
pp. 418-422
Author(s):  
WILLIAM T. GERSON ◽  
JOSEPH D. DICKERMAN ◽  
EDWIN G. BOVILL ◽  
ELIZABETH GOLDEN
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Protein C ◽  
Purpura Fulminans ◽  
Protein S ◽  
Clinical Settings ◽  
Protein C Deficiency ◽  
Intravascular Coagulation ◽  
Hemorrhagic Necrosis ◽  
Protein C Concentrate ◽  
History Of

Purpura fulminans (PF) defines an acute, often lethal syndrome of disseminated intravascular coagulation (DIC) with rapidly progressive hemorrhagic necrosis of the skin due to dermal vascular thrombosis.1-7 It is indicative of a severe disturbance in hemostasis now recognized to involve the protein C system in many cases.1,2,5,8-12 Purpura fulminans is usually seen in three clinical settings: (1) in the newborn period as a manifestation of homozygous protein C deficiency, or rarely protein S deficiency13,14; (2) in individuals with acute, severe viral or bacterial infection where an acquired deficiency in protein C activity is documented1-3,5-8,10,12,15; and (3) as a rare, postinfectious syndrome with a history of an antecedent" preparatory disease," most commonly a viral or bacterial illness involving the skin (eg, varicella or scarlet fever), with the sudden development, during an otherwise unremarkable convalescence, of progressive purpura and necrosis.3-5,7,10,12

scholarly journals Assessment of clinical parameters among patients with snake poison induced coagulopathy

2018 ◽  
Vol 5 (6) ◽  
pp. 1374
Author(s):  
Hariprasad S. ◽  
Neha Sukhani
Keyword(s):  
Hospital Stay ◽  
Disseminated Intravascular Coagulation ◽  
Fresh Frozen Plasma ◽  
Snake Bite ◽  
Systemic Complications ◽  
Intravascular Coagulation ◽  
Fresh Frozen ◽  
Life Threatening ◽  
History Of ◽  
Prolonged Hospital

Background: Snakes are poikilothermic carnivorous reptiles that have evolved the venomous apparatus for the purpose of procurement of food. Snake bite can result in local and systemic complications. Major systemic complications include acute renal failure, neurologic abnormalities requiring ventilator support and disseminated intravascular coagulation. Disseminated intravascular coagulation can result in serious life-threatening systemic complications like haemorrhage, infarction and even death if the treatment is delayed. The present study was undertaken to study the clinical profile of the snake bite patients who develop coagulopathy and to study the role of coagulation markers to evaluate the morbidity and mortality of snake bite victims.Methods: Hundred patients consecutively admitted with history of snakebite were studied. Patients who have developed local signs of envenomation due to snake bite were included in the study group. The coagulation profile was assessed by doing blood investigations.Results: In this study, patients who developed coagulopathy had prolonged hospital stay and requirement of more blood products transfusion causing increased morbidity. 43 patients (35.8%) had platelets less than 1 lakh and approximately hospitalized for 26 days sand INR was more than 1.5 in 112 patients (93.3%) and hospitalized for 22 days and they received fresh frozen plasma. The survival rate in this study was 86% followed by 13.3% deaths.Conclusions: Use of clinical and laboratory parameter evaluation needed to identify the coagulopathy very early to reduce the hospital stay and mortality.

Disseminated intravascular coagulation associated with ventriculoperitoneal shunt surgery

2010 ◽  
Vol 5 (3) ◽  
pp. 306-309 ◽  
Author(s):  
James L. Frazier ◽  
G. Steven Bova ◽  
Kathryn Jockovic ◽  
Elizabeth A. Hunt ◽  
Benjamin Lee ◽  
...  
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Cardiopulmonary Arrest ◽  
Shunt Revision ◽  
Neurosurgical Procedures ◽  
Laboratory Studies ◽  
Excessive Bleeding ◽  
Head Ct ◽  
Intravascular Coagulation ◽  
History Of ◽  
Complication Of Surgery

Disseminated intravascular coagulation (DIC) as a complication of surgery for ventriculoperitoneal (VP) shunts is extremely rare, and only one case has been documented in the literature. The authors present the case of a 9-year-old girl with shunted hydrocephalus who presented with a 3-day history of headaches and vomiting. A head CT showed enlarged ventricles compared with baseline. An emergent VP shunt revision was performed, during which an obstructed proximal catheter was found. Immediately after extubation, the patient became apneic and progressed to cardiopulmonary arrest. A breathing tube was reinserted followed by resuscitation attempts that led to extracorporeal membrane oxygenation. Soon after reintubation, bloody drainage was noted in the endotracheal tube, and subsequent laboratory studies were consistent with DIC. The patient died on postoperative Day 1, and autopsy findings confirmed DIC. Note that DIC is a recognized complication of trauma, particularly with brain injury, but it is rare with neurosurgical procedures. Disseminated intravascular coagulation should be considered if excessive bleeding occurs after any brain insult.

On The Possibility of an Autonomous History of Modern Southeast Asia

1961 ◽  
Vol 2 (2) ◽  
pp. 73-105 ◽  
Author(s):  
John R. W. Small
Keyword(s):  
Southeast Asia ◽  
Contemporary History ◽  
The Past ◽  
History Of

It is generally accepted that history is an element of culture and the historian a member of society, thus, in Croce's aphorism, that the only true history is contemporary history. It follows from this that when there occur great changes in the contemporary scene, there must also be great changes in historiography, that the vision not merely of the present but also of the past must change.

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