NT4X-167; Novel N-terminal Aβ specific antibody, prevents in vitro and in vivo toxicity of highly toxic Aβ4-42 species

2015 ◽  
Vol 48 (06) ◽  
Author(s):  
G Antonios ◽  
H Borgers ◽  
T Pilot ◽  
V Pena ◽  
T Bayer
Keyword(s):  
Specific Antibody ◽  
In Vivo Toxicity

Comparison of Specific Antibody, D-Phe-Pro-Arg-CH2Cl and Aprotinin for Prevention of In Vitro Effects of Recombinant Tissue-Type Plasminogen Activator on Haemostasis Parameters

1987 ◽  
Vol 58 (03) ◽  
pp. 921-926 ◽  
Author(s):  
E Seifried ◽  
P Tanswell
Keyword(s):  
Specific Antibody ◽  
Plasma Concentrations ◽  
Fibrinolytic Therapy ◽  
Tissue Type ◽  
Control Value ◽  
Type Plasminogen Activator ◽  
In Vitro Effects ◽  
Fibrinolytic Parameters

SummaryIn vitro, concentration-dependent effects of rt-PA on a range of coagulation and fibrinolytic assays in thawed plasma samples were investigated. In absence of a fibrinolytic inhibitor, 2 μg rt-PA/ml blood (3.4 μg/ml plasma) caused prolongation of clotting time assays and decreases of plasminogen (to 44% of the control value), fibrinogen (to 27%), α2-antiplasmin (to 5%), FV (to 67%), FVIII (to 41%) and FXIII (to 16%).Of three inhibitors tested, a specific polyclonal anti-rt-PA antibody prevented interferences in all fibrinolytic and most clotting assays. D-Phe-Pro-Arg-CH2Cl (PPACK) enabled correct assays of fibrinogen and fibrinolytic parameters but interfered with coagulometric assays dependent on endogenous thrombin generation. Aprotinin was suitable only for a restricted range of both assay types.Most in vitro effects were observed only with rt-PA plasma concentrations in excess of therapeutic values. Nevertheless it is concluded that for clinical application, collection of blood samples on either specific antibody or PPACK is essential for a correct assessment of in vivo effects of rt-PA on the haemostatic system in patients undergoing fibrinolytic therapy.

Mixed Micelles as Nano Polymer Therapeutics of Docetaxel: Increased In vitro Cytotoxicity and Decreased In vivo Toxicity

2018 ◽  
Vol 15 (4) ◽  
pp. 564-575 ◽  
Author(s):  
Arehalli S. Manjappa ◽  
Popat S. Kumbhar ◽  
Prajakta S. Khopade ◽  
Ajit B. Patil ◽  
John I. Disouza
Keyword(s):  
Mixed Micelles ◽  
In Vitro Cytotoxicity ◽  
Polymer Therapeutics ◽  
In Vivo Toxicity

Toxico-metabolomics study of a deep eutectic solvent comprising choline chloride and urea suggests in vivo toxicity involving oxidative stress and ammonia stress

2021 ◽  
Vol 23 (3) ◽  
pp. 1300-1311 ◽  
Author(s):  
Dasom Jung ◽  
Jae Back Jung ◽  
Seulgi Kang ◽  
Ke Li ◽  
Inseon Hwang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
In Vivo Toxicity ◽  
Metabolomics Study ◽  
Ammonia Stress

The in vitro and in vivo studies suggest that choline chloride-based deep eutectic solvents may not be considered as pure, safe mixtures even if they consist of safe compounds.

In vitro and in vivo toxicity of 2′,3′-dideoxycytidine in mice

1992 ◽  
Vol 85 (2-3) ◽  
pp. 255-263 ◽  
Author(s):  
Luigia Rossi ◽  
Giorgio Brandi ◽  
Giuditta F. Schiavano ◽  
Laura Chiarantini ◽  
Amedeo Albano ◽  
...  
Keyword(s):  
In Vivo Toxicity

Assessing the in vitro and in vivo toxicity of ultrafine carbon black to mouse liver

2019 ◽  
Vol 655 ◽  
pp. 1334-1341 ◽  
Author(s):  
Rui Zhang ◽  
Xun Zhang ◽  
Sichen Gao ◽  
Rutao Liu
Keyword(s):  
Carbon Black ◽  
Mouse Liver ◽  
In Vivo Toxicity

Heteroleptic mononuclear compounds of ruthenium(ii): synthesis, structural analyses, in vitro antitumor activity and in vivo toxicity on zebrafish embryos

2016 ◽  
Vol 45 (47) ◽  
pp. 19127-19140 ◽  
Author(s):  
O. A. Lenis-Rojas ◽  
A. R. Fernandes ◽  
C. Roma-Rodrigues ◽  
P. V. Baptista ◽  
F. Marques ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Dna Interaction ◽  
Zebrafish Embryos ◽  
In Vivo Toxicity ◽  
Mononuclear Compounds

Cytotoxic properties, DNA-interaction and in vivo toxicity were evaluated in Ru(ii) compounds.

Successful Transplantation of the Thymus in Nezelof's Syndrome

PEDIATRICS ◽  
1978 ◽  
Vol 61 (4) ◽  
pp. 619-624
Author(s):  
William T. Shearer ◽  
H. James Wedner ◽  
Donald B. Strominger ◽  
John Kissane ◽  
Richard Hong
Keyword(s):  
Specific Antibody ◽  
Peripheral Blood ◽  
Clinical Condition ◽  
Cell Function ◽  
Antibody Activity ◽  
Surface Immunoglobulin ◽  
Successful Transplantation ◽  
Immunoglobulin Levels

A 6-month-old girl with congenital thymic dysplasia or Nezelof's syndrome (lack of T cell function and normal levels of immunoglobulins) was given a transplant of a human thymus gland from a 14-week-old fetus and is surviving 36 months after transplant. Her clinical condition is the principal index of the success of the transplant since most in vitro and in vivo data indicate a full immunologic restoration has not been achieved. However, the number of E-rosettes in the peripheral blood has increased, the number of surface immunoglobulin-bearing cells has decreased, but there is little improvement in mitogen responsitivity. Immunoglobulin levels have increased with age, but there is no demonstrable specific antibody activity. Nevertheless, she remains free of infection, living in an unprotected environment.

In Vitro and In Vivo Toxicity and Pharmacokinetics of Silver Nanoparticles

2016 ◽  
pp. 1554-1567
Author(s):  
Meghan E. Samberg ◽  
Zhoumeng Lin ◽  
Nancy A. Monteiro-Riviere
Keyword(s):  
Silver Nanoparticles ◽  
In Vivo Toxicity
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