A Highly Efficient Method for the Bromination of Alkenes, Alkynes and Ketones Using Dimethyl Sulfoxide and Oxalyl Bromide

Synthesis ◽  
2018 ◽  
Vol 50 (21) ◽  
pp. 4325-4335 ◽  
Author(s):  
Hongyu Tian ◽  
Baoguo Sun ◽  
Rui Ding ◽  
Jiaqi Li ◽  
Wenyi Jiao ◽  
...  
Keyword(s):  
Dimethyl Sulfoxide ◽  
Efficient Method ◽  
Low Cost ◽  
Reaction Times ◽  
Attractive Alternative ◽  
Mild Conditions ◽  
Highly Efficient

The pairing of DMSO and oxalyl bromide is reported as a highly efficient brominating reagent for various alkenes, alkynes and ketones. This bromination approach demonstrates remarkable advantages, such as mild conditions, low cost, short reaction times, provides excellent yields in most cases and represents a very attractive alternative for the preparation of dibromides and α-bromoketones.

Efficient Synthesis of 3,4-Disubstituted 7-Azaindoles Employing SEM as a Dual Protecting–Activating Group

Synlett ◽  
2019 ◽  
Vol 30 (20) ◽  
pp. 2273-2278 ◽  
Author(s):  
Piroska Gyárfás ◽  
János Gerencsér ◽  
Warren S. Wade ◽  
László Ürögdi ◽  
Zoltán Novák ◽  
...  
Keyword(s):  
Functional Groups ◽  
Efficient Method ◽  
Reaction Times ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Efficient Synthesis ◽  
Mild Conditions

An efficient method for nucleophilic aromatic substitution on 7-azaindoles has been developed. The reaction is facilitated by the unique dual influence of SEM as both protecting and activating group, permitting mild conditions and short reaction times that are compatible with sensitive functional groups. The method is suitable for the synthesis of a broad range of products, most notably ethers.

scholarly journals Synthesis of 1,2,3 triazole-linked benzimidazole through a copper-catalyzed click reaction

2019 ◽  
Vol 25 (1) ◽  
pp. 122-129
Author(s):  
Mohammad Bakherad ◽  
Ali Keivanloo ◽  
Amir H. Amin ◽  
Amir Farkhondeh
Keyword(s):  
Efficient Method ◽  
Click Reaction ◽  
Low Cost ◽  
Reaction Times ◽  
Cycloaddition Reactions

AbstractAn efficient method has been developed for the synthesis of 1,2,3 triazole-linked benzimidazole through a copper-catalyzed click reaction in ethanol at 50°C. A broad range of aromatic azides were successfully reacted with n-propynylated benzimidazole via copper-catalyzed azide-alkyne cycloaddition reactions in the absence of a ligand. This method offers many advantages including short reaction times, low cost, and simple purification procedures.

scholarly journals Highly Efficient and Facile Method for Synthesis of 2-Substituted Benzimidazoles via Reductive Cyclization of O-Nitroaniline and Aryl Aldehydes

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Hossein Naeimi ◽  
Nasrin Alishahi
Keyword(s):  
Room Temperature ◽  
Reaction Times ◽  
Starting Material ◽  
Reductive Cyclization ◽  
Aryl Aldehydes ◽  
Mild Conditions ◽  
Highly Efficient ◽  
Convenient Synthesis

A versatile and convenient synthesis of 2-substituted benzimidazoles, using o-nitroaniline as starting material with several aryl aldehydes, has been accomplished by using a small amount of a reluctant agent. The reaction was carried out under very mild conditions at room temperature. The yields obtained are very good in reasonably short reaction times.

scholarly journals A Low-Cost and Highly Efficient Method of Reducing Coolant Leakage for Direct Metal Printed Injection mold with Cooling Channels Using Optimum Heat Treatment Process Procedures

2021 ◽  
Author(s):  
Chil-Chyuan Kuo ◽  
Shao-Xuan Qiu ◽  
Xin-Yi Yang
Keyword(s):  
Heat Treatment ◽  
Injection Molding ◽  
Efficient Method ◽  
Low Cost ◽  
Injection Mold ◽  
Conformal Cooling ◽  
Cooling Channels ◽  
Highly Efficient ◽  
Optimum Heat ◽  
Optimum Heat Treatment

Abstract Metal additive manufacturing (MAM) provides lots of benefits and potentials in manufacturing molds or dies with sophisticated conformal cooling channels. It is known that the conformal cooling technology provides effective cooling to reduce cycle time for increasing productivity. Ordinarily, mold inserts fabricated by general printing procedures will result in coolant leakage in the injection molding process. The yield in the manufacturing of fully dense injection molding tools was limited to the very narrow working widow. In addition, high costs of fully dense injection mold fabricated by MAM constitute the major obstacle to its application in the mold or die industry. In general, the high cost of MAM is approximately 50-70% more expensive than conventional computer numerical control machining. In this study, a low-cost and highly efficient method of reducing coolant leakage for direct metal printed injection mold with cooling channels was proposed. This new method employs general process parameters to manufacture the green injection mold rapidly and then uses optimum heat treatment (HT) procedures to improve microstructure of the green injection mold. The results of this study revealed that optimum HT procedures can prevent coolant leakage and save manufacturing time of the injection mold fabricated by direct metal laser sintering. The evolution mechanisms of microstructure were investigated experimentally. The save in the injection mold manufacture time about 67% can be obtained.

Development of New Spindle Cooling Technology That Concentrates Cooling Near Front Bearing

2015 ◽  
Vol 9 (6) ◽  
pp. 698-706 ◽  
Author(s):  
Shoichi Morimura ◽  
Keyword(s):  
High Precision ◽  
Efficient Method ◽  
Low Cost ◽  
High Rigidity ◽  
Highly Efficient ◽  
Machining Center ◽  
Cooling Technology ◽  
Low Efficiency

A spindle cooling technology that directly cools the rotating spindle near the front bearing is effective in achieving a high-precision, high-rigidity spindle for a machining center. In conventional spindle cooling technologies, the entire spindle is cooled, which results in high cost and low efficiency. The writer developed a spindle cooling technology in which cooling is concentrated only in the necessary areas, and thus realized a low-cost, highly efficient method of cooling.

scholarly journals Solvent-Free Green and Efficient One-Pot Synthesis of Dihydropyrano[3,2-c]chromene Derivatives

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Shubha Jain ◽  
Deepika Rajguru ◽  
Balwant S. Keshwal ◽  
Aman D. Acharya
Keyword(s):  
Efficient Method ◽  
Present Method ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Reaction Conditions ◽  
One Pot ◽  
Highly Efficient ◽  
One Pot Synthesis

A rapid, clean, and highly efficient method for synthesis of dihydropyrano[3,2-c]chromene derivatives by one-pot, three-component condensation of aromatic aldehydes, malononitrile, and 4-hydroxycoumarin using DABCO as catalyst in solvent-free neat conditions is described. The present method has the advantages of mild reaction conditions, short reaction times, easy isolation of products, and excellent yields.

Dimethyl Sulfoxide-Accelerated Reductive Deamination of Aromatic Amines with T-BuONO in Tetrahydrofuran

2018 ◽  
Vol 42 (11) ◽  
pp. 579-583
Author(s):  
Lu Fang ◽  
Liang Qi ◽  
Longfei Ye ◽  
Zhentao Pan ◽  
Wenjun Luo ◽  
...  
Keyword(s):  
Dimethyl Sulfoxide ◽  
Efficient Method ◽  
Aromatic Amines ◽  
One Pot ◽  
Mild Conditions ◽  
Aryl Amines ◽  
Plausible Mechanism

An efficient method for the conversion of aryl amines into arenes by a one-pot reductive deamination has been achieved. It was found the reductive deamination using t-BuONO in tetrahydrofuran could be accelerated by dimethyl sulfoxide and provided the deamination products with good yields under mild conditions. A plausible mechanism is discussed.

scholarly journals Método de marcaje masivo de abejas Apis mellifera (Hymenoptera: Apidae) para estudios ecoetológicos

2013 ◽  
Vol 29 (1) ◽  
Author(s):  
Oscar Mikery-Pacheco ◽  
Erik Solórzano-Gordillo ◽  
Daniel Sánchez-Guillén
Keyword(s):  
Apis Mellifera ◽  
Efficient Method ◽  
Low Cost ◽  
Good Method ◽  
Flight Ability ◽  
Highly Efficient ◽  
Fluorescent Powder ◽  
Large Numbers ◽  
Pass Through ◽  
Liquid Paint

A device that uses fluorescent powder to automatically mark large numbers of honeybees provides a good method to distinguish focal colony foragers from foragers of other colonies. However, when humidity is high, the powder readily forms pellets that cannot pass through the mesh and marking is diminished. We present here an apparatus to mass-mark honeybees with liquid paint. We demonstrate that this low-cost device is a highly efficient method to mark honeybees and does not produce any observable mortality on test foragers or impairing flight ability.

Iodine-induced synthesis of sulfonate esters from sodium sulfinates and phenols under mild conditions

RSC Advances ◽  
2015 ◽  
Vol 5 (35) ◽  
pp. 27439-27442 ◽  
Author(s):  
Jian Gao ◽  
Xiaojun Pan ◽  
Juan Liu ◽  
Junyi Lai ◽  
Liming Chang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Efficient Method ◽  
Room Temperature ◽  
Metal Catalysts ◽  
Transition Metal Catalysts ◽  
Mild Conditions ◽  
Highly Efficient

A facile and highly efficient method for the synthesis of sulfonate esters mediated by iodine at room temperature has been developed, without transition metal catalysts and oxidants.

Copper-Catalyzed Highly Efficient Esterification of Aldehydes with N-Hydroxyphthalimide via Cross-Dehydrogenative Coupling in Water at Room Temperature

Synlett ◽  
2017 ◽  
Vol 28 (11) ◽  
pp. 1321-1326 ◽  
Author(s):  
Can Jin ◽  
Weike Su ◽  
Zhicheng Guo ◽  
Xinpeng Jiang ◽  
Jiadi Zhou ◽  
...  
Keyword(s):  
Reaction Time ◽  
Efficient Method ◽  
Room Temperature ◽  
Coupling Reaction ◽  
Short Reaction Time ◽  
Mild Conditions ◽  
Highly Efficient ◽  
Dehydrogenative Coupling ◽  
First Time

A copper-catalyzed cross-dehydrogenative coupling reaction between N-hydroxyphthalimide and aldehydes using PhI(OAc)2 as an oxidant is described. It is reported for the first time to synthesize NHPI esters in water, providing the corresponding NHPI esters in moderate to good yields. This facile and efficient method is eco-friendly and possesses the advantages of mild conditions, short reaction time, and broad substrate scope.

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