Copper-Catalyzed Highly Efficient Esterification of Aldehydes with N-Hydroxyphthalimide via Cross-Dehydrogenative Coupling in Water at Room Temperature

Synlett ◽  
2017 ◽  
Vol 28 (11) ◽  
pp. 1321-1326 ◽  
Author(s):  
Can Jin ◽  
Weike Su ◽  
Zhicheng Guo ◽  
Xinpeng Jiang ◽  
Jiadi Zhou ◽  
...  
Keyword(s):  
Reaction Time ◽  
Efficient Method ◽  
Room Temperature ◽  
Coupling Reaction ◽  
Short Reaction Time ◽  
Mild Conditions ◽  
Highly Efficient ◽  
Dehydrogenative Coupling ◽  
First Time

A copper-catalyzed cross-dehydrogenative coupling reaction between N-hydroxyphthalimide and aldehydes using PhI(OAc)2 as an oxidant is described. It is reported for the first time to synthesize NHPI esters in water, providing the corresponding NHPI esters in moderate to good yields. This facile and efficient method is eco-friendly and possesses the advantages of mild conditions, short reaction time, and broad substrate scope.

Efficient Copper-Catalyzed Synthesis of Substituted Pyrazoles at Room Temperature

Synlett ◽  
2018 ◽  
Vol 29 (20) ◽  
pp. 2689-2692 ◽  
Author(s):  
Haifeng Wang ◽  
Xiangli Sun ◽  
Shuangling Zhang ◽  
Guanglu Liu ◽  
Chunjie Wang ◽  
...  
Keyword(s):  
Reaction Time ◽  
Catalytic System ◽  
Efficient Method ◽  
Room Temperature ◽  
Copper Catalyst ◽  
Condensation Reaction ◽  
Reaction Conditions ◽  
Short Reaction Time ◽  
Acid Catalyzed ◽  
Substituted Pyrazoles

An efficient method for the synthesis of pyrazoles through a copper-catalyzed condensation reaction has been developed. The new catalytic system not only maintained a broad substrate scope but was also active under acid-free reaction conditions, overcoming the conventional requirement for an acid-catalyzed system. Furthermore, the copper catalyst enabled this reaction to be performed at room temperature and in a short reaction time.

scholarly journals Highly Efficient Recyclable Sol Gel Polymer Catalyzed One Pot Difunctionalization of Alkynes

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1879
Author(s):  
Justin Domena ◽  
Carlos Chong ◽  
Qiaxian Johnson ◽  
Bhanu Chauhan ◽  
Yalan Xing
Keyword(s):  
Reaction Time ◽  
Room Temperature ◽  
Functional Group ◽  
Sol Gel ◽  
One Pot ◽  
Short Reaction Time ◽  
Metal Free ◽  
Highly Efficient

Amino-bridged gel polymer P1 was discovered to catalyze alkyne halo-functionalization in excellent yields, regioselectivity, functional group compatibility, and recyclability. We have observed that both aromatic and aliphatic alkynes can be converted to α,α-dihalogenated ketones in the presence of polymer P1 under metal-free conditions at room temperature within a short reaction time.

Rapid and Efficient Coupling Reaction of Azo Dyes in a Continuous-Flow Microreactor

2012 ◽  
Vol 560-561 ◽  
pp. 516-520
Author(s):  
Wu Bin Yu ◽  
Ming Ming Zheng ◽  
Jian Rong Gao
Keyword(s):  
Reaction Time ◽  
Azo Dyes ◽  
Continuous Flow ◽  
Room Temperature ◽  
High Efficiency ◽  
Coupling Reaction ◽  
Reaction Conditions ◽  
Short Reaction Time ◽  
Flow Microreactor ◽  
Efficient Coupling

A convenient, rapid efficient method for the synthesis of azo dyes has been developed by coupling in a continuous-flow microreactor at room temperature. The advantage of this protocol is its continuousness, high efficiency and selectivity, short reaction time, and milder reaction conditions.

scholarly journals An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2501 ◽  
Author(s):  
Tarek S. Ibrahim ◽  
Israa A. Seliem ◽  
Siva S. Panda ◽  
Amany M. M. Al-Mahmoudy ◽  
Zakaria K. M. Abdel-Samii ◽  
...  
Keyword(s):  
Amino Acid ◽  
Reaction Time ◽  
Microwave Irradiation ◽  
Room Temperature ◽  
Efficient Synthesis ◽  
Short Reaction Time ◽  
Mild Conditions ◽  
Drug Conjugates ◽  
Cost Efficient ◽  
High Yields

A straightforward, mild and cost-efficient synthesis of various arylamides in water was accomplished using versatile benzotriazole chemistry. Acylation of various amines was achieved in water at room temperature as well as under microwave irradiation. The developed protocol unfolds the synthesis of amino acid aryl amides, drug conjugates and benzimidazoles. The environmentally friendly synthesis, short reaction time, simple workup, high yields, mild conditions and free of racemization are the key advantages of this protocol.

Chickpea Leaf Exudates: A Highly Efficient Natural Brønsted Acidic Medium for the Synthesis of Pyran-annulated Heterocycles

2021 ◽  
Vol 18 ◽  
Author(s):  
Snehali R. Mali ◽  
Sachinkumar K. Shinde ◽  
Bhagyashree M. Patil ◽  
Rupesh C. Patil ◽  
Suresh S. Patil
Keyword(s):  
Reaction Time ◽  
Acidic Medium ◽  
Room Temperature ◽  
Reaction Medium ◽  
One Pot ◽  
Short Reaction Time ◽  
Highly Efficient ◽  
Acid Type ◽  
Cyclocondensation Reaction ◽  
Reaction Media

: We reported Chickpea leaf exudates (CLE) as a Brønsted acid type naturally available biodegradable, ecofriendly and reusable reaction medium for highly efficient and facile one-pot synthesis of pyran annulated heterocyclic systems like 7-aryl-benzopyrano[4,3-b]benzopyran-6,8-diones, tetrahydrobenzo[b]pyran and dihydropyrano[c]chromenes scaffolds. The analogous products were obtained via tandem Knoevengel-Michael addition and cyclocondensation reaction in ethanol at room temperature with 90-96 % yields in a short reaction time. Moreover, the reaction media containing Bronsted acids can be easily recovered and reused upto five times with a slight decrease in product yields.

Iodine-induced synthesis of sulfonate esters from sodium sulfinates and phenols under mild conditions

RSC Advances ◽  
2015 ◽  
Vol 5 (35) ◽  
pp. 27439-27442 ◽  
Author(s):  
Jian Gao ◽  
Xiaojun Pan ◽  
Juan Liu ◽  
Junyi Lai ◽  
Liming Chang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Efficient Method ◽  
Room Temperature ◽  
Metal Catalysts ◽  
Transition Metal Catalysts ◽  
Mild Conditions ◽  
Highly Efficient

A facile and highly efficient method for the synthesis of sulfonate esters mediated by iodine at room temperature has been developed, without transition metal catalysts and oxidants.

Tyrosine-Selective Bioconjugation with Iminoxyl Radicals

2020 ◽  
Author(s):  
Katsuya Maruyama ◽  
Takashi Ishiyama ◽  
Yohei Seki ◽  
Kounosuke Oisaki ◽  
Motomu Kanai
Keyword(s):  
Reaction Time ◽  
Steric Hindrance ◽  
Room Temperature ◽  
Water Soluble ◽  
Light Irradiation ◽  
Sodium Ascorbate ◽  
Iminoxyl Radical ◽  
Short Reaction Time ◽  
Modified Peptides ◽  
The Stability

A novel Tyr-selective protein bioconjugation using the water-soluble persistent iminoxyl radical is described. The conjugation proceeded with high Tyr-selectivity and short reaction time under biocompatible conditions (room temperature in buffered media under air). The stability of the conjugates was tunable depending on the steric hindrance of iminoxyl. The presence of sodium ascorbate and/or light irradiation promoted traceless deconjugation, restoring the native Tyr structure. The method is applied to the synthesis of a protein-dye conjugate and further derivatization to azobenzene-modified peptides.

scholarly journals Eosin Y dye-based porous organic polymers for highly efficient heterogeneous photocatalytic dehydrogenative coupling reaction

RSC Advances ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 408-414 ◽  
Author(s):  
Chang-An Wang ◽  
Yan-Wei Li ◽  
Xue-Li Cheng ◽  
Jian-Ping Zhang ◽  
Yin-Feng Han
Keyword(s):  
Coupling Reaction ◽  
Eosin Y ◽  
Organic Polymers ◽  
Porous Organic Polymers ◽  
Bottom Up ◽  
Highly Efficient ◽  
Dehydrogenative Coupling ◽  
Highly Effective

Eosin Y dye has been successfully embedded into a nanoporous network EY-POPs through a bottom-up strategy. The polymers could be used as highly effective and reusable heterogeneous organo-photocatalyst for the dehydrogenative coupling reaction.

Immobilizing AgPd alloy on Vulcan XC-72 carbon: a novel catalyst for highly efficient hydrogen generation from formaldehyde aqueous solution

RSC Advances ◽  
2016 ◽  
Vol 6 (107) ◽  
pp. 105638-105643 ◽  
Author(s):  
Shutao Gao ◽  
Tao Feng ◽  
Qiuhua Wu ◽  
Cheng Feng ◽  
Ningzhao Shang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Room Temperature ◽  
Hydrogen Generation ◽  
Bimetallic Catalyst ◽  
Highly Efficient ◽  
Novel Catalyst ◽  
First Time

A novel bimetallic catalyst, AgPd nanoalloy supported on Vulcan XC-72 carbon (AgPd@C-72), has been successfully fabricated and used for catalyzing H2 generation from formaldehyde aqueous solution at room temperature for the first time.

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