Selective Protection of Secondary Alcohols by Using Formic Acid as a Mild and Efficient Deprotection Reagent for Primary tert-Butyldimethylsilyl Ethers

Synlett ◽  
2019 ◽  
Vol 30 (16) ◽  
pp. 1895-1898
Author(s):  
Krishna Sapkota ◽  
Faqing Huang
Keyword(s):  
Formic Acid ◽  
Environmentally Friendly ◽  
Hydroxyl Groups ◽  
Secondary Alcohols ◽  
Secondary Hydroxyl ◽  
Selective Protection ◽  
Environmentally Friendly Method

A mild, efficient, and environmentally friendly method for the selective protection of secondary hydroxyl groups is described. The method involves the protection of both primary and secondary hydroxyl groups as tert-butyldimethylsilyl (TBDMS) ethers and selective deprotection of the primary TBDMS group with formic acid in acetonitrile/water. The rates of desilylation of primary and secondary TBDMS ethers by different concentrations of formic acid are determined. Formic acid of 5–20% concentration is found to selectively deprotect primary TBDMS ethers while keeping more than 95% of their secondary counterparts intact.

scholarly journals Silver-Nanocellulose Composite Used as SERS Substrate for Detecting Carbendazim

Nanomaterials ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 355 ◽  
Author(s):  
Luqiang Huang ◽  
Changji Wu ◽  
Lijuan Xie ◽  
Xue Yuan ◽  
Xinyu Wei ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Surface Area ◽  
Trace Analysis ◽  
Ag Nanoparticles ◽  
Limit Of Detection ◽  
Environmentally Friendly ◽  
Hydroxyl Groups ◽  
Sers Substrate ◽  
Environmentally Friendly Method ◽  
Good Homogeneity

Nanocellulose is an abundant green resource that, owing to the larger surface area, length, and diameter of the fibers, can be used as a framework for loading Ag nanoparticles and serve as substrate for surface enhancement Raman scattering (SERS). These properties would cause the hydroxyl groups on the surface to adsorb the Ag ions and reduce them to Ag seed to form a load fulcrum. This paper presents a convenient and environmentally friendly method for the fabrication of silver-nanocellulose composites (NCF-Ag). A commonly used pesticide, carbendazim (CBZ), was used as a SERS probe to evaluate the properties of NCF-Ag. The results showed that NCF-Ag possesses good homogeneity, reproducibility, and stability. Additionally, CBZ was found to have a low limit of detection (LOD), i.e., 1.0 × 10−8 M, which indicates the possibility for trace analysis. Furthermore, it presents good linearity with R2 = 0.98 at 1007 and 1270 cm−1 in the range from 10−4~10−7 M CBZ.

A simple and environmentally friendly method for the synthesis of N-phenylanthranilic acid derivatives

2006 ◽  
Vol 2006 (5) ◽  
pp. 342-344 ◽  
Author(s):  
Hanakere R. Girisha ◽  
Gejjalagere R. Srinivasa ◽  
D. Channe Gowda
Keyword(s):  
Environmentally Friendly ◽  
Environmentally Friendly Method

Regioselectivity among six secondary hydroxyl groups: selective acylation of the least reactive hydroxyl groups of inositol

2012 ◽  
Vol 48 (18) ◽  
pp. 2448 ◽  
Author(s):  
Amol M. Vibhute ◽  
Adiyala Vidyasagar ◽  
Saritha Sarala ◽  
Kana M. Sureshan
Keyword(s):  
Hydroxyl Groups ◽  
Secondary Hydroxyl ◽  
Selective Acylation

A multifunctional and environmentally-friendly method to fabricate superhydrophilic and self-healing coatings for sustainable antifogging

2021 ◽  
Vol 409 ◽  
pp. 128228
Author(s):  
Xiaoqin Wang ◽  
Shuhui Li ◽  
Jianying Huang ◽  
Jiajun Mao ◽  
Yan Cheng ◽  
...  
Keyword(s):  
Environmentally Friendly ◽  
Self Healing ◽  
Environmentally Friendly Method

Direct Access to S-Heterocycles by Scandium(III) Triflate Catalyzed Cyclization of Aromatic Thiols and Diols

Synlett ◽  
2021 ◽  
Author(s):  
Maki Minakawa ◽  
Keisuke Minami ◽  
Yuya Sato
Keyword(s):  
Reaction Pathway ◽  
Environmentally Friendly ◽  
Direct Access ◽  
Aromatic Thiols ◽  
Thiophene Derivatives ◽  
Environmentally Friendly Method

AbstractA simple and environmentally friendly method to prepare S-heterocycles by cyclization of aromatic thiols and diols with H2O as a byproduct is described. The Sc(OTf)3-catalyzed dehydrative cyclizations of aromatic thiols and diols provided the corresponding thiopyran and thiophene derivatives. Control experiments were also performed to obtain insights into the reaction pathway

scholarly journals FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Stefany Fanelli ◽  
Alexander Zimmermann ◽  
Eliane Gandolpho Totóli ◽  
Hérida Regina Nunes Salgado
Keyword(s):  
Environmentally Friendly ◽  
Infrared Region ◽  
Potassium Bromide ◽  
Bactericidal Action ◽  
Practical Application ◽  
Mid Infrared ◽  
Brazilian Legislation ◽  
Ich Guidelines ◽  
Ftir Spectrophotometry ◽  
Environmentally Friendly Method

Amoxicillin is an antimicrobial agent that belongs to the penicillin compounds. Its bactericidal action causes a destruction of the cell wall of bacteria. It is widely used in clinical practice, and it belongs to the Brazilian National List of Essential Drugs (RENAME). In literature, there are some green analytical methods for the amoxicillin analysis; however, none of them is focused on its quantification in capsules. Therefore, the aim of this study was to validate an environmentally friendly analytical method for the analysis of this antimicrobial action in capsules, using spectrophotometry in the mid-infrared region. The analyses were performed in the spectral range of 1815–1736 cm−1, and the samples were analyzed as potassium bromide pellets. The method was validated according to the ICH guidelines and Brazilian legislation. Linearity, selectivity, precision, accuracy, and robustness were evaluated and showed adequate results for method validation, in a concentration range of 0.5–1.5 mg/pellet. Thus, it is concluded that the validated spectrophotometric method is able to quantify amoxicillin in capsules. In addition, it is a fast, economical, and environmentally friendly method, since it does not use organic solvents, and it can be used for quality control of routine analysis of this drug.

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