A simple and environmentally friendly method for the synthesis of N-phenylanthranilic acid derivatives

AbstractA simple and environmentally friendly method to prepare S-heterocycles by cyclization of aromatic thiols and diols with H2O as a byproduct is described. The Sc(OTf)3-catalyzed dehydrative cyclizations of aromatic thiols and diols provided the corresponding thiopyran and thiophene derivatives. Control experiments were also performed to obtain insights into the reaction pathway

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FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin

Journal of Chemistry ◽

10.1155/2018/3920810 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 5

Author(s):

Stefany Fanelli ◽

Alexander Zimmermann ◽

Eliane Gandolpho Totóli ◽

Hérida Regina Nunes Salgado

Keyword(s):

Environmentally Friendly ◽

Infrared Region ◽

Potassium Bromide ◽

Bactericidal Action ◽

Practical Application ◽

Mid Infrared ◽

Brazilian Legislation ◽

Ich Guidelines ◽

Ftir Spectrophotometry ◽

Environmentally Friendly Method

Amoxicillin is an antimicrobial agent that belongs to the penicillin compounds. Its bactericidal action causes a destruction of the cell wall of bacteria. It is widely used in clinical practice, and it belongs to the Brazilian National List of Essential Drugs (RENAME). In literature, there are some green analytical methods for the amoxicillin analysis; however, none of them is focused on its quantification in capsules. Therefore, the aim of this study was to validate an environmentally friendly analytical method for the analysis of this antimicrobial action in capsules, using spectrophotometry in the mid-infrared region. The analyses were performed in the spectral range of 1815–1736 cm−1, and the samples were analyzed as potassium bromide pellets. The method was validated according to the ICH guidelines and Brazilian legislation. Linearity, selectivity, precision, accuracy, and robustness were evaluated and showed adequate results for method validation, in a concentration range of 0.5–1.5 mg/pellet. Thus, it is concluded that the validated spectrophotometric method is able to quantify amoxicillin in capsules. In addition, it is a fast, economical, and environmentally friendly method, since it does not use organic solvents, and it can be used for quality control of routine analysis of this drug.

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Simple, rapid, and environmentally friendly method for the separation of isoflavones using ultra-high performance supercritical fluid chromatography

Journal of Separation Science ◽

10.1002/jssc.201601454 ◽

2017 ◽

Vol 40 (13) ◽

pp. 2827-2837 ◽

Cited By ~ 12

Author(s):

Wenjie Wu ◽

Yuan Zhang ◽

Hanqiu Wu ◽

Weie Zhou ◽

Yan Cheng ◽

...

Keyword(s):

Supercritical Fluid ◽

Supercritical Fluid Chromatography ◽

High Performance ◽

Environmentally Friendly ◽

Environmentally Friendly Method

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Environmentally Friendly Method of Production of Nanocomposites and Nanomembranes

High Velocity Microparticles in Space ◽

10.1007/978-3-030-04158-8_7 ◽

2019 ◽

pp. 231-297

Author(s):

Anatoly Belous ◽

Vitali Saladukha ◽

Siarhei Shvedau

Keyword(s):

Environmentally Friendly ◽

Method Of Production ◽

Environmentally Friendly Method

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Environmentally friendly method for regeneration of copper chloride acidic solutions used in etching of printed circuits

E3S Web of Conferences ◽

10.1051/e3sconf/20171801021 ◽

2017 ◽

Vol 18 ◽

pp. 01021

Author(s):

Dorota Kopyto ◽

Wit Baranek ◽

Zbigniew Myczkowski ◽

Katarzyna Leszczyńska-Sejda ◽

Michał Drzazga ◽

...

Keyword(s):

Control Systems ◽

Copper Chloride ◽

Environmentally Friendly ◽

Acidic Solutions ◽

Printed Circuits ◽

Innovative Method ◽

Reactor Construction ◽

New Type ◽

Oxygen Utilisation ◽

Environmentally Friendly Method

Etching of copper with acidic CuCl2 solution is a widely used chemical method in printed circuits production. During the process, the solution is enriched in Cu(I) ions, resulting in reduction and then loss of etching bath capacity. In order to ensure the required etching kinetics, the solution is regenerated by oxidation of Cu(I) to Cu(II). The industrially applied Cu(I) oxidants are, e.g.: Cl2, chlorates. Their application is expensive and associated with drawbacks related to health, safety and environmental hazards (e.g. Cl2 emission). In the result of long-standing cooperation between the IMN and MATUSEWICZ Budowa Maszyn, an innovative, original and environmentally friendly method of acidic solutions regeneration used during printed circuits etching was developed. A new-type reactor equipped with oxidation monitoring-control systems using oxygen or oxygen-enriched air was applied. The reactor construction enables to run the process with oxygen circulation in the reactor, ensures full oxygen utilisation in the regeneration process, achievement of the required performance and process rate, and eliminates expensive, hazardous and often toxic reagents. This is an innovative method, and since there are no analogous technologies currently known and used in Europe and worldwide, the presented method is technologically, economically and ecologically unrivalled.

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