Uptake of Labelled Tallysomycin by Solid Ehrlich Ascites Tumors in Mice

1983 ◽  
Vol 22 (03) ◽  
pp. 159-161
Author(s):  
M. Rembelska ◽  
B. Koniarek ◽  
J. Liniecki
Keyword(s):  
Normal Tissue ◽  
Skeletal Muscles ◽  
Ehrlich Ascites Tumor ◽  
Tissue Uptake ◽  
Ascites Tumor ◽  
Activity Distribution ◽  
Ehrlich Ascites ◽  
Ascites Tumors ◽  
Swiss Strain

Tumor and normal tissue uptake of 51Cror 57Co-labelled bleomycin (BLEO) and tallysomycin (TLM) was compared in female solid Ehrlich ascites tumor mice of Swiss strain. The complexes were administered intraperitoneally: 30-50 μ§ of each complex with an activity of 40-120 μCi. Activity distribution factors (ADF) and tumor/non-tumor ratios for blood, bone, skeletal muscles, kidneys and liver were determined. The ratios were generally higher for complexes labelled with 57Co than for the 51Cr-labelled ones; bleomycin appears equivalent or superior to tallysomycin.

Die Beeinflussung des Wachstums des Ehrlich-Ascites-Tumors der Maus durch native und mit ultraviolettem Licht bestrahlte heterologe Desoxyribonucleinsäure

1963 ◽  
Vol 18 (7) ◽  
pp. 523-525 ◽  
Author(s):  
Rudolf K. Zahn ◽  
Ekkehard Tiesler
Keyword(s):  
Tumor Growth ◽  
Uv Irradiation ◽  
Deoxyribonucleic Acid ◽  
Tumor Development ◽  
Ehrlich Ascites Tumor ◽  
Ascites Tumor ◽  
Ehrlich Ascites ◽  
Ascites Tumors ◽  
Deoxyribonuclease Activity

1. Deoxyribonuclease activity has been determined by viscosimetry in the serum of the Ehrlich Ascites in the mouse to be equivalent to 2,3 ± 0,7·10-6 g/ml of crystalline beef pancreas DNase.2. Injections of heterologous deoxyribonucleic acid into the Ehrlich Ascites tumor under specified conditions does not alter tumor development.3. The same DNA however becomes strongly inhibitory for tumor growth after UV irradiation.4. Possible implications are discussed.

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