PLATELET FIBRONECTIN LEVELS AS A MARKER FOR THE PROGRESSION OF DIABETIC RETINOPATHY

1987 ◽  
Author(s):  
P Custodi ◽  
G P Montecchio ◽  
C Bendotti ◽  
G Vandelli ◽  
M T Tenconi ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Type I Diabetes ◽  
Microvascular Complications ◽  
Microvascular Complication ◽  
Type I ◽  
Extreme Groups ◽  
Subendothelial Matrix ◽  
The Difference ◽  
Data Group

Aim of the study was to correlate fibronectin (Fn) and von Villebrand factor (vWf) levels measured in plasma and in platelets with the progression of diabetic retinopathy. Patients were classified in five groups reflecting the progression of this microvascular complication, on the basis of fluorangiographic findings (0 = no microangiopathy; 1= simple microangiopathy; 2= oedematous retinopathy; 3= ischaemic retinopathy; 4= ischaemic proliferative retinopathy). 43 patients were studied, 22 suffering from type I diabetes and 21 from type II diabetes, according to the classification of National Diabetes Data Group. Fn and vWf were measured in plasma and in platelet samples using an original double-sandwich microELISA method and expressed as micrograms/ml or as micrograms/10* platelets. Platelets were counted and solubilized with 0.5% Triton × 100. Bleeding time and platelet adhesion to glass beads were also evaluated on every patient. Intraplatelet Fn levels were reduced in retinopathies and correlate with the severity of the microvascular alteration, being the difference significant between the two extreme groups (p<0.05). vWf intraplatelet levels were also significantly lower in patients with severe microvascular complications (p<0.05). No significant differences were detected for plasma Fn and vWf levels in the 5 groups. Intraplatelet Fn and vWf levels may therefore be considered as markers of the severity of diabetic retinopathy. The leakage of Fn and vWf from activated platelet and the incorporation of these glycoproteins in the subendothelial matrix may be responsible for the worsening of this microvascular complication.

scholarly journals Immunogenetic characteristics of diabetic microangiopathies

1999 ◽  
Vol 45 (4) ◽  
pp. 8-9
Author(s):  
B. L. Rasovsky ◽  
T. I. Severina ◽  
L. G. Akhmedyanova
Keyword(s):  
Diabetic Retinopathy ◽  
Diabetic Nephropathy ◽  
Metabolic Control ◽  
Preventive Measures ◽  
Type I Diabetes ◽  
Individual Recognition ◽  
Microvascular Complications ◽  
Hla Antigens ◽  
Type I ◽  
Nonproliferative Diabetic Retinopathy

lmmunogenetic studies were carried out in 103 diabetics with type I condition (40 men and 63 women aged 37.1+3.2 years) with disease standing of 7.6±2>3 years. Nonproliferative diabetic retinopathy was detected in 78 (75.7%)) and staring diabetic nephropathy in 88(85.4%)). The incidence of DR4, DR8, and DQ2 antigens is increased and that of Cw6 and DQ1 antigens decreased in diabetic retinopathy. В16, DR3, DR4, and DQ3 antigens predominated in diabetic nephropathy, while Cw6 and DQ7antigens were rarely detected. DR4 and DQ3 were the most incident in the patients with a combination of diabetic retinopathy and diabetic nephropathy (67.2%o of all cases). There were no notable differences in the spectrum of HLA antigens in the groups with diabetic retinopathy and diabetic nephropathy, which agrees with the reno-retinal syndrome concept. Afunctional status-metric model of individual recognition of the diabetic reno-retinal syndrome is created. A special register of patients with type I diabetes carrying immunogenetic markers of diabetic microangiopathies is proposed to be created for more stringent metabolic control and early preventive measures aimed at delay of microvascular complications.

Genetic Markers in Early Diabetic Retinopathy of Adolescents With Type I Diabetes

1997 ◽  
Vol 11 (4) ◽  
pp. 203-207 ◽  
Author(s):  
Aura A.K. Falck ◽  
J.Mikael Knip ◽  
Jorma S. Ilonen ◽  
Leila T. Laatikainen
Keyword(s):  
Diabetic Retinopathy ◽  
Genetic Markers ◽  
Type I Diabetes ◽  
Type I

Clinical and functional approaches to comprehensive treatment of periodontal diseases in children with type I diabetes

2021 ◽  
Vol 26 (1) ◽  
pp. 9-19
Author(s):  
B. N. Davydov ◽  
D. A. Domenyuk ◽  
F. V. Samedov ◽  
S. V. Dmitrienko ◽  
A. V. Lepilin
Keyword(s):  
Type I Diabetes ◽  
Periodontal Diseases ◽  
Microvascular Complications ◽  
Comprehensive Treatment ◽  
Type I ◽  
Childhood All ◽  
Doppler Flowmetry ◽  
Age Related ◽  
Vascular Congestion ◽  
Magnetic Therapy

Relevance. The high prevalence of microvascular complications in children with type I diabetes mellitus (DM) has a serious impact on the quality of life and can result in a lower working capacity and early disability. The negative effect of the drug therapy, inability to fully comply with the acceptable age-related safety limits, specific metabolism and pharmacokinetic features in childhood – all these reveals the need to improve the patterns for comprehensive treatment of periodontal diseases in children with type I diabetes.The purpose was to explain the clinical and functional effectiveness of the combined enzyme and magnet & laser therapy in comprehensive treatment of the periodontal microcirculatory disorders in children suffering from type I diabetes. Materials and methods. The study involved 97 children diagnosed with type I diabetes, aged 12-17 y.o., with the present disease history from 6 months to 12 years. The microcirculation was assessed by laser Doppler flowmetry. Microcirculatory disorder correction was performed by a local exposure to a running low-frequency pulsed magnetic field combined with enzyme therapy. Results. The dynamic magnetic therapy has proven to increase the effectiveness of capillary blood flow in children with early signs of vascular congestion and hyperemia, while Phlogenzym, a polyenzyme formulation, needs to be added in cases of vascular congestion and ischemia. Conclusion. The effectiveness of physiotherapeutic and pharmacological effect of Phlogenzym along with the dynamic magnetic therapy shows that it can be recommended as an alternative to the conventional anti-inflammatory, antiseptic and antibiotic therapy during the pre-surgical treatment and post-surgical follow-up care as well as at the maintenance phase, both in an inpatient and outpatient setting.

Influence of Long-term Insulin Infusion Pump Treatment of Type I Diabetes on Diabetic Retinopathy

Ophthalmology ◽  
1982 ◽  
Vol 89 (7) ◽  
pp. 735-747 ◽  
Author(s):  
James E. Puklin ◽  
William V. Tamborlane ◽  
Philip Felig ◽  
Myron Genel ◽  
Robert S. Sherwin
Keyword(s):  
Diabetic Retinopathy ◽  
Insulin Infusion ◽  
Type I Diabetes ◽  
Infusion Pump ◽  
Type I

Autoimmunity and the endocrine system

2013 ◽  
pp. 167-186
Author(s):  
Gavin P Spickett
Keyword(s):  
Thyroid Disease ◽  
Type I Diabetes ◽  
Endocrine System ◽  
Primary Hypothyroidism ◽  
Type I ◽  
Autoimmune Thyroid ◽  
System P ◽  
Insulin Dependent ◽  
P Type

Classification of autoimmune thyroid disease Graves’ disease Hashimoto’s thyroiditis Subacute thyroiditis syndromes Primary hypothyroidism and sporadic goitre Thyroid disease and other symptoms Classification of diabetes mellitus Type I diabetes (insulin-dependent) Immunological complications of insulin therapy Crow–Fukase syndrome (POEMS syndrome; Takatsuki syndrome) Classification of adrenal insufficiency...

scholarly journals Comparison of Serum Apolipoprotein Levels of Diabetic Children and Healthy Children with or without Diabetic Parents

Cholesterol ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Mohammad Hashemi ◽  
Mohammad Saadat ◽  
Mohaddeseh Behjati ◽  
Roya Kelishadi
Keyword(s):  
Type I Diabetes ◽  
Serum Levels ◽  
High Plasma ◽  
Apolipoprotein A1 ◽  
Type I ◽  
Healthy Children ◽  
Diabetic Children ◽  
The Mean ◽  
The Difference ◽  
Lipids And Lipoproteins

Introduction. The association of diabetes and atherosclerosis with disorders of lipids and lipoproteins, notably high apolipoprotein B (apoB) and low apolipoprotein A1(apoA1) is well established. Because of the beginning of the atherosclerosis' process from early life, in this study, the plasma levels of apoA1 and apoB were compared in diabetic children with type I diabetes mellitus(DM), healthy children with diabetic parents (HDPs),and healthy children with nondiabetic parents (HNDPs). Methods. This case-control study was conducted among 90 children aged 9–18 years. Serum levels of apoA and apoB were compared among 30 diabetic children (DM), 30 healthy children with diabetic parents (HDPs), and 30 healthy children with nondiabetic parents (HNDP). Results. The mean serum apoA1 was higher in DM (153±69 mg/dL) followed by HNDPs (138±58 mg/dL) and HDPs (128±56 mg/dl), but the difference was not statistically significant. The mean apoB value in HNDPs was significantly lower than DM and HDPs (90±21 mg/dL versus 127±47 and 128±38 mg/dL, P<0.05, respectively). The mean apoB levels in DM (127±47 mg/dl) and HDP (128±38 mg/dL) were not statistically significantly different (P>0.05). Conclusions. Diabetic children and healthy children with diabetic parent(s) are at higher risk of dyslipidemia and atherosclerosis. Thus for primordial and primary prevention of atherosclerosis, we suggest screening these children for low plasma apoA1 and high plasma apoB levels.

Bilateral pulmonary hydathidic cyst with fatal outlet: a case report

2021 ◽  
Vol 5 (1) ◽  
pp. 11-13
Author(s):  
Junior Julio Zapata Choque
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Case Report ◽  
Type I Diabetes ◽  
Signs And Symptoms ◽  
Mass Effect ◽  
Type I ◽  
Insulin Dependent ◽  
Dependent Patient ◽  
Patient Diabetes

Hydatidosis is a parasitic zoonosis caused by Echinococcus Granulosus, its life cycle includes dogs, sheep and others; liver involvement is the most frequent (65%-75%), followed by the lung (10%-25%), in Peru the pulmonary location is 60%. Its signs and symptoms are produced by the mass effect, its superinfection or anaphylactic reactions secondary to its rupture. We present the case of a 24-year-old insulin-dependent patient with type I diabetes mellitus, hypertension and diabetic retinopathy with bilateral pulmonary hydatidosis. A cystectomy was performed without complications and a lobectomy that was complicated with admission to the ICU until the death of the patient. Diabetes mellitus causes a state of immunosuppression which caused the advanced state of the patient's parasitosis, as well as being related to multiple intra- and postoperative complications and even leading to the death of the patient.

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