Genetic Markers in Early Diabetic Retinopathy of Adolescents With Type I Diabetes

1997 ◽  
Vol 11 (4) ◽  
pp. 203-207 ◽  
Author(s):  
Aura A.K. Falck ◽  
J.Mikael Knip ◽  
Jorma S. Ilonen ◽  
Leila T. Laatikainen
Keyword(s):  
Diabetic Retinopathy ◽  
Genetic Markers ◽  
Type I Diabetes ◽  
Type I

PLATELET FIBRONECTIN LEVELS AS A MARKER FOR THE PROGRESSION OF DIABETIC RETINOPATHY

1987 ◽  
Author(s):  
P Custodi ◽  
G P Montecchio ◽  
C Bendotti ◽  
G Vandelli ◽  
M T Tenconi ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Type I Diabetes ◽  
Microvascular Complications ◽  
Microvascular Complication ◽  
Type I ◽  
Extreme Groups ◽  
Subendothelial Matrix ◽  
The Difference ◽  
Data Group

Aim of the study was to correlate fibronectin (Fn) and von Villebrand factor (vWf) levels measured in plasma and in platelets with the progression of diabetic retinopathy. Patients were classified in five groups reflecting the progression of this microvascular complication, on the basis of fluorangiographic findings (0 = no microangiopathy; 1= simple microangiopathy; 2= oedematous retinopathy; 3= ischaemic retinopathy; 4= ischaemic proliferative retinopathy). 43 patients were studied, 22 suffering from type I diabetes and 21 from type II diabetes, according to the classification of National Diabetes Data Group. Fn and vWf were measured in plasma and in platelet samples using an original double-sandwich microELISA method and expressed as micrograms/ml or as micrograms/10* platelets. Platelets were counted and solubilized with 0.5% Triton × 100. Bleeding time and platelet adhesion to glass beads were also evaluated on every patient. Intraplatelet Fn levels were reduced in retinopathies and correlate with the severity of the microvascular alteration, being the difference significant between the two extreme groups (p<0.05). vWf intraplatelet levels were also significantly lower in patients with severe microvascular complications (p<0.05). No significant differences were detected for plasma Fn and vWf levels in the 5 groups. Intraplatelet Fn and vWf levels may therefore be considered as markers of the severity of diabetic retinopathy. The leakage of Fn and vWf from activated platelet and the incorporation of these glycoproteins in the subendothelial matrix may be responsible for the worsening of this microvascular complication.

Influence of Long-term Insulin Infusion Pump Treatment of Type I Diabetes on Diabetic Retinopathy

Ophthalmology ◽  
1982 ◽  
Vol 89 (7) ◽  
pp. 735-747 ◽  
Author(s):  
James E. Puklin ◽  
William V. Tamborlane ◽  
Philip Felig ◽  
Myron Genel ◽  
Robert S. Sherwin
Keyword(s):  
Diabetic Retinopathy ◽  
Insulin Infusion ◽  
Type I Diabetes ◽  
Infusion Pump ◽  
Type I

Bilateral pulmonary hydathidic cyst with fatal outlet: a case report

2021 ◽  
Vol 5 (1) ◽  
pp. 11-13
Author(s):  
Junior Julio Zapata Choque
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Case Report ◽  
Type I Diabetes ◽  
Signs And Symptoms ◽  
Mass Effect ◽  
Type I ◽  
Insulin Dependent ◽  
Dependent Patient ◽  
Patient Diabetes

Hydatidosis is a parasitic zoonosis caused by Echinococcus Granulosus, its life cycle includes dogs, sheep and others; liver involvement is the most frequent (65%-75%), followed by the lung (10%-25%), in Peru the pulmonary location is 60%. Its signs and symptoms are produced by the mass effect, its superinfection or anaphylactic reactions secondary to its rupture. We present the case of a 24-year-old insulin-dependent patient with type I diabetes mellitus, hypertension and diabetic retinopathy with bilateral pulmonary hydatidosis. A cystectomy was performed without complications and a lobectomy that was complicated with admission to the ICU until the death of the patient. Diabetes mellitus causes a state of immunosuppression which caused the advanced state of the patient's parasitosis, as well as being related to multiple intra- and postoperative complications and even leading to the death of the patient.

scholarly journals The Benefits of Flavonoids in Diabetic Retinopathy

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3169 ◽  
Author(s):  
Ana L. Matos ◽  
Diogo F. Bruno ◽  
António F. Ambrósio ◽  
Paulo F. Santos
Keyword(s):  
Diabetic Retinopathy ◽  
Fruits And Vegetables ◽  
Type I Diabetes ◽  
Developed Countries ◽  
Type I ◽  
Cellular Effects ◽  
Diabetic Retina ◽  
Working Age ◽  
Type Ii Diabetics ◽  
Almost All

Diabetic retinopathy (DR), one of the most common complications of diabetes, is the leading cause of legal blindness among adults of working age in developed countries. After 20 years of diabetes, almost all patients suffering from type I diabetes mellitus and about 60% of type II diabetics have DR. Several studies have tried to identify drugs and therapies to treat DR though little attention has been given to flavonoids, one type of polyphenols, which can be found in high levels mainly in fruits and vegetables, but also in other foods such as grains, cocoa, green tea or even in red wine. Flavonoids have anti-inflammatory, antioxidant and antiviral effects. Since it is known that diabetes induces oxidative stress and inflammation in the retina leading to neuronal death in the early stages of the disease, the use of these compounds can prove to be beneficial in the prevention or treatment of DR. In this review, we summarize the molecular and cellular effects of flavonoids in the diabetic retina.

HLA-DQB1 Subtypes Predict Diabetic Retinopathy in Patients with Type I Diabetes Mellitus

2009 ◽  
Vol 19 (4) ◽  
pp. 638-645 ◽  
Author(s):  
Mohammad Hassan Khazaee ◽  
Jalil Tavakol Afshari ◽  
Bahram Khazaee ◽  
Ramin Daneshvar ◽  
Javad Akbarzadeh ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Type I Diabetes ◽  
Disease Onset ◽  
Human Leukocyte ◽  
Hla Typing ◽  
Diabetic Patients ◽  
Type I ◽  
Study Type ◽  
Type 1 Diabetic Patients

Purpose To investigate if diabetic patients without diabetic retinopathy despite long disease duration have different human leukocyte antigen (HLA) status vs those with an early onset of retinopathy. Methods Retrospective, nonrandomized, masked comparative study. Type 1 diabetic patients with a disease onset before age 30 were recruited to the study. The study population consisted of two groups of diabetic patients: those with normal retinopathy course (retinopathy developed during the first 20 years of diabetes onset) (23 patients) and those with postponed retinopathy (no obvious retinopathy in spite of passing 20 years of diabetes) (19 patients). These groups were matched with regard to level of glycemic control, blood pressure, and lipid profile. A group of 23 healthy patients served as controls. HLA-DQB1 typing of blood samples was done using a polymerase chain reaction with sequence-specific primer (PCR-SSP) method. Results HLA-DQB1*0201/HLA-DQB1*0501 and HLA-DQB1*0201/HLA-DQB1*0504 haplotypes were more common among type 1 diabetic patients with normal retinopathy course than those with postponed retinopathy (26.1% vs 0.0%; p=0.019). HLA-DQB1*0301 and HLA-DQB1*0304 were less common among those diabetic patients with normal retinopathy course than those with a postponed retinopathy (63.2% vs 34.8%; p=0.067). Conclusions Some haplotypes seem to predispose diabetic patients to diabetic retinopathy. HLA typing may be beneficial for predicting the prognosis of diabetic retinopathy in younger diabetic patients.

scholarly journals 2221 Diabetic retinopathy in type I diabetes. Incidence and risk factors in 10-years study

1995 ◽  
Vol 35 ◽  
pp. S95
Author(s):  
G. Lodato ◽  
M. Lauricella ◽  
M. Anastasi ◽  
F. Ponte
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Type I Diabetes ◽  
Diabetes Incidence ◽  
Type I

scholarly journals Immunogenetic characteristics of diabetic microangiopathies

1999 ◽  
Vol 45 (4) ◽  
pp. 8-9
Author(s):  
B. L. Rasovsky ◽  
T. I. Severina ◽  
L. G. Akhmedyanova
Keyword(s):  
Diabetic Retinopathy ◽  
Diabetic Nephropathy ◽  
Metabolic Control ◽  
Preventive Measures ◽  
Type I Diabetes ◽  
Individual Recognition ◽  
Microvascular Complications ◽  
Hla Antigens ◽  
Type I ◽  
Nonproliferative Diabetic Retinopathy

lmmunogenetic studies were carried out in 103 diabetics with type I condition (40 men and 63 women aged 37.1+3.2 years) with disease standing of 7.6±2>3 years. Nonproliferative diabetic retinopathy was detected in 78 (75.7%)) and staring diabetic nephropathy in 88(85.4%)). The incidence of DR4, DR8, and DQ2 antigens is increased and that of Cw6 and DQ1 antigens decreased in diabetic retinopathy. В16, DR3, DR4, and DQ3 antigens predominated in diabetic nephropathy, while Cw6 and DQ7antigens were rarely detected. DR4 and DQ3 were the most incident in the patients with a combination of diabetic retinopathy and diabetic nephropathy (67.2%o of all cases). There were no notable differences in the spectrum of HLA antigens in the groups with diabetic retinopathy and diabetic nephropathy, which agrees with the reno-retinal syndrome concept. Afunctional status-metric model of individual recognition of the diabetic reno-retinal syndrome is created. A special register of patients with type I diabetes carrying immunogenetic markers of diabetic microangiopathies is proposed to be created for more stringent metabolic control and early preventive measures aimed at delay of microvascular complications.

Sign in / Sign up

Export Citation Format

Share Document