Clinical and functional approaches to comprehensive treatment of periodontal diseases in children with type I diabetes

2021 ◽  
Vol 26 (1) ◽  
pp. 9-19
Author(s):  
B. N. Davydov ◽  
D. A. Domenyuk ◽  
F. V. Samedov ◽  
S. V. Dmitrienko ◽  
A. V. Lepilin
Keyword(s):  
Type I Diabetes ◽  
Periodontal Diseases ◽  
Microvascular Complications ◽  
Comprehensive Treatment ◽  
Type I ◽  
Childhood All ◽  
Doppler Flowmetry ◽  
Age Related ◽  
Vascular Congestion ◽  
Magnetic Therapy

Relevance. The high prevalence of microvascular complications in children with type I diabetes mellitus (DM) has a serious impact on the quality of life and can result in a lower working capacity and early disability. The negative effect of the drug therapy, inability to fully comply with the acceptable age-related safety limits, specific metabolism and pharmacokinetic features in childhood – all these reveals the need to improve the patterns for comprehensive treatment of periodontal diseases in children with type I diabetes.The purpose was to explain the clinical and functional effectiveness of the combined enzyme and magnet & laser therapy in comprehensive treatment of the periodontal microcirculatory disorders in children suffering from type I diabetes. Materials and methods. The study involved 97 children diagnosed with type I diabetes, aged 12-17 y.o., with the present disease history from 6 months to 12 years. The microcirculation was assessed by laser Doppler flowmetry. Microcirculatory disorder correction was performed by a local exposure to a running low-frequency pulsed magnetic field combined with enzyme therapy. Results. The dynamic magnetic therapy has proven to increase the effectiveness of capillary blood flow in children with early signs of vascular congestion and hyperemia, while Phlogenzym, a polyenzyme formulation, needs to be added in cases of vascular congestion and ischemia. Conclusion. The effectiveness of physiotherapeutic and pharmacological effect of Phlogenzym along with the dynamic magnetic therapy shows that it can be recommended as an alternative to the conventional anti-inflammatory, antiseptic and antibiotic therapy during the pre-surgical treatment and post-surgical follow-up care as well as at the maintenance phase, both in an inpatient and outpatient setting.

scholarly journals Clinical and cytological characteristic of a condition of the oral cavity at pregnant women with various types of a diabetes mellitus

2016 ◽  
Vol 65 (6) ◽  
pp. 45-51 ◽  
Author(s):  
Ludmila Yu Orekhova ◽  
Anna A Aleksandrova ◽  
Ludmila A Aleksandrova ◽  
Ramila S Musaeva ◽  
Gulrukhsor Kh Tolibova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Oral Cavity ◽  
Pregnant Women ◽  
Inflammatory Diseases ◽  
Type I Diabetes ◽  
Periodontal Diseases ◽  
Diabetes Mellitus Type 1 ◽  
Control Group ◽  
Type I ◽  
Liquid Based Cytology

Introduction. More and more researches dedicated to the communication of diseases of the oral cavity of pregnant women with diabetes. It is proved that the intensity of caries and inflammatory periodontal diseases (gingivitis and periodontitis) increase significantly during pregnancy, while the presence of comorbidities, such as diabetes, increase these indexes.Aim. The aim of the work was to study the dental status of pregnant women with diabetes.Materials and methods. The study compared women with gestational diabetes mellitus, type 1 diabetes, and type 2 diabetes, to a control group of pregnant women without diabetes. In addition to clinical research methods, liquid-based cytology of the contents of the gingival sulcus was performed.Results. The results of clinical and laboratory studies have shown that inflammatory diseases of periodontium and teeth within pregnant women with diabetes are more common than within the pregnant women without this disease. It should be noted that the frequency of occurrence and severity of these diseases in the pregnant women with type I diabetes is higher than in the other groups.Conclusion. Pregnant women with diabetes are at risk for dental disease and require more attention from dentists, endocrinologists and obstetricians. The use of liquid-based cytology method helps in the diagnosis of inflammatory periodontal diseases.

scholarly journals ORAL CARE AND CHOICE OF MEDICINES FOR TREATING GINGIVITIS AND PERIODONTITIS IN CHILDREN WITH TYPE 1 DIABETES MELLITUS

2020 ◽  
Vol 20 (1) ◽  
pp. 199-204
Author(s):  
I.O. Kuz ◽  
O.V. Sheshukova
Keyword(s):  
Diabetes Mellitus ◽  
Inflammatory Diseases ◽  
Type I Diabetes ◽  
Periodontal Diseases ◽  
Oral Care ◽  
Time Interval ◽  
Type I ◽  
Periodontal Tissues ◽  
Prophylactic Measures ◽  
Dental Appointment

The anatomical and physiological characteristics of a growing organism require a specific approach to the prevention and treatment of periodontal diseases. Not enough attention is paid toward improving the oral health of children suffering from diabetes mellitus, as well as therapeutic and prophylactic measures aimed at preserving teeth and preventing exacerbations of the inflammatory process in periodontal tissues. The results of clinical studies indicate a high prevalence of dental diseases in patients with type I diabetes mellitus; there are not enough reliable results of such indicators depending on the age and duration of this endocrine pathology, diabetic complications, hypoglycemic therapy taking into account metabolic control. Diagnosis of periodontal diseases is complicated by the peculiarities of the child’s psychological perception, caused by age-specific characteristics and the influence of common manifestations of inflammatory diseases. Children of primary school age often demonstrate increased motor activity, a hyperergic reaction even to minor negative feelings, the difficulty of adequate behaviour in an unfamiliar environment and a correct assessment of what is happening, being stressed due to the presence of many phobias associated with doctors and medical manipulations, communicative difficulties caused by staying in the spotlight, meeting new people, talking with adults. Teaching children must necessarily be accompanied by educating parents, since within limited time interval of dental appointment a doctor does not have the opportunity to fully monitor and consolidate the knowledge and skills the child has received, and this responsibility falls on parents. In this case, some attention should be paid to issues of skills, motivation as well as on the importance dental care aspects for the development of the dentofacial system, since in the vast majority of cases, parents are not enough aware on these issues. In addition to educating and fostering the motivation, it is necessary to control the level of knowledge, the frequency and quality of tooth brushing. For young children, it is necessary to do complete cleaning up the chewing group of teeth due to the low level of children’s manual skills.

PLATELET FIBRONECTIN LEVELS AS A MARKER FOR THE PROGRESSION OF DIABETIC RETINOPATHY

1987 ◽  
Author(s):  
P Custodi ◽  
G P Montecchio ◽  
C Bendotti ◽  
G Vandelli ◽  
M T Tenconi ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Type I Diabetes ◽  
Microvascular Complications ◽  
Microvascular Complication ◽  
Type I ◽  
Extreme Groups ◽  
Subendothelial Matrix ◽  
The Difference ◽  
Data Group

Aim of the study was to correlate fibronectin (Fn) and von Villebrand factor (vWf) levels measured in plasma and in platelets with the progression of diabetic retinopathy. Patients were classified in five groups reflecting the progression of this microvascular complication, on the basis of fluorangiographic findings (0 = no microangiopathy; 1= simple microangiopathy; 2= oedematous retinopathy; 3= ischaemic retinopathy; 4= ischaemic proliferative retinopathy). 43 patients were studied, 22 suffering from type I diabetes and 21 from type II diabetes, according to the classification of National Diabetes Data Group. Fn and vWf were measured in plasma and in platelet samples using an original double-sandwich microELISA method and expressed as micrograms/ml or as micrograms/10* platelets. Platelets were counted and solubilized with 0.5% Triton × 100. Bleeding time and platelet adhesion to glass beads were also evaluated on every patient. Intraplatelet Fn levels were reduced in retinopathies and correlate with the severity of the microvascular alteration, being the difference significant between the two extreme groups (p<0.05). vWf intraplatelet levels were also significantly lower in patients with severe microvascular complications (p<0.05). No significant differences were detected for plasma Fn and vWf levels in the 5 groups. Intraplatelet Fn and vWf levels may therefore be considered as markers of the severity of diabetic retinopathy. The leakage of Fn and vWf from activated platelet and the incorporation of these glycoproteins in the subendothelial matrix may be responsible for the worsening of this microvascular complication.

scholarly journals Ultrasonic cavitation in the treatment of purulent wound occurring against the background of juvenile diabetes mellitus and massive immunosuppressive therapy. Clinical case

2020 ◽  
Vol 5 (4) ◽  
pp. 28-33
Author(s):  
P. A. Munoz Sapeda ◽  
Yu. S. Paskhalova ◽  
V. A. Mitish ◽  
I. A. Chekmareva ◽  
L. A. Blatun ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Immunosuppressive Therapy ◽  
Clinical Case ◽  
Type I Diabetes ◽  
Transplant Rejection ◽  
Healing Process ◽  
Juvenile Diabetes ◽  
Wound Healing Process ◽  
Comprehensive Treatment ◽  
Type I

The article presents a clinical case of a successful comprehensive treatment 29-years-old patient with a purulent necrotic wound of the hand, which occurs against the background of type I diabetes mellitus and massive immunosuppressive therapy (prescribed to prevent renal transplant rejection). The use of ultrasound cavitation as a part of the complex treatment after radical surgical debridement helped to normalize the wound healing process, to reduce the microbial contamination of the wound and to activate repair.

Does Type II Diabetes Predispose to Retinal Vein Occlusion?

1993 ◽  
Vol 3 (3) ◽  
pp. 109-113 ◽  
Author(s):  
P.M. Dodson ◽  
C.G. Clough ◽  
S.M. Downes ◽  
E.E. Kritzinger
Keyword(s):  
Retinal Vein Occlusion ◽  
Type I Diabetes ◽  
Microvascular Complications ◽  
Control Group ◽  
Diabetic Patients ◽  
Type I ◽  
Type Ii ◽  
Medical Conditions ◽  
Vein Occlusion ◽  
Diabetic Microvascular Complications

Retinal vein occlusion (RVO) not infrequently occurs in diabetic patients. Although the aetiology is unclear, it could relate to the other microvascular complications of diabetes. In the non-diabetic, both the central (CRVO) and branch (BRVO) forms are commonly associated with hypertension and hyperlipidaemia. We have therefore studied fifty type II diabetic patients with RVO compared to a carefully matched diabetic control group (n = 50) to elucidate underlying medical conditions and hence the aetiology of RVO in diabetic patients. The two groups were well matched. Diabetics with RVO showed a strikingly high prevalence of hypertension compared to the controls (72% versus 32%: p < 0.001) and a trend to increased hyperlipidaemia (54% versus 36%). Diabetic microvascular complications were more common in the control group (diabetic retinopathy and proteinuria). No significant differences were observed in mean HbA1 or weight, but current smoking habits and blood pressure levels were increased in the diabetics with RVO. 80% of diabetic patients with the BRVO form, were hypertensive. We conclude that the main underlying medical conditions for RVO in diabetics are hypertension and hyperlipidaemia, and these may be important in the aetiology as in the non-diabetic. RVO is more common in type II rather than type I diabetes, and does not associate with the presence of diabetic microvascular complications. Clinical assessment for hypertension and hyperlipidaemia is therefore important in diabetic patients with RVO, especially if recurrence of the condition and further visual loss is to be prevented.

scholarly journals ANALYSIS OF THE RELATIONSHIP OF BEHAVIORAL HABITS AND PERIODONTAL STATUS AND ORAL HEALTH IN CHILDREN OF PRIMARY SCHOOL AGE WITH DIABETES MELLITUS TYPE I AND PARENTS RESULTS USING DENTAL QUESTIONNAIRE

2021 ◽  
Vol 21 (1) ◽  
pp. 71-75
Author(s):  
I.O. Kuz
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Periodontal Diseases ◽  
Dental Health ◽  
Subsequent Development ◽  
Type I Diabetes Mellitus ◽  
Type I ◽  
Healthy Children ◽  
Significant Difference ◽  
The Relationship

Type I diabetes mellitus is an autoimmune disease in genetically susceptible individuals that leads to the destruction of pancreatic β-cells with the subsequent development of absolute insulin deficiency. The presence of type I diabetes mellitus in children is the main risk factor for the onset of inflammatory periodontal diseases. When comparing the values of the hygiene indices according to Fedorov - Volodkina and the simplified OHI-S index (Green-Vermillion), a statistically significant difference (p ≤ 0.05) was found when comparing groups 1 and 2, 3 and 4, 2 and 4, 1 and 4 and was not found (p≥0.05) between groups 1 and 3 (in children with healthy gums with and without type I diabetes). We also found a statistically significant difference between patients with type 1 diabetes and healthy children in periodontal indices and gingival indices. Inflammatory processes in the periodontium of children with diabetes are elevated, so it is very important to recognize and diagnose them as soon as possible. Based on the answers to the "Dental questionnaire for children and parents" (certificate of copyright registration, registration date 01.24.2020), the relationship between behavior patterns, parent’s habits and the dental status of schoolchildren was quite informative, it opens up the possibility of early detection of problems in medical and preventive work among the children. We made the following conclusions: by questioning parents, we can reveal their attitude to their dental health and dental health of children, as well as to determine in more detail the risk factors for periodontal disease and dental diseases in general. Despite the availability of educational programs and routine dental examinations in kindergartens and schools (they are mainly focused on the formation of a conscious attitude to dental health directly in children), the dental literacy of parents should be increased.

scholarly journals Immunogenetic characteristics of diabetic microangiopathies

1999 ◽  
Vol 45 (4) ◽  
pp. 8-9
Author(s):  
B. L. Rasovsky ◽  
T. I. Severina ◽  
L. G. Akhmedyanova
Keyword(s):  
Diabetic Retinopathy ◽  
Diabetic Nephropathy ◽  
Metabolic Control ◽  
Preventive Measures ◽  
Type I Diabetes ◽  
Individual Recognition ◽  
Microvascular Complications ◽  
Hla Antigens ◽  
Type I ◽  
Nonproliferative Diabetic Retinopathy

lmmunogenetic studies were carried out in 103 diabetics with type I condition (40 men and 63 women aged 37.1+3.2 years) with disease standing of 7.6±2>3 years. Nonproliferative diabetic retinopathy was detected in 78 (75.7%)) and staring diabetic nephropathy in 88(85.4%)). The incidence of DR4, DR8, and DQ2 antigens is increased and that of Cw6 and DQ1 antigens decreased in diabetic retinopathy. В16, DR3, DR4, and DQ3 antigens predominated in diabetic nephropathy, while Cw6 and DQ7antigens were rarely detected. DR4 and DQ3 were the most incident in the patients with a combination of diabetic retinopathy and diabetic nephropathy (67.2%o of all cases). There were no notable differences in the spectrum of HLA antigens in the groups with diabetic retinopathy and diabetic nephropathy, which agrees with the reno-retinal syndrome concept. Afunctional status-metric model of individual recognition of the diabetic reno-retinal syndrome is created. A special register of patients with type I diabetes carrying immunogenetic markers of diabetic microangiopathies is proposed to be created for more stringent metabolic control and early preventive measures aimed at delay of microvascular complications.

scholarly journals Diagnostic value of biochemical markers of bone metabolism in treatment of generalized periodontitis in patients with age-related osteoporosis

2018 ◽  
Vol 9 (3) ◽  
pp. 315-321 ◽  
Author(s):  
O. O. Fastovets ◽  
I. V. Masheiko ◽  
H. B. Peleshenko
Keyword(s):  
Bone Metabolism ◽  
Bone Tissue ◽  
Biochemical Markers ◽  
Alveolar Bone ◽  
Periodontal Diseases ◽  
Tartrate Resistant Acid Phosphatase ◽  
Type I ◽  
Mineral Density ◽  
Age Related ◽  
Normal Bone Mineral Density

The topicality of the problem of periodontal diseases is due to their significant prevalence. The purpose of this work is to study the dynamics of markers of bone metabolism in the process of treatment of generalized periodontitis of the II–III levels of severity in patients with age-related osteoporosis and without osteoporotic changes in the skeleton. The examination and treatment of 104 patients, aged 63–78, equal ratio of men and women, was conducted. Among the selected patients, 49 persons had normal bone mineral density, while the remaining 55 had osteoporotic changes in the bone tissue of involutory genesis. All subjects were assessed for the following indicators ; mineral density of jaw bone tissue (BMD) according to the results of the computer tomography, the concentration of C-Propeptide of Type I Procollagen (CICP) in blood plasma, the activity of tartrate-resistant acid phosphatase (TRAP), bone alkaline phosphatase (BAP), osteocalcin, parathyroid hormone in blood serum, concentration of β-CrossLaps in urine, total calcium and inorganic phosphorus content in blood with calculation of the Ca/P index. It was established that in patients with periodontitis of the II–III degree there was a decrease in the BMD of the alveolar bone in comparison with the control values (P ˂ 0.05), whereas the presence of systemic osteopenia worsened the indices (P ˂ 0.001). The least osteoregenerative activity, which was characterized by the decrease in BAP, TRAP and CICP levels, was registered in patients with generalized periodontitis of the III degree on the background of age-related osteoporosis (P ˂ 0.05). In the patients with generalized periodontitis of the III degree of severity, at the beginning of treatment, a weak negative correlation was found between BMD and TRAP activity (r = –0.292, P < 0.05) and mean strength correlation – with β-CrossLaps in urine (r = –0.348, P < 0.01). The concentration of CICP positively correlated with the mineral density of bone tissue from the third month after the start of treatment (r = 0.312, P < 0.05). As a conclusion, the mineral density of alveolar bone in the process of treatment varies unevenly depending on the severity of generalized periodontitis and the character of osteoporotic changes in the skeleton. The biochemical markers of bone metabolism allow the balance of processes of bone resorption and formation to be determined in order to correct treatment of generalized periodontitis.

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