scholarly journals Immunogenetic characteristics of diabetic microangiopathies

1999 ◽  
Vol 45 (4) ◽  
pp. 8-9
Author(s):  
B. L. Rasovsky ◽  
T. I. Severina ◽  
L. G. Akhmedyanova
Keyword(s):  
Diabetic Retinopathy ◽  
Diabetic Nephropathy ◽  
Metabolic Control ◽  
Preventive Measures ◽  
Type I Diabetes ◽  
Individual Recognition ◽  
Microvascular Complications ◽  
Hla Antigens ◽  
Type I ◽  
Nonproliferative Diabetic Retinopathy

lmmunogenetic studies were carried out in 103 diabetics with type I condition (40 men and 63 women aged 37.1+3.2 years) with disease standing of 7.6±2>3 years. Nonproliferative diabetic retinopathy was detected in 78 (75.7%)) and staring diabetic nephropathy in 88(85.4%)). The incidence of DR4, DR8, and DQ2 antigens is increased and that of Cw6 and DQ1 antigens decreased in diabetic retinopathy. В16, DR3, DR4, and DQ3 antigens predominated in diabetic nephropathy, while Cw6 and DQ7antigens were rarely detected. DR4 and DQ3 were the most incident in the patients with a combination of diabetic retinopathy and diabetic nephropathy (67.2%o of all cases). There were no notable differences in the spectrum of HLA antigens in the groups with diabetic retinopathy and diabetic nephropathy, which agrees with the reno-retinal syndrome concept. Afunctional status-metric model of individual recognition of the diabetic reno-retinal syndrome is created. A special register of patients with type I diabetes carrying immunogenetic markers of diabetic microangiopathies is proposed to be created for more stringent metabolic control and early preventive measures aimed at delay of microvascular complications.

PLATELET FIBRONECTIN LEVELS AS A MARKER FOR THE PROGRESSION OF DIABETIC RETINOPATHY

1987 ◽  
Author(s):  
P Custodi ◽  
G P Montecchio ◽  
C Bendotti ◽  
G Vandelli ◽  
M T Tenconi ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Type I Diabetes ◽  
Microvascular Complications ◽  
Microvascular Complication ◽  
Type I ◽  
Extreme Groups ◽  
Subendothelial Matrix ◽  
The Difference ◽  
Data Group

Aim of the study was to correlate fibronectin (Fn) and von Villebrand factor (vWf) levels measured in plasma and in platelets with the progression of diabetic retinopathy. Patients were classified in five groups reflecting the progression of this microvascular complication, on the basis of fluorangiographic findings (0 = no microangiopathy; 1= simple microangiopathy; 2= oedematous retinopathy; 3= ischaemic retinopathy; 4= ischaemic proliferative retinopathy). 43 patients were studied, 22 suffering from type I diabetes and 21 from type II diabetes, according to the classification of National Diabetes Data Group. Fn and vWf were measured in plasma and in platelet samples using an original double-sandwich microELISA method and expressed as micrograms/ml or as micrograms/10* platelets. Platelets were counted and solubilized with 0.5% Triton × 100. Bleeding time and platelet adhesion to glass beads were also evaluated on every patient. Intraplatelet Fn levels were reduced in retinopathies and correlate with the severity of the microvascular alteration, being the difference significant between the two extreme groups (p<0.05). vWf intraplatelet levels were also significantly lower in patients with severe microvascular complications (p<0.05). No significant differences were detected for plasma Fn and vWf levels in the 5 groups. Intraplatelet Fn and vWf levels may therefore be considered as markers of the severity of diabetic retinopathy. The leakage of Fn and vWf from activated platelet and the incorporation of these glycoproteins in the subendothelial matrix may be responsible for the worsening of this microvascular complication.

Polymorphism in the 5'-end of the aldose reductase gene is strongly associated with the development of diabetic nephropathy in type I diabetes

Diabetes ◽  
1997 ◽  
Vol 46 (2) ◽  
pp. 287-291 ◽  
Author(s):  
A. E. Heesom ◽  
M. L. Hibberd ◽  
A. Millward ◽  
A. G. Demaine
Keyword(s):  
Diabetic Nephropathy ◽  
Aldose Reductase ◽  
Type I Diabetes ◽  
Type I ◽  
Reductase Gene

A program to reduce onset distress in unselected type I diabetic patients: effects on psychological variables and metabolic control

1995 ◽  
Vol 132 (5) ◽  
pp. 580-586 ◽  
Author(s):  
K Spiess ◽  
G Sachs ◽  
P Pietschmann ◽  
R Prager
Keyword(s):  
Patient Education ◽  
Metabolic Control ◽  
Type I Diabetes ◽  
Intensive Treatment ◽  
Medical Psychology ◽  
Diabetic Patients ◽  
Type I ◽  
Psychological Variables ◽  
Reduction Program

Spiess K, Sachs G, Pietschmann P, Prager R. A program to reduce onset distress in unselected type I diabetic patients: effects on psychological variables and metabolic control. Eur J Endocrinol 1995;132:580–6. ISSN 0804–4643 This paper reports the results of a prospective controlled trial of a program addressing reduction of onset distress and better future adaptation in adults who were enrolled at the time of diagnosis of type I diabetes mellitus. Patients were assigned randomly to either standard intensive treatment and patient education with the distress reduction program (N = 10) or to standard intensive treatment and patient education without this program (N = 13). Prospective follow-up of patients with multiple validated measures of treatment outcome showed less anxious coping behavior, less depression and less denial at the 9-month follow-up and less denial at the 15-month follow-up in the group with the distress reduction program, but no differences in metabolic control between the two groups at any time. We conclude that our program has a positive impact on the crisis at diabetes onset; the lower denial in the treatment group may lead to improved regimen adherence in the long term. Klaus Spiess, Institute of Medical Psychology, University of Vienna, Severingasse 9, A-1090-Vienna, Austria

STUDY OF PREVALENCE AND CLINICAL PROFILE OF NEPHROPATHY AND RETINOPATHY IN TYPE 2 DIABETES PATIENTS AT TERTIARY CARE CENTER, UDAIPUR

2021 ◽  
pp. 6-8
Author(s):  
Yash Salil Patel
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Diabetic Nephropathy ◽  
Microvascular Complications ◽  
Tertiary Care ◽  
Positive Family History ◽  
Diabetic Patients

Microvascular complications of Type 2 Diabetes Mellitus (T2DM), (retinopathy and nephropathy) have a similar etiopathogenetic mechanism besides genetic predisposition. Even though these two complications frequently co-exist, their frequency varies. The association of these two signicant complications and their coexistence needs a relook. To study prevalence of retinopathy and nephropathy in Type 2 diabetes mel Aim: litus. Comparison of diabetic retinopathy and nephropathy in Type 2 diabetes mellitus and its correlation of diabetic retinopathy and nephropathy with duration of illness and various risk factors that affects development, progression and severity of diabetic retinopathy and nephropathy. 100 diabetic patients were taken up for study for a period of one year meeti Methodology: ng the criteria for the present study. Detailed history was taken from patient and meticulous examination was done of all patients with special emphasis on renal and ophthalmic symptoms. Clinical data and investigation prole was tabulated. Statistical analysis was done. Among 100 patients, 22 had diabetic retinopathy. Among patients with diab Results & Conclusion: etic retinopathy, 68.18% patients had positive family history. Among 100 patients, 32 had diabetic nephropathy, mean FBS was 207 mg%, PPBS was 317.8 mg% and mean HbA was 9.2%. Among patients with diabetic retinopathy, mean FBS was 211 mg%, PPBS was 324.9 1c mg%, HbA was 9.5%. From this study it is found that diabetic nephropathy starts earlier than retinopathy. In this study 1c hypertension was found to accelerate progression into nephropathy and retinopathy.

Psychological Stress and Metabolic Control in Patients with Type I Diabetes Mellitus

1986 ◽  
Vol 314 (17) ◽  
pp. 1078-1084 ◽  
Author(s):  
Friedrich W. Kemmer ◽  
Rolf Bisping ◽  
Hans J. Steingrüber ◽  
Helmut Baar ◽  
Frank Hardtmann ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Control ◽  
Psychological Stress ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Type I

Racial Differences in Metabolic Control of Children and Adolescents With Type I Diabetes Mellitus

Diabetes Care ◽  
1991 ◽  
Vol 14 (1) ◽  
pp. 20-25 ◽  
Author(s):  
A. M. Delamater ◽  
D. R. Albrecht ◽  
D. C. Postellon ◽  
J. P. Gutai
Keyword(s):  
Diabetes Mellitus ◽  
Children And Adolescents ◽  
Metabolic Control ◽  
Racial Differences ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Type I
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