DOES LOW-DOSE PERI-OPERATIVE HEPARIN ADMINISTRATION AFFECT MORTALITY FOLLOWING MAJOR ABDOMINAL SURGERY?

1987 ◽  
Author(s):  
A R Hedges ◽  
C J Parker ◽  
V V Kakkar
Keyword(s):  
Abdominal Surgery ◽  
Low Dose ◽  
Postoperative Mortality ◽  
Current Evidence ◽  
Dose Heparin ◽  
Heparin Administration ◽  
Sex Type ◽  
A Prospective Study ◽  
Low Dose Heparin ◽  
Fatal Myocardial Infarction

Current evidence suggests that peri-operative low-dose heparin administration reduces the post-operative frequency of fatal pulmonary embolism and may also reduce the frequency of fatal myocardial infarction. Evidence is now accumulating that anticoagulants affect the course of malignant disease, in particular the formation of metastases. Malignant cells disseminated during surgery may be responsible for metastasis formation.The aim of this study was to discover whether administration of peri-operative low-dose heparin had any effect on mortality. A retrospective analysis of 1,232 patients undergoing elective abdominal surgery was performed. 658 patients received no heparin and 574 patients received heparin prophylaxis subcutaneously. The two groups were well matched for age, sex, type of operation performed and distribution of pre-existing disease. The number and causes of death are shown below.Low-dose peri-operative heparin administration reduces postoperative mortality. This reduction is only partly explained by a reduction in cardiopulmonary cases, more significantly there Is a reduction in death due to disseminated malignancy.A prospective study is planned in patients undergoing operations for malignancy to confirm this finding.

Prophylactic, Low-Dose Heparin Administration Inhibits Pulmonary Growth and Development

2020 ◽  
Vol 231 (4) ◽  
pp. S209-S210
Author(s):  
Victoria H. Ko ◽  
Lumeng J. Yu ◽  
Duy T. Dao ◽  
Jordan D. Secor ◽  
Amy Pan ◽  
...  
Keyword(s):  
Growth And Development ◽  
Low Dose ◽  
Dose Heparin ◽  
Heparin Administration ◽  
Low Dose Heparin

Observations on Antithrombin-III-Concentration and its Biological Function During Low Dose Heparin Administration in Patients Suffering from Stroke

1979 ◽  
Author(s):  
Kh. Nienhaus ◽  
Ch. Wenig ◽  
E. Wenzel ◽  
L. Pfordt ◽  
I. Biewer
Keyword(s):  
Blood Donors ◽  
Low Dose ◽  
Antithrombin Iii ◽  
Vein Thrombosis ◽  
Antithrombin Activity ◽  
Heparin Treatment ◽  
Heparin Administration ◽  
A Prospective Study ◽  
Deep Vein ◽  
Low Dose Heparin

A prospective study was performed on 100 patients suffering from stroke (50 patients were treated with 70 USP heparin/kg b.w./12 hours sc., and Simultaneously, the other 50 patients were treated with 0.9% NaCl twice every 24 hours). The concentration of Antithrombin III (A. III conc.) was measured immunologically (Mancini-technique). The “Antithrombin activity” of the patients’ plasma was evaluated photometrically using chromogenic substrate Chromozym TH (incubation of diluted plasma with 3.5 NIH Thrombin, 5, 15 and 30 min., 37°C). In 50 of these patients (N = 100) the A.III conc. as well as the Antithrombin activity of plasma was found to be decreased, compared with the group of healthy blood donors (N = 50). In 30% of the patients A.III conc.was found to be increased while the plasma’s Antithrombin activity was significantly decreased. Normal values of A.III conc. were observed in less than 20% of the patients. A significant higher rate of deep vein thrombosis was observed in patients not receiving heparin treatment (6/45). No correlation was found between A.III conc. or heparin treatment and the severity of cerebral infarction. Also, no significant differences in A.III conc . (Mancinit technigue) were evaluated between these two groups. Significant differences between parents treated with heparin and those not treated were evaluated by the photometrical measurement of Antithrombin activity in the plasma.

scholarly journals Thrombocytopenia and low-dose heparin administration

1987 ◽  
Vol 87 (8) ◽  
pp. 79-86
Author(s):  
Thomas F. Morley ◽  
Gregory Bannett ◽  
Teresa Morone ◽  
James C. Giudice ◽  
Nathan Freed
Keyword(s):  
Low Dose ◽  
Dose Heparin ◽  
Heparin Administration ◽  
Low Dose Heparin

scholarly journals The clinical evaluation of low-dose heparin in haemodialysis: a prospective study using the heparin-coated AN69 ST membrane

2008 ◽  
Vol 23 (6) ◽  
pp. 2003-2009 ◽  
Author(s):  
J. Chanard ◽  
S. Lavaud ◽  
H. Maheut ◽  
I. Kazes ◽  
F. Vitry ◽  
...  
Keyword(s):  
Prospective Study ◽  
Clinical Evaluation ◽  
Low Dose ◽  
Dose Heparin ◽  
A Prospective Study ◽  
Low Dose Heparin

Low Molecular Weight Heparin and Prevention of Postoperative Thrombosis in Abdominal Surgery

1992 ◽  
Vol 67 (06) ◽  
pp. 627-630 ◽  
Author(s):  
K Koppenhagen ◽  
J Adolf ◽  
M Matthes ◽  
E Tröster ◽  
J D Roder ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Abdominal Surgery ◽  
Low Molecular Weight Heparin ◽  
Low Dose ◽  
Low Molecular Weight ◽  
Heparin Group ◽  
Vein Thrombosis ◽  
Dose Heparin ◽  
Deep Vein ◽  
Low Dose Heparin

SummaryIn a prospective, double-blind, randomized multicenter trial the efficacy and safety of low molecular weight heparin and unfractionated heparin were compared for the prevention of postoperative deep vein thrombosis in patients undergoing abdominal surgery. Six hundred and seventy-three patients were randomly allocated to the two prophylaxis groups; 20 of these, however, did not undergo surgery and did not receive any prophylaxis. Of the remaining 653 patients 323 received one subcutaneous injection of 3,000 anti-Xa units of low molecular weight heparin and 330 received subcutaneously 5,000 U heparin three times a day. Treatment was initiated 2 h preoperatively and continued for 7 to 10 days. The occurrence of DVT was determined by the 125I-labelled fibrinogen uptake test and phlebography. Venous thrombosis was diagnosed in 24 of 323 patients (7.4%) treated with low molecular weight heparin and in 26 of 330 patients (7.9%) treated with low-dose heparin. DVT of proximal veins was detected in four patients of the low molecular weight heparin group and in three patients of the low-dose heparin group. During the observation period three pulmonary emboli - one fatal and two non-fatal - occurred in patients receiving prophylaxis with low-dose heparin. No pulmonary embolism was found in patients treated with low molecular weight heparin. Both prophylactic schemes were well tolerated. Intra-and postoperative blood loss, incidence of wound hematoma, frequency and volume of intra- and postoperative blood transfusion were similar in both groups with a slight advantage for the low molecular weight heparin group. The results of this trial show that the investigated low molecular weight heparin is at least as effective and safe as low-dose heparin in preventing deep vein thrombosis in patients undergoing elective abdominal surgery.

Monitoring Low-Dose Heparin Administration In Hip Surgery

1981 ◽  
Author(s):  
L Poller ◽  
D A Tabemer
Keyword(s):  
Low Dose ◽  
Factor Xa ◽  
Hip Surgery ◽  
Fixed Dose ◽  
Heparin Group ◽  
Dose Heparin ◽  
Heparin Administration ◽  
Risk Patients ◽  
Calcium Heparin ◽  
Low Dose Heparin

Fifty-five patients requiring selective hip replacement or emergency surgery for hip fractures were randomly given fixed low-dose subcutaneous calcium heparin 5,000 units 8-hourly (30 patients) or monitored subcutaneous calcium heparin (25 patients). The aim was to prolong the activated partial thromboplastin time (APTT), using the NRLARC method, to 5 seconds above the upper limit of normal.Adjusting the dose of heparin was moderately successful in achieving the target value for the APTT (46% of observations) compared to the fixed dose group (27%) p<0.005. In nine patients prophylaxis failed to prevent DVT detected by 125I-fibrinogen scan; three were in the adjusted dose, six in the fixed dose heparin group. In all nine patients the APTT showed less than the desired prolongation the day before the scan became positive although in six patients with positive scans, measurable heparin levels were detected by anti-factor Xa assay. The APTT appears, therefore, to give a better guide during hip surgery to the antithrombotic effect of heparin than the anti-factor Xa assay in low-dose heparin prophylaxis. Maintaining the APTT at or above 50 seconds with the NRLARC method protected these high risk patients from post-operative DVT.

A Multivariate Pattern Recognition Study of Risk-Factors Indicating Postoperative Thromboembolism Despite Low-Dose Heparin in Major Abdominal Surgery

1985 ◽  
Vol 54 (02) ◽  
pp. 409-412 ◽  
Author(s):  
J Kjærgaard ◽  
K Esbensen ◽  
P Wille-Jørgensen ◽  
T Jørgensen ◽  
J Thorup ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
High Risk ◽  
Abdominal Surgery ◽  
Low Dose ◽  
Major Abdominal Surgery ◽  
High Risk Patients ◽  
Dose Heparin ◽  
Risk Patients ◽  
Low Dose Heparin ◽  
Heparin Prophylaxis

SummaryThe object of the present investigation was to identify those who, among high-risk patients, would “break through” low-dose heparin prophylaxis and develop thromboembolism after major abdominal surgery.Twenty-nine variables (clinical characteristics, pre- and postoperative coagulation and fibrinolytic factors) from 19 patients with and 26 patients without thromboembolism were analyzed by means of a multivariate supervised pattern recognition technique (SIMCA).We found no statistically significant difference between patients with and without thromboembolism. Thus, in the studied group of high-risk patients it was not possible to identify a predictive index for selection of individual patients liable to develop postoperative thromboembolism despite low-dose heparin prophylaxis in major abdominal surgery.

Effects of short-term low-dose heparin administration on biochemical parameters of bone turnover

1993 ◽  
Vol 22 (1) ◽  
pp. 27-32 ◽  
Author(s):  
H.E. van der Wiel ◽  
P. Lips ◽  
P.C. Huijgens ◽  
J.C. Netelenbos
Keyword(s):  
Bone Turnover ◽  
Biochemical Parameters ◽  
Low Dose ◽  
Short Term ◽  
Dose Heparin ◽  
Heparin Administration ◽  
Low Dose Heparin

Low-Dose Heparin and Deep-Vein Thrombosis after Total Hip Replacement

1976 ◽  
Vol 36 (01) ◽  
pp. 157-164 ◽  
Author(s):  
P. M Mannucci ◽  
Luisa E. Citterio ◽  
N Panajotopoulos
Keyword(s):  
Deep Vein Thrombosis ◽  
Total Hip Replacement ◽  
Hip Replacement ◽  
Low Dose ◽  
Control Group ◽  
Total Hip ◽  
Vein Thrombosis ◽  
Dose Heparin ◽  
Deep Vein ◽  
Low Dose Heparin

SummaryThe effect of subcutaneous low-dose heparin on postoperative deep-vein thrombosis (D. V. T.) (diagnosed by the 125I-labelled fibrinogen test) has been investigated in a trial of 143 patients undergoing the operation of total hip replacement. Two randomized studies were carried out: in one the scanning for D.V.T. was carried out daily for 7 days post operatively and in the other for 15 days. In both, the incidence of D.V.T. was significantly lower in the heparin-treated patients (P<0.005). Bilateral D.V.T. was also prevented (P<0.05), through the extension of D.V.T. to the distal veins of the thigh was not significantly reduced. Heparin treatment was, however, followed by a higher incidence of severe postoperative bleeding (P< 0.02) and wound haematoma formation (P< 0.005), and the postoperative haemoglobin was significantly lower than in the control group (P<0.005). A higher number of transfused blood units was also needed by the heparin treated patients (P<0.001).

Sign in / Sign up

Export Citation Format

Share Document