Increase in Plasma Concentrationof Plasminogen Activator Inhibitor, Fibrinogen, von Willebrand Factor, Factor VIII: Cand in Erythrocyte Sedimentation Rate with Age

SummaryElderly patients have previously been shown to have an increased plasma concentration of tissue plasminogen activator (t-PA) antigen (t-PAAg). Since the concentration of t-PA Ag dependson both free t-PA and t-PA complexed with inhibitors, mainly plasminogen activator inhibitor (PA inhibitor), we have investigated the relationship between the plasma concentration of PA inhibitor and age in 20 elderly and 20 young individuals. Elderly individuals showed a slight increase in PA inhibitor, in parallel with increase on others, acute-phase proteins, fibrinogen, von Willebrand factor, factor VIII :C, and the erythrocyte sedimentation rate. The increase i PA inhibitor as well as other acute-phase proteins in the elderly may be significant in relation to the increased incidence of thrombotic disease.

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Enhanced thrombin generation, P-von willebrand factor, P-fibrin D-dimer and P-plasminogen activator inhibitor 1: Predictive for venous thrombosis in asparaginase-treated children

Fibrinolysis and Proteolysis ◽

10.1016/0268-9499(94)90248-8 ◽

1994 ◽

Vol 8 ◽

pp. 63-65 ◽

Cited By ~ 19

Author(s):

U. Nowak-Göttl ◽

J.E.A. Wolff ◽

N. Kuhn ◽

J. Boos ◽

B. Kehrel ◽

...

Keyword(s):

Venous Thrombosis ◽

Plasminogen Activator ◽

Von Willebrand Factor ◽

Thrombin Generation ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Von Willebrand ◽

Willebrand Factor ◽

Activator Inhibitor ◽

D Dimer

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Von Willebrand Factor, Plasminogen Activator Inhibitor-1 and C-Reactive Protein Are Markers of Thrombolytic Efficacy in Acute Myocardial Infarction

Thrombosis and Haemostasis ◽

10.1055/s-0038-1646343 ◽

1992 ◽

Vol 68 (06) ◽

pp. 678-682 ◽

Cited By ~ 11

Author(s):

F Andreotti ◽

D R Hackett ◽

A W Haider ◽

M C Roncaglioni ◽

G J Davies ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Plasminogen Activator ◽

Von Willebrand Factor ◽

Plasminogen Activator Inhibitor ◽

C Reactive Protein ◽

Reactive Protein ◽

Von Willebrand ◽

Willebrand Factor ◽

Activator Inhibitor

SummaryPlasma von Willebrand factor, plasminogen activator inhibitor activity and C-reactive protein were assessed as markers of coronary recanalisation in 30 patients with acute myocardial infarction receiving tissue-type plasminogen activator (t-PA). Blood samples were taken before t-PA (time 0), 4-hourly for 24 h and daily up to 72 h. A continuous electrocardiogram was recorded in the first 24 h. Coronary arteriography was performed 90 min and 24 h after the start of t-PA. Patients with a patent infarct artery (n = 17), compared to those with occluded artery (n = 13), showed a fall in von Willebrand factor from 0 to 24 h (p = 0.001), a greater fall in plasminogen activator inhibitor from 24 to 48 h (p = 0.04) and a fall in C-reactive protein from 48 to 72 h (p = 0.002). The accuracy of these indices compared favourably with time to peak plasma MB creatine kinase and ≥ 50% resolution of maximal ST-deviation on the electrocardiogram.Thus, changes in plasma von Willebrand factor, plasminogen activator inhibitor and C-reactive protein during the first 3 days of myocardial infarction are indicative of thrombolytic efficacy. Their concordant behaviour may reflect a common regulatory mechanism.

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von Willebrand Factor, Soluble P-Selectin, Tissue Plasminogen Activator and Plasminogen Activator Inhibitor in Atherosclerosis

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649788 ◽

1995 ◽

Vol 74 (02) ◽

pp. 626-630 ◽

Cited By ~ 96

Author(s):

A D Blann ◽

M Dobrotova ◽

P Kubisz ◽

C N McCollum

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Von Willebrand Factor ◽

Plasminogen Activator Inhibitor ◽

Tissue Plasminogen ◽

Soluble P ◽

Von Willebrand ◽

Willebrand Factor ◽

Activator Inhibitor ◽

Pai 1

SummaryTissue plasminogen activator antigen (tPA), plasminogen activator inhibitor antigen (PAI-1), soluble P-selectin and von Willebrand factor antigen (vWf) were measured by ELISA in 41 patients with peripheral vascular disease (PVD), 41 with ischaemic heart disease (IHD) and in 46 age and sex matched asymptomatic controls. Increased vWf was found in patients with IHD (p = 0.0002) and in patients with PVD (p = 0.0011) relative to the controls but levels did not differ between the two patients groups. Raised tPA found in both PVD (p = 0.0006) and IHD (p = 0.0061) compared to the controls also failed to differentiate the two groups of patients. Soluble P-selectin was also raised in both groups (p = 0.003 in IHD and p = 0.0102 in PVD) with no difference between the groups. There were no differences in levels of PAI-1 between the groups. In the subjects taken as a whole, there were significant Spearman’s correlations between tPA and vWf (r = 0.37, p <0.001), tPA and triglycerides (r = 0.38, p <0.001), tPA and P-selectin (r = 0.19, p = 0.032), vWf and age (r = 0.25, p = 0.005) and inversely between vWf and HDL (r = -0.25, p = 0.006). These data support the concept that increased levels of tPA may be important in atherosclerosis, and indicate that soluble P-selectin may be useful in further analysis of the role of platelets and the endothelial cell in this disease.

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