scholarly journals Crestal Bone Preservation with Platform Switching

2016 ◽  
Vol 04 (03) ◽  
pp. 135-143
Author(s):  
Manjit Kumar ◽  
Megha Chopra ◽  
Udey Singh
Keyword(s):  
Soft Tissue ◽  
Large Diameter ◽  
Point Of View ◽  
Implant Design ◽  
Soft Tissue Management ◽  
Site Development ◽  
Implant Positioning ◽  
Bone Preservation ◽  
Platform Switching ◽  
Surgical Treatment Planning

AbstractNew implant designs have appeared in the literature which claim that certain modifications may be helpful for maintaining crestal bone levels and consequently preserving normal soft tissue contours. Maintenance of soft tissue has been shown to depend on preservation of bone surrounding the implant. In order to achieve this goal, each step of the treatment must be managed carefully. This requires knowledge of pre-surgical treatment planning, site development, implant positioning, soft tissue management, provisionalization and prosthetic management.Placement of a smaller diameter abutment on a large diameter implant platform (platform switching) has been proposed as an effective way to control circumferential bone loss around dental implants. The purpose of this paper is to evaluate the literature from an evidence based point of view regarding implant design modifications for preserving soft and hard tissue around implants.

scholarly journals Translating Molecular Profiling of Soft Tissue Sarcomas into Daily Clinical Practice

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 512
Author(s):  
Celine Jacobs ◽  
Lore Lapeire
Keyword(s):  
Soft Tissue ◽  
Unmet Need ◽  
Soft Tissue Sarcomas ◽  
Molecular Profiling ◽  
Point Of View ◽  
Molecular Techniques ◽  
Mesenchymal Tumors ◽  
The Past ◽  
Cancer Types ◽  
Sarcoma Treatment

Soft tissue sarcomas are a group of rare mesenchymal tumors with more than 70 subtypes described. Treatment of these subtypes in an advanced setting is mainly according to a one-size-fits-all strategy indicating a high unmet need of new and more targeted therapeutic options in order to optimize survival. The introduction of advanced molecular techniques in cancer has led to better diagnostics and identification of new therapeutic targets, leading to more personalized treatment and improved prognosis for several cancer types. In sarcoma, a likewise evolution is seen, albeit at a slower pace. This manuscript describes how in the past years advanced molecular profiling in soft tissue sarcomas was able to identify specific and often pathognomonic aberrations, deferring standard sarcoma treatment in favor of more targeted treatment from an oncologist’s point of view.

scholarly journals Molecular Determinants of Soft Tissue Sarcoma Immunity: Targets for Immune Intervention

2021 ◽  
Vol 22 (14) ◽  
pp. 7518
Author(s):  
Marcella Tazzari ◽  
Laura Bergamaschi ◽  
Alessandro De Vita ◽  
Paola Collini ◽  
Marta Barisella ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Malignant Tumors ◽  
Soft Tissue Sarcomas ◽  
Point Of View ◽  
Molecular Features ◽  
Molecular Determinants ◽  
Genetic Landscape ◽  
Current Therapies ◽  
Cumulative Evidence

Soft tissue sarcomas (STSs) are a family of rare malignant tumors encompassing more than 80 histologies. Current therapies for metastatic STS, a condition that affects roughly half of patients, have limited efficacy, making innovative therapeutic strategies urgently needed. From a molecular point of view, STSs can be classified as translocation-related and those with a heavily rearranged genotype. Although only the latter display an increased mutational burden, molecular profiles suggestive of an “immune hot” tumor microenvironment are observed across STS histologies, and response to immunotherapy has been reported in both translocation-related and genetic complex STSs. These data reinforce the notion that immunity in STSs is multifaceted and influenced by both genetic and epigenetic determinants. Cumulative evidence indicates that a fine characterization of STSs at different levels is required to identify biomarkers predictive of immunotherapy response and to discover targetable pathways to switch on the immune sensitivity of “immune cold” tumors. In this review, we will summarize recent findings on the interplay between genetic landscape, molecular profiling and immunity in STSs. Immunological and molecular features will be discussed for their prognostic value in selected STS histologies. Finally, the local and systemic immunomodulatory effects of the targeted drugs imatinib and sunitinib will be discussed.

Advanced Navigation Planning Including Soft Tissue Management

Orthopedics ◽  
2005 ◽  
Vol 28 (10) ◽  
Author(s):  
Ulrich Clemens ◽  
Rolf Klaus Miehlke
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Management ◽  
Navigation Planning

scholarly journals Soft tissue management of children's open tibial fractures – a review of seventy children over twenty years

2010 ◽  
Vol 92 (4) ◽  
pp. 320-325 ◽  
Author(s):  
P Rao ◽  
MV Schaverien ◽  
KJ Stewart
Keyword(s):  
Soft Tissue ◽  
Tibial Fractures ◽  
Soft Tissue Management ◽  
Retrospective Case ◽  
Open Tibial Fractures ◽  
Fractures In Children ◽  
Superficial Wound ◽  
Patient Stay ◽  
Grade Ii ◽  
Distally Based

INTRODUCTION The management of open tibial fractures in children represents a unique reconstructive challenge. The aim of the study was to evaluate the management of paediatric open tibial fractures with particular regard to soft tissue management. PATIENTS AND METHODS A retrospective case-note analysis was performed for all children presenting with an open tibial fracture at a single institution over a 20-year period for 1985 to 2005. RESULTS Seventy children were reviewed of whom 41 were males and 29 females. Overall, 91% (n = 64) of children suffered their injury as a result of a vehicle-related injury. The severity of the fracture with respect to the Gustilo classification was: Grade I, 42% (n = 29); Grade II, 24% (n = 17); Grade III, 34% (n = 24; 7 Grade 3a, 16 Grade 3b, 1 Grade 3c). The majority of children were treated with external fixation and conservative measures, with a mean hospital in-patient stay of 13.3 days. Soft tissue cover was provided by plastic surgeons in 31% of all cases. Four cases of superficial wound infection occurred (6%), one case of osteomyelitis and one case of flap failure. The limb salvage was greater than 98%. CONCLUSIONS In this series, complications were associated with delayed involvement of plastic surgeons. Retrospective analysis has shown a decreased incidence of open tibial fractures which is reported in similar studies. Gustilo grade was found to correlate with length of hospital admission and plastic surgery intervention. We advocate, when feasible, the use of local fas-ciocutaneous flaps (such as distally based fasciocutaneous and adipofascial flaps), which showed a low complication rate in children.

scholarly journals The Ortho-Plastic Approach to Soft Tissue Management in Trauma

2014 ◽  
Vol 8 (1) ◽  
pp. 399-408 ◽  
Author(s):  
Daniel J Jordan ◽  
Marco Malahias ◽  
Wasim Khan ◽  
Sandip Hindocha
Keyword(s):  
Emergency Department ◽  
Soft Tissue ◽  
Soft Tissue Injuries ◽  
British Association ◽  
Current Evidence ◽  
Soft Tissue Management ◽  
Initial Management ◽  
Accident And Emergency ◽  
Accident And Emergency Department ◽  
British Orthopaedic Association

Fractures with associated soft tissue injuries, or those termed ‘open,’ are not uncommon. There has been much discussion regarding there management, with the guidance from the combined British Orthopaedic Association and British Association and Aesthetic Surgeons teams widely accepted as the gold level of therapy. We aim to discuss the current evidence about the initial management of this group of injuries, taking a journey from arrival in the accident and emergency department through to the point of definitive closure. Other modes of therapy are also reviewed.

scholarly journals Marginal bone and soft tissue behavior following platform switching abutment connection/disconnection- a dog model study

2014 ◽  
Vol 26 (9) ◽  
pp. 983-991 ◽  
Author(s):  
Célia C. Alves ◽  
Fernando Muñoz ◽  
António Cantalapiedra ◽  
Isabel Ramos ◽  
Manuel Neves ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Dog Model ◽  
Model Study ◽  
Platform Switching
Sign in / Sign up

Export Citation Format

Share Document