scholarly journals Methemoglobinemia After Isolated Lidocain Spray: A Rare Phenomenon

2015 ◽  
Vol 01 (01) ◽  
pp. 005-007
Author(s):  
Priyank Khandelwal ◽  
Rachna Malani ◽  
Soor Kothari ◽  
Tannvi Prakash ◽  
Amer Malik
Keyword(s):  
Case Report ◽  
Oxygen Delivery ◽  
Oxygen Affinity ◽  
Anesthetic Agents ◽  
Rare Phenomenon

AbstractMethemoglobinemia is a state recognized by the increased production of met-hemoglobin, which is a form of oxidized hemoglobin, which is unable to bind oxygen. As a result the patient has a functional anemia, in which the remaining oxyhemoglobin has increased oxygen affinity, shifting the oxygen curve to left and perpetuating the impairment of oxygen delivery to tissues. Methemoglobinemia is a rare, but serious cause of hypoxemia, which can be difficult to recognize. It has been traditionally associated with the use of benzocaine class of anesthetic agents and FDA has issued warning for the use of benzocaine class of anesthetic agents for the same reason. It has been very seldom reported with the use of lidocaine class of agents alone. Through this case report we want to emphasize development of methemoglobinemia through the isolated use of lidocaine.

scholarly journals Tumor vascular status controls oxygen delivery facilitated by infused polymerized hemoglobins with varying oxygen affinity

2020 ◽  
Vol 16 (8) ◽  
pp. e1008157
Author(s):  
Donald A. Belcher ◽  
Alfredo Lucas ◽  
Pedro Cabrales ◽  
Andre F. Palmer
Keyword(s):  
Oxygen Delivery ◽  
Oxygen Affinity ◽  
Vascular Status

scholarly journals Natal Teeth: A Case Report and Review

2018 ◽  
Vol 1 (3) ◽  
pp. 49-51
Author(s):  
Sandeep Shrestha ◽  
S. Namrata ◽  
K. Bhumesh ◽  
M. Sarita
Keyword(s):  
Case Report ◽  
Breast Feeding ◽  
Topical Anaesthesia ◽  
Mandibular Incisor ◽  
Live Births ◽  
Rare Phenomenon ◽  
Natal Teeth

A rare phenomenon, natal teeth are observed in infants at birth .The incidence of this anomaly has been approximately 1:1000 to 1:6000 live births. Presence of natal tooth may lead to numerous complications. Natal teeth can interfere with breastfeeding and, if excessively mobile, may be swallowed or aspirated during nursing. In this article, a case report is presented where a natal tooth was present in the mandibular incisor region. Due to the possibility of aspiration because of the presence of mobility and also as the teeth are causing discomfort to the mother during breast feeding, the teeth was extracted under topical anaesthesia and the healing was found to be satisfactory.

Parasitic Conjoined Twins: A Case Report

2000 ◽  
Vol 19 (5) ◽  
pp. 9-13
Author(s):  
Linda Juretschke
Keyword(s):  
Case Report ◽  
Conjoined Twins ◽  
Prenatal Ultrasound ◽  
Unusual Condition ◽  
Rare Phenomenon ◽  
Embryologic Development

Parasitic twins are a rare phenomenon and a challenge for caregivers. Occurring as a result of abnormal processes in the first several weeks of embryologic development, this condition is oftentimes diagnosed by prenatal ultrasound. This unusual condition may go undiagnosed until the time of delivery, however, despite the availability and use of advanced ultrasound techniques. The challenges presented by this condition are multiple and complex. The following case report demonstrates some of these challenges.

scholarly journals Anesthetic Management of a Child with Mitochondrial Neurogastrointestinal Encephalopathy

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Vianey Q. Casarez ◽  
Acsa M. Zavala ◽  
Pascal Owusu-Agyemang ◽  
Katherine Hagan
Keyword(s):  
Case Report ◽  
Anesthetic Management ◽  
Volatile Anesthetic ◽  
Autosomal Recessive Disorder ◽  
Hearing Impairments ◽  
Hematopoietic Stem ◽  
Gastrointestinal Dysmotility ◽  
Anesthetic Agents ◽  
Medication Selection ◽  
Repeated Use

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder associated with deficiency of thymidine phosphorylase (TP). Associated manifestations include visual and hearing impairments, peripheral neuropathies, leukoencephalopathy, and malnutrition from concomitant gastrointestinal dysmotility and pseudoobstruction. Given the altered metabolic state in these patients, specific consideration of medication selection is advised. This case report will describe the anesthetic management used in a 10-year-old girl with MNGIE. She had multiple anesthetics while undergoing allogeneic hematopoietic stem cell transplantation. This case report will discuss the successful repeated use of the same anesthetic in this pediatric patient, with the avoidance of volatile anesthetic agents, propofol, and muscle relaxant.

scholarly journals Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin

Blood ◽  
2021 ◽  
Author(s):  
Eric R Henry ◽  
Belhu Metaferia ◽  
Quan Li ◽  
Julia Harper ◽  
Robert B Best ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Oxygen Delivery ◽  
Cell Damage ◽  
Oxygen Affinity ◽  
Red Cell ◽  
Cell Disease ◽  
Oxygen Dissociation ◽  
Dissociation Curves

The issue of treating sickle cell disease with drugs that increase hemoglobin oxygen affinity has come to the fore with the FDA approval in 2019 of voxelotor, the only anti-sickling drug approved since hydroxyurea in 1998. Voxelotor reduces sickling by increasing the concentration of the non-polymerizing, high oxygen affinity R (oxy) conformation of HbS. Treatment of sickle cell patients with voxelotor increases Hb levels and decreases indicators of hemolysis, but with no indication as yet that it reduces the frequency of pain episodes. Here we use the allosteric model of Monod, Wyman, and Changeux to simulate whole blood oxygen dissociation curves and red cell sickling in the absence and presence of voxelotor under the in vivo conditions of rapid oxygen pressure decreases. Our modeling agrees with experiments using a new robust assay, which shows the very large, expected decrease in sickling from the drug. The modeling indicates, however, that the increase in oxygen delivery from reduced sickling is largely offset by the increase in oxygen affinity. The net result is that the drug increases overall oxygen delivery only at the very lowest oxygen pressures. Reduction of sickling does, however, mitigate against red cell damage and explains the observed decrease in hemolysis. More importantly, our modeling of in vivo oxygen dissociation, sickling, and oxygen delivery suggests that drugs that increase fetal hemoglobin or decrease MCHC, should be more therapeutically effective than drugs that increase oxygen affinity.

scholarly journals A Case Report of a Cecal Bascule with Internal Herniation through the Foramen of Winslow

2021 ◽  
Author(s):  
Eric Mulkey ◽  
Gregory Stewart ◽  
Ernesto Enrique ◽  
Rafik El-Sabrout
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Internal Herniation ◽  
Foramen Of Winslow ◽  
Internal Hernias ◽  
Abdominal Symptoms ◽  
Rare Phenomenon

Internal hernias are a rare phenomenon, and even rarer is a herniation through the foramen of Winslow. We report a rare case of an 81 year old female presenting with vague abdominal symptoms who was found to have a cecal bascule herniating through the foramen of Winslow treated with surgery.

scholarly journals Cone Beam Computed Tomography Application in Finding Ectopic Tooth: A Systemic Analysis and a Case Report

2019 ◽  
Vol 7 (24) ◽  
pp. 4333-4336
Author(s):  
Vo Truong Nhu Ngoc ◽  
Le Quynh Anh ◽  
Nguyen Minh Duc ◽  
Thien Chu Dinh ◽  
Toi Chu Dinh
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Maxillary Sinus ◽  
Cone Beam Computed Tomography ◽  
Cone Beam ◽  
Ct Scanner ◽  
Systemic Analysis ◽  
Rare Phenomenon ◽  
Asymptomatic Patients ◽  
Ectopic Tooth

BACKGROUND: Nowadays, cone beam computed tomography (CBCT) are commonly used in dentistry with an advantage about significantly lower dose comparing with CT-Scanner. Utilizing CBCT images which are indicated in dentistry like orthodontics can help diagnose diseases beyond dentistry field. One rare phenomenon can be seen in maxillary sinus, which is often overlooked by dentists, is ectopic teeth. CASE REPORT: This article describes one orthodontic case found accidentally an ectopic tooth in maxillary sinus by inspecting CBCT images. CONCLUSION: Dentists and oral radiologists should carefully inspect non-dental structures, like maxillary sinus, even its distance from the dentoalveolar region, especially in asymptomatic patients.

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