scholarly journals Cardiac Biomarkers: What Is and What Can Be

2018 ◽  
Vol 03 (04) ◽  
pp. 240-244 ◽  
Author(s):  
Rachel Jacob ◽  
Mahmood Khan
Keyword(s):  
Acute Coronary Syndrome ◽  
Cardiac Dysfunction ◽  
Circulatory System ◽  
Myocardial Damage ◽  
Accurate Diagnosis ◽  
Cardiac Biomarkers ◽  
Diagnosis And Management ◽  
Coronary Syndrome ◽  
Early Markers ◽  
The Many

AbstractCardiac biomarkers are of great importance in the timely, accurate diagnosis and management of acute coronary syndrome as well as the prognosis. Diagnosis in the golden period is of utmost importance to institute therapy at the earliest and possibly reverse the myocardial damage. Cardiac biomarkers are also a powerful tool for triaging. Among the many biomarkers, the earliest examined were the myocardial enzymes, several myocardial proteins, peptides, and many other molecules. The latest addition to the repertoire is the microRNAs, which are stable molecules detectable in circulation. About four groups are found to be involved in regulation of circulatory system, and some show promise as specific and early markers of acute coronary syndrome and cardiac dysfunction. As in other fields of medicine, personalized precise treatment may be possible with the use of microRNAs. However, as of now, a multipronged approach, involving different markers of which troponins are necessary, seems to be the best way forward.

Assessing the Performance of a Novel Point-of-Care Qualitative Assay for Early Diagnosis of Acute Coronary Syndrome

Cardiology ◽  
2020 ◽  
pp. 1-8
Author(s):  
Ronny Alcalai ◽  
Boris Varshisky ◽  
Ahmad Marhig ◽  
David Leibowitz ◽  
Larissa Kogan-Boguslavsky ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Chest Pain ◽  
Diagnostic Accuracy ◽  
Diagnostic Performance ◽  
Troponin I ◽  
Point Of Care ◽  
Final Diagnosis ◽  
Cardiac Biomarkers ◽  
Fatty Acid Binding ◽  
Coronary Syndrome

<b><i>Background:</i></b> Early and accurate diagnosis of acute coronary syndrome (ACS) is essential for initiating lifesaving interventions. In this article, the diagnostic performance of a novel point-of-care rapid assay (SensAheart<sup>©</sup>) is analyzed. This assay qualitatively determines the presence of 2 cardiac biomarkers troponin I and heart-type fatty acid-binding protein that are present soon after onset of myocardial injury. <b><i>Methods:</i></b> We conducted a prospective observational study of consecutive patients who presented to the emergency department with typical chest pain. Simultaneous high-sensitive cardiac troponin T (hs-cTnT) and SensAheart testing was performed upon hospital admission. Diagnostic accuracy was computed using SensAheart or hs-cTnT levels versus the final diagnosis defined as positive/negative. <b><i>Results:</i></b> Of 225 patients analyzed, a final diagnosis of ACS was established in 138 patients, 87 individuals diagnosed with nonischemic chest pain. In the overall population, as compared to hs-cTnT, the sensitivity of the initial SensAheart assay was significantly higher (80.4 vs. 63.8%, <i>p</i> = 0.002) whereas specificity was lower (78.6 vs. 95.4%, <i>p</i> = 0.036). The overall diagnostic accuracy of SensAheart assay was similar to the hs-cTnT (82.7% compared to 76.0%, <i>p</i> = 0.08). <b><i>Conclusions:</i></b> Upon first medical contact, the novel point-of-care rapid SensAheart assay shows a diagnostic performance similar to hs-cTnT. The combination of 2 cardiac biomarkers in the same kit allows for very early detection of myocardial damage. The SensAheart assay is a reliable and practical tool for ruling-in the diagnosis of ACS.

scholarly journals Diagnosis and management of acute coronary syndrome

2013 ◽  
Vol 3 (3) ◽  
pp. 124-133 ◽  
Author(s):  
Baker Hamilton ◽  
Edward Kwakyi ◽  
Alex Koyfman ◽  
Mark Foran
Keyword(s):  
Acute Coronary Syndrome ◽  
Diagnosis And Management ◽  
Coronary Syndrome

Abstract 12644: Growth Differentiation Factor-15 (GDF-15) for Risk Stratification in Patients After an Acute Coronary Syndrome: Insights From the SOLID-TIMI 52 trial

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Eri Toda Kato ◽  
David A Morrow ◽  
Christopher P Cannon ◽  
Mary Ann Lukas ◽  
Andrzej Budaj ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Cardiac Biomarkers ◽  
Individual Element ◽  
Clinical Predictors ◽  
Coronary Syndrome ◽  
Differentiation Factor ◽  
Increased Risk ◽  
Prognostic Utility ◽  
Traditional Risk Factors ◽  
Risk Predictors

Background: Growth differentiation factor (GDF)-15, a stress responsive cytokine, is associated with the risk of CV events after an acute coronary syndrome (ACS). Unlike other established cardiac biomarkers, the level of GDF-15 remains elevated in sub-acute phase after ACS and gradually decreases over time. We evaluated the prognostic utility of GDF-15 in patients after ACS accounting for established markers and risk predictors. Methods: GDF-15 (R&D Systems) and other established cardiac biomarkers (BNP, hsCRP and hsTnI) were measured at baseline in a randomly selected cohort of 4,968 patients enrolled within 30 days of hospitalization with ACS (median=14d) in SOLID-TIMI 52. Previously defined cutpoints were applied for GDF-15 concentration: <1200 (n=3451), 1200-1800 (n=919), and > 1800 ng/L (n=598). Analyses were adjusted for established risk predictors, days from the ACS event and other markers. MACE was defined as CV death, MI or stroke. Median follow-up was 2.5 years. Results: Patients with higher GDF-15 tended to be older, more likely to have diabetes, hypertension, history of revascularization, and CKD at baseline. Higher baseline levels of GDF-15 identified patients with higher rates of MACE as well as each individual element (p-trend <0.001 for all endpoints, Fig). The rate of MI was ∼2-fold higher in those with GDF-15 concentration >1800ng/L compared to patients with GDF-15 concentration <1200 ng/L. After adjustment for clinical predictors and other markers, GDF-15 was independently associated with the risk of MACE (HR 1.4, 95% CI 1.1-1.7; HR 1.8, 95% CI 1.4-2.3 for GDF-15 1200-1800, >1800, respectively). Individuals with GDF-15 >1800 ng/L had an increased risk of MI (adj HR 1.4, 95% CI 1.1-2.0) and stroke (adj HR 2.3, 95% CI 1.3-3.9). Conclusion: In patients after ACS, GDF-15 concentration is associated with the risk of MACE including MI and stroke independent of traditional risk factors and risk markers.

Emergencies in diseases of the circulatory system of the adult population of the Khabarovsk krai: the current status and trends

2021 ◽  
Vol 89 (3) ◽  
pp. 16-25
Author(s):  
K.P. Topalov ◽  
◽  
T.V. Zaitseva ◽  
T.G. Trembach ◽  
◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Cerebral Circulation ◽  
Adult Population ◽  
Circulatory System ◽  
Cerebrovascular Diseases ◽  
Current Status ◽  
Newly Diagnosed ◽  
Khabarovsk Krai ◽  
Coronary Syndrome ◽  
Status And Trends

The indicators of morbidity of the adult population of the Khabarovsk Krai with diseases of the circulatory system and mortality caused by these diseases in 2002–2019 were studied. Special attention is paid to urgent pathology - acute coronary syndrome and acute disorders of cerebral circulation. It was found that acute coronary syndrome and acute disorders of cerebral circulation in the region account for about 75–85% of all newly diagnosed diseases of the circulatory system - ischemic heart disease, cerebrovascular diseases; they result in up to 32% of deaths from diseases of the circulatory system

Emergencies in diseases of the circulatory system in the adult population of the Khabarovsk Territory: the current status and trends Part 3. Acute disorders of cerebral circulation

2021 ◽  
Vol 90 (4) ◽  
pp. 37-42
Author(s):  
K.P. Topalov ◽  
◽  
T.E. Zaitseva ◽  
T.G. Trembach ◽  
◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Cerebral Circulation ◽  
Adult Population ◽  
Circulatory System ◽  
Cerebrovascular Diseases ◽  
Current Status ◽  
Newly Diagnosed ◽  
Khabarovsk Krai ◽  
Coronary Syndrome ◽  
Status And Trends

The indicators of morbidity of the adult population of the Khabarovsk Krai with diseases of the circulatory system and mortality from them in 2002–2019 have been studied. Special attention is paid to urgent pathology – acute coronary syndrome and acute disorders of cerebral circulation. It was found that acute coronary syndrome and acute disorders of cerebral circulation in the region account for about 75–85% of all newly diagnosed diseases of the circulatory system – ischemic heart disease, cerebrovascular diseases; they give up to 32% of deaths from diseases of the circulatory system

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