Significance of Fibrinogen/Fibrin Degradation Products (FDP) after Cardiovascular Surgery
The frequent appearance of FDP during the postoperative of cardiovascular surgery using extracorporeal circulation, induced us to determine its diagnostic value. 17 patients were studied. Fibrinolytic activity was determinated using the staphylococcal clumping test (SCT) and the latex plasmmin-antiplasmin immunoassay (LPA). Normal value of LPA in plasma previously studied in 15 normal patients was negative to positive up to a dilution of 1/4. Normal value of SCT in our laboratory (in 200 normal patients studied) was less than lug/ml. All postoperative periods were normal and from 1 to 6 tests using both methods were performed. From 36 SCT readings, 27 were positive (in 13 patients) with a mean of 10.2ug/ml (range 1.2-96.8). Positive LPA was found in 5 readings in 4 patients. In only 2 cases the SCT detected high concentration of FDP together with strong positive LPA (dilutions 1/10 and 1/20). It is concluded that the frequent appearance of FDP during early postoperative period of cardiovascular surgery, because of the low incidence of positive LPA, does not necessarily indicate plasmatic fibrinolytic activity, as it is possible that this should appear as a result of absortion of extravascular resolution of fibrin related material.