Fibrinolytic Activity in Patients with Acute Tonsillitis

1979 ◽  
Vol 88 (3) ◽  
pp. 366-367 ◽  
Author(s):  
T. Kosugi ◽  
O. Matsuo ◽  
M. Hamaya ◽  
H. Mihara
Keyword(s):  
Fibrinolytic Activity ◽  
Degradation Products ◽  
Healthy Adults ◽  
Fibrinolytic System ◽  
Acute Tonsillitis ◽  
Fibrin Degradation Products ◽  
Fibrinogen Content

Three parameters in blood fibrinolysis, viz, the levels of fibrinogen, plasminogen, and fibrinogen and/or fibrin degradation products (FDP), were measured in patients with acute tonsillitis and the results were compared with those for healthy adults. The fibrinogen content in acute tonsillitis increased significantly ( P <.001), that of plasminogen decreased significantly ( P <.005), while FDP showed a higher value ( P <.01). The significance of the fibrinolytic system in acute tonsillitis is discussed.

Effects of exercise and conditioning on clotting and fibrinolytic activity in men

1987 ◽  
Vol 62 (4) ◽  
pp. 1416-1421 ◽  
Author(s):  
E. W. Ferguson ◽  
L. L. Bernier ◽  
G. R. Banta ◽  
J. Yu-Yahiro ◽  
E. B. Schoomaker
Keyword(s):  
Fibrinolytic Activity ◽  
Blood Clotting ◽  
Degradation Products ◽  
Clot Lysis ◽  
Plasma Clot ◽  
Fitness Program ◽  
Fibrin Degradation Products ◽  
Before And After ◽  
Plasmin Inhibitor ◽  
Sedentary Subjects

Sixty healthy men in three physical fitness categories (sedentary, on no organized fitness program; joggers, running 5–15 miles/wk; and marathoners, running greater than 50 miles/wk) were evaluated for changes in blood clotting and fibrinolytic activity before and after maximum exercise on a treadmill according to the Bruce protocol. The rate of blood clotting, as measured by prothrombin times, partial thromboplastin times and thrombin times, was accelerated by exercise (all P less than 0.005). The ability of euglobulin clots and plasma clots to lyse incorporated 125I-fibrin, termed 125I-euglobulin clot lysis (IEL) and 125I-plasma clot lysis (IPCL), were used as indexes of fibrinolytic activity. Marathoners had greater increases in fibrinolytic activity with exercise (76% compared with 63% for joggers and 55% for sedentary subjects by IEL; 427% compared with 418% for joggers and 309% for sedentary subjects by IPCL; all P less than 0.05). Fibrin degradation products increased with exercise (P less than 0.005 for the total group of 60 subjects). The absolute concentrations of alpha 2-plasmin inhibitor, alpha 2-macroglobulin, and antithrombin III increased with exercise (all P less than 0.005), but when concentrations were corrected for acute shifts of plasma water during exercise, the quantity of these inhibitors actually decreased (all P less than 0.005). The changes in clotting assays with exercise were not significantly correlated with changes in whole blood lactate, blood pyruvate, or rectal temperatures. Fibrinolytic assays before and after exercise correlated poorly to moderately with blood lactates (IEL: r = 0.441 and r = 0.425, respectively; IPCL: r = 0.294 and r = 0.544, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

The Resistance of Soluble Derivatives of Fibrinogen and the Sensitivity of Its Insoluble Forms to Fibrinolytic Degradation in Blood

1974 ◽  
Vol 32 (02/03) ◽  
pp. 582-591 ◽  
Author(s):  
Victor Gurewich ◽  
Andrzej Nowak ◽  
Izabella Lipinska ◽  
Boguslaw Lipinski
Keyword(s):  
Fibrinolytic Activity ◽  
Degradation Products ◽  
Venous Occlusion ◽  
Protamine Sulfate ◽  
Electrophoretic Method ◽  
Soluble Fibrin ◽  
Fibrin Degradation Products ◽  
Fibrin Monomer ◽  
Derivatives Of

SummaryThe effect of naturally induced fibrinolytic activity on fibrinogen and certain soluble and insoluble derivatives was studied. Experiments were performed on blood removed after venous occlusion of the arm and immediately after death. A previously described electrophoretic method was used by which the heterogeneity of fibrinogen can be demonstrated directly in intact plasma. It was shown that fibrinogen, soluble fibrin monomer (FM) complexes and fibrin degradation products are resistant to degradation by naturally-induced fibrinolytic activity. By contrast, rapid lysis of fibrin, protamine sulfate (PS) precipitated fibrinogen, and PS and ethanol induced gels of FM occurred. The observations are believed relevant to our understanding of the pathway of fibrinogen and FM catabolism and the interpretation of the origin of serum FDP.

Sustained Fibrinolysis After Administration of t-PA Despite Its Short Half-Life in the Circulation

1987 ◽  
Vol 57 (01) ◽  
pp. 035-040 ◽  
Author(s):  
Paul R Eisenberg ◽  
Laurence A Sherman ◽  
Alan J Tiefenbrunn ◽  
Philip A Ludbrook ◽  
Burton E Sobel ◽  
...  
Keyword(s):  
Half Life ◽  
Fibrinolytic Activity ◽  
Degradation Products ◽  
Clinical Success ◽  
Tissue Type ◽  
Tissue Type Plasminogen Activator ◽  
Fibrin Degradation Products ◽  
Short Half Life ◽  
Type Plasminogen Activator ◽  
The Difference

SummaryTo characterize the duration of the fibrinolytic response to tissue-type plasminogen activator (t-PA) and streptokinase (SK) in patients with acute myocardial infarction we serially assayed crosslinked fibrin degradation products (XL-FDP) and Bβ15-42 fibrinopeptide. Use of specific monoclonal antibodies permitted quantification and differentiation of fibrin from fibrinogen degradation products. Marked elevations of XL-FDP occurred within 1 hour after administration of t-PA (n = 13) or SK (n = 35) to >1000 ng/ml in 79% of the patients. All patients given t-PA exhibited elevations of XL-FDP >1000 ng/ml, most exhibited values >5000 ng/ml (79% of patients). In contrast 6 of the patients given SK failed to exhibit XL-FDP >1000 ng/ml. XL-FDP >5000 ng/ml occurred in only 14%. The difference in the response to t-PA compared to SK was particularly striking 7 hours or more after administration of activator at which time XL-FDP were markedly elevated in patients given t-PA (5821 ± 1683 ng/ ml) compared with decreasing values in patients given SK (2924 ± 1186 ng/ml) (p <0.01). Levels of Bβ315-42 were significantly higher after t-PA compared with SK beginning 3 hours after treatment, consistent with a greater intensity of fibrinolytic response to t-PA. Marked elevations of this short lived degradation product of fibrin (t1/2 = 10-20 minutes) in the samples drawn late after administration of t-PA (44.3 ±12.8 nM) but not after SK (11.7 ± 4.5 nM) confirmed prolonged fibrinolytic activity of plasmin after t-PA. There was no discernible relationship between the extent of fibrinolysis as assessed by XL-FDP and Bβ 15-42 and the total dose of t-PA administered or the duration of the infusion. Elevations of XL-FDP invariably occurred after SK, and were not significantly different in patients with or without recanalization. Thus “clinical success” of coronary thrombolysis appears to depend on a favorable balance between thrombosis and fibrinolysis rather than the intensity of fibrinolysis alone. The prolonged fibrinolytic activity after t-PA appears to reflect the enhanced binding of this activator to fibrin and is likely to result in more sustained and hence more effective fibrinolysis with t-PA compared to SK despite the short half-life of t-PA (t1/2 = 6 minutes) in the circulation.

Relationship between Plasma Fibrinolytic Activity and Serum Fibrinogen Degradation Products (FDP) Tested by Various Methods

1971 ◽  
Vol 26 (01) ◽  
pp. 083-087 ◽  
Author(s):  
B Lipiński ◽  
A Nowak ◽  
A Odrzywolska ◽  
J Dosiak
Keyword(s):  
Healthy Subjects ◽  
Fibrinolytic Activity ◽  
Degradation Products ◽  
Clot Lysis ◽  
Proteolytic Degradation ◽  
Fibrinogen Degradation Products ◽  
Lysis Time ◽  
Euglobulin Clot Lysis Time ◽  
Fibrinogen Content ◽  
Clot Lysis Time

SummaryIt was found in the present work that the level of serum fibrinogen degradation products (FDP) determined by the immunoassay method correlated well with the staphylococcal clumping titer in serum (correlation coefficient r = 0.68). The content of FDP in serum of 30 healthy subjects and patients with various diseases did not correlate, however, neither with blood fibrinolytic activity estimated by the euglobulin clot lysis time, nor with fibrinogen content and plasma anticlotting activity. It is concluded, that FDP appear in circulation as a result of local proteolytic degradation of intravascularly deposited fibrin without generalized activation of fibrinolysis.

scholarly journals Fibrinogen, Fibrinogen Heterogeneity and Fibrinolytic Activity in Diabetes Mellitus

1977 ◽  
Author(s):  
Victor Gurewich ◽  
Izabella Lipinska ◽  
Maria Pulini ◽  
Edwin Gordon ◽  
Boguslaw Lipinski
Keyword(s):  
Diabetes Mellitus ◽  
Molecular Weight ◽  
Fibrinolytic Activity ◽  
Degradation Products ◽  
Microvascular Disease ◽  
Vascular Lesions ◽  
Mean Values ◽  
Fibrin Degradation Products ◽  
Degree Of Control ◽  
The Mean

Fibrinogen (F) concentration, fibrinogen heterogeneity on 3.5% Polyacrylamide gels, fibrinolytic activity (FA) measured by euglobulin fraction on fibrin plates and fibrin degradation products (FDP) were measured in 66 patients with well documented diabetes mellitus (DM) and in 50 healthy subjects of comparable age. A high molecular weight and 2 lower molecular weight (LMW and LMW1) fibrinogen fractions were identified. The mean values and statistical evaluation of their differences were as follows:The clinical duration of DM, degree of control or type of medication did not appear to influence these findings. However, within the patient group, those with clinical evidence of microvascular disease had significantly (p<0.02) higher LMW1 fibrinogen and lower FDP (p<0.01) than the remainder. These findings suggest that DM is associated with fibrin deposition, and accelerated F degradation to LMW and LMW1 fractions and that these processes may be associated with the development of vascular lesions.

scholarly journals The Effect of Enhanced Fibrinolytic Activity on the Red Cell Membrane Transport

1977 ◽  
Author(s):  
S.B. Ulutin ◽  
N. B. Emekli ◽  
T. U. Yardimici
Keyword(s):  
Active Transport ◽  
Fibrinolytic Activity ◽  
Time Course ◽  
Degradation Products ◽  
Human Subjects ◽  
Red Cells ◽  
Fibrinolytic System ◽  
Red Cell ◽  
Red Cell Membrane ◽  
Before And After

In dogs and in human subjects, using hepatic vein catheterization before and after the activation of the fibrinolytic system, the blood samples were obtained and the red cell amino acid transport was investigated. The time course accumulation of radioactive histidine in isolated red cells was followed together with the measurements of the fibrinolytic activity.A decrease in the active transport of histidine was observed in the red cells after the stimulation of the fibrinolytic system. Also a correlation between the decrease of active transport and the increase of fibrin-fibrinogen degradation products was seen.

scholarly journals Significance of Fibrinogen/Fibrin Degradation Products (FDP) after Cardiovascular Surgery

1977 ◽  
Author(s):  
R. Altman ◽  
A. Zielinsky ◽  
J. Rouvier ◽  
R.G. Favaloro
Keyword(s):  
Postoperative Period ◽  
Fibrinolytic Activity ◽  
Cardiovascular Surgery ◽  
Degradation Products ◽  
Diagnostic Value ◽  
Early Postoperative Period ◽  
High Concentration ◽  
Normal Value ◽  
Fibrin Degradation Products ◽  
Low Incidence

The frequent appearance of FDP during the postoperative of cardiovascular surgery using extracorporeal circulation, induced us to determine its diagnostic value. 17 patients were studied. Fibrinolytic activity was determinated using the staphylococcal clumping test (SCT) and the latex plasmmin-antiplasmin immunoassay (LPA). Normal value of LPA in plasma previously studied in 15 normal patients was negative to positive up to a dilution of 1/4. Normal value of SCT in our laboratory (in 200 normal patients studied) was less than lug/ml. All postoperative periods were normal and from 1 to 6 tests using both methods were performed. From 36 SCT readings, 27 were positive (in 13 patients) with a mean of 10.2ug/ml (range 1.2-96.8). Positive LPA was found in 5 readings in 4 patients. In only 2 cases the SCT detected high concentration of FDP together with strong positive LPA (dilutions 1/10 and 1/20). It is concluded that the frequent appearance of FDP during early postoperative period of cardiovascular surgery, because of the low incidence of positive LPA, does not necessarily indicate plasmatic fibrinolytic activity, as it is possible that this should appear as a result of absortion of extravascular resolution of fibrin related material.

The Measurement of Fibrinolysis in the Rat

1971 ◽  
Vol 26 (02) ◽  
pp. 295-310 ◽  
Author(s):  
M. J Gallimore ◽  
H. M Tyler ◽  
J. T. B Shaw
Keyword(s):  
Whole Blood ◽  
Fibrinolytic Activity ◽  
Factor Xiii ◽  
Degradation Products ◽  
Blood Clot ◽  
Clot Lysis ◽  
Plate Assay ◽  
Fibrin Degradation Products ◽  
Fibrin Plate ◽  
Dilute Blood

SummaryMethods are described for measuring fibrinolytic activity in the rat. These include dilute blood clot lysis, euglobulin clot lysis, a fibrin plate assay with euglobulin solutions, and an accelerated whole blood clot lysis technique in which limited fibrinolysis is induced with urokinase. In addition, methods have been worked out for the estimation of four plasma components closely involved in fibrinolysis: fibrinogen, factor XIII, plasma inhibitors and fibrin degradation products. The sensitivity and validity of the assays were tested by studying their capacity to detect changes resulting from the administration of eledoisin, Neohydrin and turpentine.

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