Inhibitory Effect of Aprotinin on the Activation Process of Contact Factors and Platelet Aggregation
It has been reported by several investigators that aprotinin demonstrates inhibitory action on the process of intrinsic blood thromboplastin generation. In this paper the authors will present the facts that on the hydrolytic action of plasma kallikrein, and on the activation process of plasma prekallikrein as well, the inhibitory action of aprotinin is indicated by the use of chromozym PK assay and the latter process might be caused by the inhibition of factor XII activated with Kaolin, and as to platelet aggregation induced by thrombin, aprotinin also plays the inhibitory effect which is more sensitive than the antithrombin activity of aprotinin measured by thrombin clotting time. However, the inhibitory effect of aprotinin on platelets might be caused not only by antithrombic action of this enzyme inhibitor, but also other influence of the inhibitor on release mechanism of the platelets, because epinephrine induced platelet aggregation can be disturbed by the addition of this inhibitor. In summary it mighy be suggested in this study that the clinical use of aprotinin preparation might be one way for anticoagulant thrapy on thrombotic deseases associated with intrinsic hypercoagulability of plasma factors and platelets.