scholarly journals Biological Properties of an Heparin-Poly (Methyl Methacrylate) Copolymer

1977 ◽  
Author(s):  
D. Labarre ◽  
G.A. Boffa ◽  
M. Jozefowicz ◽  
M.C. Boffa
Keyword(s):  
Aqueous Solution ◽  
Methyl Methacrylate ◽  
Antithrombin Iii ◽  
Biological Properties ◽  
Anticoagulant Effect ◽  
Factor V ◽  
Clotting Factors ◽  
Poly Methyl Methacrylate ◽  
Methacrylate Copolymer ◽  
Ig G

The heparin-poly(methyl methacrylate) copolymer was prepared by polymerization of methyl methacrylate on an heparin radical. It was initiated by cerium IV ions and heparin in nitric aqueous solution.An heparin effect was present in the plasma in contact with the copolymer. It was not due to a release of heparin in the plasma, but to a contact effect. The anticoagulant effect was depending upon the concentration of the copolymer. The activity of clotting factors in plasma, after a contact with the copolymer was not decreased except for factor V. Antithrombin III was selectively adsorbed on the surface of the copolymer.The copolymer lost progressively its anticoagulant properties after each contact with the plasma. This might be due to the adsorption of fibrinogen on the copolymer. Labelled 125I albumin, transferrin, Ig G and fibrinogen were not similarly desorbed in the presence of serum and of plasma.This copolymer seems to offer interesting properties for blood devices.

Interactions between Human Plasma Proteins and Heparin-Poly(Methyl Methacrylate) Copolymer

1979 ◽  
Vol 41 (02) ◽  
pp. 346-356 ◽  
Author(s):  
M C Boffa ◽  
D Labarre ◽  
M Jozefowicz ◽  
G A Boffa
Keyword(s):  
Methyl Methacrylate ◽  
Antithrombin Iii ◽  
Factor Ix ◽  
Factor V ◽  
Antithrombin Activity ◽  
Leading Role ◽  
High Concentrations ◽  
Covalently Linked ◽  
Albumin Adsorption ◽  
Methacrylate Copolymer

SummaryA solid Heparin-PMMA copolymer has been synthetized by a radical polymerization of methyl methacrylate from oxidative reaction initiated by Ce4+ ions in the presence of heparin. Covalently linked heparin was 10% of copolymer weight. The antithrombin activity of the copolymer corresponded to 1% of grafted heparin. PMMA sequence of the copolymer played the leading role in fibrinogen, immunoglobulins, transferrin and albumin adsorption. These proteins adsorbed on the copolymer, showed different competitive desorption pattern in the presence of whole plasma: fibrinogen presented the highest degree of affinity for the copolymer. The heparin part of the copolymer was responsible for antithrombin III adsorption and for decrease of factor V activity. Active antithrombin III was eluted. An inactivation of factor V in plasma was observed using high concentrations of soluble heparin. This result suggested that copolymer heparin chains, even devoid of antithrombin activity, were involved in this inactivation. With Heparin-PMMA copolymer, plasma clotting pro-enzymes behaved differently than on heparin-sepharose copolymer: disappearance of factor XI activity, decrease in prekallikrein activity and activation of factor IX were observed. PMMA sequences were responsible for factor IX activation.

scholarly journals Effect of Added Salt on Disordered Poly(ethylene oxide)-Block-Poly(methyl methacrylate) Copolymer Electrolytes

2021 ◽  
Vol 54 (3) ◽  
pp. 1414-1424
Author(s):  
Neel J. Shah ◽  
Sajjad Dadashi-Silab ◽  
Michael D. Galluzzo ◽  
Saheli Chakraborty ◽  
Whitney S. Loo ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Methyl Methacrylate ◽  
Poly Methyl Methacrylate ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Methacrylate Copolymer ◽  
Added Salt

Biodegradable poly(ester)-poly(methyl methacrylate) copolymer for marine anti-biofouling

2018 ◽  
Vol 124 ◽  
pp. 55-60 ◽  
Author(s):  
Guoxiong Dai ◽  
Qingyi Xie ◽  
Shanshan Chen ◽  
Chunfeng Ma ◽  
Guangzhao Zhang
Keyword(s):  
Methyl Methacrylate ◽  
Poly Methyl Methacrylate ◽  
Biodegradable Poly ◽  
Methacrylate Copolymer

A comparison of pyrolytical and oxidative degradation of poly(methyl methacrylate) and methyl methacrylate-styrene copolymer using the capillary GC and GC-MS methods

1989 ◽  
Vol 54 (4) ◽  
pp. 934-939 ◽  
Author(s):  
Věra Pacáková ◽  
Ramona Dieckmann ◽  
Piet A. Leclercq ◽  
Karel Hoch
Keyword(s):  
Thermal Degradation ◽  
Methyl Methacrylate ◽  
High Frequency ◽  
Oxidative Degradation ◽  
Combustion Products ◽  
Inert Atmosphere ◽  
Tubular Furnace ◽  
Capillary Gc ◽  
Poly Methyl Methacrylate ◽  
Methacrylate Copolymer

The thermal degradation of poly(methyl methacrylate) (PMMA) and of a methyl methacrylate copolymer with styrene (MMA-ST) were studied in an inert atmosphere and in the air, under conditions simulating a fire. Tubular furnace and high-frequency pyrolyzers were compared. The combustion products were analyzed using the capillary GC and GC-MS methods.

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