Coexistence of Temporo-Occipital Polymicrogyria with Choroidal Fissure Cyst in a Case of Focal Onset Seizures

AbstractFocal-onset seizures can be caused by underlying brain lesions including focal lesions such as granulomas, low-grade neoplasms, vascular lesions, or neuronal migration disorders. Polymicrogyria is a congenital abnormality of cortical formation occurring during embryonic life. Choroidal fissure cysts are either arachnoid or neuroepithelial cysts arising at the choroidal fissure, and mostly they are incidental findings having no significant clinical implications. Coexistence of both of these can lead to dilemma in the management decisions. We present a case of focal-onset seizures with an unreported coexistence of polymicrogyria with choroidal fissure cyst.

Download Full-text

Various Findings in Surgically Treated Epilepsy Patients with Dysembryoplastic Neuroepithelial Tumors in Comparison with Those of Patients with Other Low-grade Brain Tumors and Other Neuronal Migration Disorders

Epilepsia ◽

10.1046/j.1528-1157.2002.15201.x ◽

2002 ◽

Vol 43 (11) ◽

pp. 1379-1384 ◽

Cited By ~ 24

Author(s):

Rolf Degen ◽

Aloys Ebner ◽

Rainer Lahl ◽

Stephanie Leonhardt ◽

Heinz W. Pannek ◽

...

Keyword(s):

Brain Tumors ◽

Neuronal Migration ◽

Low Grade ◽

Neuroepithelial Tumors ◽

Dysembryoplastic Neuroepithelial Tumors ◽

Neuronal Migration Disorders ◽

Migration Disorders

Download Full-text

Recent Development in Neuronal Migration Disorders: Clinical, Neuroradiologic and Genetics Aspects

Current Pediatric Reviews ◽

10.2174/157339608787407681 ◽

2008 ◽

Vol 4 (4) ◽

pp. 216-226

Author(s):

Paola Iannetti ◽

Alberto Spalice ◽

Laura Papetti ◽

Pasquale Parisi

Keyword(s):

Neuronal Migration ◽

Neuronal Migration Disorders ◽

Migration Disorders

Download Full-text

Lactate and Other Metabolic Changes in Neuronal Migration Disorders

Epilepsia ◽

10.1046/j.1528-1157.2001.29300-3.x ◽

2001 ◽

Vol 42 (2) ◽

pp. 288-291

Author(s):

Else Rubaek Danielsen ◽

Carsten Thomen

Keyword(s):

Neuronal Migration ◽

Metabolic Changes ◽

Neuronal Migration Disorders ◽

Migration Disorders

Download Full-text

How can scanned proton beam treatment planning for low‐grade glioma cope with increased distal RBE and locally increased radiosensitivity for late MR‐detected brain lesions?

Medical Physics ◽

10.1002/mp.14739 ◽

2021 ◽

Author(s):

Julia Bauer ◽

Emanuel Bahn ◽

Semi Harrabi ◽

Klaus Herfarth ◽

Jürgen Debus ◽

...

Keyword(s):

Treatment Planning ◽

Proton Beam ◽

Brain Lesions ◽

Low Grade Glioma ◽

Low Grade

Download Full-text

Thrombotic complications in adult patients with lymphoma: a meta-analysis of 29 independent cohorts including 18 018 patients and 1149 events

Blood ◽

10.1182/blood-2010-01-258624 ◽

2010 ◽

Vol 115 (26) ◽

pp. 5322-5328 ◽

Cited By ~ 68

Author(s):

Vanesa Caruso ◽

Augusto Di Castelnuovo ◽

Susana Meschengieser ◽

Maria A. Lazzari ◽

Giovanni de Gaetano ◽

...

Keyword(s):

Hodgkin Lymphoma ◽

Meta Analysis ◽

Hematologic Malignancies ◽

Incidence Rates ◽

Clinical Implications ◽

Low Grade ◽

Thrombotic Risk ◽

Non Hodgkin Lymphoma ◽

Thrombotic Complications ◽

Exact Maximum Likelihood

AbstractThrombotic complications in hematologic malignancies have important clinical implications. In this meta-analysis we sought to obtain accurate estimates of the thrombotic risk in lymphoma patients. Articles were searched in electronic databases and references. Eighteen articles were identified (29 cohorts, 18 018 patients and 1149 events). Pooled incidence rates (IRs) were calculated by the use of a method based on the exact maximum likelihood binomial distribution. The global IR of thrombosis was 6.4% (95% confidence interval [CI] 6.0%-6.8%). The global IRs of venous or arterial events were 5.3% (95% CI, 5.0%-5.7%) and 1.1% (95% CI, 0.9%-1.2%), respectively. The IR of thrombosis observed in subjects with non-Hodgkin lymphoma (NHL) was 6.5% (95% CI, 6.1%-6.9%), significantly greater than that observed for patients with Hodgkin lymphoma (4.7%; 95% CI, 3.9%-5.6%). Within NHL, patients with high-grade disease had a greater risk of events (IR 8.3%; 95% CI, 7.0%-9.9%) than low-grade disease (IR 6.3%; 95% CI, 4.5%-8.9%). This meta-analysis shows that the IR of thrombosis in lymphoma patients is quite high, especially in those with NHL at an advanced stage of the disease. These results may help better defining lymphoma populations at high thrombotic risk, to whom prophylactic approaches could be preferentially applied.

Download Full-text

Neuronal migration disorders in humans and in mouse models—an overview

Epilepsy Research ◽

10.1016/s0920-1211(99)00047-9 ◽

1999 ◽

Vol 36 (2-3) ◽

pp. 133-141 ◽

Cited By ~ 28

Author(s):

Andrew J Copp ◽

Brian N Harding

Keyword(s):

Mouse Models ◽

Neuronal Migration ◽

Neuronal Migration Disorders ◽

Migration Disorders

Download Full-text

CNTM-03. Functional connectivity networks in patients with brain tumors and vascular lesions in the occipital cortex

Neuro-Oncology ◽

10.1093/neuonc/noab196.901 ◽

2021 ◽

Vol 23 (Supplement_6) ◽

pp. vi224-vi225

Author(s):

Katharina Rosengarth ◽

Katharina Hense ◽

Tina Plank ◽

Mark Greenlee ◽

Christina Wendl ◽

...

Keyword(s):

Functional Connectivity ◽

Brain Tumors ◽

Visual Processing ◽

Network Connectivity ◽

Occipital Cortex ◽

Brain Lesions ◽

Vascular Lesions ◽

Surrounding Tissue ◽

Tumor Patients ◽

Default Mode

Abstract OBJECTIVE Space-occupying brain lesions as brain tumors in the occipital lobe have only been sparsely investigated so far, as this localization is extremely rare with only 1% of cases. It is still unclear how this affects the overall organization of the visual system. We investigated functional connectivity of functional networks associated with higher visual processing between patients with occipital space-occupying lesion in the occipital cortex and healthy controls. METHODS 12 patients with brain tumors, 7 patients with vascular lesions in the occipital cortex and 19 healthy subjects matched for age and sex were included. During functional MRI patients and subjects performed a visual excentricity mapping task. Data analysis was done using CONN toolbox based on Matlab. See-to-ROI connectivities of 23 Regions of Interest (ROIs) implemented in the CONN toolbox which were assigned to the Default Mode, Visual, Salience, Dorsal Attention, and Frontoparietal network were assessed. For each subject, connectivity was calculated using Fischer transformed pairwise correlations. These correlations were first considered separately for each group in one-sample analyses and then compared between the groups. RESULTS Main results show, that compared to control subjects and vascular patients, tumor patients showed weaker intra-network connectivity of components of all networks except the default-network. Tumor patients showed even stronger between-network connectivity in the default-mode network compared to the other groups. Weaker connectivity was observed within the salience network in both patient groups compared to controls. CONCLUSION The results indicate that in the course of the disease, compensatory countermeasures take place in the brain against a brain tumor or a space-occupying brain lesion with the aim of maintaining the performance level and cognitive processes for as long as possible. However, more research is needed in this area to understand the mechanisms and effects of brain tumors and space-consuming brain lesions on surrounding tissue.

Download Full-text