scholarly journals Dermatomyositis as a paraneoplastic syndrome associated with head and neck tumors: Case series and literature review

2019 ◽  
Author(s):  
J Klukas ◽  
A Pudszhun ◽  
VM Hofmann
2015 ◽  
Vol 139 (1) ◽  
pp. 55-66 ◽  
Author(s):  
Shaobo Zhu ◽  
Conrad Schuerch ◽  
Jennifer Hunt

Context Immunohistochemistry is a useful tool for diagnosing salivary gland and head and neck tumors. Objective To review immunohistochemical markers, which can aid in the diagnosis of selected salivary gland and head and neck tumors. Data Sources Literature review and authors' personal practice experience. Conclusions Salivary gland and head and neck tumors include a large diverse group of tumors with complex and overlapping histologic features. Immunohistochemistry plays an important role in resolving the differential diagnosis of some salivary gland and head and neck tumors and can provide information for the prognosis of certain tumors.


2021 ◽  
Vol 7 (3) ◽  
pp. 163
Author(s):  
Anastasia D. Rodina ◽  
Vladimir Sh. Vanesyan ◽  
Tatiana V. Gorbunova ◽  
Natalia V. Ivanova ◽  
Vladimir G. Polyakov

1999 ◽  
Vol 117 (3) ◽  
pp. 113-120 ◽  
Author(s):  
Cláudia Malheiros Coutinho ◽  
Alessandra Simões Bassini ◽  
Leonardo Guilhermino Gutiérrez ◽  
Ossamu Butugan ◽  
Luiz Paulo Kowalski ◽  
...  

CONETXT: Ras gene mutations have been associated to a wide range of human solid tumors. Members of the ras gene family (Ki-ras, Ha-ras and N-ras) are structurally related and code for a protein (p21) known to play an important role in the regulation of normal signal transduction and cell growth. The frequency of ras mutations is different from one type of tumor to another, suggesting that point mutations might be carcinogen-specific. OBJECTIVES: To study the occurrence of Ki-ras and Ha-ras mutations. We also studied the relative level of Ha-ras mRNA in 32 of the head and neck tumors. DESIGN: Case series. SETTING: University referral unit. PARTICIPANTS: 60 head and neck tumors and in 28 Juvenile Nasopharyngeal Angiofibromas (JNA). DIAGNOSTIC TEST: Using PCR-SSCP we examined the occurrence of Ki-ras and Ha-ras mutations. The relative level of Ha-ras mRNA was examined by Northern blot analysis. RESULTS: None of the head and neck tumors or JNA samples showed evidence of mutations within codons 12, 13, 59 and 61 of Ki-ras or Ha-ras genes. However, 17 (53%) of the tumors where gene expression could be examined exhibited increased levels of Ha-ras mRNA compared with the normal tissue derived from the same patient. CONCLUSIONS: Our results demonstrate for the first time that mutations of Ki-ras and Ha-ras genes are not associated with the development of JNA and confirm previous reports indicating that activating ras mutations are absent or rarely involved in head and neck tumors from western world patients. Furthermore, our findings suggest that overexpression of Ha-ras, rather than mutations, might be an important factor in the development and progression of head and neck tumors.


2021 ◽  
Vol 1 ◽  
pp. 0-0
Author(s):  
Jingcun Shi ◽  
Liya Wang ◽  
Ahmed Abdelrehem ◽  
Yi Zhang ◽  
Ziqian Wu ◽  
...  

Oral Oncology ◽  
2021 ◽  
Vol 114 ◽  
pp. 105145
Author(s):  
Charlotte Benoit ◽  
Daniel Orbach ◽  
Stacy Cyrille ◽  
Kahina Belhous ◽  
Véronique Minard-Colin ◽  
...  

2020 ◽  
Vol 36 (1) ◽  
Author(s):  
Ahmed Abdullah Hamd ◽  
Essam Abd El-Wanes Behiry ◽  
Adel Tharwat Atallah ◽  
Sherif Maher Elaini ◽  
Ahmed Hamdy Alshafai

Abstract Background Nowadays, radiotherapy is widely used in management of many types of tumors including head and neck tumors; in this study, we concerned with its reverse effects on the Eustachian tube functions and if this effect is temporary or permanent. Results The whole (30) patients have tympanogram at both ears before starting radiotherapy; all patients (100%) were normal. In the immediate post radiotherapy tympanogram at the contralateral side, 6.7% of patients had effusion, and 20% had Eustachian tube dysfunction, while at the ipsilateral side, 20% of patients had effusion, and 33.3% had ET dysfunction. In the follow-up tympanogram 12 weeks post radiotherapy, we found that 6.7% of patients had effusion, and (10%) had Eustachian tube dysfunction at the contralateral side, while 6.7% of patients had effusion, and only 20% had Eustachian tube dysfunction at the ipsilateral side. Conclusion From this study, we concluded that patients with head and neck tumors treated by radiotherapy (apart from the nasopharynx) have a high incidence of affection of Eustachian tube function namely middle ear effusion and Eustachian tube dysfunction. The possibility for development of middle ear effusion and Eustachian tube dysfunction increases with increased tumor stage. Eustachian tube functions immediately post radiotherapy and after 12 weeks of the end of radiotherapy was affected by different effects according to the tumor site. The Eustachian tube functions significantly improved within 12 weeks after the last dose of radiotherapy, and we recommend audiological follow-up for patients with head and neck tumors treated with radiotherapy.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Steve Durante ◽  
Vincent Dunet ◽  
François Gorostidi ◽  
Periklis Mitsakis ◽  
Niklaus Schaefer ◽  
...  

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