Azaheterocyclic Derivatives of ortho-Carborane: Synthetic Strategies and Application Opportunities

Synthesis ◽  
2019 ◽  
Vol 52 (03) ◽  
pp. 337-352 ◽  
Author(s):  
Lidiia A. Smyshliaeva ◽  
Mikhail V. Varaksin ◽  
Valery N. Charushin ◽  
Oleg N. Chupakhin
Keyword(s):  
Materials Science ◽  
Cross Coupling ◽  
General Character ◽  
Advanced Technologies ◽  
Substituted Acetylenes ◽  
Synthetic Approaches ◽  
Derivatives Of ◽  
Coupling Strategies

Azaheterocyclic derivatives of 1,2-dicarba-closo-dodeca­borane (ortho-carborane) are known to be of particular interest due to numerous plausible applications, particularly, in medicine, materials science, and advanced technologies. Three principal synthetic strategies resulting in azaheterocyclic carboranes, in which boron-enriched and azaheterocyclic fragments are linked to each other, either directly by means of the C–C bonds or through a short spacer (CH2, CH2S, CH2O, etc.), have been outlined. These synthetic approaches are of general character and can be used both individually and in combination to afford promising organoboron clusters of diverse architectures.1 Introduction2 C–C Cross-Coupling Strategies in the Synthesis of Azahetero­cyclic Carboranes3 Carboryne-Based Transformation Strategies4 Condensation Strategies: Reactions of Decaborane B10H14 with Substituted Acetylenes5 Conclusion and Outlook

Synthesis and Biological Potentials of Quinoline Analogues: A Review of Literature

2019 ◽  
Vol 16 (7) ◽  
pp. 653-688 ◽  
Author(s):  
Leena Kumari ◽  
Salahuddin ◽  
Avijit Mazumder ◽  
Daman Pandey ◽  
Mohammad Shahar Yar ◽  
...  
Keyword(s):  
Biological Activity ◽  
Heterocyclic Compounds ◽  
Building Blocks ◽  
Vital Role ◽  
Review Of Literature ◽  
Drug Discovery Process ◽  
Active Compounds ◽  
Lead Compounds ◽  
Synthetic Approaches ◽  
Derivatives Of

Heterocyclic compounds are well known for their different biological activity. The heterocyclic analogs are the building blocks for synthesis of the pharmaceutical active compounds in the organic chemistry. These derivatives show various type of biological activity like anticancer, antiinflammatory, anti-microbial, anti-convulsant, anti-malarial, anti-hypertensive, etc. From the last decade research showed that the quinoline analogs plays a vital role in the development of newer medicinal active compounds for treating various type of disease. Quinoline reported for their antiviral, anticancer, anti-microbial and anti-inflammatory activity. This review will summarize the various synthetic approaches for synthesis of quinoline derivatives and to check their biological activity. Derivatives of quinoline moiety plays very important role in the development of various types of newer drugs and it can be used as lead compounds for future investigation in the field of drug discovery process.

Directed Metalation–Suzuki–Miyaura Cross-Coupling Strategies: Regioselective Synthesis of Hydroxylated 1-Methyl-phenanthrenes

2015 ◽  
Vol 80 (19) ◽  
pp. 9410-9424 ◽  
Author(s):  
Kåre B. Jørgensen ◽  
Toni Rantanen ◽  
Thilo Dörfler ◽  
Victor Snieckus
Keyword(s):  
Cross Coupling ◽  
Regioselective Synthesis ◽  
Coupling Strategies

Integrated Pd-catalyzed cross-coupling strategies for furnishing α-carbolines

Tetrahedron ◽  
2017 ◽  
Vol 73 (40) ◽  
pp. 5946-5958 ◽  
Author(s):  
Misayo Sera ◽  
Hideya Mizufune ◽  
Tsuyoshi Ueda ◽  
Masahiro Mineno ◽  
Atsuhiko Zanka
Keyword(s):  
Cross Coupling ◽  
Coupling Strategies

Cross Coupling Strategies towards the Synthesis of the Streptonigrin CD Moiety

Heterocycles ◽  
1999 ◽  
Vol 51 (4) ◽  
pp. 721 ◽  
Author(s):  
Cedric W. Holzapfel ◽  
Renier Crous ◽  
Catherine Dwyer
Keyword(s):  
Cross Coupling ◽  
Coupling Strategies

Recent Developments in C–C Bond Formation Using Catalytic Reductive Coupling Strategies

Synthesis ◽  
2020 ◽  
Vol 52 (18) ◽  
pp. 2623-2638
Author(s):  
Joshua D. Sieber ◽  
Toolika Agrawal
Keyword(s):  
Bond Formation ◽  
Cross Coupling ◽  
Short Review ◽  
Reductive Coupling ◽  
Recent Developments ◽  
Molecular Complexity ◽  
Metal Catalyzed ◽  
Coupling Processes ◽  
Coupling Strategies

Metal-catalyzed reductive coupling processes have emerged as a powerful methodology for the introduction of molecular complexity from simple starting materials. These methods allow for an orthogonal approach to that of redox-neutral strategies for the formation of C–C bonds by enabling cross-coupling of starting materials not applicable to redox-neutral chemistry. This short review summarizes the most recent developments in the area of metal-catalyzed reductive coupling utilizing catalyst turnover by a stoichiometric reductant that becomes incorporated in the final product.1 Introduction2 Ni Catalysis3 Cu Catalysis4 Ru, Rh, and Ir Catalysis4.1 Alkenes4.2 1,3-Dienes4.3 Allenes4.4 Alkynes4.5 Enynes5 Fe, Co, and Mn Catalysis6 Conclusion and Outlook

2-Azaanthraquinones: Building Blocks for New Ring-Fused Imidazoles and their Transformation into Benzo[f]isoindole-4,9-diones

2005 ◽  
Vol 60 (7) ◽  
pp. 771-779 ◽  
Author(s):  
Birgit Frank ◽  
Rainer Beckert ◽  
Sven Rau ◽  
Helmar Görls
Keyword(s):  
Building Blocks ◽  
Substituted Acetylenes ◽  
Derivatives Of

The modification of 2-azaanthraquinones with selected C1 building blocks gives a series of new imidazo-fused derivatives. Employing 2,3-dichloro-5,6-dicyanopyrazine as cyclization partner a rearrangement to yield derivatives of benzo[f ]isoindole-4,9-dione takes place. The Sonogashira crosscoupling reaction of the aminalester derivative of the azaanthraquinone resulted in well soluble silyl substituted acetylenes as well as ethinyl aniline which allows further derivatization reactions.

scholarly journals Synthesis of 4-Alkyl-4H-1,2,4-triazole Derivatives by Suzuki Cross-coupling Reactions and Their Luminescence Properties

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 652 ◽  
Author(s):  
Monika Olesiejuk ◽  
Agnieszka Kudelko ◽  
Marcin Swiatkowski ◽  
Rafal Kruszynski
Keyword(s):  
Ionic Liquids ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Boronic Acids ◽  
Luminescence Properties ◽  
Coupling Reactions ◽  
Triazole Derivatives ◽  
Cross Coupling Reactions ◽  
Cross Coupling Reaction ◽  
Derivatives Of

New derivatives of 4-alkyl-3,5-diaryl-4H-1,2,4-triazole were synthesized utilizing the Suzuki cross-coupling reaction. The presented methodology comprises of the preparation of bromine-containing 4-alkyl-4H-1,2,4-triazoles and their coupling with different commercially available boronic acids in the presence of ionic liquids or in conventional solvents. The obtained compounds were tested for their luminescence properties.

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