Advanced Catalyst-Free Pseudo-Six-Component Synthesis of Tetrahydrodipyrazolopyridines in Water by Using Ammonium Carbonate as an Ecofriendly Source of Nitrogen

Synlett ◽  
2020 ◽  
Vol 31 (07) ◽  
pp. 691-694
Author(s):  
Fatemeh Tamaddon ◽  
Ali Khorram
Keyword(s):  
Organic Solvent ◽  
Hydrazine Hydrate ◽  
Hazardous Waste ◽  
Room Temperature ◽  
Ammonium Carbonate ◽  
Environmentally Benign ◽  
Methyl Acetoacetate ◽  
Catalyst Free ◽  
Dihydropyridine Ring ◽  
Environmentally Friendly Method

This work describes an improved environmentally friendly method for the synthesis of tetrahydrodipyrazolopyridines (THDPPs) in water through a catalyst-free pseudo-six-component reaction of alkyl acetoacetates, hydrazine hydrate, and ammonium carbonate with an aldehyde in a mole ratio of 2:2:1:1 at room temperature. The ammonium carbonate serves as a green source of nitrogen for the central 1,4-dihydropyridine ring in the THDPPs. Methyl acetoacetate reacts faster than either ethyl or propyl acetoacetate in this method. The product precipitates during the reaction and is simply collected by filtration. Advantages of this environmentally benign method include no use of an organic solvent, no hazardous waste, rapid clean reactions, and excellent yields of products.

scholarly journals Solvent- and catalyst-free mechanochemical synthesis of alkali metal monohydrides

2016 ◽  
Vol 4 (31) ◽  
pp. 12188-12196 ◽  
Author(s):  
Ihor Z. Hlova ◽  
Andra Castle ◽  
Jennifer F. Goldston ◽  
Shalabh Gupta ◽  
Timothy Prost ◽  
...  
Keyword(s):  
Alkali Metal ◽  
Mechanochemical Synthesis ◽  
Room Temperature ◽  
Metal Hydrides ◽  
Free Alkali ◽  
Environmentally Benign ◽  
Mechanochemical Process ◽  
Catalyst Free ◽  
Highly Efficient ◽  
Scalable Synthesis

A simple, highly efficient and environmentally benign mechanochemical process is described for potentially scalable synthesis of catalyst and additive-free alkali-metal hydrides at room-temperature.

Naturally Occurring Organic Acid-catalyzed Facile Diastereoselective Synthesis of Biologically Active (E)-3-(arylimino)indolin-2-one Derivatives in Water at Room Temperature

2019 ◽  
Vol 23 (16) ◽  
pp. 1778-1788 ◽  
Author(s):  
Gurpreet Kaur ◽  
Arvind Singh ◽  
Kiran Bala ◽  
Mamta Devi ◽  
Anjana Kumari ◽  
...  
Keyword(s):  
Room Temperature ◽  
Biologically Active ◽  
Environmentally Benign ◽  
Diastereoselective Synthesis ◽  
Substituted Anilines ◽  
Reaction Conditions ◽  
Naturally Occurring ◽  
Acid Catalyzed ◽  
Reaction Media ◽  
Column Chromatographic

A simple, straightforward and efficient method has been developed for the synthesis of (E)-3-(arylimino)indolin-2-one derivatives and (E)-2-((4-methoxyphenyl)imino)- acenaphthylen-1(2H)-one. The synthesis of these biologically-significant scaffolds was achieved from the reactions of various substituted anilines and isatins or acenaphthaquinone, respectively, using commercially available, environmentally benign and naturally occurring organic acids such as mandelic acid or itaconic acid as catalyst in aqueous medium at room temperature. Mild reaction conditions, energy efficiency, good to excellent yields, environmentally benign conditions, easy isolation of products, no need of column chromatographic separation and the reusability of reaction media are some of the significant features of the present protocol.

Visible-light-initiated Catalyst-free Oxidative Cleavage of Triaryl-Substituted Alkenes C=C Bonds under Ambient Conditions

2021 ◽  
Author(s):  
Wenjing Li ◽  
Shun Li ◽  
Lihua Luo ◽  
Yichen Ge ◽  
Jiaqi Xu ◽  
...  
Keyword(s):  
Visible Light ◽  
Room Temperature ◽  
Ambient Air ◽  
Oxidative Cleavage ◽  
Ambient Conditions ◽  
Blue Led ◽  
Catalyst Free

The catalyst-free oxidative cleavage of (Z)-triaryl-substituted alkenes bearing pyridyl motif with ambient air under irradiation of blue LED at room temperature has been developed. The reaction was facile and scalable,...

scholarly journals Organophotocatalytic selective deuterodehalogenation of aryl or alkyl chlorides

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yanjun Li ◽  
Ziqi Ye ◽  
Yu-Mei Lin ◽  
Yan Liu ◽  
Yumeng Zhang ◽  
...  
Keyword(s):  
Room Temperature ◽  
Sodium Formate ◽  
Bioactive Molecules ◽  
Co Catalyst ◽  
Aryl Chlorides ◽  
Aryl Amine ◽  
Drug Molecules ◽  
Photocatalytic System ◽  
Site Selective ◽  
Environmentally Friendly Method

AbstractDevelopment of practical deuteration reactions is highly valuable for organic synthesis, analytic chemistry and pharmaceutic chemistry. Deuterodehalogenation of organic chlorides tends to be an attractive strategy but remains a challenging task. We here develop a photocatalytic system consisting of an aryl-amine photocatalyst and a disulfide co-catalyst in the presence of sodium formate as an electron and hydrogen donor. Accordingly, many aryl chlorides, alkyl chlorides, and other halides are converted to deuterated products at room temperature in air (>90 examples, up to 99% D-incorporation). The mechanistic studies reveal that the aryl amine serves as reducing photoredox catalyst to initiate cleavage of the C-Cl bond, at the same time as energy transfer catalyst to induce homolysis of the disulfide for consequent deuterium transfer process. This economic and environmentally-friendly method can be used for site-selective D-labeling of a number of bioactive molecules and direct H/D exchange of some drug molecules.

An efficient construction of CN bond under catalyst‐free and room temperature conditions

2021 ◽  
Vol 58 (5) ◽  
pp. 1179-1191
Author(s):  
Jinpeng Zhang ◽  
Jing Liu ◽  
Lei Dai ◽  
Yuqian Ge ◽  
Linlin Xu ◽  
...  
Keyword(s):  
Room Temperature ◽  
Catalyst Free ◽  
Temperature Conditions ◽  
Efficient Construction

In situ formation of luminescent CdSe QDs in a metallohydrogel: a strategy towards synthesis, isolation, storage and re-dispersion of the QDs

Nanoscale ◽  
2017 ◽  
Vol 9 (36) ◽  
pp. 13820-13827 ◽  
Author(s):  
Sayantan Chatterjee ◽  
Uday Maitra
Keyword(s):  
Organic Solvent ◽  
Bile Salt ◽  
Room Temperature ◽  
Cdse Qds ◽  
One Step ◽  
In Situ Formation

We describe a practical, one step, room temperature in situ synthesis of luminescent CdSe QDs using a bile salt derived metallogel, followed by their isolation from the gel and re-dispersion in an organic solvent.

Rapid high conversion of high free fatty acid feedstock into biodiesel using continuous flow vortex fluidics

RSC Advances ◽  
2015 ◽  
Vol 5 (3) ◽  
pp. 2276-2280 ◽  
Author(s):  
Joshua Britton ◽  
Colin L. Raston
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Continuous Flow ◽  
Room Temperature ◽  
Flow Chemistry ◽  
Environmentally Benign ◽  
High Free Fatty Acid ◽  
Rapid Reduction ◽  
Biodiesel Feedstock ◽  
Flow Vortex

Rapid reduction of free fatty acids in biodiesel feedstock: the rapid conversion of problematic free fatty acids in bio-oils has been achieved using room temperature, environmentally benign vortex fluidic flow chemistry.

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