scholarly journals DAPSONE HYPERSENSITIVITY SYNDROME - A CASE REPORT

2014 ◽  
Vol 04 (03) ◽  
pp. 124-126
Author(s):  
Aneseya P. Varghese ◽  
Deepthi R. V. ◽  
Vijaya Shenoy ◽  
Seema Pavaman
Keyword(s):  
Case Report ◽  
Adverse Effects ◽  
Hypersensitivity Syndrome ◽  
Skin Lesions ◽  
Low Grade ◽  
Salient Features ◽  
Systemic Examination

AbstractDapsone is widely used for a variety of infectious, immune and hypersensitivity disorders. However, the use of dapsone may be associated with a plethora of adverse effects.We are reporting a 6 year old who was treated with dapsone for one month. He presented to us with low grade fever and skin lesions all over body with normal systemic examination. He was evaluated and was diagnosed as having Dapsone Hypersensitivity Syndrome (DHS) and treated with steroids.The incidence of DHS ranges from 0.5% to3%. DHS can present as early as 7–10 days after administration of the drug uptil 6 months into. therapy DHS must be promptly identified, asUntreated the disorder could be fatal. This syndrome is best approached with the immediate discontinuation of the offending drug and prompt administration of oral or intravenous glucocorticoids.Since dapsone is used for various indications, the salient features about the syndrome and its management should be familiarized.

scholarly journals Early optic neuropathy during pegylated alfa 2-B interferon and ribavirin HCV treatment. A case report

2019 ◽  
Author(s):  
Bogdan Augustin Chis ◽  
Cristina Nicula ◽  
Dan Dumitrascu
Keyword(s):  
Case Report ◽  
Hepatitis C ◽  
Adverse Effects ◽  
Viral Hepatitis ◽  
Optic Neuropathy ◽  
Standard Of Care ◽  
Low Grade ◽  
Blurred Vision ◽  
Viral Hepatitis C ◽  
Ifn Treatment

Introduction. Hepatitis C viral infection (HCV) represents an important health problem worldwide. Natural evolution, with its complications, remains a high cause of mortality and morbidity. Interferon (IFN) treatment, along with ribavirin (RBV), was for several years the standard of care. However, many adverse effects have been described during this therapy. We report a very elusive case of optic neuropathy. Case report. We report the case of a female patient, 50 years old, who underwent pegylated IFN alfa 2B and RBV treatment for viral hepatitis C with low grade fibrosis, in a period when she was not qualified for free oral therapy (with direct acting agents according regulations in this country at that time). After 10 weeks of treatment, she experienced blurred vision and an optic neuropathy was diagnosed, attributed to the HCV. The symptoms and eye fundus alterations (hemorrhage, exudates) remitted after discontinuation of therapy. Conclusion. IFN treatment remains an option for viral hepatitis, but the adverse effects are to be considered. Optic neuropathy can occur during the former standard of care HCV therapy. Patients submitted to IFN plus RBV therapy should be monitored for ocular adverse effects.

scholarly journals Pigmentation and Scaring Management after Hypodermoclysis, a Case Report

Cosmetics ◽  
2022 ◽  
Vol 9 (1) ◽  
pp. 10
Author(s):  
Kamal Alhallak ◽  
Adel Abdulhafid ◽  
Salem Tomi ◽  
Dima Omran
Keyword(s):  
Case Report ◽  
Adverse Effects ◽  
Skin Diseases ◽  
Skin Lesions ◽  
Subcutaneous Infusion ◽  
Laser Technology ◽  
Dermal Tissue ◽  
Continuous Subcutaneous Infusion ◽  
Laser Treatments ◽  
Cutaneous Damage

Hypodermoclysis is the continuous subcutaneous infusion of a parenteral solution into dermal tissue, which is typically associated with skin lesions and cosmetic issues in the majority of patients. Scarring and pigmentation are two of the potential skin lesions after hypodermoclysis. The way skin diseases and cosmetic issues are treated has altered dramatically as a result of laser technology. This is the first article to our knowledge that describes the treatment of pigmentation and scarring produced by Hypodermoclysis cutaneous damage by using laser treatment. It was vital to select the appropriate endpoint, technology, and configuration parameters. The lesion was completely resolved after five months of treatment with four laser sessions. The first session used a fractional Er-Yag laser to perform cold ablation. The remaining sessions used 1064 and 585 nm Nd-Yag Q-switch lasers to operate in the nanosecond region. To minimize the danger of post-inflammatory hyperpigmentation (PIH), the treated region was prepped between laser treatments with 4% hydroquinone (HQ) cream. Our protocol may reduce scars and pigmentation while minimizing adverse effects and downtime.

scholarly journals A case report of life threatening Dapsone Hypersensitivity Syndrome

2017 ◽  
Vol 6 (2) ◽  
pp. 471
Author(s):  
Santoshkumar R. Jeevangi ◽  
Amreen Saba
Keyword(s):  
Case Report ◽  
Adverse Effects ◽  
Hypersensitivity Syndrome ◽  
Organ Damage ◽  
Successful Outcome ◽  
High Grade ◽  
High Grade Fever ◽  
Prompt Treatment ◽  
Life Threatening ◽  
Generalized Lymphadenopathy

Dapsone is widely used for a variety of infections, immune and hypersensitivity disorders. However, the use of Dapsone may be associated with a plethora of adverse effects, the most serious being Dapsone Hypersensitivity Syndrome (DHS) wherein the patient typically presents with a triad of fever, skin eruption and internal organ involvement, that occurs during first 2 to 8 weeks of initiating the treatment. The incidence of DHS ranges from 0.5% to 3%.  Here we report a case of severe life threatening Dapsone induced hypersensitivity reaction in a 21year old female who presented with high grade fever, generalized lymphadenopathy, skin rash and hepato-splenomegaly. This condition is best approached with immediate discontinuation of offending drug and prompt administration of oral or IV glucocorticoids. The case is being reported to emphasize the need for timely diagnosis and prompt treatment for successful outcome as it can cause irreversible organ damage or death if untreated early.

scholarly journals Morbilliform rashes in a patient with COVID-19 infection: A case report

2021 ◽  
Vol 59 (236) ◽  
Author(s):  
Kiran Ghimire ◽  
Nabin Adhikari
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Skin Lesions ◽  
Low Grade ◽  
Cytokine Storm ◽  
Skin Manifestation ◽  
Poor Countries ◽  
Immune Mediated ◽  
Resource Poor ◽  
Common Skin

As the current COVID-19 pandemic is evolving, skin lesions are being reported more, the most common skin manifestation being morbilliform rashes. We describe a patient of severe COVID-19 infection, 48-year-old who initially presented with fever, cough and constitutional symptoms who developed morbilliform macular rashes during his illness. The rash appeared on 6th day of illness in the trunk, arms with sparing of palms and soles, associated with itching. He later developed features of the cytokine-storm syndrome. The exact mechanism for the rashes is yet to be elaborated, however, it is postulated that it is either due to immune-mediated vasodilation or micro thrombosis secondary to low-grade-coagulopathy associated with COVID-19. Recognition of rashes as a feature of this disease is particularly significant to clinicians as it aids in early diagnosis, particularly in resource-poor countries. There is no evident association, however, between the severity and the rashes in COVID-19 infection.

Low-grade Osteosarcoma of the Spine: A Case Report

2007 ◽  
Vol 56 (6) ◽  
pp. 575
Author(s):  
Young Chul Kim ◽  
Jin-Suck Suh ◽  
Myung In Kim ◽  
Hye-Jung Choo ◽  
Yong-Min Huh
Keyword(s):  
Case Report ◽  
Low Grade

scholarly journals Delayed-Type Hypersensitivity Reaction to Red Tattoo Ink Triggered by Ledipasvir/Sofosbuvir for Hepatitis C: A Case Report

2021 ◽  
pp. 379-383
Author(s):  
Meghan L. McPhie ◽  
Kevin Y.M. Ren ◽  
J. Michael Hendry ◽  
Sonja Molin ◽  
Thomas Herzinger
Keyword(s):  
Case Report ◽  
Hepatitis C ◽  
Adverse Effects ◽  
Hypersensitivity Reaction ◽  
Allergic Reaction ◽  
Delayed Type Hypersensitivity ◽  
Histological Features

Tattoos have become increasingly popular worldwide making adverse effects from tattoos a growing concern. In our report, we present a 51-year-old man who developed an unusual allergic reaction to the red ink portions of his tattoos that coincided with the initiation of ledipasvir/sofosbuvir treatment for his hepatitis C. Clinical and histological features were consistent with a delayed-type hypersensitivity reaction to red ink.

scholarly journals CT, MRI, and FDG-PET imaging findings of low-grade extrauterine endometrial stromal sarcoma arising from the mesentery: A case report

2021 ◽  
Vol 16 (9) ◽  
pp. 2774-2779
Author(s):  
Satoshi Suzuki ◽  
Ryo Kurokawa ◽  
Tetsushi Tsuruga ◽  
Mayuyo Mori‑Uchino ◽  
Haruka Nishida ◽  
...  
Keyword(s):  
Case Report ◽  
Pet Imaging ◽  
Fdg Pet ◽  
Endometrial Stromal Sarcoma ◽  
Low Grade ◽  
Imaging Findings ◽  
Stromal Sarcoma

Dermal fibrosarcoma in a Cashmere goat

2019 ◽  
Vol 47 (03) ◽  
pp. 192-195
Author(s):  
Julia Schoiswohl ◽  
Bianca Lambacher ◽  
Andrea Klang ◽  
Reinhild Krametter-Frötscher
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Connective Tissue ◽  
Malignant Tumors ◽  
Histopathological Examination ◽  
Low Grade ◽  
Cashmere Goat ◽  
Short Lifespan ◽  
Production Processes

AbstractFibrosarcomas are malignant tumors of the connective tissue, which are characterized by proliferation of fibroblasts. Most of these tumors are localized subcutaneously and cause different symptoms depending on their location. The case report describes a dermal tumor on the outside of the pinna in a 7-year-old female Cashmere goat. The tumor was surgically removed and histopathological examination revealed a low grade fibrosarcoma. Although tumors are rare in ruminants because of the animals’ short lifespan (age of slaughtering in most cases < 24 months) in modern production processes, they should be considered as a differential diagnosis.

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