Morbilliform rashes in a patient with COVID-19 infection: A case report

As the current COVID-19 pandemic is evolving, skin lesions are being reported more, the most common skin manifestation being morbilliform rashes. We describe a patient of severe COVID-19 infection, 48-year-old who initially presented with fever, cough and constitutional symptoms who developed morbilliform macular rashes during his illness. The rash appeared on 6th day of illness in the trunk, arms with sparing of palms and soles, associated with itching. He later developed features of the cytokine-storm syndrome. The exact mechanism for the rashes is yet to be elaborated, however, it is postulated that it is either due to immune-mediated vasodilation or micro thrombosis secondary to low-grade-coagulopathy associated with COVID-19. Recognition of rashes as a feature of this disease is particularly significant to clinicians as it aids in early diagnosis, particularly in resource-poor countries. There is no evident association, however, between the severity and the rashes in COVID-19 infection.

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Necrotizing leukocytoclastic vasculitis mimicking necrotizing fasciitis: a case report

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20163130 ◽

2016 ◽

Vol 2 (3) ◽

pp. 193

Author(s):

Mehmet Salih Soylemez ◽

Korhan Ozkan ◽

Bulent Kılıc ◽

Samet Erinc ◽

Irfan Esenkaya ◽

...

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Laboratory Test ◽

Necrotizing Fasciitis ◽

Immunofluorescence Microscopy ◽

Leukocytoclastic Vasculitis ◽

Maculopapular Rash ◽

Skin Manifestation ◽

Biopsy Specimens ◽

Common Skin

<p>There are several subtypes of necrotizing leukocytoclastic vasculitis, which are classified according to their morphological features in biopsy specimens using immunofluorescence microscopy. Necrotizing leukocytoclastic vasculitis is limited to the skin, predominantly that of the lower extremities, and usually spares the palms and soles. The most common skin manifestation is palpable purpura. Other skin manifestations include maculopapular rash, bullae, papules, nodules, ulcers and livedo reticularis. There is no specific laboratory test to determine the diagnosis. There are various diseases presenting with these nonspecific symptoms, and a rapid differential diagnosis must be conducted, because the appropriate differentiation and diagnosis markedly influence the treatment strategy and survival of patients. In this study, we report a case of necrotizing leukocytoclastic vasculitis<strong> </strong>presenting with internal organ involvement and symptoms of necrotizing fasciitis, with emphasis on the clinical differentiation.</p>

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The Mote in thy Brother’s Eyes - Fusarium Solani in Leukemia Host

10.21203/rs.3.rs-787465/v1 ◽

2021 ◽

Author(s):

Rawan AlAgha ◽

Wee Lee Chan ◽

Thong Edwin Wei Sheng ◽

Joanne Lee ◽

Jen Wei Ying ◽

...

Keyword(s):

Case Report ◽

Early Diagnosis ◽

High Mortality ◽

Combination Chemotherapy ◽

Fusarium Solani ◽

Immunocompromised Host ◽

Skin Lesions ◽

Acute Onset ◽

Source Control ◽

Anti Fungal

Abstract Fusariosis is increasingly seen among immunocompromised host. The organism is known for its virulence and spectrum of infections. Presenting here a case of relapse acute myeloblastic leukemia on chemotherapy with acute onset of red painful eye followed by widespread painful skin lesions. Microbiological and radiological investigations diagnosed her with disseminated fusariosis. Treatment was challenging in view its inherent resistance to multiple anti-fungal agents and the need for early aggressive source control. The case report reflects the importance of early diagnosis and combination chemotherapy to salvage the patient from high mortality.

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Extensive Lepromatous Lymphadenitis Preceding Lesions on the Face and Earlobes: An Unusual Presentation of Leprosy in Singapore

Case Reports in Dermatology ◽

10.1159/000462959 ◽

2018 ◽

Vol 10 (1) ◽

pp. 35-40

Author(s):

Shi Yao Sam Yang ◽

Wai Mun Sean Leong ◽

Cruz Maria Teresa Kasunuran ◽

Jing Xiang Huang ◽

Sue-Ann Ju Ee Ho ◽

...

Keyword(s):

Early Stage ◽

Developed Countries ◽

Skin Lesions ◽

The Body ◽

The Other ◽

Cutaneous Lesions ◽

Poor Countries ◽

Geographical Regions ◽

Resource Poor ◽

The Face

Leprosy is also known as Hansen disease, as in some countries the diagnosis of leprosy carries a negative stigma and patients fear being shunned as outcasts. Presently, leprosy is primarily limited to specific geographical regions in resource-poor countries. As a result, there is increased difficulty for the younger generation of physicians today to correctly identify leprosy due to a lack of exposure and a low-index of suspicion, particularly in developed countries. In this case, the indurated lesions over the face demonstrated a preference for the outer lateral aspects over the maxillary areas, the nose bridge, and the pinna of the ears consistent with the organism’s preference for cooler regions of the body. This was also evident in the other skin lesions affecting the more acral regions of the limbs in the early stage of disease progression. There is a need to keep this infective condition as an alternate diagnosis to all unusual cutaneous lesions.

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Multicentric Cutaneous Crohn's Disease: A Case Report and Review of Literature

Canadian Journal of Gastroenterology ◽

10.1155/1990/480817 ◽

1990 ◽

Vol 4 (2) ◽

pp. 59-63 ◽

Cited By ~ 2

Author(s):

Robert Prokopetz ◽

J Barrie Ross ◽

Peter Smith ◽

Joseph J Sidorov

Keyword(s):

Crohn’S Disease ◽

Case Report ◽

Crohn's Disease ◽

Erythema Nodosum ◽

Skin Lesions ◽

Review Of Literature ◽

Histological Features ◽

The Past ◽

Common Skin ◽

Skin Conditions

A patient presented with skin lesions at sites not contiguous with Crohn's disease of the bowel and with specific histological features of Crohn's disease occurring two weeks from the onset of bowel symptoms. Currently a number of nonspecific skin conditions such as erythema nodosum, pyoderma gangrenosum and erythema multiforme are accepted as being the most common skin manifestations of Crohn's disease. It is likely, however, that specific lesions of Crohn's disease in the skin have been underdiagnosed either because of lack of biopsy or misinterpretation of the histology. Twenty-three cases with specific Crohn's disease in the skin have been recorded in the past 25 years, since the condition has been recognized. Sarcoidosis has been a common misdiagnosis. The literature relating to multicentric Crohn's disease is reviewed and attention drawn to its protean and masquerading features. An argument is made for the use of the term 'multicentric' rather than 'metastatic' in relation to cutaneous Crohn's disease.

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Case report on tuberous sclerosis

Vestnik dermatologii i venerologii ◽

10.25208/vdv1211 ◽

2021 ◽

Vol 97 (2) ◽

pp. 56-60

Author(s):

Nadezhda V. Krasnova ◽

Geliya G. Gimalieva ◽

Larisa G. Sinitsyna

Keyword(s):

Case Report ◽

Early Diagnosis ◽

Ct Scan ◽

Tuberous Sclerosis ◽

Skin Lesions ◽

Visual Examination ◽

Comprehensive Examination ◽

The Face ◽

The Brain ◽

Tubular Bones

Patient M., 23 years old, consulted a dermatologist with complaints of rashes on the face, which had bothered since childhood. On objective examination, skin lesions were widespread. A visual examination revealed spots of hypopigmentation, angiofibromas of the face, shagreen fate of the skin, periungual fibromas. She was diagnosed with tuberous sclerosis. Further examination revealed a neoplasm in the brain and right kidney, damage to the lungs, tubular bones, lymphadenopathy. The patient continues to be monitored by a neurologist and therapist. Based on the results of CT scan of the chest organs, an oncologist's consultation was scheduled to conduct an oncology search. Thus, with skin manifestations characteristic of this disease, it is necessary to conduct a comprehensive examination to identify concomitant pathology and early diagnosis of complications.

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TRICHILEMMAL CYST OF THE THIRD FINGERTIP: A CASE REPORT

Hand Surgery ◽

10.1142/s0218810414720113 ◽

2014 ◽

Vol 19 (01) ◽

pp. 131-133 ◽

Cited By ~ 3

Author(s):

Cenk Melikoglu ◽

Fikret Eren ◽

Barış Keklik ◽

Cem Aslan ◽

Mustafa Sutcu ◽

...

Keyword(s):

Case Report ◽

Histopathological Examination ◽

Surgical Excision ◽

Skin Lesions ◽

Hair Follicles ◽

Nodular Lesion ◽

Case Presentation ◽

The Third ◽

Trichilemmal Cyst ◽

Common Skin

Introduction: Trichilemmal cysts (TCs) are common skin lesions that occur in hairy areas. A TC involving a fingertip has not been previously described in the literature. We herein report a case of a TC occupying a fingertip region. Case presentation: A 43-year-old woman presented with a 1.5 × 1.5 cm nodular lesion on the third fingertip. The lesion was completely excised, and histopathological examination revealed a TC. Conclusion: TCs may involve atypical locations, such as fingertips, where there are no hair follicles. After surgical excision, a careful histopathological examination should be performed to differentiate TCs from proliferating pilar tumors.

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Case report on tuberous sclerosis

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20171119 ◽

2017 ◽

Vol 6 (4) ◽

pp. 997

Author(s):

Zeebaish S. ◽

Hemalatha P. ◽

Anusha Y. ◽

Surendra Reddy N. ◽

Durga Prasad T. S.

Keyword(s):

Case Report ◽

Early Diagnosis ◽

Tuberous Sclerosis ◽

Female Child ◽

Skin Lesions ◽

Multisystem Disorder ◽

Three Generations ◽

Pigmented Skin Lesions ◽

The Brain

Tuberous sclerosis is a genetic multisystem disorder characterized by widespread hamartomas in several organs, including the brain, heart, skin, eyes, kidney, lung and liver. The affected genes are TSC1 and TSC2, encoding hamartin and tuberin respectively. Most features of tuberous sclerosis become evident only in childhood, limiting their usefulness for early diagnosis. We report a case of 3months old female child with seizures and hypo-pigmented skin lesions. The case is rare as it is documented in a family affected continuously in three generations involving four members.

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DAPSONE HYPERSENSITIVITY SYNDROME - A CASE REPORT

Journal of Health and Allied Sciences NU ◽

10.1055/s-0040-1703819 ◽

2014 ◽

Vol 04 (03) ◽

pp. 124-126

Author(s):

Aneseya P. Varghese ◽

Deepthi R. V. ◽

Vijaya Shenoy ◽

Seema Pavaman

Keyword(s):

Case Report ◽

Adverse Effects ◽

Hypersensitivity Syndrome ◽

Skin Lesions ◽

Low Grade ◽

Salient Features ◽

Systemic Examination

AbstractDapsone is widely used for a variety of infectious, immune and hypersensitivity disorders. However, the use of dapsone may be associated with a plethora of adverse effects.We are reporting a 6 year old who was treated with dapsone for one month. He presented to us with low grade fever and skin lesions all over body with normal systemic examination. He was evaluated and was diagnosed as having Dapsone Hypersensitivity Syndrome (DHS) and treated with steroids.The incidence of DHS ranges from 0.5% to3%. DHS can present as early as 7–10 days after administration of the drug uptil 6 months into. therapy DHS must be promptly identified, asUntreated the disorder could be fatal. This syndrome is best approached with the immediate discontinuation of the offending drug and prompt administration of oral or intravenous glucocorticoids.Since dapsone is used for various indications, the salient features about the syndrome and its management should be familiarized.

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