Association between rs1421085 and rs9939609 Polymorphisms of Fat Mass and Obesity-Associated Gene with High-Density Lipoprotein Cholesterol and Triglyceride in Obese Turkish Children and Adolescents

Fat Mass ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Healthy Children ◽

Obese Children ◽

Fto Gene ◽

Turkish Children

AbstractSeveral studies have shown that rs9939609 and rs1421085 in fat mass and obesity-associated (FTO) gene rs17782313 and rs12970134 in melanocortin-4 receptor (MC4R) gene influence obesity. In the present study, we aimed to determine association between rs9939609, rs1421085, rs17782313, and rs12970134 polymorphism, and their relation with body mass index (BMI), glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and lipid values in obese children. We included 100 newly diagnosed obese children and 100 healthy children. The rs1421085 (CC/CT) (p = 0.019) and rs9939609 (AA/AT) (p = 0.002) polymorphism regions were higher in the obese group. Additionally, we found that both the rs1421085 (CC/CT) and rs9939609 (AA/AT) polymorphism associated with high-density lipoprotein cholesterol (p = 0.011 and p = 0.003) and triglycerides (p = 0.01 and p = 0.004) level, respectively. Further, the rs9939609 and rs1421085 variants of FTO gene associated with HDL-cholesterol and triglycerides levels in obese children; however, updated studies with a large sample size are required to establish strong links with genetic variants and risk factors in childhood obesity.

Serum adiponectin is related to plasma high-density lipoprotein cholesterol but not to plasma insulin-concentration in healthy children: the FLVS II study

Metabolism ◽

10.1016/j.metabol.2006.04.015 ◽

2006 ◽

Vol 55 (9) ◽

pp. 1171-1176 ◽

Cited By ~ 11

Author(s):

Adrien Kettaneh ◽

Barbara Heude ◽

Jean-Michel Oppert ◽

Philipp Scherer ◽

David Meyre ◽

...

Keyword(s):

Plasma Insulin ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Insulin Concentration ◽

Healthy Children ◽

Plasma Insulin Concentration ◽

Plasma High Density

Low levels of high density lipoprotein cholesterol in Turkish children: An important risk factor

Pediatrics International ◽

10.1111/j.1442-200x.1998.tb01400.x ◽

2007 ◽

Vol 40 (1) ◽

pp. 41-46 ◽

Cited By ~ 6

Author(s):

AKIN IŞsLCAN ◽

M RAMAZAN YIǦITOǦL̈ ◽

NUREDDIN VURGUN ◽

B SAMI UYANIK ◽

MUHITTIN AKYILDIZ

Keyword(s):

Risk Factor ◽

Density Lipoprotein ◽

High Density ◽

Important Risk Factor ◽

Lipoprotein Cholesterol ◽

Turkish Children ◽

Low Levels

The roles of triglyceride/high-density lipoprotein cholesterol ratio and uric acid as predisposing factors for metabolic syndrome in healthy children

Annals of Pediatric Endocrinology & Metabolism ◽

10.6065/apem.2019.24.3.172 ◽

2019 ◽

Vol 24 (3) ◽

pp. 172-179 ◽

Cited By ~ 2

Author(s):

Maria Efthymia Katsa ◽

Anastasios Ioannidis ◽

Athanasios Sachlas ◽

Ioannis Dimopoulos ◽

Stylianos Chatzipanagiotou ◽

...

Keyword(s):

Metabolic Syndrome ◽

Uric Acid ◽

Density Lipoprotein ◽

Predisposing Factors ◽

High Density ◽

Lipoprotein Cholesterol ◽

Healthy Children ◽

Cholesterol Ratio

Impact of Vitamin D and Vitamin D Receptor on Risk of Cardiovascular Diseases in Children and Adolescents with Obesity in Sichuan, China: A Cross-Sectional Study

Annals of Nutrition and Metabolism ◽

10.1159/000513287 ◽

2020 ◽

Vol 76 (6) ◽

pp. 396-404

Author(s):

Hongjian Xie ◽

Min Min ◽

Siqi Guo ◽

Yang Xian ◽

Fan Yang ◽

...

Keyword(s):

Vitamin D ◽

Children And Adolescents ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Obese Children ◽

Cvd Risk ◽

Vitamin D Levels

Background: Previous studies have demonstrated the close relationship between vitamin D, vitamin D receptor (VDR), and obesity. Nevertheless, few studies have reported wherther the relationship among these is associated with the risk of cardiovascular diseases (CVDs) in Chinese children and adolescents. Objective: The present study aimed to reveal the effects of obesity, serum vitamin D levels, and VDR FokI genotype on the risk of CVDs in children and adolescents in Sichuan, China. Methods: Children and adolescents were recruited into a cross-sectional study. Serum vitamin D levels, serum lipid levels, and VDR FokI gene polymorphisms were measured in the laboratory. The selected lipid factors were used as biomarkers of CVD risk. The impact of obesity, vitamin D levels and VDR FokI genotype on CVD risk factors were investigated. Results: Higher lipid levels were observed in children and adolescents in the obese group, when compared to the nonobese group. In the obese group, the C allele carriers had significantly lower concentrations of lipids, when compared to the TT genotype. C allele carriers who were vitamin D deficient had lower levels of total cholesterol (TC), triglycerides (TG), apolipoprotein B (Apo-B), total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C), low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C), and triglycerides/high-density lipoprotein cholesterol (TG/HDL-C), when compared to those with the TT genotype in obese children and adolescents. For vitamin D-insufficient obese children and adolescents, the TC, Apo-B, and TC/HDL-C in the C allele carriers were significantly lower, when compared to those in the TT genotype in obese children and adolescents. Conclusion: Obese children with low vitamin D levels, who are carriers of the C allele of the FokI gene, have lower levels of several biochemical markers of CVD risk, when compared to those who were TT homozygous. Obese children and adolescents may benefit from vitamin D supplementation, terms of lowering their CVD risk, particularly when they are carriers of the C allele of the FokI gene.

Triglyceride to high density lipoprotein cholesterol ratio, total cholesterol to high density lipoprotein cholesterol ratio and low ankle brachial index in an elderly population

VASA ◽

10.1024/0301-1526/a000348 ◽

2014 ◽

Vol 43 (3) ◽

pp. 189-197 ◽

Cited By ~ 10

Author(s):

Yiqiang Zhan ◽

Jinming Yu ◽

Rongjing Ding ◽

Yihong Sun ◽

Dayi Hu

Keyword(s):

Total Cholesterol ◽

Ankle Brachial Index ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Lipid Lowering ◽

Cholesterol Ratio ◽

Potential Biomarker

Background: The associations of triglyceride (TG) to high-density lipoprotein cholesterol ratio (HDL‑C) and total cholesterol (TC) to HDL‑C ratio and low ankle brachial index (ABI) were seldom investigated. Patients and methods: A population based cross-sectional survey was conducted and 2982 participants 60 years and over were recruited. TG, TC, HDL‑C, and low-density lipoprotein cholesterol (LDL-C) were assessed in all participants. Low ABI was defined as ABI ≤ 0.9 in either leg. Multiple logistic regression models were applied to study the association between TG/HDL‑C ratio, TC/HDL‑C ratio and low ABI. Results: The TG/HDL‑C ratios for those with ABI > 0.9 and ABI ≤ 0.9 were 1.28 ± 1.20 and 1.48 ± 1.13 (P < 0.0001), while the TC/HDL‑C ratios were 3.96 ± 1.09 and 4.32 ± 1.15 (P < 0.0001), respectively. After adjusting for age, gender, body mass index, obesity, current drinking, physical activity, hypertension, diabetes, lipid-lowering drugs, and cardiovascular disease history, the odds ratios (ORs) with 95 % confidence intervals (CIs) of low ABI for TG/HDL‑C ratio and TC/HDL‑C ratio were 1.10 (0.96, 1.26) and 1.34 (1.14, 1.59) in non-smokers. When TC was further adjusted, the ORs (95 % CIs) were 1.40 (0.79, 2.52) and 1.53 (1.21, 1.93) for TG/HDL‑C ratio and TC/HDL‑C ratio, respectively. Non-linear relationships were detected between TG/HDL‑C ratio and TC/HDL‑C ratio and low ABI in both smokers and non-smokers. Conclusions: TC/HDL‑C ratio was significantly associated with low ABI in non-smokers and the association was independent of TC, TG, HDL‑C, and LDL-C. TC/HDL‑C might be considered as a potential biomarker for early peripheral arterial disease screening.