scholarly journals High Signal Intensity on Diffusion-Weighted Images Reflects Acute Phase of Deep Vein Thrombus

2020 ◽  
Vol 120 (10) ◽  
pp. 1463-1473
Author(s):  
Toshihiro Gi ◽  
Yasuyoshi Kuroiwa ◽  
Atsushi Yamashita ◽  
Yuko Mizutani ◽  
Taketoshi Asanuma ◽  
...  
Keyword(s):  
Acute Phase ◽  
Human Blood ◽  
Signal Intensity ◽  
High Signal ◽  
Dependent Manner ◽  
Venous Thrombus ◽  
Diffusion Weighted Images ◽  
Diffusion Weighted ◽  
Deep Vein

AbstractThe effects of antithrombotic therapy on deep vein thrombosis (DVT) can be affected by thrombus age, which cannot be reliably determined by noninvasive imaging modalities. We investigated whether magnetic resonance (MR) diffusion-weighted imaging (DWI) can localize and determine the age of venous thrombus in patients with DVT, animal models, and human blood in vitro. Signal intensity (SI) on DWI and the apparent diffusion coefficient (ADC) of thrombi were assessed in eight patients with DVT using a 1.5-T MR imaging (MRI) system. We assessed the organizing processes as venous thrombus developed in the rabbit jugular vein using a 3.0-T MRI system over time. We also assessed MRI signals of human blood in vitro using the 1.5-T MRI system. Venous thrombi were detected by DWI as areas of high or mixed high and iso SI in all patients. The ADCs were lower in the proximal, than in the distal portion of the thrombi. The thrombi of rabbit jugular veins histologically organized in a time-dependent manner, with high SI on DWI at 4 hours, mixed high and iso SI at 1 and 2 weeks, and iso SI at 3 weeks. The ADC correlated negatively with erythrocyte content, and positively with smooth muscle cells, macrophages, hemosiderin, and collagen content. MRI signals of human blood in vitro showed that ADCs were affected by erythrocyte content, but not by blood clotting. MR-DWI can detect venous thrombus, and high SI on DWI accompanied by a low ADC might reflect erythrocyte-rich, acute-phase thrombi.

Abstract 511: High Signal Intensity on Diffusion Weighted Magnetic Resonance Imaging Reflects Acuity of Deep Vein Thrombus

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Toshihiro Gi ◽  
Atsushi Yamashita ◽  
Yasuyoshi Kuroiwa ◽  
Yuko Konishi ◽  
Taketoshi Asanuma ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Mr Imaging ◽  
Signal Intensity ◽  
Fibrous Tissue ◽  
Blood Stasis ◽  
High Signal Intensity ◽  
High Signal ◽  
Venous Thrombus ◽  
Diffusion Weighted ◽  
Deep Vein

Objective: Acuity of deep vein thrombus/ thrombosis (DVT) may affect effectiveness of anti-thrombotic therapy. However, the acuity of DVT is not reliably detected by current noninvasive imaging techniques. This study investigated whether diffusion weighted magnetic resonance (MR) imaging can detect DVT and define the acuity of thrombus in patients with DVT and a rabbit model of venous thrombus. Methods: Diffusion weighted MR imaging was performed with a 1.5-T MR system in 8 patients with DVT. Venous thrombus was induced in rabbit jugular vein by endothelial denudation and 10 minutes blood stasis with a balloon catheter. The thrombus was imaged with a 3.0-T MR system at 4 hours and at 1, 2 and 3 weeks, and the jugular veins were histologically assessed. Results: All patients were detected DVT with diffusion weighted MR imaging, and the DVT showed high or mixed high and iso signal intensity on the diffusion sequence. The rabbit venous thrombi were rich in erythrocyte and fibrin at 4 hours, and showed focal organizing reaction at 1 and 2 weeks, and was replaced by fibrous tissue at 3 weeks. The rabbit thrombi showed high signal intensity on diffusion weighted MR imaging at 4 hours, mixed high and iso signal intensity at 1 and 2 weeks, or mixed iso and low signal intensity at 3 weeks. The signal intensity was positively correlated with erythrocyte and fibrin contents, and negatively correlated with macrophage and collagen contents. Conclusions: Diffusion weighted MR imaging can detect DVT and high signal intensity on the sequence may reflect acuity of DVT.

DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING OF THE ULNAR NERVE IN CUBITAL TUNNEL SYNDROME

Hand Surgery ◽  
2010 ◽  
Vol 15 (01) ◽  
pp. 11-15 ◽  
Author(s):  
K. Iba ◽  
T. Wada ◽  
M. Tamakawa ◽  
M. Aoki ◽  
T. Yamashita
Keyword(s):  
Magnetic Resonance ◽  
Ulnar Nerve ◽  
Signal Intensity ◽  
Cubital Tunnel Syndrome ◽  
Cubital Tunnel ◽  
High Signal ◽  
Diffusion Weighted Mri ◽  
Diffusion Weighted Images ◽  
Diffusion Weighted ◽  
Tunnel Syndrome

Diffusion-weighted images based on magnetic resonance reveal the microstructure of tissues by monitoring the random movement of water molecules. In this study, we investigated whether this new technique could visualize pathologic lesions on ulnar nerve in cubital tunnel. Six elbows in six healthy males without any symptoms and eleven elbows in ten patients with cubital tunnel syndrome underwent on diffusion-weighted MRI. No signal from the ulnar nerve was detected in normal subjects. Diffusion-weighted MRI revealed positive signals from the ulnar nerve in all of the eleven elbows with cubital tunnel syndrome. In contrast, conventional T2W-MRI revealed high signal intensity in eight elbows and low signal intensity in three elbows. Three elbows with low signal MRI showed normal nerve conduction velocity of the ulnar nerve. Diffusion-weighted MRI appears to be an attractive technique for diagnosis of cubital tunnel syndrome in its early stages which show normal electrophysiological and conventional MRI studies.

scholarly journals The Mechanism Causing High-signal Intensity on Diffusion-weighted Imaging in Adnexal Torsion: Two Case Reports

2017 ◽  
Vol 16 (3) ◽  
pp. 262-264 ◽  
Author(s):  
Shinya Fujii ◽  
Naoko Mukuda ◽  
Kanae Nosaka ◽  
Takeru Fukunaga ◽  
Chie Inoue ◽  
...  
Keyword(s):  
Signal Intensity ◽  
Diffusion Weighted Imaging ◽  
Case Reports ◽  
High Signal Intensity ◽  
High Signal ◽  
Adnexal Torsion ◽  
Diffusion Weighted

scholarly journals A vaginal fibroepithelial stromal polyp: a case report with magnetic resonance images

2022 ◽  
Author(s):  
Naoko Ogura ◽  
Mieko Inagaki ◽  
Ritsuko Yasuda ◽  
Shigeki Yoshida ◽  
Tetsuo Maeda
Keyword(s):  
Magnetic Resonance ◽  
Signal Intensity ◽  
Vaginal Wall ◽  
Magnetic Resonance Images ◽  
High Signal ◽  
Soft Tissue Tumour ◽  
Mri Findings ◽  
Vaginal Mass ◽  
Diffusion Weighted Images ◽  
Tissue Tumour

A fibroepithelial stromal polyp is a benign soft tissue tumour that can occur in the vagina, vulva and uterine cervix. Magnetic resonance imaging (MRI) findings have been reported in patients with vulvar fibroepithelial stromal polyps, not in those with vaginal polyps. We present MRI findings of vaginal fibroepithelial stromal polyp in a postmenopausal female. A 1 to 2 cm firm vaginal mass arising from the left side of the vaginal wall with hypointense signal changes on T1W MRI was identified. A well-defined vaginal mass (1 cm diameter) was detected with inhomogeneous signal intensity on T2W images. However, a major portion had high signal intensity on diffusion-weighted images. A benign vaginal lesion with oedematous changes or myxoid degeneration was suspected. Vaginal resection was performed, and fibroepithelial stromal polyp was pathologically diagnosed. MRI may be a useful non-invasive modality for preoperatively diagnosing vaginal fibroepithelial stromal polyps.

Case 11.13

2014 ◽  
pp. 550-551
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Postmenopausal Woman ◽  
Pelvic Pain ◽  
Signal Intensity ◽  
Pelvic Mass ◽  
Solid Component ◽  
Axial Diffusion ◽  
Diffusion Weighted Images ◽  
Diffusion Weighted ◽  
Cystic Component ◽  
T2 Weighted Images

54-year-old postmenopausal woman with vague pelvic pain Axial T2-weighted images from a DWI acquisition (b=0 s/mm2) (Figure 11.13.1) demonstrate a complex central pelvic mass containing an anterior cystic component, as well as a lobulated posterior solid component with mixed, but predominantly low, signal intensity. Corresponding axial diffusion-weighted images (b=800 s/mm...

scholarly journals Pitfalls of diffusion-weighted imaging of the female pelvis

2018 ◽  
Vol 51 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Ana Luisa Duarte ◽  
João Lopes Dias ◽  
Teresa Margarida Cunha
Keyword(s):  
Signal Intensity ◽  
Diffusion Weighted Imaging ◽  
Structural Information ◽  
Biological Tissues ◽  
High Signal ◽  
Female Pelvis ◽  
Diffusion Weighted ◽  
Apparent Diffusion ◽  
Mri Sequences ◽  
Magnetic Resonance Imaging Mri

Abstract Diffusion-weighted imaging (DWI) is widely used in protocols for magnetic resonance imaging (MRI) of the female pelvis. It provides functional and structural information about biological tissues, without the use of ionizing radiation or intravenous administration of contrast medium. High signal intensity on DWI with simultaneous low signal intensity on apparent diffusion coefficient maps is usually associated with malignancy. However, that pattern can also be seen in many benign lesions, a fact that should be recognized by radiologists. Correlating DWI findings with those of conventional (T1- and T2-weighted) MRI sequences and those of contrast-enhanced MRI sequences is mandatory in order to avoid potential pitfalls. The aim of this review article is the description of the most relevant physiological and benign pathological conditions of the female pelvis that can show restricted diffusion on DWI.

A pituitary abscess showing high signal intensity on diffusion-weighted imaging

2006 ◽  
Vol 29 (3) ◽  
pp. 246-248 ◽  
Author(s):  
Takeshi Takayasu ◽  
Fumiyuki Yamasaki ◽  
Atsushi Tominaga ◽  
Toshikazu Hidaka ◽  
Kazunori Arita ◽  
...  
Keyword(s):  
Signal Intensity ◽  
Diffusion Weighted Imaging ◽  
High Signal Intensity ◽  
High Signal ◽  
Pituitary Abscess ◽  
Diffusion Weighted

scholarly journals Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis

2011 ◽  
Vol 208 (2) ◽  
pp. 217-225 ◽  
Author(s):  
Saskia C.A. de Jager ◽  
Beatriz Bermúdez ◽  
Ilze Bot ◽  
Rory R. Koenen ◽  
Martine Bot ◽  
...  
Keyword(s):  
Cell Death ◽  
Acute Phase ◽  
Transforming Growth Factor ◽  
Inflammatory Responses ◽  
Density Lipoprotein ◽  
Transforming Growth Factor Β ◽  
Dependent Manner ◽  
Differentiation Factor ◽  
Macrophage Chemotaxis

Growth differentiation factor (GDF) 15 is a member of the transforming growth factor β (TGF-β) superfamily, which operates in acute phase responses through a currently unknown receptor. Elevated GDF-15 serum levels were recently identified as a risk factor for acute coronary syndromes. We show that GDF-15 expression is up-regulated as disease progresses in murine atherosclerosis and primarily colocalizes with plaque macrophages. Hematopoietic GDF-15 deficiency in low density lipoprotein receptor−/− mice led to impaired initial lesion formation and increased collagen in later lesions. Although lesion burden in GDF-15−/− chimeras was unaltered, plaques had reduced macrophage infiltrates and decreased necrotic core formation, all features of improved plaque stability. In vitro studies pointed to a TGFβRII-dependent regulatory role of GDF-15 in cell death regulation. Importantly, GDF-15−/− macrophages displayed reduced CCR2 expression, whereas GDF-15 promoted macrophage chemotaxis in a strictly CCR2- and TGFβRII-dependent manner, a phenomenon which was not observed in G protein–coupled receptor kinase 2+/− macrophages. In conclusion, GDF-15 deletion has a beneficial effect both in early and later atherosclerosis by inhibition of CCR2-mediated chemotaxis and by modulating cell death. Our study is the first to identify GDF-15 as an acute phase modifier of CCR2/TGFβRII-dependent inflammatory responses to vascular injury.

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