The Risk of Preterm Birth in Low Risk Pregnant Women with Urinary Tract Infections

Objective Urinary tract infections are among the most common infections during pregnancy. The association between symptomatic lower urinary tract infections during pregnancy and fetal and maternal complications such as preterm birth and low birthweight remains unclear. The aim of this research is to evaluate the association between urinary tract infections during pregnancy and maternal and neonatal outcomes, especially preterm birth. Study Design This study is a secondary analysis of a multicenter prospective cohort study, which included patients between October 2011 and June 2013. The population consists of women with low risk singleton pregnancies. We divided the cohort into women with and without a symptomatic lower urinary tract infection after 20 weeks of gestation. Baseline characteristics and maternal and neonatal outcomes were compared between the two groups. Multivariable logistic regression analysis was used to correct for confounders. The main outcome was spontaneous preterm birth at <37 weeks. Results We identified 4,918 pregnant women eligible for enrollment, of whom 9.4% had a symptomatic lower urinary tract infection during their pregnancy. Women with symptomatic lower urinary tract infections were at increased risk for both preterm birth in general (12 vs. 5.1%, adjusted OR 2.5; 95% CI 1.7–3.5) as well as a spontaneous preterm birth at <37 weeks (8.2 vs. 3.7%, adjusted OR 2.3; 95% CI 1.5–3.5). This association was also present for early preterm birth at <34 weeks. Women with symptomatic lower urinary tract infections during pregnancy are also at increased risk of endometritis (8.9 vs. 1.8%, adjusted OR 5.3; 95% CI 1.4–20) and mastitis (7.8 vs. 1.8%, adjusted OR 4.0; 95% CI 1.6–10) postpartum. Conclusion Low risk women with symptomatic lower urinary tract infections during pregnancy are at increased risk of spontaneous preterm birth. In addition, an increased risk for endometritis and mastitis postpartum was found in women with symptomatic lower urinary tract infection during pregnancy. Key Points

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The efficacy of fosfomycin trometamol in prevention of postoperative urinary tract infection in pregnant women after endoscopic procedures: open clinical trial

African Journal of Urology ◽

10.1186/s12301-021-00266-3 ◽

2021 ◽

Vol 27 (1) ◽

Author(s):

Mohamed Radwan ◽

Ayman Hagras ◽

Salah Nagla ◽

Nareman Elhamamy ◽

Mohammed Abou Farha

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Pregnant Women ◽

Urinary Tract Infections ◽

Lower Urinary Tract ◽

Oral Antibiotic ◽

Endoscopic Procedures ◽

Tract Infections ◽

Lower Urinary

Abstract Background Fosfomycin tromethamine is recommended (category B) for the treatment of urinary tract infections in pregnant women. We aimed to evaluate the efficacy of single-dose preoperative fosfomycin tromethamine in the prevention of urinary tract infection in pregnant women who underwent lower urinary tract endoscopic surgeries. Methodology The subjects of this study were pregnant women who underwent lower urinary tract endoscopic procedures. All patients received Fosfomycin tromethamine1 packet (3 g) dissolved in water the day before surgery. Routine pre- and postoperative urine analysis and urine cultures were performed when needed. Patients were monitored for urinary tract infections and the side effects of the drug. Moreover, maternal and fetal complications were monitored. Results The study was conducted on 31 pregnant women with a mean age of 24.48 ± 5.35 years. The endoscopic procedures were as follows: 28 (90.3%) DJ ureteric insertions for hydronephrosis, 2 (6.5%) urinary bladder stones, and cystoscopy (3.2%) for gross hematuria. Two (6.5%) patients had postoperative asymptomatic bacteriuria that resolved with oral antibiotic therapy. Conclusion Fosfomycin tromethamine is safe in preventing urinary tract infection and decreases the need for postoperative parenteral antibiotics in pregnant women who require lower urinary tract endoscopic procedures.

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CRITICAL EVALUATION OF THE ACTION OF VARIVIDARYADI KASHAYA IN LOWER URINARY TRACT INFECTIONS

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj2209112021 ◽

2021 ◽

Vol 9 (11) ◽

pp. 2784-2788

Author(s):

Anshu S ◽

Miharjan K ◽

Arjun Chand C P ◽

Arun Pratap

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Urinary Tract Infections ◽

Lower Urinary Tract ◽

Critical Evaluation ◽

Gram Positive Bacteria ◽

Human Illness ◽

Tract Infections ◽

Lower Urinary

Urinary tract infection (UTI) is a common and painful human illness that is rapidly responsive to modern antibi- otic therapy. UTI is caused by both Gram-negative and Gram-positive bacteria, as well as by certain fungi. The typical symptoms of lower urinary tract infections (LUTI) are dysuria, urinary frequency, and urgency, nocturia, hesitancy, suprapubic discomfort, and gross hematuria. The features of LUTI can be found under the heading Pit- taja Mutrakrichra Lakshana. As Pitta and Vata are the main Doshas involved in the Samprapti of this disease, drugs having Madhura Rasa, Vata-Pitta Samana properties are the ideal choice for the treatment. In Varividar- yadi Kashaya, all the drugs are having Sita Virya and most of the drugs are having Madhura Rasa, Guru- Snigdha Guna, and Madhura Vipaka. So, there is a very need to understand the scope of the usage of Varividaryadi Kashaya in the management of LUTI. Keywords: Urinary tract infection, Pittaja Mutrakrichra, Varividaryadi Kashaya

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Risk Indicators for Urinary Tract Infections in Low Risk Pregnancy and the Subsequent Risk of Preterm Birth

Antibiotics ◽

10.3390/antibiotics10091055 ◽

2021 ◽

Vol 10 (9) ◽

pp. 1055

Author(s):

Dominique E. Werter ◽

Brenda M. Kazemier ◽

Caroline Schneeberger ◽

Ben W. J. Mol ◽

Christianne J. M. de Groot ◽

...

Keyword(s):

Urinary Tract Infection ◽

Preterm Birth ◽

Urinary Tract ◽

Tract Infection ◽

Urinary Tract Infections ◽

Asymptomatic Bacteriuria ◽

Risk Indicators ◽

Recurrent Urinary Tract Infections ◽

Increased Risk ◽

Tract Infections

Symptomatic urinary tract infections are associated with preterm birth. However, data on risk indicators for urinary tract infections are limited and outdated. The research is a secondary analysis. The study was a prospective multicenter cohort study of low-risk pregnant women. Logistic regression was used to identify risk indicators for urinary tract infections. The incidence of urinary tract infections was 9.4%. Multivariate logistic regression showed that a history of recurrent urinary tract infections and the presence of asymptomatic bacteriuria in the present pregnancy were associated with urinary tract infections (resp. OR 3.14, 95%CI 1.40–7.02 and OR 1.96 95%CI 1.27–3.03). Women with a urinary tract infection were at increased risk of preterm birth compared to women without a urinary tract infection (12 vs. 5.1%; adjusted HR 2.5 95%CI 1.8–3.5). This increased risk was not found in women with the identified risk indicators (resp. 5.3% vs. 5.1%, adjusted HR 0.35 95%CI 0.00–420 and adjusted HR 1.5 95CI% 0.59–3.9). In conclusion, in low-risk pregnant women, risk indicators for urinary tract infections are: a history of recurrent urinary tract infections and the presence of asymptomatic bacteriuria. The risk of preterm birth is increased in women with a urinary tract infection in this pregnancy. However, women with recurrent urinary tract infections and asymptomatic bacteriuria this pregnancy appear not to be at increased risk of preterm birth.

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Effectiveness of D-mannose, Hibiscus sabdariffa and Lactobacillus plantarum therapy in prevention of infectious events following urodynamic study

Urologia Journal ◽

10.1177/0391560318798291 ◽

2018 ◽

Vol 86 (3) ◽

pp. 122-125 ◽

Cited By ~ 2

Author(s):

Riccardo Milandri ◽

Matteo Maltagliati ◽

Tommaso Bocchialini ◽

Chiara Del Prete ◽

Giampaolo Bianchi ◽

...

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Urinary Tract Infections ◽

Lower Urinary Tract ◽

The Other ◽

Hibiscus Sabdariffa ◽

Urodynamic Study ◽

Tract Infections ◽

Lower Urinary

Introduction and aim: The urodynamic study is an invasive examination that allows a thorough evaluation of the functional activity of the lower urinary tract (bladder, urethra). The execution of urodynamic study exposes the patient to the risk of contracting infections of the lower urinary tract. Prevention of urinary tract infections consists in the avoidance of risk factors and prophylaxis with antimicrobial and non-antimicrobial measures. In this article, we aimed to evaluate the effectiveness of a phytotherapeutic product composed of D-mannose, Hibiscus sabdariffa, and Lactobacillus plantarum in the prevention of infectious events following invasive urodynamic examination. Materials and methods: We selected 100 female consecutive patients (age 19–87 years) that underwent urodynamic invasive procedure. We prescribed 14-day therapy with D-mannose, H. sabdariffa, and L. plantarum to these 100 patients after urodynamic invasive test. After that, we have examined urine cultures and urinary symptoms through telephone interviews and hospital outpatient visits to evaluate the possible presence of urinary tract infections. Results: Urinary tract infections were observed through urine culture in 13% of the selected patients; of the 13 urinary tract infections, 9 were observed in patients with urinary tract recurrent infections in the last year and the other 4 cases were associated with patients with no urinary infection in the last year. Three women reported some urinary symptoms and underwent antibiotic therapy. The other 10 cases were classified as asymptomatic bacteriuria. Three cases were related to patients presenting with pelvic organ prolapse. Eight cases were instead related to significant post-voiding residue (>100). Six patients with urinary tract infection reported constipation in the last year. All patients completed the prescribed therapy due to the affordable price of the product and no side effects have been reported. Conclusion: Our study about the administration of D-mannose, H. sabdariffa, and L. plantarum after invasive urodynamic examination underlined how this phytotherapeutic product can reduce the risk of bacteriuria and urinary tract infection in women.

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Acute lower urinary tract infections: aetiology, antimicrobial resistance patterns and treatment results

10.26226/morressier.56d6be72d462b80296c97225 ◽

2016 ◽

Author(s):

Ilknur Erdem

Keyword(s):

Urinary Tract ◽

Antimicrobial Resistance ◽

Urinary Tract Infections ◽

Lower Urinary Tract ◽

Treatment Results ◽

Resistance Patterns ◽

Tract Infections ◽

Lower Urinary

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Faculty Opinions recommendation of Effect of meteorological variables on the incidence of lower urinary tract infections.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1141894.599004 ◽

2009 ◽

Author(s):

Yong-Hyun Cho

Keyword(s):

Urinary Tract ◽

Urinary Tract Infections ◽

Lower Urinary Tract ◽

Meteorological Variables ◽

Tract Infections ◽

Lower Urinary

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Faculty Opinions recommendation of Antibiotics for treating lower urinary tract infection in children.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717954927.793462557 ◽

2012 ◽

Author(s):

Susan Coffin

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Lower Urinary Tract ◽

Lower Urinary Tract Infection ◽

Lower Urinary

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Risk of Cancer after Lower Urinary Tract Infection: A Population-Based Cohort Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16030390 ◽

2019 ◽

Vol 16 (3) ◽

pp. 390 ◽

Cited By ~ 2

Author(s):

Chia-Hung Huang ◽

Ying-Hsiang Chou ◽

Han-Wei Yeh ◽

Jing-Yang Huang ◽

Shun-Fa Yang ◽

...

Keyword(s):

Urinary Tract Infection ◽

Cohort Study ◽

Urinary Tract ◽

Urinary Bladder ◽

Tract Infection ◽

Lower Urinary Tract ◽

Population Based ◽

Control Group ◽

Lower Urinary Tract Infection ◽

Lower Urinary

To investigate the association among lower urinary tract infection (UTI), the type and timing of antibiotic usage, and the subsequent risk of developing cancers, especially genitourinary cancers (GUC), in Taiwan. This retrospective population-based cohort study was conducted using 2009–2013 data from the Longitudinal Health Insurance Database. This study enrolled patients who were diagnosed with a UTI between 2010 and 2012. A 1:2 propensity score-matched control population without UTI served as the control group. Multivariate analysis with a multiple Cox regression model was applied to analyze the data. A total of 38,084 patients with UTI were included in the study group, and 76,168 participants without UTI were included in the control group. The result showed a higher hazard ratio of any cancer in both sexes with UTI (for males, adjusted hazard ratio (aHR) = 1.32; 95% confidence interval (CI) = 1.12–1.54; for females, aHR = 1.21; 95% CI = 1.08–1.35). Patients with UTI had a higher probability of developing new GUC than those without UTI. Moreover, the genital organs, kidney, and urinary bladder of men were significantly more affected than those of women with prior UTI. Furthermore, antibiotic treatment for more than 7 days associated the incidence of bladder cancer in men (7–13 days, aHR = 1.23, 95% CI = 0.50–3.02; >14 days, aHR = 2.73, CI = 1.32–5.64). In conclusion, UTI is significantly related to GUC and may serve as an early sign of GUC, especially in the male genital organs, prostate, kidney, and urinary bladder. During UTI treatment, physicians should cautiously prescribe antibiotics to patients.

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