Impact of Prematurity on the Buccal Epithelial Cells of the Neonates via Wnt/Beta-Catenin Signaling Pathway and Apoptosis

Objective Understanding the reflections of prematurity is necessary for the management of neonatal complications. We focused on the impact of prematurity and related “maternal risk factors/obstetric complications” on buccal cells of the neonates via evaluation of the Wnt/β-catenin signaling pathway and apoptosis. Study Design This study consisted of “early preterm neonates (EPN) (≤34th gestational week [gw]) (n = 36),” “late preterm neonates (LPN) (34th– < 37th gw) (n = 46),” and “term neonates (control) (≥37th gw) (n = 56).” Cohort was also subclassified according to the presence of maternal risk factors, obstetric complications, and neonatal complications. Wnt/β-catenin signaling and caspase-3 activation pathways were studied immunocytochemically. Results Wnt/β-catenin signaling positivity was statistically more frequent at buccal smears of the EPN and LPN groups compared with controls (p < 0.001). The cutoff for gestational age at delivery in receiver operating characteristic curve with the best balance of sensitivity (67.4%) and specificity (67.3%) was 35.8th gw for determining the reduction of Wnt/β-catenin signaling positivity (p < 0.001). The study demonstrated that obstetric complications significantly affected the activity of signaling, while maternal risk factors do not have any effect on Wnt/β-catenin signaling pathway (p = 0.003 and p = 0.828, respectively). This study also demonstrated a significant relationship between Wnt/β-catenin signaling pathway and the presence of neonatal complications (p = 0.015). Conclusion Dynamic characteristics of buccal cells are influenced by prematurity and related obstetric and neonatal problems. Buccal smear is a good tool to investigate the impact of prematurity and obstetric problems on perinatal outcome. Key Points

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Morbidity and mortality profile of preterm neonates admitted in neonatal intensive care unit of a tertiary care centre in Western Uttar Pradesh, India

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20193154 ◽

2019 ◽

Vol 6 (5) ◽

pp. 1859

Author(s):

Najia Hassan ◽

Sujaya Mukhopadhyay ◽

Sneha Mohan

Keyword(s):

Risk Factors ◽

Neonatal Intensive Care ◽

Tertiary Care ◽

Preterm Neonates ◽

Pregnancy Induced Hypertension ◽

Care Centre ◽

Maternal Risk Factors ◽

Tertiary Care Centre ◽

Maternal Risk ◽

Induced Hypertension

Background: Preterm birth is a major cause of mortality and morbidity for newborns. Complications of prematurity are becoming more common as more survivors are spending time in Neonatal intensive care unit.Methods: A retrospective hospital based clinical observational study was conducted in NICU in Sharda hospital, a tertiary care centre in Greater Noida. Data regarding neonates′ age, sex, clinical presentation, maternal risk factors, complications and outcome were recorded.Results: A total of 133 preterm neonates were enrolled in the study. Maternal risk factors like Pregnancy induced hypertension (PIH) was seen in 19.5% cases, Urinary tract infection in 15% and Antepartum haemorrhage in 14.2% cases. Among the complications of prematurity, RDS was noted in 38.3% cases, Hyperbilirubinemia in 16.5% and feed intolerance in 15% cases. Sepsis was present in 3% of the preterm. Mortality rate was 7.5%. Most common cause of death was RDS.Conclusions: Pregnancy induced hypertension and Antepartum haemorrhage were important maternal risk factors for prematurity. Respiratory distress syndrome and perinatal asphyxia were the important causes of mortality in the present study.

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Impact of maternal risk factors on the outcome of pregnancy in Baghdad city

Baghdad Science Journal ◽

10.21123/bsj.7.1.813-820 ◽

2010 ◽

Vol 7 (1) ◽

pp. 813-820

Author(s):

Baghdad Science Journal

Keyword(s):

Risk Factors ◽

Pregnancy Outcome ◽

Teaching Hospital ◽

Maternal Employment ◽

Maternal Risk Factors ◽

Self Monitoring ◽

Maternal Risk ◽

The Impact ◽

Poor Pregnancy Outcome

To find out the impact of maternal risk factors on the outcome of pregnancy in Baghdad city. A descriptive purposive study was carried out on 100 postpartum women who had delivered for 1 hr. to 24 hrs. ago . the study sample was selected from three hospitals in Baghdad city ( Baghdad teaching hospital ,Fatima Al-Zahra'a maternity and pediatric teaching hospital and Al-Yarmook teaching hospital),during the period from 25 Jan. to 25 Feb. 2006. The data were collected through the use of questionnaire format reviewing pregnants' records and personal interview and were analyzed by using descriptive and inferential statistical approaches. The finding revealed that maternal pregnancy complications had weak effects on pregnancy outcome , while maternal employment & spouse's consanguinity were predictors for poor pregnancy outcome . The study recommended the necessity of establishing health education programs for pregnant to be self monitoring & early detection of complications that associate the pregnancy . In addition promote the system of follow up care during antenatal ,perinatal,& postnatal.

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CLINICAL PREDICTION OF EARLY ONSET SEPSIS IN PRETERM NEONATES

Wiadomości Lekarskie ◽

10.36740/wlek202010121 ◽

2020 ◽

Vol 73 (10) ◽

pp. 2219-2223

Author(s):

Valeriy Pokhylko ◽

Yuliia Cherniavska ◽

Nataliia Adamchuk ◽

Svitlana Tsvirenko ◽

Yuliia Klimchuk

Keyword(s):

Risk Factors ◽

Predictive Value ◽

Early Onset ◽

Prognostic Model ◽

Preterm Neonates ◽

Monocyte Count ◽

Maternal Risk Factors ◽

Maternal Risk ◽

Early Onset Sepsis ◽

Diagnostic Characteristics

The aim of the study was to analyze and identify risk factors for the development of early onset sepsis in preterm neonates and to develop a clinical prognostic model. Materials and methods: A retrospective cohort study included 152 newborns with birth weight from 1000 to 2500 g, who were treated in the neonatal intensive care units of medical institutions in the Poltava region. Among 152 children, 121 had clinical and laboratory symptoms of infection, which were regarded as manifestations of early onset sepsis, the rest of the children (n = 31) had no manifestations of infection. Results: According to the results of multiple stepwise logistic regression analysis, the predictive model has been developed. It included gestational age, visual changes of placenta, Apgar score at the 1st minute, the level of monocytes more than 6.5%, the history of abortions and premature rupture of membranes. The diagnostic characteristics of the developed model had high: sensitivity – 82.2%, specificity – 93.55%, positive predictive value – 97.98%, negative predictive value – 58%. Conclusions: The prognostic model developed by us, which showed high diagnostic characteristics, includes information on maternal risk factors, the state of the newborn immediately after birth, and biomarkers of infection (C-reactive protein and monocyte count). Therefore, we believe that when interpreting biomarkers, the decision to prescribe antibiotics should be based on the presence of maternal risk factors and clinical symptoms of infection in the prematurely born child, which may be nonspecific

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Maternal risk factors and obstetric complications in late preterm prematurity

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/j.ejogrb.2014.05.030 ◽

2014 ◽

Vol 179 ◽

pp. 105-109 ◽

Cited By ~ 9

Author(s):

Cristina C. Trilla ◽

Maria C. Medina ◽

Gemma Ginovart ◽

Jocelyn Betancourt ◽

Josep A. Armengol ◽

...

Keyword(s):

Risk Factors ◽

Obstetric Complications ◽

Late Preterm ◽

Maternal Risk Factors ◽

Maternal Risk

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987 Emipediology and Morbidity of Late Preterm Neonates in Correlation with Maternal Risk Factors in Hessen, Germany

Archives of Disease in Childhood ◽

10.1136/archdischild-2012-302724.0987 ◽

2012 ◽

Vol 97 (Suppl 2) ◽

pp. A282-A282

Author(s):

D. Faas ◽

M. Vajz ◽

U. Hennewig ◽

B. Misselwitz ◽

F. Oehmke ◽

...

Keyword(s):

Risk Factors ◽

Late Preterm ◽

Preterm Neonates ◽

Maternal Risk Factors ◽

Maternal Risk

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Maternal risk factors and early neonatal outcome among late preterm and term neonates in a neonatal intensive care unit in Punjab, India

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20180565 ◽

2018 ◽

Vol 5 (2) ◽

pp. 612

Author(s):

Kambiakdik T. ◽

Anish D. Leelalanslat ◽

Inderpreet Sohi ◽

Varughese P. Varkey

Keyword(s):

Risk Factors ◽

Intensive Care Unit ◽

Intensive Care ◽

Neonatal Intensive Care Unit ◽

Neonatal Intensive Care ◽

Late Preterm ◽

Preterm Neonates ◽

Maternal Risk Factors ◽

Term Neonates ◽

Maternal Risk

Background: Late preterm neonates (34 to 36 weeks 6/7 days) were considered as ‘near term’ as they appeared apparently mature and comparable to term neonates. Many studies have now reported significantly higher rates of morbidity and mortality among this group of neonates. This study aims to evaluate the maternal risk factors associated with and short-term outcome of late preterm neonates compared to term neonates.Methods: A Retrospective cohort study was conducted in the Neonatal Intensive Care Unit of a tertiary care teaching hospital. All intramural late preterm neonates with gestational age of 34-36 weeks born during the study period were enrolled. The control group included term neonates (37-42 weeks) born during the study period. Data regarding the maternal risk factors and neonatal outcomes for both the late preterm and term neonates were collected from records maintained in the NICU. Results: There were 3275 deliveries during the study period, of which 2447 (74.8%) were term. Among the 828 preterm neonates, 500 (60.4%) were late preterms. The maternal risk factors significantly associated with late preterm neonates were PIH, eclampsia, APH, multiple gestation, PROM, oligohydramnios and abnormal dopplers. Incidence of Respiratory distress syndrome (RDS), sepsis and hypoglycemia were higher among the late preterm group with an odd’s ratio of 56.01, 9.9 and 7.8 respectively. Incidence of hypocalcemia, seizures and Persistent Pulmonary Hypertension (PPHN) were also higher among this group. There was no statistically significant difference in mortality among the two groups.Conclusions: Late preterm neonates have a significantly higher neonatal morbidity compared to term neonates.

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