Morbidity and mortality profile of preterm neonates admitted in neonatal intensive care unit of a tertiary care centre in Western Uttar Pradesh, India

Background: Preterm birth is a major cause of mortality and morbidity for newborns. Complications of prematurity are becoming more common as more survivors are spending time in Neonatal intensive care unit.Methods: A retrospective hospital based clinical observational study was conducted in NICU in Sharda hospital, a tertiary care centre in Greater Noida. Data regarding neonates′ age, sex, clinical presentation, maternal risk factors, complications and outcome were recorded.Results: A total of 133 preterm neonates were enrolled in the study. Maternal risk factors like Pregnancy induced hypertension (PIH) was seen in 19.5% cases, Urinary tract infection in 15% and Antepartum haemorrhage in 14.2% cases. Among the complications of prematurity, RDS was noted in 38.3% cases, Hyperbilirubinemia in 16.5% and feed intolerance in 15% cases. Sepsis was present in 3% of the preterm. Mortality rate was 7.5%. Most common cause of death was RDS.Conclusions: Pregnancy induced hypertension and Antepartum haemorrhage were important maternal risk factors for prematurity. Respiratory distress syndrome and perinatal asphyxia were the important causes of mortality in the present study.

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Risk factors for necrotizing enterocolitis in neonates:a prospective study

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20192762 ◽

2019 ◽

Vol 6 (4) ◽

pp. 1598

Author(s):

Manas Ranjan Sahoo ◽

Pydi Nagasree ◽

Lanka Swetha ◽

Arigela Vasundhara

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Prospective Study ◽

Necrotizing Enterocolitis ◽

Neonatal Intensive Care ◽

Ductus Arteriosus ◽

Pregnancy Induced Hypertension ◽

Mortality And Morbidity ◽

Maternal Risk ◽

Induced Hypertension

Background: Necrotizing enterocolitis (NEC) is mostly limited to preterm babies due to immaturity of gut. NEC is one of important cause of neonatal mortality and morbidity in the neonatal intensive care units all over the world.Aim of study is to find the antenatal and post-natal risk factors associated with necrotizing enterocolitis in neonates admitted to NICU.Methods: A prospective study was conducted on 45 neonates with necrotizing enterocolitis fulfilling the predetermined inclusion criteria. A detailed antenatal history including all maternal risk factors, birth history including the need for resuscitation and type of resuscitation was recorded. The gestational assessment was done by the New Ballard Score.Results: Pregnancy induced hypertension accounts as a risk factor to most of the cases of NEC 18 (40%), followed by setting for sepsis 12 (26.6%), least being gestational diabetes mellitus 1 (2.2%).Conclusions: Prematurity is found to be the most common risk factor followed by patent ductus arteriosus and sepsis. Most common antenatal risk factor was PIH (Pregnancy induced hypertension).

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A study of the incidence of retinopathy of prematurity in a tertiary care centre in Karnataka

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20212043 ◽

2021 ◽

Vol 8 (6) ◽

pp. 1033

Author(s):

Manjunathaswmy R. ◽

Anjana H. Rao ◽

Vinayaka P. Hegade ◽

Pradeep Kumar ◽

Ravindra B. Patil

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Gestational Age ◽

Retinopathy Of Prematurity ◽

Tertiary Care ◽

Argon Laser ◽

Preterm Neonates ◽

Multiple Gestation ◽

Care Centre ◽

Tertiary Care Centre

Background: Retinopathy of prematurity is a preventable cause of childhood blindness. Proper understanding of the classification, risk factors and treatment methods is a must in tackling this disease. The aim of this study was to know the incidence of ROP in preterm infants in a tertiary care centre and to improvise the selection criteria in future in Indian babies.Methods: A retrospective study of all infants admitted to the NICU from 2016 to 2018 who met the criteria for ROP screening were included in the study. Examination of the eyes was done by a trained technician using a Ret Cam digital imaging in collaboration with KIDROP, Narayana Nethralaya and later interpreted by trained ophthalmologists using the concept of teleopthalmology. Babies were followed up and screened accordingly. Qualified infants were treated with argon laser photocoagulation within 48h of diagnosis. They were followed until the disease was successfully treated.Results: In current study, incidence of ROP was found to be 10.2%. The gestational age ranged from 28-36 weeks with a mean of 30.5±1.5 weeks. In current study, the most prevalent prenatal risk factor was multiple gestation and postnatal risk factors was anemia, low birth weight ,low gestational age and the use of oxygen therapy.Conclusions: Screening for ROP, in India, should be performed in all preterm neonates who are born <34 weeks gestation and/or <1800 grams birth weight; as well as in babies 34-36 weeks gestation or 1800-2000 grams birth weight if they have risk factors for ROP.

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Risk factor and perinatal outcome of preterm delivery in a tertiary care centre in rural Haryana

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20204311 ◽

2020 ◽

Vol 9 (10) ◽

pp. 4187

Author(s):

Sunaina Singla ◽

Banashree Das

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Preterm Delivery ◽

Perinatal Outcome ◽

Neonatal Intensive Care ◽

Tertiary Care ◽

Preterm Births ◽

Care Centre ◽

Tertiary Care Centre ◽

History Of

Background: Aim of the study was to identify risk factors and to assess neonatal mortality and morbidity associated with preterm delivery in patient attending a tertiary care centre in rural Haryana.Methods: This retrospective cohort study was conducted in Shree Guru Gobind Singh Tricentenary Medical College, over a period of one year (January to December). All pre-term deliveries were included in the study. They were followed up from admission till delivery and till discharge from hospital. Various, parameters like maternal age, associated medical disorder, obstetric complications, gestational age, neonatal mortality, need of neonatal intensive care and condition of baby at discharge were analyzed.Results: In the present study, incidence of preterm deliveries was 16.1%. The most common risk factor found to be history of previous abortion (23.6%), preterm premature rupture of membrane (17.1%), Intra-uterine growth restriction (IUGR) with oligohydramnios (10.5%), hypertensive disorder during pregnancy (5.9%), and antepartum hemorrhage (4.6%). But majority of the patient (56.5%) no cause could be identify. Out of total 160 preterm births 3 were still born and 157 live preterm births, and out of which total Neonatal intensive care (NICU) admission were 60. Mortality rate was 100% in neonate weighing less than 1000 gm and 18% in babies weighing less than 2000 gm.Conclusions: The commonest risk factor for preterm delivery is previous history of abortion and adverse perinatal outcome is inversely proportionate to the period of gestation at the time of delivery. All efforts should be made to prolong the pregnancy beyond 34 weeks by identifying and actively managing the risk factors for better neonatal outcome.

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Incidence and risk factors of retinopathy of prematurity in Goa, India: a report from tertiary care centre

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20192017 ◽

2019 ◽

Vol 6 (3) ◽

pp. 1228

Author(s):

Sarvesh Kossambe ◽

Shilpa Joglekar ◽

Annely D'lima ◽

M. P. Silveira

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Retinopathy Of Prematurity ◽

Neonatal Intensive Care ◽

Laser Photocoagulation ◽

Very Low Birth Weight ◽

Care Center ◽

Tertiary Care ◽

Preterm Neonates ◽

Tertiary Care Centre

Background: To report the incidence and risk factors leading to the development of retinopathy of prematurity (ROP) from a tertiary care center in the western Indian state of Goa, India.Methods: This was a prospective observational study carried out in a level II neonatal intensive care unit (NICU) for a period of 18 months. Babies born at < 34 weeks’ gestation and having a birth weight of <1500gm were screened for ROP and laser photocoagulation was done for those who developed threshold ROP. Group differences between any ROP and threshold ROP were analysed using the chi-square test.Results: Out of the 244 preterm neonates screened, 37 developed ROP (15.16%), and 14 out of them (5.73%) developed threshold ROP requiring laser photocoagulation. Very low birth weight, prematurity, apnea, anemia, sepsis, respiratory distress syndrome, bronchopulmonary dysplasia, blood transfusions, exchange transfusions and days taken to reach full enteral feeds and regain birth weight were significantly associated with the development of ROP.Conclusions: This is the first report of ROP from Goa where less than 1 in 5 babies developed ROP. This is similar to that reported across the rest of the country. Judicious oxygen use, ventilation strategies, transfusions guidelines, control of sepsis, early enteral feeds and adequate nutrition may help prevent the development of ROP in the future.

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Retinopathy of prematurity: study of incidence, risk factors and outcome in level 3 neonatal intensive care unit in a tertiary care centre

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20195732 ◽

2019 ◽

Vol 7 (1) ◽

pp. 90

Author(s):

Uma Devi Rachamadugu ◽

Sravani Devana ◽

Srikanth Sandanala

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Gestational Age ◽

Retinopathy Of Prematurity ◽

Neonatal Intensive Care ◽

Tertiary Care ◽

Preterm Neonates ◽

P Value ◽

Prospective Clinical Study ◽

Tertiary Care Centre

Background: Advancing technology in antenatal and neonatal care has resulted in better survival of preterm neonates in developing countries in the past few decades. This has resulted in an apparent increase in the incidence of Retinopathy of Prematurity (ROP), which is the most important cause of preventable blindness in infants.Methods: A prospective clinical study was done for 18 months in 400 preterm babies less than 34 weeks of Gestational Age (GA) or less than 1750 gm of Birth Weight (BW). ROP screening was performed. The babies who developed any stage of ROP were taken as cases and the babies who did not have ROP were taken as controls. Statistical analysis was performed using SPSS software (Version 20.0). p value <0.05 was taken as statistically significant.Results: Four hundred babies were thus examined. The overall incidence of ROP in the study group was 10.25% (41 babies). Out of them, 38 babies (92.6%) had stage-1 ROP and 3 babies (7.31%) had stage-2 ROP. three babies (7.31%) required laser treatment. Risk factor analysis revealed that gestational age at birth, low birth weight, need foroxygenation, RDS, clinical sepsis, HIE, AKI, NNS, resuscitation, apnea.Conclusions: Screening should be intensified in the presence of risk factors like resuscitation, oxygen requirement, apnoea and prolonged hospital stay, which can reduce the incidence of severe stages of ROP as shown by this study.

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Maternal Risk Factors and Morbidity Pattern of Very Low Birth Weight Infants: A NICU Based Study at Eastern Nepal

Journal of Nepal Paediatric Society ◽

10.3126/jnps.v29i2.2040 ◽

2009 ◽

Vol 29 (2) ◽

pp. 59-66 ◽

Cited By ~ 2

Author(s):

Prakash Poudel ◽

Sunil Budhathoki ◽

Manoj Kumar Shrivastava

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Low Birth Weight ◽

Very Low Birth Weight ◽

Ductus Arteriosus ◽

Pregnancy Induced Hypertension ◽

Maternal Risk Factors ◽

Maternal Risk ◽

Factors Associated ◽

Induced Hypertension

Background: Preterm deliveries of babies weighing less than 1500 grams (VLBW, very low birth weight) are of major concern because of maximum perinatal morbidity and mortality found in this group. VLBW babies overload the neonatal intensive care unit (NICU) and their mortality contributes significantly to neonatal and infant mortality. Objectives: To study the common maternal risk factors associated with VLBW births. To study the morbidity and mortality patterns of VLBW babies. Methods: This was a hospital based retrospective study done in NICU of BP Koirala Institute of Health Sciences. Data were collected from medical records of VLBW babies admitted in NICU over a period of three years (13 April 2005 to 12 April 2008). Data were analyzed with SPSS 10.0 software. Results: Data of 140 VLBW babies were analyzed. Mean birth weight was 1188.9 (±212.78), 10.7% were home deliveries, 24.3% were twins, 31.4% required active resuscitation at birth and 46.4% were exposed to antenatal steroid. Common maternal risk factors associated with premature deliveries were inadequate antenatal check up (ANC) visits (95.7%), twin pregnancy (24.3%), antepartum hemorrhage (APH, 28.6%), premature rupture of membrane (23.6%), pregnancy induced hypertension (12.9%), bad obstetric history (12.9%) and maternal age less than 20 years (8.6%). Common morbidities among VLBW babies were clinical sepsis (77.1%), non physiological hyperbilirubinemia (73.6%), apnea (48.6%), shock (42.9%), hypoglycemia(39.3%), anemia (29.3%), hyaline membrane disease (HMD, 21.4%), patent ductus arteriosus (15.0%), severe hypothermia (12.1%), culture proven sepsis (15.7%), retinopathy of prematurity (5.7%), and bronchopulmonary dysplasia (3.6%). Overall survival was 54.3% and major causes of death were HMD (51.0%) and sepsis (34.7%). Median durations of hospital stay were 17.5 days for survivors and five days for expired cases.Conclusion: Increasing the coverage of ANC visits, early diagnosis and treatment of APH and pregnancy induced hypertension, discouraging the childbirth at too young age, early diagnosis and treatment of acute infections and chronic medical diseases in mothers are important measures to decrease the burden of VLBW births. Common morbidities in VLBW babies are sepsis, HMD, apnea, hyperbilirubinemia, patent ductus arteriosus, shock, anemia, hypoglycemia, hypothermia and hypocalcemia. Common causes death of VLBW babies are HMD and sepsis. Overall survival of VLBW babies in our settings is less. More numbers of well equipped NICUs and services like surfactant therapy are needed to improve survival of VLBW infants in our set up. Key words: Maternal risk factors, Morbidity, Mortality, Very low birth weight. doi: 10.3126/jnps.v29i2.2040 J. Nepal Paediatr. Soc. Vol 29, No. 2, pp.59-66

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Maternal risk factors and early neonatal outcome among late preterm and term neonates in a neonatal intensive care unit in Punjab, India

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20180565 ◽

2018 ◽

Vol 5 (2) ◽

pp. 612

Author(s):

Kambiakdik T. ◽

Anish D. Leelalanslat ◽

Inderpreet Sohi ◽

Varughese P. Varkey

Keyword(s):

Risk Factors ◽

Intensive Care Unit ◽

Intensive Care ◽

Neonatal Intensive Care Unit ◽

Neonatal Intensive Care ◽

Late Preterm ◽

Preterm Neonates ◽

Maternal Risk Factors ◽

Term Neonates ◽

Maternal Risk

Background: Late preterm neonates (34 to 36 weeks 6/7 days) were considered as ‘near term’ as they appeared apparently mature and comparable to term neonates. Many studies have now reported significantly higher rates of morbidity and mortality among this group of neonates. This study aims to evaluate the maternal risk factors associated with and short-term outcome of late preterm neonates compared to term neonates.Methods: A Retrospective cohort study was conducted in the Neonatal Intensive Care Unit of a tertiary care teaching hospital. All intramural late preterm neonates with gestational age of 34-36 weeks born during the study period were enrolled. The control group included term neonates (37-42 weeks) born during the study period. Data regarding the maternal risk factors and neonatal outcomes for both the late preterm and term neonates were collected from records maintained in the NICU. Results: There were 3275 deliveries during the study period, of which 2447 (74.8%) were term. Among the 828 preterm neonates, 500 (60.4%) were late preterms. The maternal risk factors significantly associated with late preterm neonates were PIH, eclampsia, APH, multiple gestation, PROM, oligohydramnios and abnormal dopplers. Incidence of Respiratory distress syndrome (RDS), sepsis and hypoglycemia were higher among the late preterm group with an odd’s ratio of 56.01, 9.9 and 7.8 respectively. Incidence of hypocalcemia, seizures and Persistent Pulmonary Hypertension (PPHN) were also higher among this group. There was no statistically significant difference in mortality among the two groups.Conclusions: Late preterm neonates have a significantly higher neonatal morbidity compared to term neonates.

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Prevalence of congenital anomalies in babies and associated maternal etiological factors at tertiary care hospital

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20214330 ◽

2021 ◽

Vol 10 (11) ◽

pp. 4189

Author(s):

Shahana I. Chandniwala

Keyword(s):

Congenital Anomalies ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Care Centre ◽

Maternal Risk Factors ◽

Tertiary Care Centre ◽

Cross Sectional ◽

Maternal Risk ◽

Factors Associated

Background: The objective of this study was to know the local prevalence of congenital anomaly and study the maternal risk factors associated with it.Methods: Cross sectional descriptive study was carved out. All live babies were examined for presence of congenital anomalies and mother were looked for presence of socio-demographic factor.Results: In this study of 1 year 5767 live birth took place at tertiary care centre out of which 63 babies had congenital anomalies. Therefore, prevalence of congenital anomalies at tertiary care centre was 1.08%.Conclusions: The incidence of malformations were significantly higher in babies born to mothers over the age of 35 years and with parity 4 and above.

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Antepartum haemorrhage: a retrospective analysis in a tertiary care centre

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20204805 ◽

2020 ◽

Vol 9 (11) ◽

pp. 4531

Author(s):

Mohini Rajoriya ◽

Saurabh Dubey ◽

Sanju Agarwal

Keyword(s):

Risk Factors ◽

Maternal Morbidity ◽

Tertiary Care ◽

Care Centre ◽

Tertiary Care Centre ◽

Medical College ◽

Obstetrics And Gynaecology ◽

Maternal Morbidity And Mortality ◽

Induced Hypertension ◽

Very High

Background: Aim of the present study was to found the incidence of APH, demographic profile risk factors and maternal outcome.Methods: This was a retrospective study carried out in Department of Obstetrics and Gynaecology, MGM Medical College and associated M.Y., Hospital, Indore from August 2019 to July 2020.Results: The incidence of APH was 3.27%. 68.7% cases of APH were associated with pregnancy induced hypertension suggesting PIH is one of the major risk factors. Maternal morbidity was very high with increased rates cesarean section 91.7%, postpartum hemorrhage (32.6%), need of blood transfusion (86%). There were 2 mortalities and 3.1 % patients underwent Obstetric Hystrectomy and 24% required CCU admission.Conclusions: There is very high maternal morbidity and mortality in APH.

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