Lack of Seasonal Differences in Basal Metabolic Rate in Humans: A Cross-Sectional Study

Abstract Background Recent studies have shown that dietary carbohydrate quantity and quality as well as genetic variants may contribute to determining metabolic rate and general and central obesity. This study aimed to examine interactions between melanocortin 4 receptor gene (MC4R) rs17782313 and dietary carbohydrate intake, glycemic index (GI), and glycemic load (GL) on body mass index (BMI), waist circumferences (WC), basal metabolic rate (BMR), and BMR/kg in overweight/obese women. Methods A total of 282 Iranian women (BMI ≥ 25) aged 18–56 years were enrolled in this cross-sectional study. All participants were assessed for blood parameters, body composition, BMR, and dietary intake. Dietary carbohydrate intake, GI and GL were determined using a valid, reliable 147-item food frequency questionnaire. MC4R rs17782313 was genotyped by the restriction fragment length polymorphism (PCR-RFLP) method. Results After adjustment for age and energy intake, significant interactions were observed between carbohydrate intake and MC4R rs17782313 in terms of BMI (P Interaction = 0.007), WC (P Interaction = 0.02), and RMR/kg (P Interaction = 0.003) in this way that higher carbohydrate intake, compared with lower intake, was associated with an increase in BMI and WC for individuals with C allele carriers (TC + CC genotypes), while related to an increase in BMR/kg for those carrying the TT genotype. No significant interaction was found between MC4R rs17782313 and GI and GL on BMI, WC, BMR/kg, and BMR. Conclusions Interactions between the MC4R rs17782313 and carbohydrate intake probably can have an effect on BMI, WC, and RMR/kg in overweight/obese women.

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The Association of Dietary Acid Load with Resting Metabolic Rate and Metabolic Components in Overweight and Obese Women: A Cross Sectional Study

10.21203/rs.3.rs-141018/v1 ◽

2021 ◽

Author(s):

Atieh Mirzababaei ◽

Farideh Shiraseb ◽

Leila Setayesh ◽

Atefeh Tavakoli ◽

Cain C. T. Clark ◽

...

Keyword(s):

Metabolic Rate ◽

Resting Metabolic Rate ◽

Cross Sectional Study ◽

The Body ◽

Adult Women ◽

Sectional Study ◽

Cross Sectional ◽

Dietary Acid Load ◽

Dietary Acid ◽

Acid Load

Abstract Background: Several epidemiologic studies have reported that dietary acid load is associated with metabolic profiles; however, to our knowledge, the relationship of this dietary pattern with resting metabolic rate (RMR) among obese and overweight females remains unreported. Therefore, this study aimed to evaluate the association of dietary acid load RMR and metabolic components among overweight and obese adult women.Methods: This cross-sectional study was conducted on 375 Iranian adults, aged 18–48 years. Dietary acid load indexes were calculated by using a validated 147-item semi-quantitative FFQ. Biochemical and anthropometric measures were assessed using standard methods. An impedance fat analyzer was used to obtain the body composition and an indirect calorimeter was used to assess the RMR. Result: It was observed that after correction for potential confounders, DBP and NEAP and PRAL scores were inversely associated (P<0.05). NEAP index was inversely associated with RMR (β= -0.25, 95% CI=-0.1.5 to 2.08, P=0.02), and positively associated with WC (β= 1.009, 95% CI=-1.43 to 3.45, P=0.05) and WHR (β= 0.01, 95% CI= -0.01 to0.04, P=0.03), such that subjects with higher scores in NEAP had lower RMR and higher WC and WHR. We also observed that DAL (β= -0.02, 95% CI= -0.08 to0.03, P=0.08) and PRAL (β= -0.037, 95% CI= -1.05 to 0.03 P=0.07) were marginally associated with RMR.Conclusion:The results of the present study suggested that higher dietary acid load scores may be negatively associated with lower RMR, while directly associated with greater WC, WHR, DBP, and HOMA-IR.

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Korelasi Usia Metabolik terhadap Indeks Massa Tubuh

Jurnal Surya Medika ◽

10.33084/jsm.v5i2.1289 ◽

2020 ◽

Vol 5 (2) ◽

pp. 35-41

Author(s):

Ni Nyoman Sri Yuliani ◽

Elsa Trinovita

Keyword(s):

Body Mass Index ◽

Metabolic Rate ◽

Sampling Method ◽

Cross Sectional Study ◽

The Body ◽

Sectional Study ◽

Cross Sectional ◽

Male And Female ◽

Metabolic Age ◽

The Individual

Excessive fat accumulation in the body causes an increase in Body Mass Index (BMI). Increased BMI and comorbidities affect the metabolic rate. Metabolic age was influenced by the individual metabolic rate. The purpose of this study was to determine the description of metabolic age to BMI increasement. This cross-sectional study used a purposive sampling method to obtain 82 male and female subjects. Subjects were measured for BMI and metabolic age. Collected data was analyzed univariately and bivariate correlatively. The result showed a significant correlation between metabolic age and BMI (p = 0,001) with r = 0,812. The conclusion of this study is the increase in BMI, the higher the metabolic age.

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The Association of Dietary Acid Load with Resting Metabolic Rate and Metabolic Components in Overweight and Obese Women: A Cross Sectional Study

10.21203/rs.3.rs-141018/v2 ◽

2021 ◽

Author(s):

Atieh Mirzababaei ◽

Farideh Shiraseb ◽

Leila Setayesh ◽

Atefeh Tavakoli ◽

Cain C. T. Clark Clark ◽

...

Keyword(s):

Metabolic Rate ◽

Resting Metabolic Rate ◽

Cross Sectional Study ◽

The Body ◽

Adult Women ◽

Sectional Study ◽

Cross Sectional ◽

Dietary Acid Load ◽

Dietary Acid ◽

Acid Load

Abstract Background: Several epidemiologic studies have reported that dietary acid load is associated with metabolic profiles; however, to our knowledge, the relationship of this dietary pattern with resting metabolic rate (RMR) among obese and overweight females remains unreported. Therefore, this study aimed to evaluate the association of dietary acid load RMR and metabolic components among overweight and obese adult women.Methods: This cross-sectional study was conducted on 375 Iranian adults, aged 18–48 years. Dietary acid load indexes were calculated by using a validated 147-item semi-quantitative FFQ. Biochemical and anthropometric measures were assessed using standard methods. An impedance fat analyzer was used to obtain the body composition and an indirect calorimeter was used to assess the RMR. Result: It was observed that after correction for potential confounders, DBP and NEAP and PRAL scores were inversely associated (P<0.05). NEAP index was inversely associated with RMR (β= -0.25, 95% CI=-0.1.5 to 2.08, P=0.02), and positively associated with WC (β= 1.009, 95% CI=-1.43 to 3.45, P=0.05) and WHR (β= 0.01, 95% CI= -0.01 to0.04, P=0.03), such that subjects with higher scores in NEAP had lower RMR and higher WC and WHR. We also observed that DAL (β= -0.02, 95% CI= -0.08 to0.03, P=0.08) and PRAL (β= -0.037, 95% CI= -1.05 to 0.03 P=0.07) were marginally associated with RMR.Conclusion:The results of the present study suggested that higher dietary acid load scores may be negatively associated with lower RMR, while directly associated with greater WC, WHR, DBP, and HOMA-IR.

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Variants of the Cry 1 Gene May Influence the Effect of Fat Intake on Resting Metabolic Rate In Overweight and Obese Women: A Cross-sectional Study

10.21203/rs.3.rs-304833/v1 ◽

2021 ◽

Author(s):

Atieh Mirzababaei ◽

Elnaz Daneshzad ◽

Farideh Shiraseb ◽

Sanaz Pourreza ◽

Leila Setayesh ◽

...

Keyword(s):

Dietary Intake ◽

Metabolic Rate ◽

Resting Metabolic Rate ◽

Cross Sectional Study ◽

Overweight And Obesity ◽

Allele Carrier ◽

Fat Intake ◽

Obese Women ◽

Sectional Study ◽

Cross Sectional

Abstract Background: Previous studies have shown that the minor allele (C allele) for Cry 1 rs2287161, may be associated with increased risk of cardiovascular diseases (CVDs). Low resting metabolic rate (RMR) caused by the diet has been shown to have, potentially, unfavorable effects on obesity. This study sought to investigate the interactions between the Cry 1 Gene and fat intake on RMR in overweight and obese women.Methods: This comparative cross-sectional study was conducted on 377 Iranian women with overweight and obesity. A food frequency questionnaire (FFQ), with 147 items, was used to assess dietary intake. Individuals were categorized into two groups based on the rs2287161 genotype. Body composition, dietary intake, and RMR were assessed for all participants.Results: There was a significant difference between genotypes for FBS (P=0.04), fat free mass (FFM) (P=0.0009), RMR per FFM (P =0.05), RMR per body mass index (BMI) (P=0.02), and RMR deviation (P=0.01). Our findings also showed significant interactions between total fat and C allele carrier group on RMR per kg, RMR per body surface area (BSA), RMR per FFM, and RMR deviation (P for interaction <0.1), in addition to a significant interaction between CC+CG group genotype and PUFA intake on RMR per BMI (P for interaction =0.009) and RMR per kg (P for interaction=0.02) and RMR per BSA (P=0.07), compared to the GG group, after control for confounder factors.Conclusion: These results highlight that dietary compositions, gene variants, and their interaction, should be acutely considered in lower RMR.

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The Relationship Between Modified Nordic Diet and Resting Metabolic Rate Among Overweight and Obese Participants: A Cross Sectional Study

10.21203/rs.3.rs-117903/v1 ◽

2020 ◽

Author(s):

Ghazaleh Khalili ◽

Atieh Mirzababaei ◽

Farideh Shiraseb ◽

Khadijeh Mirzaei

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Metabolic Rate ◽

Body Mass ◽

Resting Metabolic Rate ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Lower Odds ◽

Nordic Diet

Abstract Objective: Obesity as a worldwide phenomenon is a multifactorial condition. Healthy diets have effect on obesity related factors like resting metabolic rate (RMR). In present study, we investigate association between adherence to modified Nordic diet and RMR among overweight and obese participants.Methods: We enrolled 404 overweight and obese (BMI ≥25 kg/m2) women aged 18-48 years in this cross-sectional study. For each participant anthropometrics measurements, biochemical tests and blood pressure were evaluated. RMR was measured by indirect calorimetry. RMR/kg was also measured. Modified Nordic diet score was measured using a validated 147-item food frequency questionnaire (FFQ).Results: Among all participants, the mean and standard deviation (SD) for age and body mass index (BMI) were 36.67 years (SD=9.10) and 31.26 kg/m2 (SD=4.29). There was a significant association between RMR/kg status and age, body mass index (BMI), RMR (P<0.001), respiratory quotient (RQ), fat percentage (P= 0.01), systolic blood pressure (SBP) (P= 0.03), and diastolic blood pressure (DBP) (P= 0.04), after adjustment for age, BMI, energy intake and physical activity. Participants with the highest adherence to modified Nordic diet had lower odds of hypometabolic status after adjusting for confounders and it was significant (odds ratio (OR) = 3.15, 95% CI= 0.97-10.15, P=0.05).Conclusions: The present results indicate that adherence to modified Nordic diet is associated with lower odds of hypometabolic status in overweight and obese women. However more studies are needed to confirm our findings.

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