scholarly journals Incidence of small bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

2017 ◽  
Vol 05 (07) ◽  
pp. E622-E626 ◽  
Author(s):  
Jasmijn Haanstra ◽  
Abdul Al-Toma ◽  
Evelien Dekker ◽  
Steven Vanhoutvin ◽  
Fokko Nagengast ◽  
...  
Keyword(s):  
Small Bowel ◽  
Early Detection ◽  
Lynch Syndrome ◽  
Prospective Study ◽  
Capsule Endoscopy ◽  
Bowel Cancer ◽  
Video Capsule Endoscopy ◽  
Small Bowel Cancer ◽  
Increased Risk ◽  
Malignant Lesions

Abstract Background and study aims Lynch syndrome (LS) patients have an increased risk of small bowel cancer. The question is whether surveillance will lead to early detection of (pre)malignant lesions. We recently reported on prevalence of small bowel neoplasia (SBN) in LS patients as assessed by video capsule endoscopy (VCE). The aim of this prospective study was to determine the incidence of SBN. Patients and methods Asymptomatic LS patients who underwent a VCE were invited to undergo a second VCE procedure 2 years later. If abnormalities or polypoid lesions larger than 1 cm were detected, subsequent endoscopic procedures were performed. Results A total of 155 (78 %) of the initial 200 patients underwent a second VCE procedure after a mean of 2.2 (range 1 – 6) years. In 17 of the 155 (11 %) patients possibly significant lesions were detected, which required further investigation by means of gastroduodenoscopy (n = 8) or balloon-assisted endoscopy (n = 9). These procedures revealed no SBN. Conclusion No SBN was found after 2 years. Surveillance of the small bowel by VCE does not seem to be warranted in asymptomatic LS patients. This study was registered in the Clinical Trials.gov registry with identifier NCT00898768.

scholarly journals Malignant Small Bowel Tumors: Diagnosis, Management and Prognosis

2015 ◽  
Vol 28 (4) ◽  
pp. 448 ◽  
Author(s):  
Hélder Cardoso ◽  
João Tiago Rodrigues ◽  
Margarida Marques ◽  
Armando Ribeiro ◽  
Filipe Vilas-Boas ◽  
...  
Keyword(s):  
Small Bowel ◽  
Capsule Endoscopy ◽  
Imaging Techniques ◽  
Bowel Cancer ◽  
First Year ◽  
Small Bowel Tumors ◽  
Small Bowel Cancer ◽  
Endoscopic Techniques ◽  
High Degree ◽  
Late Stages

<p><strong>Purpose:</strong> Despite being rare entities, the incidence of malignant small bowel tumors seems to be rising. The development of capsule endoscopy and balloon assisted enteroscopy provided an advance in the assessment of small bowel lesions. We aim to describe the clinical and pathological characteristics of patients with small bowel cancer and ascertain what roles these endoscopic techniques currently have.<br /><strong>Material and Methods:</strong> A retrospective study of patients diagnosed with small bowel cancer, from January 2010 to October 2014, was performed. The data was submitted to statistical analysis.<br /><strong>Results:</strong> Of the 28 diagnosed patients, 54% were female. The mean age at diagnosis was 61 years. Adenocarcinoma was the most frequent tumor (n = 11), followed by sarcoma (n = 6), lymphoma (n = 6) and neuroendocrine tumors (n = 3). The main form of presentation was related to blood loss or intestinal obstruction. By the time of diagnosis, 46% of patients had distant metastasis/ unresectable cancer. Most of the tumors were diagnosed by endoscopic (41%) or imaging techniques (35%). In the first year after diagnosis, 29% of patients died. In multivariate analysis, adenocarcinoma remained an independent factor for worse survival.<br /><strong>Discussion:</strong> Patients with adenocarcinoma presented at late stages and with unresectable tumors, contributing to a worse outcome. A high degree of clinical suspicion for the diagnosis of small bowel cancer is necessary.<br /><strong>Conclusion: </strong>The characteristics of the patients were generally consistent with those described in the literature. Capsule endoscopy and balloon assisted enteroscopy are useful in the diagnosis, management and surveillance of small bowel cancer.</p>

scholarly journals Small bowel malignancy in patients undergoing capsule endoscopy at a tertiary care academic center: Case series and review of the literature

2017 ◽  
Vol 05 (06) ◽  
pp. E463-E470 ◽  
Author(s):  
Connor Johnston ◽  
Diana Yung ◽  
Alka Joshi ◽  
John Plevris ◽  
Anastasios Koulaouzidis
Keyword(s):  
Small Bowel ◽  
Capsule Endoscopy ◽  
Tertiary Care ◽  
Case Series ◽  
Bowel Cancer ◽  
Deficiency Anemia ◽  
Gastrointestinal Neoplasms ◽  
Small Bowel Cancer ◽  
Tertiary Center ◽  
Small Bowel Malignancy

Abstract Background and study aims Small bowel cancer is rare, accounting for < 5 % of all gastrointestinal neoplasms. Capsule endoscopy has become the procedure of choice for non-invasive diagnosis of small bowel diseases. Data on capsule endoscopy diagnosis of small bowel cancer are limited. The objective of the study was to determine the frequency, indications and diagnostic work-up of patients with small bowel malignancy found by capsule endoscopy at a Scottish tertiary center. Patients and methods In this retrospective study, records all patients who underwent small bowel capsule endoscopy at our center over a 10-year period were reviewed for possible malignancy. Further data were gathered on preceding and subsequent investigations, management and outcome of these patients.  Results From 1949 studies, small bowel malignancies were diagnosed in only 7 patients (0.36 %; 2F/5M; median age 50, range 34 – 67). The main indication was iron-deficiency anemia (n = 5). Prior to capsule endoscopy, 6 of 7 patients had bidirectional endoscopies and one had gastroscopy. All prior investigations were normal or nondiagnostic. Two of 7 experienced capsule retention. Five of 7 underwent surgery. Four patients died, giving a 5-year survival rate of 42.9 %. Conclusion Small bowel malignancies diagnosed by capsule endoscopy are rare, and the median age of 50 indicates they are more common in relatively younger patients. Capsule endoscopy is effective at diagnosing a rare malignancy when other imaging modalities have failed.

scholarly journals Small Bowel Cancer Associated with Lynch Syndrome—Two Case Reports and a Review of the Literature—

2015 ◽  
Vol 76 (9) ◽  
pp. 2225-2230
Author(s):  
Hirokazu KODAMA ◽  
Hiromichi SONODA ◽  
Tomoharu SHIMIZU ◽  
Hiroyuki OHTA ◽  
Eiji MEKATA ◽  
...  
Keyword(s):  
Small Bowel ◽  
Lynch Syndrome ◽  
Case Reports ◽  
Bowel Cancer ◽  
Review Of The Literature ◽  
Small Bowel Cancer

scholarly journals Prevalence of small-bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

Gut ◽  
2014 ◽  
Vol 64 (10) ◽  
pp. 1578-1583 ◽  
Author(s):  
Jasmijn F Haanstra ◽  
Abdul Al-Toma ◽  
Evelien Dekker ◽  
Steven A L W Vanhoutvin ◽  
Fokko M Nagengast ◽  
...  
Keyword(s):  
Small Bowel ◽  
Lynch Syndrome ◽  
Capsule Endoscopy ◽  
Video Capsule Endoscopy

P.05.7 SMALL BOWEL NEOPLASIA DETECTION IN LYNCH SYNDROME USING VIDEO CAPSULE ENDOSCOPY

2019 ◽  
Vol 51 ◽  
pp. e186
Author(s):  
A. Contaldo ◽  
C. Notaristefano ◽  
R.A. Zuppardo ◽  
M. Di Leo ◽  
M.B. Principi ◽  
...  
Keyword(s):  
Small Bowel ◽  
Lynch Syndrome ◽  
Capsule Endoscopy ◽  
Video Capsule Endoscopy

scholarly journals Prevalence of mismatch repair deficiency and Lynch syndrome in a cohort of unselected small bowel adenocarcinomas

2020 ◽  
pp. jclinpath-2020-207040
Author(s):  
Manon Suerink ◽  
Gül Kilinç ◽  
Diantha Terlouw ◽  
Hristina Hristova ◽  
Lily Sensuk ◽  
...  
Keyword(s):  
Small Bowel ◽  
Lynch Syndrome ◽  
Mismatch Repair ◽  
Promoter Hypermethylation ◽  
Bowel Cancer ◽  
Family Management ◽  
Small Bowel Cancer ◽  
Repair Deficiency ◽  
Mmr Deficiency ◽  
Mmr Proteins

AimsPrevious estimates of the prevalence of mismatch repair (MMR) deficiency and Lynch syndrome in small bowel cancer have varied widely. The aim of this study was to establish the prevalence of MMR deficiency and Lynch syndrome in a large group of small bowel adenocarcinomas.MethodsTo this end, a total of 400 small bowel adenocarcinomas (332 resections, 68 biopsies) were collected through the Dutch nationwide registry of histopathology and cytopathology (Pathologisch-Anatomisch Landelijk Geautomatiseerd Archief (PALGA)). No preselection criteria, such as family history, were applied, thus avoiding (ascertainment) bias. MMR deficiency status was determined by immunohistochemical staining of MMR proteins, supplemented by MLH1 promoter hypermethylation analysis and next generation sequencing of the MMR genes.ResultsMMR deficiency was observed in 22.3% of resected and 4.4% of biopsied small bowel carcinomas. Prevalence of Lynch syndrome was 6.2% in resections and 0.0% in biopsy samples. Patients with Lynch syndrome-associated small bowel cancer were significantly younger at the time of diagnosis than patients with MMR-proficient and sporadic MMR-deficient cancers (mean age of 54.6 years vs 66.6 years and 68.8 years, respectively, p<0.000).ConclusionsThe prevalence of MMR deficiency and Lynch syndrome in resected small bowel adenocarcinomas is at least comparable to prevalence in colorectal cancers, a finding relevant both for treatment (immunotherapy) and family management. We recommend that all small bowel adenocarcinomas should be screened for MMR deficiency.

Small bowel cancer risk in Lynch syndrome

Gut ◽  
2008 ◽  
Vol 57 (11) ◽  
pp. 1629-1630 ◽  
Author(s):  
K. Schulmann ◽  
C. Engel ◽  
P. Propping ◽  
W. Schmiegel
Keyword(s):  
Small Bowel ◽  
Cancer Risk ◽  
Lynch Syndrome ◽  
Bowel Cancer ◽  
Small Bowel Cancer

Inflammatory bowel disease and risk of small bowel cancer: a binational population-based cohort study from Denmark and Sweden

Gut ◽  
2020 ◽  
pp. gutjnl-2020-320945 ◽  
Author(s):  
Jordan E Axelrad ◽  
Ola Olén ◽  
Michael C Sachs ◽  
Rune Erichsen ◽  
Lars Pedersen ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Cohort Study ◽  
Small Bowel ◽  
Bowel Disease ◽  
Cox Regression ◽  
Population Based ◽  
Bowel Cancer ◽  
Small Bowel Cancer ◽  
Increased Risk ◽  
Inflammatory Bowel

ObjectiveCrohn’s disease (CD) is associated with increased risk of small bowel cancer (SBC), but previous studies have been small. We aimed to examine the risk of incident SBC and death from SBC in patients with inflammatory bowel disease (IBD).DesignIn a binational, population-based cohort study from Sweden and Denmark of patients with IBD during 1969–2017 and matched reference individuals from the general population, we evaluated the risk of incident SBC and death from SBC. Cox regression was used to estimate adjusted hazard ratios (aHRs).ResultsWe identified 161 896 individuals with IBD (CD: 47 370; UC: 97 515; unclassified IBD: 17 011). During follow-up, 237 cases of SBC were diagnosed in patients with IBD (CD: 24.4/100 000 person-years; UC: 5.88/100 000 person-years), compared with 640 cases in reference individuals (2.81/100 000 person-years and 3.32/100 000 person-years, respectively). This corresponded to one extra case of SBC in 385 patients with CD and one extra case in 500 patients with UC, followed up for 10 years. The aHR for incident SBC was 9.09 (95% CI 7.34 to 11.3) in CD and 1.85 (95% CI 1.43 to 2.39) in UC. Excluding the first year after an IBD diagnosis, the aHRs for incident SBC decreased to 4.96 in CD and 1.69 in UC. Among patients with CD, HRs were independently highest for recently diagnosed, childhood-onset, ileal and stricturing CD. The relative hazard of SBC-related death was increased in both patients with CD (aHR 6.59, 95% CI 4.74 to 9.15) and patients with UC (aHR 1.57; 95% CI 1.07 to 2.32).ConclusionSBC and death from SBC were more common in patients with IBD, particularly among patients with CD, although absolute risks were low.

Sign in / Sign up

Export Citation Format

Share Document