Direct current electrical potential shift reflects immediate signaling of systemic insulin to the human brain

2003 ◽  
Vol 111 (06) ◽  
Author(s):  
M Hallschmid ◽  
B Schultes ◽  
C Zabukovec ◽  
HL Fehm ◽  
J Born
Diabetes ◽  
2004 ◽  
Vol 53 (9) ◽  
pp. 2202-2208 ◽  
Author(s):  
M. Hallschmid ◽  
B. Schultes ◽  
L. Marshall ◽  
M. Molle ◽  
W. Kern ◽  
...  

1937 ◽  
Vol 83 (343) ◽  
pp. 137-155 ◽  
Author(s):  
F. Golla ◽  
S. Graham ◽  
W. Grey Walter

In 1929 Berger (1) discovered that changes of electrical potential in the human brain could be detected through the unopened skull. Since that time the study of electro-encephalography has occupied the attention of many workers, and the literature is already too extensive for adequate review in this place. A brief description of the technique for obtaining an electro-encephalogram, or “EEG”, and a summary of its normal and pathological characters may be found in a communication by one of us (2) on the relation between the EEG and the presence of intracranial neoplasms. The cortex in the region of a tumour was found to produce abnormally slow potential waves, which were provisionally called “delta” (δ) waves to distinguish them from the normal “alpha” (α) waves which are the original “Berger rhythm”. In the same paper a case was reported in which a focus of δ waves was found in the left parieto-occipital region associated with an area of degenerating cortex. The history in this case was of occasional minor attacks and one major fit and an indefinite severe illness in infancy, the only sign being a right homonymous hemianopia in accordance with the left-sided focus. Ether and nitrous oxide anæsthesia are also accompanied by the production of slow waves, but in this condition there is no fixed focus, the whole cortex being engaged in abnormal electrical activity. Since the publication of the above-mentioned results, a case of cerebral abscess has been examined, and the EEG was found to indicate a δ focus similar in character to those which have been found in cases of new growth.


2016 ◽  
Vol 37 (5) ◽  
pp. 1857-1870 ◽  
Author(s):  
Jed A Hartings ◽  
Chunyan Li ◽  
Jason M Hinzman ◽  
C William Shuttleworth ◽  
Griffin L Ernst ◽  
...  

Spreading depolarizations cause cortical electrical potential changes over a wide spectral range that includes slow potentials approaching the direct current (or 0 Hz) level. The negative direct current shift (<0.05 Hz) is an important identifier of cortical depolarization and its duration is a measure of potential tissue injury associated with longer lasting depolarizations. To determine the feasibility of monitoring the full signal bandwidth of spreading depolarizations in patients, we performed subdural electrocorticography using platinum electrode strips and direct current-coupled amplifiers in 27 patients with acute brain injury at two neurosurgical centers. While large baseline direct current offsets developed, loss of data due to amplifier saturation was minimal and rates of baseline drift throughout recordings were generally low. Transient negative direct current shifts of spreading depolarizations were easily recognized and in 306/551 (56%) cases had stereotyped, measurable characteristics. Following a standardized training session, novice scorers achieved a high degree of accuracy and interobserver reliability in identifying depolarizations, suggesting that direct current-coupled recordings can facilitate bedside diagnosis for future trials or clinical decision-making. We conclude that intracranial monitoring of slow potentials can be achieved with platinum electrodes and that unfiltered, direct current-coupled recordings are advantageous for identifying and assessing the impact of spreading depolarizations.


1961 ◽  
Vol 44 (6) ◽  
pp. 1165-1176 ◽  
Author(s):  
Alan Finkelstein

The rhythmical variations of electrical potential and DC resistance resulting from the exposure of the anatomical outside of isolated frog skin to a concentration of lithium ion greater than 20 millinormal were reinvestigated. In general, the potential and resistance changes were in phase, although in some skins, a phase shift occurred after the first few waves. The mean level of the resistance declined during the exposure to lithium, returning to its former level upon reintroduction of sodium in place of lithium. The oscillations, with a period of from 3 to 15 minutes, could last for 2 hours or more before damping out; the amplitude of the waves could be altered during this time by the passage of direct current or by the introduction of a hydrostatic pressure difference across the skin. Even after the oscillations damped out, the system remained "excitable," responding to a step of direct current or hydrostatic pressure with an oscillatory train. The nature and magnitude of the response to current and pressure were dependent upon the "polarity" of the applied perturbation. Direct observation of the skin revealed no evidence of oscillatory water movement concomitant with the electrical events.


2006 ◽  
Vol 129 (3) ◽  
pp. 441-448 ◽  
Author(s):  
Naoya Tada ◽  
Masayoshi Okada ◽  
Jun Iwamoto

A method of three-dimensional identification of a semi-elliptical surface crack by direct-current electrical potential difference method with a multiple-probe sensor was proposed and its validity was numerically examined. The condition of the surface crack embedded in a conductive plate was specified by the two-dimensional location of the crack center, length, and depth of the crack, and the surface and inward angles of the crack plane. Identification was carried out based on the distribution of the electrical potential difference around the crack measured on the surface of the plate with the “multiple-probe sensor” which is composed of many probes aligned in two orthogonal directions. The location and surface angle were evaluated using the point symmetry of the potential difference distribution. The inward angle was determined by the magnitude of symmetry of potential difference distribution with reference to the evaluated crack line. Finally, length and depth of the crack were determined using the exact solution of potential difference for an inclined inner elliptical crack which yields similar potential difference to that of the inclined semi-elliptical surface crack. The validity of the method was numerically confirmed by carrying out the evaluation based on the result obtained by finite element analysis.


Sign in / Sign up

Export Citation Format

Share Document