Gene-diet interactions in the aetiology of colorectal cancer: results from a population-based case-control study in north-east Scotland

ObjectiveResearch indicates that shiftwork may be associated with increased risks of adverse health outcomes, including some cancers. However, the evidence of an association between shiftwork and colorectal cancer risk is limited and inconclusive. Further, while several possible pathways through which shiftwork might result in cancer have been proposed, few studies have taken these factors into account. We investigated the association between two types of shiftwork (graveyard shiftwork and early-morning shiftwork) and six mechanistic shiftwork variables (including light at night and phase shift) and the risk of colorectal cancer among females in an Australian population-based case–control study. Graveyard shiftwork was the primary exposure of interest.MethodsParticipants (350 cases and 410 controls) completed a lifetime occupational history, and exposure to each of the eight shiftwork variables was assigned to participants through a job exposure matrix. We used logistic regression to calculate odds ratios (OR) and corresponding 95% confidence intervals (CI) for the association between different shiftwork variables and the risk of colorectal cancer, adjusting for potential demographic, lifestyle and medical confounders.ResultsWorking in an occupation involving long-term exposure (>7.5 years) to graveyard shiftwork was not associated with colorectal cancer risk (adjusted OR 0.95, 95% CI 0.57 to 1.58). Similarly, no increased risks of colorectal cancer were seen for any of the other seven shiftwork variables examined.ConclusionsNo evidence of an increased risk of colorectal cancer among females who had worked in occupations involving shiftwork was observed in this study.

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Risk of colorectal cancer in patients with alcoholism: A nationwide, population-based nested case-control study

PLoS ONE ◽

10.1371/journal.pone.0232740 ◽

2020 ◽

Vol 15 (5) ◽

pp. e0232740 ◽

Cited By ~ 1

Author(s):

Tzu-Chiao Lin ◽

Wu-Chien Chien ◽

Je-Ming Hu ◽

Nian-Sheng Tzeng ◽

Chi-Hsiang Chung ◽

...

Keyword(s):

Colorectal Cancer ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Nested Case Control ◽

Control Study

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Proton Pump Inhibitor Use and Risk of Colorectal Cancer: A Population-Based, Case–Control Study

Gastroenterology ◽

10.1053/j.gastro.2007.06.014 ◽

2007 ◽

Vol 133 (3) ◽

pp. 755-760 ◽

Cited By ~ 83

Author(s):

Douglas J. Robertson ◽

Heidi Larsson ◽

Søren Friis ◽

Lars Pedersen ◽

John A. Baron ◽

...

Keyword(s):

Colorectal Cancer ◽

Proton Pump Inhibitor ◽

Proton Pump ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Control Study

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Colorectal cancer and risk of atrial fibrillation and flutter: a population-based case–control study

Internal and Emergency Medicine ◽

10.1007/s11739-011-0701-9 ◽

2011 ◽

Vol 7 (5) ◽

pp. 431-438 ◽

Cited By ~ 45

Author(s):

Rune Erichsen ◽

Christian Fynbo Christiansen ◽

Frank Mehnert ◽

Noel Scott Weiss ◽

John Anthony Baron ◽

...

Keyword(s):

Colorectal Cancer ◽

Atrial Fibrillation ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Atrial Fibrillation And Flutter ◽

Control Study

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Risk of Colorectal Cancer After Detection and Removal of Adenomas at Colonoscopy: Population-Based Case-Control Study

Journal of Clinical Oncology ◽

10.1200/jco.2011.41.3377 ◽

2012 ◽

Vol 30 (24) ◽

pp. 2969-2976 ◽

Cited By ~ 69

Author(s):

Hermann Brenner ◽

Jenny Chang-Claude ◽

Alexander Rickert ◽

Christoph M. Seiler ◽

Michael Hoffmeister

Keyword(s):

Colorectal Cancer ◽

High Risk ◽

Risk Reduction ◽

Large Bowel ◽

Case Control Study ◽

Significant Risk ◽

Population Based ◽

Case Control ◽

Odds Ratios ◽

Control Study

Purpose Empirical evidence for recommendations of surveillance intervals after detection and removal of adenomas at colonoscopy is still sparse and mostly based on observations of adenoma recurrence. We aimed to assess risk of colorectal cancer (CRC) according to time since polypectomy and factors that might be relevant for risk stratification. Methods In a population-based case-control study conducted in Germany, detailed history and results of previous large-bowel endoscopies were obtained by interview and from medical records. Risk of CRC among participants with detection of at least one adenoma at a preceding colonoscopy compared with participants without previous large-bowel endoscopy was assessed according to time since polypectomy among 2,582 cases with CRC and 1,798 matched controls. Results Adjusted odds ratios (95% CIs) of CRC for participants with polypectomy less than 3, 3 to 5, and 6 to 10 years ago (using participants without previous endoscopy as reference group) were 0.2 (0.2 to 0.3), 0.4 (0.3 to 0.6), and 0.9 (0.5 to 1.5), respectively. Strong, significant risk reduction within 5 years was consistently seen for women and men, younger and older participants, patients with and without high-risk polyps (three or more polyps, at least one polyp ≥ 1 cm, at least one polyp with villous components), and those with and without polypectomy in the right colon. With adjusted odds ratios of 0.1 (0.1 to 0.2), 0.3 (0.2 to 0.5) and 0.4 (0.2 to 0.8) for patients with polypectomy less than 3, 3 to 5, and 6 to 10 years ago, risk reduction was particularly strong for left-sided CRC. Conclusion Extension of surveillance intervals to 5 years should be considered, even after detection and removal of high-risk polyps.

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