Cryopreserved human allografts for arterial repair in case of graft infection

2006 ◽  
Vol 54 (S 1) ◽  
Author(s):  
S Brand ◽  
O Teebken ◽  
A Haverich ◽  
M Pichlmaier
Keyword(s):  
Graft Infection ◽  
Arterial Repair

The safety of bovine tissue arterial repair in removal of infected prosthetic hemodialysis grafts

2020 ◽  
pp. 112972982094787
Author(s):  
Patrick Sowa ◽  
Peggie Halandras ◽  
Matthew Blecha
Keyword(s):  
Graft Infection ◽  
Morbidity And Mortality ◽  
Causative Organism ◽  
Arteriovenous Graft ◽  
Significant Morbidity ◽  
Autologous Vein ◽  
Wound Debridement ◽  
Bovine Tissue ◽  
Arterial Repair

Background: More than 400,000 Americans require dialysis, and many receive it via a prosthetic arteriovenous graft. Infection of these grafts is rare, but associated with significant morbidity and mortality. The gold standard is total graft excision with arteriotomy closure. This was previously done with autologous vein, but bovine tissue offers a reasonable alternative. The objective of this article is to evaluate a community hospital experience with bovine tissue arterial repair after total graft excision of infected prosthetic arteriovenous graft. Methods: A retrospective review was performed of all cases of infected prosthetic arteriovenous graft removal with bovine tissue arterial repair was performed. Thirteen cases were identified. Presentation, location of graft, and causative organism were reviewed; outcomes including reoperation and mortality were recorded. Results: Of the 13 patients, 12 (92%) had positive cultures of the graft, bloodstream, or wound. Methicillin-resistant Staphylococcus aureus was the most commonly isolated organism (54%). There were two unplanned reoperations including hematoma drainage and wound debridement within the first year. Over the 1-year follow-up period, 1 patient died for a mortality of 8%. There were no re-infections during follow-up. Discussion: Prosthetic arteriovenous graft infection remains a difficult challenge and is associated with significant morbidity and mortality. It presents in a variety of ways, including within an old thrombosed graft. Over the last several years, the causative organism has increasingly become drug resistant. Treatment with total graft excision requires arteriotomy closure, and for this bovine tissue has been demonstrated to be a viable option.

In-vivo evaluation of the effect of cyanoacrylate on prosthetic vascular graft infection – does cyanoacrylate increase the severity of infection?

VASA ◽  
2020 ◽  
Vol 49 (4) ◽  
pp. 281-284
Author(s):  
Atıf Yolgosteren ◽  
Gencehan Kumtepe ◽  
Melda Payaslioglu ◽  
Cuneyt Ozakin
Keyword(s):  
Vascular Graft ◽  
Graft Infection ◽  
Vascular Graft Infection ◽  
Group 4 ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Prosthetic Vascular Graft Infection ◽  
Group 1

Summary. Background: Prosthetic vascular graft infection (PVGI) is a complication with high mortality. Cyanoacrylate (CA) is an adhesive which has been used in a number of surgical procedures. In this in-vivo study, we aimed to evaluate the relationship between PVGI and CA. Materials and methods: Thirty-two rats were equally divided into four groups. Pouch was formed on back of rats until deep fascia. In group 1, vascular graft with polyethyleneterephthalate (PET) was placed into pouch. In group 2, MRSA strain with a density of 1 ml 0.5 MacFarland was injected into pouch. In group 3, 1 cm 2 vascular graft with PET piece was placed into pouch and MRSA strain with a density of 1 ml 0.5 MacFarland was injected. In group 4, 1 cm 2 vascular graft with PET piece impregnated with N-butyl cyanoacrylate-based adhesive was placed and MRSA strain with a density of 1 ml 0.5 MacFarland was injected. All rats were scarified in 96th hour, culture samples were taken where intervention was performed and were evaluated microbiologically. Bacteria reproducing in each group were numerically evaluated based on colony-forming unit (CFU/ml) and compared by taking their average. Results: MRSA reproduction of 0 CFU/ml in group 1, of 1410 CFU/ml in group 2, of 180 200 CFU/ml in group 3 and of 625 300 CFU/ml in group 4 was present. A statistically significant difference was present between group 1 and group 4 (p < 0.01), between group 2 and group 4 (p < 0.01), between group 3 and group 4 (p < 0.05). In terms of reproduction, no statistically significant difference was found in group 1, group 2, group 3 in themselves. Conclusions: We observed that the rate of infection increased in the cyanoacyrylate group where cyanoacrylate was used. We think that surgeon should be more careful in using CA in vascular surgery.

Endovascular Graft Infection: Preliminary Results of an International Enquiry

2003 ◽  
Vol 10 (5) ◽  
pp. 919-927 ◽  
Author(s):  
Paolo Fiorani ◽  
Francesco Speziale ◽  
Annalisa Calisti ◽  
Maria Misuraca ◽  
Davide Zaccagnini ◽  
...  
Keyword(s):  
Graft Infection ◽  
Preliminary Results ◽  
Endovascular Graft

scholarly journals Surgical Management of Vascular Graft Infection in Severely Ill Patients by Partial Resection of the Infected Prosthesis

2007 ◽  
Vol 33 (5) ◽  
pp. 610-613 ◽  
Author(s):  
M. Mirzaie ◽  
J.D. Schmitto ◽  
T. Tirilomis ◽  
S. Fatehpur ◽  
O.J. Liakopoulos ◽  
...  
Keyword(s):  
Surgical Management ◽  
Vascular Graft ◽  
Graft Infection ◽  
Partial Resection ◽  
Vascular Graft Infection

Sources and prevention of graft infection during long term ex situ liver perfusion

2021 ◽  
Author(s):  
Dilmurodjon Eshmuminov ◽  
Matteo Mueller ◽  
Silvio D. Brugger ◽  
Lucia Bautista Borrego ◽  
Dustin Becker ◽  
...  
Keyword(s):  
Liver Perfusion ◽  
Graft Infection ◽  
Ex Situ

Factors Influencing Clinical Success Following Endovascular Treatment of Type II Endoleaks

2020 ◽  
pp. 084653712098110
Author(s):  
Ramin Hamidizadeh ◽  
Emeka Nzekwu ◽  
Oliver Halliwell
Keyword(s):  
Clinical Success ◽  
Strong Predictor ◽  
Graft Infection ◽  
Mortality Data ◽  
Complication Rates ◽  
Type Ii ◽  
Success Rates ◽  
Cyanoacrylate Glue ◽  
Embolic Agents ◽  
Predictor Of Success

Purpose: To compare long-term outcomes of transarterial (TA) and translumbar (TL) embolization of type II endoleaks (T2E) following EVAR, as well as factors that predict clinical success. Methods: 129 (mean age, 71.4y; range, 53-95) with T2E referred for embolization from August-2003 to December-2017 were retrospectively reviewed. One-hundred-eighty procedures were performed via TA (n = 139) and TL (n = 41) approaches, with 37 patients undergoing 51 reinterventions. Clinical success was defined as absence of endoleak and/or absence of aneurysm sac enlargement on follow-up imaging. Medical comorbidities, procedural data, embolic agents used, presence of successful sac embolization, and 30-day morbidity and mortality data were collected. Results: TL approaches had higher technical success (41/41 vs.122/139, p = .014). Clinical success rates were 52% (N = 58/111) and 62% (N = 23/37) for TA and TL procedures respectively ( p = .34). Looking at all procedures, sac embolization using n-butyl cyanoacrylate glue had higher clinical success compared to other embolic agents ( p = .017-.037). Successful sac access was a strong predictor of success for TA procedures (46/78 vs.12/33, p = .0379). 30-day complication rates were similar between TA (5.8%) and TL (4.9%) approaches. There was 1 death secondary to graft infection following TA embolization. Conclusions: Overall clinical success of TA and TL embolization when considering re-interventions is high. n-butyl cyanoacrylate glue had significantly higher success than other embolic agents ( p = .017-.037). Successful sac access was associated with success for TA procedures.

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