Effects of Growth Hormone on the Oxidation of [1-14C]-Pyruvate in Adipose Tissue of Hypophysectomized Rats

1981 ◽  
Vol 13 (06) ◽  
pp. 351-355 ◽  
Author(s):  
H. Goodman ◽  
G. Frick
Keyword(s):  
Growth Hormone ◽  
Adipose Tissue ◽  
Hypophysectomized Rats

scholarly journals Influence of hormones on the nicotinamide nucleotide coenzymes of adipose tissue

1967 ◽  
Vol 105 (3) ◽  
pp. 1013-1018 ◽  
Author(s):  
Patricia McLean ◽  
A. L. Greenbaum ◽  
J. Brown ◽  
K. R. Greenslade
Keyword(s):  
Growth Hormone ◽  
Adipose Tissue ◽  
Lipid Synthesis ◽  
Total Content ◽  
Diabetic Rats ◽  
Tissue Protein ◽  
Significant Difference ◽  
Hypophysectomized Rats ◽  
Reduced Forms ◽  
Fat Pads

The concentrations of the oxidized and reduced forms of the nicotinamide nucleotides were measured in the epididymal fat pads of normal, alloxan-diabetic and hypophysectomized rats. In both alloxan-diabetic rats and hypophysectomized rats the weight of the adipose tissue fell, as did the total content of NADH and NADPH; in addition, NAD+ was decreased in the alloxan-diabetic group. Of these changes the most marked was in NADPH and this was the only significant difference when the results were expressed as nicotinamide nucleotides/mg. of tissue protein. The concentration of NADPH in the hypophysectomized rats was not altered by treatment with growth hormone but was restored to normal by treatment with thyroxine. These results are discussed in relation to the known effect of these hormonal conditions on lipid synthesis in adipose tissue.

Effect of Insulin Treatment of Hypophysectomized Rats on Adipose Tissue Responsiveness to Insulin and Growth Hormone*

Endocrinology ◽  
1985 ◽  
Vol 116 (3) ◽  
pp. 945-951 ◽  
Author(s):  
INGRID GAUSE ◽  
OLLE ISAKSSON ◽  
ANDERS LINDAHL ◽  
STAFFAN EDÉN
Keyword(s):  
Growth Hormone ◽  
Adipose Tissue ◽  
Insulin Treatment ◽  
Hypophysectomized Rats

Glucose transport in adipocytes and its control by growth hormone in vivo

1982 ◽  
Vol 242 (6) ◽  
pp. E368-E372 ◽  
Author(s):  
E. Schoenle ◽  
J. Zapf ◽  
E. R. Froesch
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Adipose Tissue ◽  
Glucose Transport ◽  
Human Growth ◽  
Limiting Factor ◽  
Glucose Transport System ◽  
Hypophysectomized Rats ◽  
Tibial Epiphyseal

Previous results showed maximally enhanced basal glucose transport in adipocytes of hypophysectomized rats and restoration to normal after human growth hormone (hGH) administration. The data suggested a hGH-dependent "limiting factor" for glucose transport in the adipocyte membrane, which is acutely inhibited by insulin resulting in enhanced glucose transport. In this study the effect of hGH was investigated with respect to dose and time dependence. hGH was administered by continuous infusion from subcutaneously implanted Alzet minipumps. A significant decrease of basal glucose transport was obtained at the lowest hGH dose of 50 mU/day for 6 days. This effect of hGH was strictly correlated to the effects on growth (tibial epiphyseal width, DNA synthesis, body weight, serum level of insulin-like growth factor). The effect of hGH on basal glucose transport was already observed after 12 h of infusion, and it increased to a maximum after 3 days. The data support the concept that GH regulates the glucose transport system in adipose tissue in vivo.

GROWTH HORMONE AND RADIO-SULFATE INCORPORATION IN COSTAL CARTILAGE

1961 ◽  
Vol 37 (2) ◽  
pp. 176-182 ◽  
Author(s):  
Elliott J. Collins ◽  
Vernon F. Baker
Keyword(s):  
Growth Hormone ◽  
Costal Cartilage ◽  
Time Response ◽  
Hormone Activity ◽  
Reliable Estimation ◽  
Hypophysectomized Rats ◽  
Related Response ◽  
Sulfate Incorporation

ABSTRACT The characteristics and nature of the effect of growth hormone on the incorporation of radio-sulfate into the costal cartilage of hypophysectomized rats has been studied. The time-response studies indicate that a reliable estimation of growth hormone activity can be ascertained within a 24 hour period, and a reproducible dose-related response can be obtained at dosage levels ranging from 12-48 μg. Growth hormone stimulates the synthesis of organic sulfates and accumulation of inorganic sulfates within 48 hours.

SENSITIVITY OF THE RAT DIAPHRAGM TO GROWTH HORMONE.

1967 ◽  
Vol 54 (4) ◽  
pp. 645-662 ◽  
Author(s):  
Å. Hjalmarson ◽  
K. Ahrén
Keyword(s):  
Growth Hormone ◽  
Inhibitory Effect ◽  
Rat Diaphragm ◽  
Intracellular Accumulation ◽  
Slight Effect ◽  
Kidney Capsule ◽  
Muscle Tissues ◽  
Hypophysectomized Rats ◽  
Isolated Rat

ABSTRACT The effect of growth hormone (GH) in vitro on the rate of intracellular accumulation of the non-utilizable amino acid α-aminoisobutyric acid (AIB) was studied in the intact rat diaphragm preparation. Bovine or ovine GH (25 μg/ml incubation medium) markedly stimulated the accumulation of AIB-14C by diaphragms from hypophysectomized rats, while there was no or only a very slight effect on diaphragms from normal rats. In diaphragms from rats with the pituitary gland autotransplanted to the kidney capsule GH in vitro stimulated the accumulation of AIB-14C significantly more than in diaphragms from normal rats but significantly less than in diaphragms from hypophysectomized rats. Injections of GH intramuscularly for 4 days to hypophysectomized rats made the diaphragms from these rats less sensitive or completely insensitive to GH in vitro. These results indicate strongly that the relative insensitivity to GH in vitro of diaphragms from normal rats is due to the fact that the muscle tissues from these rats has been exposed to the endogenously secreted GH. The results show that GH can influence the accumulation of AIB-14C in the isolated rat diaphragm in two different ways giving an acute or »stimulatory« effect and a late or »inhibitory« effect, and that it seems to be a time-relationship between these two effects of the hormone.

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