Reliability and Validity of a Continuous Incremental Treadmill Protocol for the Determination of Lactate Threshold, Fixed Blood Lactate Concentrations, and V̇O2max

Fourteen sedentary 50- to 55-year-old men were exercised to exhaustion using an incremental treadmill protocol. Mean (±SEM) peak oxygen uptake (V̇O2peak) was 40.5 ± 1.19 ml · kg1· min−1, and maximum heart rate was 161 ± 4 beats · min−1. Blood lactate concentration was measured regularly to identify the lactate threshold (oxygen consumption at which blood lactate concentration begins to systematically increase). Threshold occurred at 84 ± 2% of V̇O2peak. The absolute lactate value at threshold was 2.9 ± 0.2 mmol · L−1. On a separate occasion, 6 subjects exercised continuously just below their individual lactate thresholds for 25 min without significantly raising their blood lactate levels from the 10th minute to the 25th. The absolute blood lactate level over the last 20 min of the steady-state test averaged 3.7 ± 1.2 mmol · L−1. This value is higher than that elicited at the threshold in the incremental test because of the differing nature of the protocols. It was concluded that although the lactate threshold occurs at a high percentage of V̇O2peak, subjects are still able to sustain exercise at that intensity for 25 min.

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The Effect of Aging on the Lactate Threshold in Untrained Men

Journal of Aging and Physical Activity ◽

10.1123/japa.5.1.39 ◽

1997 ◽

Vol 5 (1) ◽

pp. 39-49 ◽

Cited By ~ 6

Author(s):

K. Fiona Iredale ◽

Myra A. Nimmo

Keyword(s):

Oxygen Consumption ◽

Correlation Coefficient ◽

Blood Lactate ◽

Lactate Threshold ◽

Lactate Concentration ◽

Blood Lactate Concentration ◽

Peak Oxygen Consumption ◽

Reserve Capacity ◽

The Difference ◽

Treadmill Protocol

Thirty-three men (age 26–55 years) who did not exercise regularly were exercised to exhaustion using an incremental treadmill protocol. Blood lactate concentration was measured to identify lactate threshold (LT, oxygen consumption at which blood lactate concentration begins to systematically increase). The correlation coefficient for LT (ml · kg−1 · min−1) with age was not significant, but when LT was expressed as a percentage of peak oxygen consumption (VO2 peak), the correlation was r = +.69 (p < .01). This was despite a lack of significant correlation between age and VO2 peak (r = −.33). The correlation between reserve capacity (the difference between VO2 peak and LT) and age was r = −.73 (p < .01 ), and reserve capacity decreased at a rate of 3.1 ml · kg−1 · min−1 per decade. It was concluded that the percentage of VO2 peak at which LT occurs increases progressively with age, with a resultant decrease in reserve capacity.

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Determination of the lactate threshold and maximal blood lactate steady state intensity in aged rats

Cell Biochemistry and Function ◽

10.1002/cbf.1580 ◽

2009 ◽

Vol 27 (6) ◽

pp. 351-357 ◽

Cited By ~ 23

Author(s):

Rafael Rodrigues Cunha ◽

Verusca Najara de Carvalho Cunha ◽

Paulo Russo Segundo ◽

Sérgio Rodrigues Moreira ◽

Eduardo Kokubun ◽

...

Keyword(s):

Steady State ◽

Blood Lactate ◽

Lactate Threshold ◽

Aged Rats

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EFFECT OF WORK STAGE DURATION ON DETERMINATION OF THE LACTATE THRESHOLD DURING TREADMILL RUNNING

Medicine & Science in Sports & Exercise ◽

10.1249/00005768-198604001-00478 ◽

1986 ◽

Vol 18 (supplement) ◽

pp. S97

Author(s):

R. B. Read ◽

R. A. Boileau ◽

B. H. Hassey ◽

J. E. Misner ◽

B. Bhattacharya

Keyword(s):

Lactate Threshold ◽

Treadmill Running ◽

Stage Duration

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Effects of Pedal Frequency on V̇O2and Work Output at Lactate Threshold (LT), Fixed Blood Lactate Concentrations of 2mM and 4mM, and max in Competitive Cyclists

International Journal of Sports Medicine ◽

10.1055/s-2008-1025832 ◽

1985 ◽

Vol 06 (03) ◽

pp. 163-168 ◽

Cited By ~ 5

Author(s):

M. Buchanan ◽

A. Weltman

Keyword(s):

Blood Lactate ◽

Lactate Threshold ◽

Work Output ◽

Competitive Cyclists ◽

Pedal Frequency

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Measuring Mobility of the Metacarpophalangeal Joints II, III, IV, and V in the Dorso-Volar Plane

Engineering in Medicine ◽

10.1243/emed_jour_1984_013_006_02 ◽

1984 ◽

Vol 13 (1) ◽

pp. 15-20 ◽

Cited By ~ 3

Author(s):

C Wagner ◽

D Drescher

Keyword(s):

Healthy Subjects ◽

Reliability And Validity ◽

Repeated Measurements ◽

Interrater Agreement ◽

Range Of Movement ◽

Men And Women ◽

Examination Method ◽

Total Range ◽

Flexion And Extension

An electronic gravity goniometer was developed for determining the passive range of movement of the MCP joints II, III, IV, and V in the dorso-volar plane by the use of preset torques. Test–retest measurements on 23 healthy subjects between the ages of 18 and 57 demonstrated high intrarater and interrater agreement for determining the total range. In the determination of the amounts of flexion and extension the measurement of the flexion was less reliable. There was overall evidence of a declining tendency of reliability from MCP joint II to MCP joint V, probably caused by different reactions of the joints to repeated measurements. The higher total range of the MCP joints in women was principally caused by a higher range of extension. In the case of men and women the range of MCP joint V was noticeably greater than that of the other three joints. The mobility of the four MCP joints correlates relatively closely as a whole, however, in the case of the non-adjacent joints less closely than with the adjacent joints. Reliability and validity of the examination method were balanced against one another with regard to testing of the biomechanical pre-conditions for manual dexterity.

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Are the Naranjo Criteria Reliable and Valid for Determination of Adverse Drug Reactions in the Intensive Care Unit?

Annals of Pharmacotherapy ◽

10.1345/aph.1g177 ◽

2005 ◽

Vol 39 (11) ◽

pp. 1823-1827 ◽

Cited By ~ 32

Author(s):

Sandra L Kane-Gill ◽

Levent Kirisci ◽

Dev S Pathak

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Adverse Drug Reactions ◽

Reliability And Validity ◽

Kappa Statistic ◽

Weighted Kappa ◽

Drug Reactions ◽

Rater Reliability ◽

Cronbach Alpha

BACKGROUND The Naranjo criteria are frequently used for determination of causality for suspected adverse drug reactions (ADRs); however, the psychometric properties have not been studied in the critically ill. OBJECTIVE To evaluate the reliability and validity of the Naranjo criteria for ADR determination in the intensive care unit (ICU). METHODS All patients admitted to a surgical ICU during a 3-month period were enrolled. Four raters independently reviewed 142 suspected ADRs using the Naranjo criteria (review 1). Raters evaluated the 142 suspected ADRs 3–4 weeks later, again using the Naranjo criteria (review 2). Inter-rater reliability was tested using the kappa statistic. The weighted kappa statistic was calculated between reviews 1 and 2 for the intra-rater reliability of each rater. Cronbach alpha was computed to assess the inter-item consistency correlation. The Naranjo criteria were compared with expert opinion for criterion validity for each rater and reported as a Spearman rank (rs) coefficient. RESULTS The kappa statistic ranged from 0.14 to 0.33, reflecting poor inter-rater agreement. The weighted kappa within raters was 0.5402–0.9371. The Cronbach alpha ranged from 0.443 to 0.660, which is considered moderate to good. The rs coefficient range was 0.385–0.545; all rs coefficients were statistically significant (p < 0.05). CONCLUSIONS Inter-rater reliability is marginal; however, within-rater evaluation appears to be consistent. The inter-item correlation is expected to be higher since all questions pertain to ADRs. Overall, the Naranjo criteria need modification for use in the ICU to improve reliability, validity, and clinical usefulness.

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