Relationship Between Critical Power and Different Lactate Threshold Markers in Recreational Cyclists

Purpose: To analyze the relationship between critical power (CP) and different lactate threshold (LT2) markers in cyclists.Methods: Seventeen male recreational cyclists [33 ± 5 years, peak power output (PO) = 4.5 ± 0.7 W/kg] were included in the study. The PO associated with four different fixed (onset of blood lactate accumulation) and individualized (Dmaxexp, Dmaxpol, and LTΔ1) LT2 markers was determined during a maximal incremental cycling test, and CP was calculated from three trials of 1-, 5-, and 20-min duration. The relationship and agreement between each LT2 marker and CP were then analyzed.Results: Strong correlations (r = 0.81–0.98 for all markers) and trivial-to-small non-significant differences (Hedges’ g = 0.01–0.17, bias = 1–9 W, and p > 0.05) were found between all LT2 markers and CP with the exception of Dmaxexp, which showed the strongest correlation but was slightly higher than the CP (Hedges’ g = 0.43, bias = 20 W, and p < 0.001). Wide limits of agreement (LoA) were, however, found for all LT2 markers compared with CP (from ±22 W for Dmaxexp to ±52 W for Dmaxpol), and unclear to most likely practically meaningful differences (PO differences between markers >1%, albeit <5%) were found between markers attending to magnitude-based inferences.Conclusion: LT2 markers show a strong association and overall trivial-to-small differences with CP. Nevertheless, given the wide LoA and the likelihood of potentially meaningful differences between these endurance-related markers, caution should be employed when using them interchangeably.

Effect of Carbohydrate Content in a Pre-event Meal on Endurance Performance-Determining Factors: A Randomized Controlled Crossover-Trial

The current study aimed to investigate the effect of the relative CHO content in a pre-event meal on time to exhaustion (TTE), peak oxygen uptake (V∙O2peak), the 2nd lactate threshold (LT2), onset of blood lactate accumulation (OBLA), and work economy (WE) and to compare responses between well-trained and recreationally trained individuals. Eleven well-trained and 10 recreationally trained men performed three trials in a randomized cross-over design, in which they performed exercise tests (1) after a high-CHO pre-event meal (3 g · kg−1), (2) a low-CHO pre-event meal (0.5 g · kg−1), or (3) in a fasted-state. The test protocol consisted of five submaximal 5-min constant-velocity bouts of increasing intensity and a graded exercise test (GXT) to measure TTE. A repeated measure ANOVA with a between-subjects factor (well-trained vs. recreational) was performed. A main effect of pre-event meal was found (p = 0.001), with TTE being 8.0% longer following the high-CHO meal compared to the fasted state (p = 0.009) and 7.2% longer compared to the low-CHO meal (p = 0.010). No significant effect of pre-event meal on V∙O2peak, LT2, OBLA, or WE (p ≥ 0.087) was found and no significant interaction effect between training status and pre-event CHO intake was found for TTE or any of the performance-determining variables (p ≥ 0.257). In conclusion, high-CHO content in the pre-event meal led to a longer TTE compared to a meal with a low-CHO content or exercising in a fasted state, both in well-trained and recreationally trained participants. However, the underlying physiological reason for the increased TTE is unclear, as no effect of pre-event meal on the main physiological performance-determining variables was found. Thus, pre-event CHO intake should be standardized when the goal is to assess endurance performance but seems to be of less importance when assessing the main performance-determining variables.

The Acute Effect of Hyperoxia on Onset of Blood Lactate Accumulation (OBLA) and Performance in Female Runners during the Maximal Treadmill Test

The objective of this study was to analyze the acute effect of hyperoxia during the maximal treadmill test (MTT) of runners. Participants included 10 female street runners who performed the MTT under two different conditions: hyperoxia (HYPX), inhaling oxygen (60% O2) every 3 min; and normoxia (NORM), without additional oxygen inhalation. Both groups performed the MTT with increases in the slope of the run every 3 min until voluntary exhaustion. The variables of lactate concentration, the onset of blood lactate accumulation (OBLA), peripheral oxygen saturation (SpO2), heart rate (HR), and Borg scale were evaluated. It was verified after the comparison (HYPX vs. NORM) that stage 3 (p = 0.012, Cohen’s d = 1.76) and stage 4 (p < 0.001; Cohen’s d = 5.69) showed a reduction in lactate under the HYPX condition. OBLA under the HYPX condition was identified at a later stage than NORM. There were no differences in Borg scale, SpO2, and HR between the different conditions. It was concluded that the HYPX condition contributed to a reduction in lactate concentration and delayed OBLA in runners.

Positional differences in some physiological parameters obtained by the incremental field endurance test among elite handball players

The purpose of the study was to assess assumed differences in some physiological parameters, obtained by an incremental intermittent running field test 30–15IFT, among elite handball players to get an insight into the specifics of aerobic capacity profiles of players in different playing positions. Twenty-four elite male handball players were tested using the Cosmed K4 portable telemetry system. The following parameters were analysed: running velocity, heart rate, oxygen uptake, relative oxygen uptake, pulmonary ventilation breath-by-breath, at the three points—lactate threshold (LT), onset of blood lactate accumulation (OBLA), and at the peak velocity achieved on the test (v30–15IFT). Additionally, blood lactate concentration was analysed at v30–15IFT. The players were divided in three groups based on their playing positions: eight backcourt players, eight wing players and eight pivot players. In terms of both the statistically significant and non-significant differences, the wings achieved slightly different results in comparison to the backcourt players and pivots. The wings reached a statistically significant higher velocity at the LT than the players of the other two groups and a significantly higher velocity than the pivots at the OBLA. At all the three points, wings presented the highest HR values, meaning they can operate at higher intensities still within the aerobic work zone. This would probably allow wing players to longer persist in handball game.

On the Use of the Repeated-Sprint Training in Hypoxia in Tennis

PurposeTo examine physiological and technical responses to repeated-sprint training in normobaric hypoxia at ∼3,000 m (RSH, n = 11) or in normoxia (RSN, n = 11) compared to a control group (CON, n = 8) in well-trained tennis players. Participants were 28.8 ± 5.9 years old without any previous experience of training in hypoxia.MethodsIn addition to maintaining their usual training (CON), both RSH and RSN groups completed five tennis specific repeated-shuttle sprint sessions (4 × 5 × ∼8 s maximal sprints with ∼22 s passive recovery and ∼5 min rest between sets) over 12 days. Before (Pre), the week after (Post-1) and 3 weeks after Post-1 (Post-2), physical/technical performance during Test to Exhaustion Specific to Tennis (TEST), repeated-sprint ability (RSA) (8 × ∼20 m shuttle runs—departing every 20 s) and heart rate variability (HRV) were assessed.ResultsFrom Pre to Post-1 and Post-2, RSH improved TEST time to exhaustion (+18.2 and +17.3%; both P &lt; 0.001), while the “onset of blood lactate accumulation” at 4 mmol L–1 occurred at later stages (+24.4 and +19.8%, both P &lt; 0.01). At the same time points, ball accuracy at 100% V̇O2max increased in RSH only (+38.2%, P = 0.003 and +40.9%, P = 0.007). Markers of TEST performance did not change for both RSN and CON. Compared to Pre, RSA total time increased significantly at Post-1 and Post-2 (−1.9 and −2.5%, P &lt; 0.05) in RSH only and this was accompanied by larger absolute Δ total hemoglobin (+82.5 and +137%, both P &lt; 0.001). HRV did not change either supine or standing positions.ConclusionFive repeated sprint training sessions in hypoxia using tennis specific shuttle runs improve physiological and technical responses to TEST, RSA, and accompanying muscle perfusion responses in well-trained tennis players.

Melatonin, the advance-guard in oxidative myocardial assault instigated by exercise stress: a physiological and biochemical insight

Exercise conducted at an optimum training load is usually beneficial for the overall health of an individual. However, an unaccustomed intense exercise carried out by untrained individuals or elite athletes during over-training and/or competition-related stress often bear inevitable cardiovascular risks. Although many alterations occurring in the cardiovascular system during exercise are the results of training adaptations, sudden cardiovascular deaths reported in competitive athletes is a matter of grave concern. Several oxidative biomarkers that depict the underlying structural and functional impairment of the myocardial tissue have been identified in the individuals subjected to extensive exercise. The exercise-mediated cardiomyopathy is free radical related and also associated with pro-inflammatory response. In this review we will highlight the possible role of melatonin in obviating irrevocable oxidative cardiovascular injury triggered by extensive exercise stress. Melatonin effectively reduces exercise-induced lipid peroxidation, restores natural cellular antioxidant pool and supresses the innate immune cascade reaction that, otherwise, jeopardize cardiovascular integrity. Melatonin blocks the IKK/IκB/NFκB signaling as well as suppress iNOS and COX-2 mediated inflammation in cardiac tissue. In addition, melatonin reduces blood lactate accumulation and accelerates glucose utilization, thereby, promoting energy metabolism in athletes during their training and competition. Physical exertion associated overheating and the resultant sympathetic outflow impede cardiovascular homeostasis. Melatonin not only attenuates the sympathomedullary stimulation but also protects the cardiac cells from the cytotoxic effect of catecholamines. The available information regarding the efficacy of melatonin in amelioration of exercise-driven oxidative insult in cardiac tissue has been discussed and summarized.

The emerging role of lactate as a mediator of exercise-induced appetite suppression

Lactate, a molecule originally considered metabolic waste, is now associated with a number of important physiological functions. Although the roles of lactate as a signaling molecule, fuel source, and gluconeogenic substrate have garnered significant attention in recent reviews, a relatively underexplored and emerging role of lactate is its control of energy intake (EI). To expand our understanding of the physiological roles of lactate, we present evidence from early infusion studies demonstrating the ability of lactate to suppress EI in both rodents and humans. We then discuss findings from recent human studies that have utilized exercise intensity and/or sodium bicarbonate supplementation to modulate endogenous lactate and examine its impact on appetite regulation. These studies consistently demonstrate that greater blood lactate accumulation is associated with greater suppression of the hunger hormone ghrelin and subjective appetite, thereby supporting a role of lactate in the control of EI. To stimulate future research investigating the role of lactate as an appetite-regulatory molecule, we also highlight potential underlying mechanisms explaining the appetite-suppressive effects of lactate using evidence from rodent and in vitro cellular models. Specifically, we discuss the ability of lactate to 1) inhibit the secretory function of ghrelin producing gastric cells, 2) modulate the signaling cascades that control hypothalamic neuropeptide expression/release, and 3) inhibit signaling through the ghrelin receptor in the hypothalamus. Unravelling the role of lactate as an appetite-regulatory molecule can shed important insight into the regulation of EI, thereby contributing to the development of interventions aimed at combatting overweight and obesity.