Lactate Threshold in 50- to 55-Year-Old Men

1996 ◽  
Vol 4 (3) ◽  
pp. 286-296
Author(s):  
Fiona Iredale ◽  
Frank Bell ◽  
Myra Nimmo
Keyword(s):  
Blood Lactate ◽  
Lactate Threshold ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Peak Oxygen Uptake ◽  
State Test ◽  
The Absolute ◽  
Lactate Levels ◽  
Old Men ◽  
Treadmill Protocol

Fourteen sedentary 50- to 55-year-old men were exercised to exhaustion using an incremental treadmill protocol. Mean (±SEM) peak oxygen uptake (V̇O2peak) was 40.5 ± 1.19 ml · kg1· min−1, and maximum heart rate was 161 ± 4 beats · min−1. Blood lactate concentration was measured regularly to identify the lactate threshold (oxygen consumption at which blood lactate concentration begins to systematically increase). Threshold occurred at 84 ± 2% of V̇O2peak. The absolute lactate value at threshold was 2.9 ± 0.2 mmol · L−1. On a separate occasion, 6 subjects exercised continuously just below their individual lactate thresholds for 25 min without significantly raising their blood lactate levels from the 10th minute to the 25th. The absolute blood lactate level over the last 20 min of the steady-state test averaged 3.7 ± 1.2 mmol · L−1. This value is higher than that elicited at the threshold in the incremental test because of the differing nature of the protocols. It was concluded that although the lactate threshold occurs at a high percentage of V̇O2peak, subjects are still able to sustain exercise at that intensity for 25 min.

The Effect of Aging on the Lactate Threshold in Untrained Men

1997 ◽  
Vol 5 (1) ◽  
pp. 39-49 ◽  
Author(s):  
K. Fiona Iredale ◽  
Myra A. Nimmo
Keyword(s):  
Oxygen Consumption ◽  
Correlation Coefficient ◽  
Blood Lactate ◽  
Lactate Threshold ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Peak Oxygen Consumption ◽  
Reserve Capacity ◽  
The Difference ◽  
Treadmill Protocol

Thirty-three men (age 26–55 years) who did not exercise regularly were exercised to exhaustion using an incremental treadmill protocol. Blood lactate concentration was measured to identify lactate threshold (LT, oxygen consumption at which blood lactate concentration begins to systematically increase). The correlation coefficient for LT (ml · kg−1 · min−1) with age was not significant, but when LT was expressed as a percentage of peak oxygen consumption (VO2 peak), the correlation was r = +.69 (p < .01). This was despite a lack of significant correlation between age and VO2 peak (r = −.33). The correlation between reserve capacity (the difference between VO2 peak and LT) and age was r = −.73 (p < .01 ), and reserve capacity decreased at a rate of 3.1 ml · kg−1 · min−1 per decade. It was concluded that the percentage of VO2 peak at which LT occurs increases progressively with age, with a resultant decrease in reserve capacity.

Blood lactate concentration in COVID-19: a systematic literature review

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Giovanni Carpenè ◽  
Diletta Onorato ◽  
Riccardo Nocini ◽  
Gianmarco Fortunato ◽  
John G. Rizk ◽  
...  
Keyword(s):  
Literature Review ◽  
Blood Lactate ◽  
Systematic Literature Review ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Organ Injury ◽  
Respiratory Condition ◽  
Therapeutic Decisions ◽  
Lactate Levels ◽  
Elevated Lactate

Abstract Coronavirus disease 2019 (COVID-19) is an infectious respiratory condition sustained by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which manifests prevalently as mild to moderate respiratory tract infection. Nevertheless, in a number of cases the clinical course may deteriorate, with onset of end organ injury, systemic dysfunction, thrombosis and ischemia. Given the clinical picture, baseline assessment and serial monitoring of blood lactate concentration may be conceivably useful in COVID-19. We hence performed a systematic literature review to explore the possible association between increased blood lactate levels, disease severity and mortality in COVID-19 patients, including comparison of lactate values between COVID-19 and non-COVID-19 patients. We carried out an electronic search in Medline and Scopus, using the keywords “COVID-19” OR “SARS-CoV-2” AND “lactate” OR “lactic acid” OR “hyperlactatemia”, between 2019 and present time (i.e. October 10, 2021), which allowed to identify 19 studies, totalling 6,459 patients. Overall, we found that COVID-19 patients with worse outcome tend to display higher lactate values than those with better outcome, although most COVID-19 patients in the studies included in our analysis did not have sustained baseline hyperlactatemia. Substantially elevated lactate values were neither consistently present in all COVID-19 patients who developed unfavourable clinical outcomes. These findings suggest that blood lactate monitoring upon admission and throughout hospitalization may be useful for early identification of higher risk of unfavourable COVID-19 illness progression, though therapeutic decisions based on using conventional hyperlactatemia cut-off values (i.e., 2.0 mmol/L) upon first evaluation may be inappropriate in patients with SARS-CoV-2 infection.

Disposal of blood [1-13C]lactate in humans during rest and exercise

1986 ◽  
Vol 60 (1) ◽  
pp. 232-241 ◽  
Author(s):  
R. S. Mazzeo ◽  
G. A. Brooks ◽  
D. A. Schoeller ◽  
T. F. Budinger
Keyword(s):  
Blood Lactate ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Curvilinear Relationship ◽  
O2 Consumption ◽  
Lactate Oxidation ◽  
Respiratory Parameters ◽  
Steady Rate ◽  
Lactate Levels

Lactate irreversible disposal (RiLa) and oxidation (RoxLa) rates were studied in six male subjects during rest (Re), easy exercise [EE, 140 min of cycling at 50% of maximum O2 consumption (VO2max)] and hard exercise (HE, 65 min at 75% VO2max). Twenty minutes into each condition, subjects received a Na+-L(+)-[1–13C]lactate intravenous bolus injection. Blood was sampled intermittently from the contralateral arm for metabolite levels, acid-base status, and enrichment of 13C in lactate. Expired air was monitored continuously for determination of respiratory parameters, and aliquots were collected for determination of 13C enrichment in CO2. Steady-rate values for O2 consumption (VO2) were 0.33 +/- 0.01, 2.11 +/- 0.03, and 3.10 +/- 0.03 l/min for Re, EE, and HE, respectively. Corresponding values of blood lactate levels were 0.84 +/- 0.01, 1.33 +/- 0.05, and 4.75 +/- 0.28 mM in the three conditions. Blood lactate disposal rates were significantly correlated to VO2 (r = 0.78), averaging 123.4 +/- 20.7, 245.5 +/- 40.3, and 316.2 +/- 53.7 mg X kg-1 X h-1 during Re, EE, and HE, respectively. Lactate oxidation rate was also linearly related to VO2 (r = 0.81), and the percentage of RiLa oxidized increased from 49.3% at rest to 87.0% during exercise. A curvilinear relationship was found between RiLa and blood lactate concentration. It was concluded that, in humans, 1) lactate disposal (turnover) rate is directly related to the metabolic rate, 2) oxidation is the major fate of lactate removal during exercise, and 3) blood lactate concentration is not an accurate indicator of lactate disposal and oxidation.

Effect of Storage Techniques on Blood Lactate Concentration and Determination of Various Lactate Threshold Definitions

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S514
Author(s):  
Matthew J. Garver ◽  
Leland J. Nielsen ◽  
Jared M. Dickinson ◽  
Derek S. Campbell ◽  
Charilaos Papadopoulos ◽  
...  
Keyword(s):  
Blood Lactate ◽  
Lactate Threshold ◽  
Lactate Concentration ◽  
Blood Lactate Concentration

scholarly journals Detection of the Lactate Threshold in Runners: What is the Ideal Speed to Start an Incremental Test?

2015 ◽  
Vol 45 (1) ◽  
pp. 217-224 ◽  
Author(s):  
José Luiz Dantas ◽  
Christian Doria
Keyword(s):  
Blood Lactate ◽  
Lactate Threshold ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Endurance Athletes ◽  
Incremental Test ◽  
Average Speed ◽  
Third Stage ◽  
The Relationship ◽  
The Ideal

Abstract Incremental tests on a treadmill are used to evaluate endurance athletes; however, no criterion exists to determine the intensity at which to start the test, potentially causing the loss of the first lactate threshold. This study aimed to determine the ideal speed for runners to start incremental treadmill tests. The study consisted of 94 runners who self-reported the average speed from their last competitive race (10-42.195 km) and performed an incremental test on a treadmill. The speeds used during the first three test stages were normalised in percentages of average competition speed and blood lactate concentration was analysed at the end of each stage. The relationship between speed in each stage and blood lactate concentration was analysed. In the first stage, at an intensity corresponding to 70% of the reported average race speed, only one volunteer had blood lactate concentration equal to 2 mmol·L-1, and in the third stage (90% of the average race speed) the majority of the volunteers had blood lactate concentration ≥2 mmol·L-1. Our results demonstrated that 70% of the average speed from the subject’s last competitive race - from 10 to 42.195 km - was the best option for obtaining blood lactate concentration <2 mmol·L-1 in the first stage, however, 80% of the average speed in marathons may be a possibility. Evaluators can use 70% of the average speed in competitive races as a strategy to ensure that the aerobic threshold intensity is not achieved during the first stage of incremental treadmill tests.

Blood Lactate Levels in Free-Swimming Rainbow Trout (Salmo gairdneri) Before and After Strenuous Exercise Resulting in Fatigue

1976 ◽  
Vol 33 (1) ◽  
pp. 173-176 ◽  
Author(s):  
William R. Driedzic ◽  
Joe W. Kiceniuk
Keyword(s):  
Rainbow Trout ◽  
Blood Lactate ◽  
White Muscle ◽  
Recovery Period ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Strenuous Exercise ◽  
Salmo Gairdneri ◽  
Before And After ◽  
Lactate Levels

Rainbow trout (Salmo gairdneri) were exercised to fatigue in a series of 60-min stepwise increasing velocity increments. There was no increase in blood lactate concentration, serially sampled during swimming by means of indwelling dorsal and ventral aortic catheters, at velocities as high as 93% of critical velocity of individuals. The data show that under these conditions the rate of production of lactate by white muscle, at less than critical velocities, is minimal or that the rate of elimination of lactate from white muscle is equal to its rate of utilization elsewhere. Immediately following fatigue blood lactate level increases rapidly. During the recovery period there appears to be a net uptake of lactate by the gills.

Effect of endurance training on activators of glycolysis in muscle during exercise

1994 ◽  
Vol 76 (2) ◽  
pp. 846-852 ◽  
Author(s):  
C. Duan ◽  
W. W. Winder
Keyword(s):  
Endurance Training ◽  
Blood Lactate ◽  
Lactate Concentration ◽  
Lactate Production ◽  
Blood Lactate Concentration ◽  
Quadriceps Muscle ◽  
Muscle Lactate ◽  
Cyclic Monophosphate ◽  
Lactate Levels ◽  
Exercise Induced

Endurance training attenuates exercise-induced increases in blood lactate at the same submaximal work rate. Three intramuscular compounds that influence muscle lactate production were measured in fasted non-trained (NT) and endurance-trained (T) rats. The T rats were subjected to a progressive endurance-training program. At the end of the program (11 wk), they were running 2 h/day at 31 m/min up a 15% grade 5 days/wk. NT and T rats were fasted for 24 h and then anesthetized (pentobarbital, iv) at rest or after running for 30 min at 21 m/min (15% grade). Blood lactate levels were significantly lower in the T rats than in the NT rats after 30 min of running (2.3 +/- 0.2 vs. 3.9 +/- 0.2 mM). The lower blood lactate concentration was accompanied by lower plasma epinephrine (2.8 +/- 0.4 vs. 6.0 +/- 0.8 nM), adenosine 3′, 3′,5′-cyclic monophosphate (0.36 +/- 0.02 vs. 0.50 +/- 0.03 pmol/mg), mg), glucose 1,6-diphosphate (26 +/- 2 vs. 40 +/- 5 pmol/mg), and fructose 2,6-diphosphate (3.2 +/- 0.2 vs. 4.3 +/- 0.3 pmol/mg) in white quadriceps muscle in T than in NT rats. Red quadriceps muscle glucose 1,6-diphosphate and adenosine 3′,5′-cyclic monophosphate were also lower in T than in NT rats. These adaptations may be responsible in part for the lower exercise-induced blood lactate in fasted rats as a consequence of endurance training.

Effects of detraining on responses to submaximal exercise

1985 ◽  
Vol 59 (3) ◽  
pp. 853-859 ◽  
Author(s):  
E. F. Coyle ◽  
W. H. Martin ◽  
S. A. Bloomfield ◽  
O. H. Lowry ◽  
J. O. Holloszy
Keyword(s):  
Blood Lactate ◽  
Lactate Threshold ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Absolute Intensity ◽  
Submaximal Exercise ◽  
Activity Levels ◽  
Mitochondrial Enzyme ◽  
Ldh Activity ◽  
Long Time

Seven endurance-trained subjects were studied 12, 21, 56, and 84 days after cessation of training. Heart rate, ventilation, respiratory exchange ratio, and blood lactate concentration during submaximal exercise of the same absolute intensity increased (P less than 0.05) progressively during the first 56 days of detraining, after which a stabilization occurred. These changes paralleled a 40% decline (P less than 0.001) in mitochondrial enzyme activity levels and a 21% increase in total lactate dehydrogenase (LDH) activity (P less than 0.05) in trained skeletal muscle. After 84 days of detraining, the experimental subjects' muscle mitochondrial enzyme levels were still 50% above, and LDH activity was 22% below, sedentary control levels. The blood lactate threshold of the detrained subjects occurred at higher absolute and relative (i.e., 75 +/- 2% vs. 62 +/- 3% of maximal O2 uptake) exercise intensities in the subjects after 84 days of detraining than in untrained controls (P less than 0.05). Thus it appears that a portion of the adaptation to prolonged and intense endurance training that is responsible for the higher lactate threshold in the trained state persists for a long time (greater than 85 days) after training is stopped.

scholarly journals Evaluation of a Lactate Sensor for Rapid Repeated Measurements of Blood Lactate Concentration

1998 ◽  
Vol 26 (2) ◽  
pp. 184-188 ◽  
Author(s):  
J. V. Divatia ◽  
T. Jacques ◽  
P. Day ◽  
D. J. Bihari
Keyword(s):  
Blood Lactate ◽  
Coefficient Of Variation ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Laboratory Method ◽  
Repeated Measurements ◽  
Arterial Blood ◽  
Lactate Levels ◽  
Lactate Sensor ◽  
Serial Measurements

In critically ill patients, serial measurements of blood lactate may indicate adequacy of therapy and predict development of multi-organ failure. We studied the accuracy, precision, and repeatability of the newly developed 800 Series Lactate Sensor (Ciba Corning Diagnostic Corp., Medfield, U.S.A.). Lactate levels determined with the sensor were compared with the standard laboratory method (Abbott TDX) in 75 paired arterial blood samples from 20 patients. Agreement between methods was determined and the mean coefficient of variation calculated for repeated measurements. The bias of the sensor was -0.38 mmol/l (CI -0.23 to -0.53), and the precision ±0.67. The coefficient of variation for repeated measurements was 1.95% with the sensor, and 11.5% with the TDX (P=0.007). The new sensor offers a more reproducible, rapid method of measuring lactate, vital for serial measurements. The relatively wide limits of agreement between the methods reflect the greater variability of the TDX assay.

scholarly journals Post-analysis methods for lactate threshold depend on training intensity and aerobic capacity in runners. An experimental laboratory study

2015 ◽  
Vol 134 (3) ◽  
pp. 193-198 ◽  
Author(s):  
Tiago Lazzaretti Fernandes ◽  
Rômulo dos Santos Sobreira Nunes ◽  
Cesar Cavinato Cal Abad ◽  
Andrea Clemente Baptista Silva ◽  
Larissa Silva Souza ◽  
...  
Keyword(s):  
Blood Lactate ◽  
Laboratory Study ◽  
Lactate Threshold ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
University Hospital ◽  
Trained Group ◽  
Analysis Methods ◽  
Experimental Laboratory ◽  
Endurance Runners

ABSTRACT CONTEXT AND OBJECTIVE: This study aimed to evaluate different mathematical post-analysis methods of determining lactate threshold in highly and lowly trained endurance runners. DESIGN AND SETTING: Experimental laboratory study, in a tertiary-level public university hospital. METHOD: Twenty-seven male endurance runners were divided into two training load groups: lowly trained (frequency < 4 times per week, < 6 consecutive months, training velocity ≥ 5.0 min/km) and highly trained (frequency ≥ 4 times per week, ≥ 6 consecutive months, training velocity < 5.0 min/km). The subjects performed an incremental treadmill protocol, with 1 km/h increases at each subsequent 4-minute stage. Fingerprint blood-lactate analysis was performed at the end of each stage. The lactate threshold (i.e. the running velocity at which blood lactate levels began to exponentially increase) was measured using three different methods: increase in blood lactate of 1 mmol/l at stages (DT1), absolute 4 mmol/l blood lactate concentration (4 mmol), and the semi-log method (semi-log). ANOVA was used to compare different lactate threshold methods and training groups. RESULTS: Highly trained athletes showed significantly greater lactate thresholds than lowly trained runners, regardless of the calculation method used. When all the subject data were combined, DT1 and semi-log were not different, while 4 mmol was significantly lower than the other two methods. These same trends were observed when comparing lactate threshold methods in the lowly trained group. However, 4 mmol was only significantly lower than DT1 in the highly trained group. CONCLUSION: The 4 mmol protocol did not show lactate threshold measurements comparable with DT1 and semi-log protocols among lowly trained athletes.

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