Liquid technology in the cytological diagnosis of bladder pathology

Objective. To study the effectiveness of liquid cytological diagnosis of bladder cancer and its local relapses using the Cellprep Plus technology as an example.Materials and methods. We analyzed outpatient records of patients with urothelial pathology (n = 806) who underwent a urine cytology exam by the methods of liquid (n = 383) and conventional (n = 423) cytology.Results. The diagnostic sensitivity and specificity of the cytological examination method for diagnosing urothelial carcinoma using the method of liquid cytology have been found to be 93.4 % and 95.4 % respectively, which significantly exceeds the similar indices in the use of the method of conventional cytology – 42.4 % and 93.6 % respectively. The use of the method of liquid cytology considerably increases the accuracy of the cytological examination of bladder pathology and allows obtaining conclusions that coincide with the histological conclusion in 94.0 % of cases. In the use of the method of conventional cytology, the coincidence with histological findings is only 44.6 % (χ2 = 25.08, p < 0.001).Conclusion. The Cellprep Plus liquid technology standardizes the pre-analytical stage and increases the efficiency of the cytological method in the primary diagnosis and monitoring of patients with urothelial pathology. A promising direction of using the method of liquid cytology in the diagnosis of urothelial carcinoma is the development and implementation of the cytological criteria of differential diagnosis between reactive cell atypia and atypia characteristic of a malignant tumor.

GAMBARAN HEALTH BELIEF MODEL WUS DALAM DETEKSI DINI KANKER LEHER RAHIM MENGGUNAKAN PEMERIKSAAN IVA DIPUSKESMAS BAREGBEG 2021

Kanker leher rahim merupakan keganasan yang terjalin pada leher rahim merupakan bagian terendah dari rahim yang menonjol ke puncak liang vagina, kanker leher rahim dapat dideteksi dini dengan menggunakan metode pemeriksaan IVA. Masalah yang utama yaitu rendahnya peminat pemeriksaan IVA. Health Belief menjadi penyebab yang mengakibatkan peminat rendah, karena health belief yang kurang. Penelitian ini bertujuan untuk menggambarkan health belief WUS di wilayah kerja PUSKESMAS Baregbeg dalam deteksi dini kanker leher rahim menggunakan metode pemeriksaan IVA. Metode penelitian ini deskriptif. Teknik sampling menggunakan non probality sampling (consecutive sampling) dengan jumlah responden 126 WUS. Hasil penelitian 46 (36,5%) WUS dengan health belief baik, dan 80 (63,5%) dengan health belief kurang. Diharapkan bagi penyelenggara program IVA untuk meningkatkan penyuluhan dan penyebaran informasi terkait adanya program gratis pemeriksaan IVA untuk meningkatkan kesadaran WUS dan meningkatkan kunjungan program skrining deteksi dini kanker leher rahim menggunakan metode pemeriksaan IVA.Cervical cancer is a malignancy that is entwined in the cervix, which is the lowest part of the uterus that protrudes to the top of the vaginal canal. Moreover, cervical cancer can be early detected by using the IVA examination method. Furthermore, the main problem is the low interest in conducting the IVA examination. In addition, Health Belief is recognized as the cause of low interest. In the meantime, this study aims to describe the health beliefs of WUS in the working area of Baregbeg Public health center in early detection of cervical cancer using the IVA examination method. On the other hand, the study carried out a descriptive method. The sampling technique used non-probability sampling (consecutive sampling) with 126 WUS respondents. The results of the study 46 (36.5%) WUS indicated the good awareness of healt beliefs and 80 (63.5%) indicated the unawareness of health beliefs. Regarding the result, it is hoped that the organizers of the IVA program will conduct counseling and inform more information related to the free IVA examination program to increase awareness of WUS and increase visits to the screening program for early detection of cervical cancer using the IVA examination method.

Studi Kasus Pada Ibu Hamil Ny K Dengan Jarak Kehamilan Dekat Dan Anemia

Anemia is defined as a condition with Hb levels in the blood below the normal 11gr/dL, anemia in Indonesia that often occurs is iron deficiency anemia. According to WHO that pregnant women who experience iron deficiency are around 35-37% and will increase with gestational age, iron deficiency anemia in pregnant women has a bad impact on both the mother and the fetus. Pregnant women with severe anemia are more likely to have premature labor and have low birth weight (LBW) babies and increase perinatal mortality. The design method used in this case describes midwifery care in pregnant women with anemia. Data was collected by anamnesis physical examination method, through inspection, palpation, auscultation, percussion. For this reason, midwives are expected to provide care to overcome anemia in pregnancy so that it does not cause ongoing problemsKeywords: Anemia; Pregnancy AbstrakAnemia didefinisikan sebagai kondisi dengan kadar Hb dalam darah di bawah normal 11gr/dL, anemia di indonesia yang sering terjadi adalah anemia defisiensi zat besi. Menurut WHO bahwa ibu hamil yang mengalami defisiensi besi sekitar 35-37% dan akan semakin meningkat seiring dengan usia kehamilan, anemia defisiensi zat besi pada ibu hamil mempunyai dampak buruk baik pada ibunya maupun pada janin yang dikandungnya. ibu hamil dengan anemia berat lebih memungkinkan terjadinya partus premature dan memiliki bayi berat badan lahir rendah (BBLR) serta meningkatkan kematian perinatal. Rancangan metode yang dilakukan pada kasus ini menggambarkan asuhan kebidanan pada kehamilan dengan anemia. Pengumpulan data dilakukan dengan metode anamnesa pemeriksaan fisik, melalui inspeksi, palpasi, auskltasi, perkusi. Untuk itu bidan di harapkan dapat memberikan asuhan untuk mengatasi anemia pada kehamilan sehingga tidak menimbulkan masalah yang berkelanjutanKata kunci: Anemia;Kehamilan

NT-proBNP as an Additional Marker of Significant Coronary Atherosclerotic Lesions

Coronary artery disease (CAD) is the leading cause for morbidity and mortality both in Ukraine and in the world, so the relevance of this problem for the society is undeniable. The priority is still to study the factors that affect both more severe CAD in patients with chronic coronary syndrome and after myocardial revascularization. The aim. To investigate the patterns of correlation between blood level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and CAD severity, especially in patients with multivessel lesion, to confirm its status of a useful additional marker for assessing the condition of cardiovascular system and one of the instruments to affect the tactics of treatment. Materials and methods. The study is based on data obtained from a prospective analysis of 40 patients at the age of 51 to 82 years old from January to December 2019, whose complaints could indicate the CAD. All the patients underwent a comprehensive clinical and laboratory examination (complete blood count, biochemical blood test). The main instrumental examination method was coronary angiography; the patients were divided into 2 groups on the basis of the examination results. The quantitative degree of lesion was assessed using the SYNTAX Score for each patient. Results. The groups were comparable in terms of age, sex, and comorbidities. The groups differed significantly in terms of body mass index. Moreover, the groups differed in the level of the following biochemical markers: NT-proBNP (p=0.0001), cholesterol (p=0.02), low-density lipoproteins (p=0.009), creatinine (p=0.02), glomerular filtration rate (p=0.08). A significant correlation was found between the NT-proBNP level and the degree of CAD ρ=0.718 (p=0.0001). Conclusion. NT-proBNP significantly correlates with the SYNTAX Score and is the highest in the group of patients with multivessel coronary disease. This indicator requires further study as an additional marker for assessing the state of the cardiovascular system and can influence the choice of treatment.

Evaluation of 3D-CEUS in the Recurrence of Liver Cancer after Radiofrequency Ablation

Background. Radiofrequency ablation (RFA) has the similar curative effects to surgery, but RFA will lead to higher postoperative local recurrence rate. 3D-CEUS is a minimally invasive examination method, which is used to analyze the sensitivity to postoperative recurrence in this study. Methods. The clinical data of 60 patients with liver cancer admitted to our hospital (February 2018-February 2020) were retrospectively analyzed. All patients were treated with RFA and were followed up with 3D-CEUS, MRI, and enhanced CT examination after surgery. The ROC curve was used to analyze the differences of different examination methods in judging postoperative recurrence. Results. For the 60 patients, 52 patients (86.7%) had a single lesion and 8 patients (13.3%) had multiple lesions, with a total of 72 lesions. After RFA, 56 lesions (77.8%) were completely inactivated and 16 lesions (22.2%) remained. Totally inactivated lesions were detected as follows: 51 (91.1%) by 3D-CEUS, 42 (75.0%) by MRI, and 50 (89.3%) by enhanced CT. During a 2-year follow-up, a total of 26 recurrent lesions were detected, 24 (92.3%) by 3D-CEUS, 12 (46.2%) by MRI, and 25 (96.2%) by enhanced CT, indicating that the sensitivity of 3D-CEUS and enhanced CT was obviously higher than that of MRI ( P < 0.001 ), without conspicuous difference between sensitivity of 3D-CEUS and enhanced CT ( P > 0.05 ). Conclusion. As a new imaging examination method based on artificial intelligence, 3D-CEUS has a high sensitivity in patients with liver cancer who underwent RFA, which can effectively judge the recurrence after surgery and should be widely used in practice.

Validation of a Novel Boxing Monitoring System to Detect and Analyse the Centre of Pressure Movement on the Boxer’s Fist

The examination of force distribution and centre of pressure (CoP) displacement is a common method to analyse motion, load, and load distribution in biomechanical research. In contrast to gait analysis, the force progression in boxing punches is a new field of investigation. The centre of pressure displacement and distribution of forces on the surface of the fist during a boxing punch is of great interest and crucial to understanding the effect of the punch on the biological structures of the hand as well as the technical biomechanical aspects of the punching action. This paper presents a new method to display the CoP progression on the boxer’s fist Therefore, this study presents the validation of the developed novel boxing monitoring system in terms of CoP displacement. In addition, the CoP progression of different punching techniques in boxing is analysed on the athlete’s fist. The accuracy of the examination method of the CoP course was validated against the gold standard of a Kistler force plate. High correlations were detected between the developed sensor system and the force plate CoP with a Pearson correlation coefficient ranging from 0.93 to 0.97. The information obtained throughout the experimental study is of great importance in order to gain further knowledge into the technical execution of boxing punches as well as to provide a novel measuring method for determining CoP on the surface of the fist, to improve the understanding of the etiology of boxing-related hand injuries.

Image-Matching Digital Macro-Slide—A Novel Pathological Examination Method For Microvascular Invasion Detection In Hepatocellular Carcinoma

Background: Microvascular invasion (MVI) is a prominent risk factor of postoperative recurrence for hepatocellular carcinoma (HCC). The MVI detection rate of conventional pathological examination approaches is relatively low and unsatisfactory.Methods: By integrating pathological macro-slide with whole-mount slide imaging, we first created a novel pathological examination method called image-matching digital macro-slide (IDS). Surgical samples from eligible patients were collected to make IDS. The MVI detection rates, tumor recurrence rates and recurrence-free survival were compared among conventional 3-Point and 7-Point baseline sampling protocols and IDS. Additionally, biomarkers to recognize MVI false negative patients were probed via combining conventional pathological sampling protocols and IDS. Receiver operating characteristic curve (ROC) analysis was used to obtain the optimal cutoff of biomarkers to distinguish MVI false negative status.Results: The MVI detection rates were 21.98%, 32.97% and 63.74%, respectively, in 3-Point, 7-Point baseline sampling protocols and IDS (P< 0.001). Tumor recurrence rate of patients with MVI negative status in IDS (6.06%) was relatively lower than that of patients with MVI negative status in 3-Point (16.90%) and 7-Point (16.39%) sampling protocols. Alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) was selected as potential biomarkers to distinguish MVI false negative patients.Conclusions: Our study demonstrated that IDS can help enhance the detection rate of MVI in HCC and refine the prediction of HCC prognosis. Alpha-fetoprotein is identified as a suitable and robust biomarker to recognize MVI false-negative patients in conventional pathological protocols.

Factors affecting the follow-up time after a positive result in the fecal occult blood test

In 2010, Taiwan included the fecal occult blood test (FOBT) under preventive health insurance services. For patients whose test positive, receiving follow-ups is paramount. This study investigated factors affecting the follow-up time of these patients. This retrospective study used data from the colorectal cancer screening archives. The study period was from 2010 to 2013, and the subjects were 50–75-year-old persons who tested positive for FOBT. The t test, one-way ANOVA, and multiple regression were performed to address the differences in the mean tracking period between variables such as the population’s demographic characteristics. The mean follow-up time for the 98,482 participants whose screening results were positive exhibited significant differences (p < 0.001) according to medical unit region and classification, age, screening location, family history, examination method, and diagnosis. The model predicting the mean follow-up time predicted a period of 10.079 days longer for those whose hospital was on an offshore island than that of those whose hospital was in the eastern regions. The follow-up time was 1.257 days shorter for people who were inpatients than those who were outpatients and was 8.902 days longer for people who underwent double contrast barium enema plus flexible sigmoidoscopy than those who underwent other examination methods. Patients with a family history of colorectal cancer and those whose examination results indicated cancer had a follow-up time of 2.562 and 2.476 days shorter than those who did not know their family history and those with other results, respectively. Factors affecting the follow-up time of people whose FOBT results were positive consisted of the location and classification of the follow-up institution, age, screening location, family history, examination method, and diagnosis. This provides valuable references for improving the cancer screening program.

Employee Transfer, Work Motivation and Employee Performance

This study was pointed to decide: employees’ transfer, work inspiration, performance, the impact of representatives transfer on the performance; work inspiration towards the performance; workers transfer and work inspiration towards the employees’ performance of BPK Representative of JawaTimur Province. This investigate employments quantitative approach with clear affiliated inquire about. The information examination method utilized in this considers is path analysis. The comes about of this ponder demonstrate that: recognition of workers transfers in BPK Representative of JawaTimur province is moo, the work inspiration of representatives is exceptionally sufficient, the performance is sufficient, workers transfer isn’t noteworthy to workers performance. The conclusion from this study is that employees’ exchange doesn’t have noteworthy impact on employees’ performance somewhat. Work inspiration has positive and noteworthy impact on employees’ performance. Workers exchange and work inspiration together have a critical commitment on representatives performance.