Investigations on the main neolignan constituent methylhonokiol of Magnolia grandiflora as a new anti-inflammatory lead compound

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
W Schühly ◽  
A Hüfner ◽  
EM Wenzig ◽  
O Kunert ◽  
E Haslinger ◽  
...  
Keyword(s):  
Lead Compound ◽  
Magnolia Grandiflora ◽  
Anti Inflammatory

scholarly journals Design and synthesis of novel 1,3,5-triphenyl pyrazolines as potential anti-inflammatory agents through allosteric inhibition of protein kinase Czeta (PKCζ)

MedChemComm ◽  
2018 ◽  
Vol 9 (6) ◽  
pp. 1076-1082 ◽  
Author(s):  
Mohammad Abdel-Halim ◽  
Ashraf H. Abadi ◽  
Matthias Engel
Keyword(s):  
Protein Kinase ◽  
Mouse Models ◽  
Cell Lines ◽  
Lead Compound ◽  
Allosteric Inhibition ◽  
Murine Cell ◽  
Design And Synthesis ◽  
Anti Inflammatory

A new focused library of PKCζ inhibitors was synthesized, leading to the identification of compound2h. Owing to its improved cellular potency in human and murine cell lines, this new lead compound opens up the possibility to evaluate allosteric PKCζ inhibitors in rat or mouse models.

scholarly journals Antitussive and Anti-inflammatory Dual-active Agents Developed from Natural Product Lead Compound 1-Methylhydantoin

Molecules ◽  
2019 ◽  
Vol 24 (13) ◽  
pp. 2355 ◽  
Author(s):  
Yang Xu ◽  
Fang Wang ◽  
Hongye Guo ◽  
Shihan Wang ◽  
Shuling Ni ◽  
...  
Keyword(s):  
Natural Product ◽  
Binding Pocket ◽  
In Vivo Model ◽  
Lead Compound ◽  
Pm 2.5 ◽  
In Silico Study ◽  
Acute Pneumonia ◽  
Long Time ◽  
Anti Inflammatory

Natural products play an important role in drug discovery. This work employed a natural product 1-methylhydantoin as the lead compound to develop novel dual-active drugs. 1-Methylhydantoin was isolated from Oviductus Ranae, which is a traditional Chinese medicine that has been used for tussive and inflammation treatment for a long time. An in silico study screened the more active 1-methylhydantoin derivatives. Antitussive assessment indicated that the newly synthesized agent had similar bioactivity with the natural product. An anti-inflammatory model used xylene induced ear edema model. At the same dosage (100 mg/Kg), the newly prepared agent had an inhibition rate 53.18% which was much higher than that of the lead compound (22.69%). The results might be ascribed to the cyclooxygenases-1 (COX-1) and cyclooxygenases-2 (COX-2) selectivity, and the fitness of the compound, and the binding pocket. The anti-particulate matter (PM 2.5) acute pneumonia was evaluated through an in vivo model constructed by nasal instillation with PM 2.5 suspension. The results of the above models suggested that this novel agent had remarkable antitussive, anti-inflammatory, and anti-PM 2.5 acute pneumonia activities.

Anti-inflammatory and antinociceptive activity profile of a new lead compound – LQFM219

2020 ◽  
Vol 88 ◽  
pp. 106893
Author(s):  
Gustavo M. Galvão ◽  
Iziara F. Florentino ◽  
Germán Sanz ◽  
Boniek G. Vaz ◽  
Luciano M. Lião ◽  
...  
Keyword(s):  
Antinociceptive Activity ◽  
Lead Compound ◽  
Activity Profile ◽  
Anti Inflammatory

Anti-inflammatory effects of 4- o -methyl-benzenesulfonyl benzoxazolone (MBB) in vivo and in vitro as a novel NSAIDs lead compound

2018 ◽  
Vol 70 (3) ◽  
pp. 558-564 ◽  
Author(s):  
Li Tang ◽  
Jie-ran Luo ◽  
Dai-tian Li ◽  
Rui Ge ◽  
Yun-long Ma ◽  
...  
Keyword(s):  
Lead Compound ◽  
Anti Inflammatory

scholarly journals Investigation of nepetolide as a novel lead compound: Antioxidant, antimicrobial, cytotoxic, anticancer, anti-inflammatory, analgesic activities and molecular docking evaluation

2018 ◽  
Vol 26 (3) ◽  
pp. 422-429 ◽  
Author(s):  
Tanzeel ur Rehman ◽  
Arif-ullah Khan ◽  
Azar Abbas ◽  
Javid Hussain ◽  
Farman Ullah Khan ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Lead Compound ◽  
Anti Inflammatory ◽  
Analgesic Activities

Electron Microscopy of Silicon Deposits in Foliar Idioblasts of Magnolia Grandiflora

1976 ◽  
Vol 34 ◽  
pp. 374-375
Author(s):  
Michael T. Postek
Keyword(s):  
Electron Microscopy ◽  
Water Loss ◽  
Normal Development ◽  
Magnolia Grandiflora ◽  
Plant Body ◽  
Normal Metabolism ◽  
Hydrated Oxide

Silicon occurs naturally in plants in the form of its hydrated oxide (SiO2.nH2O) commonly called silica. Silica has been shown to be a necessary element in the normal development of many plants, playing an array of roles including strengthening, protection, and reduction of water loss. Deposition of silica in various portions of the plant body, especially the leaves, may also be viewed as a way for the plant to dispose of any excess silica taken up beyond that necessary for normal metabolism.Studies of this “opaline” silica have thus far been limited to species of the Cyperaceae and Gramineae known to possess significant quantities of silica. Within the Magnoliaceae, certain “glistening” idioblast cells at the foliar veinlet termini and vein sheaths of Magnolia grandiflora (1) have been suspected to be siliceous in nature.

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