Clinical evaluation of the efficacy and safety of Bioaron C® in children with recurrent bacterial and viral infections of the upper respiratory tract

According to WHO, the respiratory system diseases are currently inside the ten most common pathologies. The modern strategy for treating influenza and ARVI gives priority to the antiviral and immunostimulating agents, but the symptomatic drugs, which include preparations based on silver and its compounds, also play an important role. The large positive experience in using silver preparations supported by numerous clinical studies shows their high efficacy and satisfactory safety profile in the treatment of infectious and inflammatory diseases of the nose and upper respiratory tract in children and adults.

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1583. The Utility of the Immunodeficiency Scoring Index (ISI) to Predict Outcomes of Coronavirus (HCoV) Infections in Hematopietic Cell Transplant (HCT) Recipients

Open Forum Infectious Diseases ◽

10.1093/ofid/ofy210.1411 ◽

2018 ◽

Vol 5 (suppl_1) ◽

pp. S495-S495

Author(s):

Fareed Khawaja ◽

Terri Lynn Shigle ◽

Shashank S Ghantoji ◽

Marjorie Batista ◽

Ella Ariza-Heredia ◽

...

Keyword(s):

Mechanical Ventilation ◽

Respiratory Tract ◽

Viral Infections ◽

Fatal Outcome ◽

High Morbidity ◽

Cell Transplant ◽

Upper Respiratory Tract ◽

Upper Respiratory ◽

Tract Infections ◽

Overall Mortality

Abstract Background Respiratory viral infections in HCT recipients are associated with high morbidity and mortality, especially after progression from upper respiratory tract infection (URI) to lower respiratory tract infections (LRI). Data on risk factors (RF) for LRI and mortality is lacking for HCoV infections after HCT. We aimed to validate our ISI in HCoV infections. Methods All adult HCT recipients with HCoV infection from 2015 to 2017 were evaluated. An ISI based on RF was used to classify patients as low (0–2), moderate (3–6), or high (7 or higher) risk for progression to LRI or death. We defined LRI as HCoV detected in nasal wash and/or bronchoalveolar lavage and new lung infiltrates on diagnostic imaging. Clinical parameters were collected and ISI were calculated for comparison. Results A total of 144 adult HCT recipients with 166 episodes of HCoV infections were analyzed. The most common HCoV serotype for LRI and URI was 229E (42.4%) and OC43 (37.6%), respectively, and most patients were infected between November and March each year (Figures 1 and 2). When compared with URI, patients with LRI were more likely in the pre-engraftment period, had multiple respiratory viruses infections, had nosocomially acquired HCoV, required hospitalization, ICU transfer, and mechanical ventilation (all, P < 0.05). Overall mortality rate was 4% at Day 30 from diagnosis and all patients who died had LRI with an 18% mortality. Among those who died, 33% had nosocomial infection, 67% were co-infected with another respiratory virus and 67% required mechanical ventilation. Using an ISI cut off of <4, the negative predictive value (NPV) for progression to LRI was 86% with a specificity of 76%. Conclusion HCT recipients with HCoV LRI were more likely to have a fatal outcome. The NPV of the ISI for progression to LRI was high and could be used as a prognostic tool for future studies and for therapeutic clinical trials. Disclosures All authors: No reported disclosures.

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Antibiotic therapy of acute upper respiratory tract infections and otitis media in adults

Polski Przegląd Otorynolaryngologiczny ◽

10.5604/01.3001.0011.6681 ◽

2018 ◽

Vol 7 (1) ◽

pp. 1-7

Author(s):

Aleksandra Paź ◽

Magdalena Arimowicz

Keyword(s):

Respiratory Tract ◽

Antibiotic Therapy ◽

Respiratory Tract Infections ◽

Viral Infections ◽

Respiratory Infections ◽

Symptomatic Treatment ◽

Upper Respiratory Tract Infections ◽

Upper Respiratory Tract ◽

Upper Respiratory ◽

Tract Infections

An estimated 50% of antibiotic prescriptions may be unjustified in the outpatient setting. Viruses are responsible for most acute respiratory tract infections. The viral infections are often self-limiting and only symptomatic treatment remains effective. Bacteria are involved in a small percentage of infections etiology in this area. In the case of a justified or documented suspicion of a bacterial infection, antibiotic therapy may be indicated. Based on the Polish „Recommendations for the management of non-hospital respiratory infections 2016”, the indications, the rules of choice, the appropriate dosing schedules and the therapy duration, in the most frequent upper respiratory tract infections in adults, have been presented. Implementation of the presented recommendations regarding our Polish epidemiological situation, will significantly reduce the tendency to abuse antibiotics, and thus will limit the spread of drug-resistant microorganisms.

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A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold™) in patients with uncomplicated upper respiratory tract infection

Phytomedicine ◽

10.1016/j.phymed.2009.12.001 ◽

2010 ◽

Vol 17 (3-4) ◽

pp. 178-185 ◽

Cited By ~ 47

Author(s):

R.C. Saxena ◽

R. Singh ◽

P. Kumar ◽

S.C. Yadav ◽

M.P.S. Negi ◽

...

Keyword(s):

Tract Infection ◽

Respiratory Tract ◽

Respiratory Tract Infection ◽

Clinical Evaluation ◽

Upper Respiratory Tract Infection ◽

Andrographis Paniculata ◽

Upper Respiratory Tract ◽

Double Blind ◽

Double Blind Placebo ◽

Upper Respiratory

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Perspectives in Olfactory Loss Following Viral Infections of the Upper Respiratory Tract

Archives of Otolaryngology - Head and Neck Surgery ◽

10.1001/archotol.126.6.802 ◽

2000 ◽

Vol 126 (6) ◽

pp. 802 ◽

Cited By ~ 17

Author(s):

Thomas Hummel

Keyword(s):

Respiratory Tract ◽

Viral Infections ◽

Upper Respiratory Tract ◽

Olfactory Loss ◽

Upper Respiratory

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Acute respiratory viral infections in children

Russian Family Doctor ◽

10.17816/rfd2019319-22 ◽

2019 ◽

Vol 23 (3) ◽

pp. 19-22

Author(s):

Irina E. Moiseeva

Keyword(s):

Respiratory Tract ◽

General Condition ◽

Viral Infections ◽

Clinical Manifestations ◽

Symptomatic Therapy ◽

Upper Respiratory Tract ◽

Child Morbidity ◽

Upper Respiratory ◽

Respiratory Viral Infections ◽

Instrumental Methods

Acute respiratory viral infections in children lead in the structure of child morbidity. The defeat of the upper respiratory tract accompanied by fever and impaired general condition, the main symptoms of acute respiratory viral infections. Diagnosis of most acute respiratory viral infections is based on the assessment of clinical manifestations and does not require the use of specific laboratory and instrumental methods. Modern approaches to treatment are timely and adequate symptomatic therapy.

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