Aortoiliac and femoropopliteal lesions in patients with concomitant peripheral arterial disease and medial arterial calcification

2007 ◽  
Vol 28 (S 1) ◽  
Author(s):  
S Crisan ◽  
D Crisan ◽  
S Vesa ◽  
M Chirila ◽  
C Pestrea ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Arterial Calcification ◽  
Peripheral Arterial ◽  
Medial Arterial Calcification

The Limitations of Ankle Brachial Index when used Alone for the Detection/Screening of Peripheral Arterial Disease in a Population with an Increased Prevalence of Diabetes

2007 ◽  
Vol 31 (3) ◽  
pp. 149-151 ◽  
Author(s):  
Brian P. Hembling ◽  
Kelley C. Hubler ◽  
Peter M. Richard ◽  
William A. O'Keefe ◽  
Chelsey Husfloen ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Waveform Analysis ◽  
Arterial Calcification ◽  
Normal Limits ◽  
High Prevalence ◽  
High Incidence ◽  
Doppler Waveform ◽  
Peripheral Arterial

A retrospective analysis was performed comparing the effectiveness of ankle brachial index (ABI) to Doppler waveform analysis for the detection of peripheral arterial disease (PAD) in a group of patients with an estimated 31% prevalence of diabetes. A total of 21,199 ankle pressures and corresponding Doppler waveforms were correlated; 8,628, or 41%, of the ankle pressures were within normal limits; 8,335, or 40%, of the ankle pressures were below normal limits; and 4,042, or 19%, of the ankle pressures were noncompressible. Using ABI alone for screening in a population with a high incidence of diabetes is significantly limited because of noncompressible ankle pressures caused by arterial calcification. A total of 19% of the segments evaluated in this population yielded noncompressible vessels. The prevalence of PAD, detected by Doppler waveform analysis in the segments with non-compressible ankle pressures, was 69%. Additional modalities such as Doppler waveform analysis would further increase the accuracy of screening for PAD in this population. Alternately, using the ABI alone for the detection of PAD can be improved by interpreting ABIs greater than 1.2 as positive results because of the high prevalence of PAD in this group.

scholarly journals Arterial Calcification Increases in Distal Arteries in Patients with Peripheral Arterial Disease

2008 ◽  
Vol 22 (6) ◽  
pp. 799-805 ◽  
Author(s):  
Paul D. Bishop ◽  
Lindsay E. Feiten ◽  
Kenneth Ouriel ◽  
Sean P. Nassoiy ◽  
Mircea L. Pavkov ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Arterial Calcification ◽  
Peripheral Arterial

scholarly journals Increased Elastin Degradation in Pseudoxanthoma Elasticum Is Associated with Peripheral Arterial Disease Independent of Calcification

2020 ◽  
Vol 9 (9) ◽  
pp. 2771
Author(s):  
Jonas W. Bartstra ◽  
Wilko Spiering ◽  
Jody M. W. van den Ouweland ◽  
Willem P. T. M. Mali ◽  
Rob Janssen ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Ankle Brachial Index ◽  
Pseudoxanthoma Elasticum ◽  
Arterial Disease ◽  
Arterial Calcification ◽  
Elastin Degradation ◽  
Liquid Chromatography Tandem Mass ◽  
Peripheral Arterial ◽  
Fontaine Classification

Pseudoxanthoma elasticum (PXE) results in extensive fragmentation and calcification of elastin fibers in the peripheral arteries, which results in peripheral arterial disease (PAD). Current research focuses on the role of calcifications in the pathogenesis of PXE. Elastin degradation and calcification are shown to interact and may amplify each other. This study aims to compare plasma desmosines, a measure of elastin degradation, between PXE patients and controls and to investigate the association between desmosines and (1) arterial calcification, (2) PAD, and (3) PAD independent of arterial calcification in PXE. Plasma desmosines were quantified with liquid chromatography-tandem mass spectrometry in 93 PXE patients and 72 controls. In PXE patients, arterial calcification mass was quantified on CT scans. The ankle brachial index (ABI) after treadmill test was used to analyze PAD, defined as ABI < 0.9, and the Fontaine classification was used to distinguish symptomatic and asymptomatic PAD. Regression models were built to test the association between desmosines and arterial calcification and arterial functioning in PXE. PXE patients had higher desmosines than controls (350 (290–410) ng/L vs. 320 (280–360) ng/L, p = 0.02). After adjustment for age, sex, body mass index, smoking, type 2 diabetes mellitus, and pulmonary abnormalities, desmosines were associated with worse ABI (β (95%CI): −68 (−132; −3) ng/L), more PAD (β (95%CI): 40 (7; 73) ng/L), and higher Fontaine classification (β (95%CI): 30 (6; 53) ng/L), but not with arterial calcification mass. Lower ABI was associated with higher desmosines, independent from arterial calcification mass (β (95%CI): −0.71(−1.39; −0.01)). Elastin degradation is accelerated in PXE patients compared to controls. The association between desmosines and ABI emphasizes the role of elastin degradation in PAD in PXE. Our results suggest that both elastin degradation and arterial calcification independently contribute to PAD in PXE.

Correlation between ankle-brachial index and thermography measurements in patients with peripheral arterial disease

Vascular ◽  
2021 ◽  
pp. 170853812199657
Author(s):  
Jesus Antônio de Carvalho Abreu ◽  
Rauirys Alencar de Oliveira ◽  
Airton Abrahão Martin
Keyword(s):  
Peripheral Arterial Disease ◽  
Strong Correlation ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Lower Limbs ◽  
Wilcoxon Test ◽  
Arterial Calcification ◽  
The Mean ◽  
Peripheral Arterial ◽  
Spearman’S Correlation

Objectives To correlate the ankle-brachial index and photographic thermography findings in patients with peripheral arterial disease. Methods Photographic thermography was performed at the foot level, and ankle-brachial index was measured in 72 lower limbs of 53 patients with peripheral arterial disease who were divided into calcified artery, patients with an ankle-brachial index greater than 1.4; and non-calcified artery classified as asymptomatic, mild, moderate, and severe on the basis of peripheral arterial disease severity. Fisher’s exact test was used for categorical data, and Wilcoxon test was used for numerical data. Results Spearman’s correlation analysis showed a strong correlation (R = 0.7) between the ankle-brachial index and the mean plantar temperature in patients without lower limb artery calcification. Linear regression yielded the predictor equation Y = 3.296 × X + 29.75, wherein ankle-brachial index (X) can be predicted on the basis of temperature values. Spearman’s correlation test showed no significance ( p = 0.2174) in patients with arterial calcification. Kruskal–Wallis test with post hoc analysis using Dunn’s test for multiple comparisons showed that the mean plantar temperature was lower in patients with arterial calcification. Conclusion Photographic thermography findings show a strong correlation with ankle-brachial index in patients with non-calcified arteries.

Utilization and in-hospital outcomes associated with atherectomy in the treatment of peripheral vascular disease: An observational analysis from the National Inpatient Sample

Vascular ◽  
2018 ◽  
Vol 26 (5) ◽  
pp. 464-471 ◽  
Author(s):  
Rajkumar Doshi ◽  
Evan Shlofmitz ◽  
Perwaiz Meraj
Keyword(s):  
Length Of Stay ◽  
Propensity Score ◽  
Peripheral Arterial Disease ◽  
Hospital Mortality ◽  
Arterial Disease ◽  
Arterial Calcification ◽  
National Inpatient Sample ◽  
Hospital Outcomes ◽  
Percutaneous Revascularization ◽  
Peripheral Arterial

Objective Percutaneous revascularization for patients with peripheral arterial disease has become a treatment of choice for many symptomatic patients. The presence of severe arterial calcification presents many challenges for successful revascularization. Atherectomy is an adjunctive treatment option for patients with severe calcification undergoing percutaneous intervention. We sought to analyze the impact of atherectomy on in-hospital outcomes, length of stay, and cost in the percutaneous treatment of peripheral arterial disease. Methods Patients with lower extremity peripheral arterial disease undergoing percutaneous revascularization were assessed, utilizing the National Inpatient Sample (2012–2014) and appropriate International Classification of Diseases, 9th Revision, Clinical Modification diagnostic and procedural codes. Patients who were not treated with atherectomy ( n = 51,037) were compared to those treated with atherectomy ( n = 11,408). Propensity score-matched analysis was performed to address baseline differences. Results After performing propensity score-matched analysis, 11,037 patients were included in each group. Utilization of atherectomy was associated with lower in-hospital mortality (2% vs. 1.4% p = 0.0006). All secondary outcomes were lower when using atherectomy except acute renal failure. Length of stay was slightly lower when using atherectomy (7.2 vs. 7.0 days, p = 0.0494). However, median cost was higher in patients treated with atherectomy ($21,589 vs. $24,060, p = <0.0001). Conclusion The use of atherectomy was associated with significantly decreased in-hospital mortality, adverse events, and length of stay. Though, cost associated with atherectomy use is increased, this is offset by decreased in-hospital adverse outcomes. Appropriate use of atherectomy devices is an important tool in revascularization of peripheral arterial disease in select patients.

scholarly journals The Contribution of Arterial Calcification to Peripheral Arterial Disease in Pseudoxanthoma Elasticum

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e96003 ◽  
Author(s):  
Georges Leftheriotis ◽  
Gilles Kauffenstein ◽  
Jean François Hamel ◽  
Pierre Abraham ◽  
Olivier Le Saux ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Pseudoxanthoma Elasticum ◽  
Arterial Disease ◽  
Arterial Calcification ◽  
Peripheral Arterial
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