Exaggerated Spontaneous Release of Platelet-Derived Growth Factor by Alveolar Macrophages from Patients with Idiopathic Pulmonary Fibrosis

1987 ◽  
Vol 317 (4) ◽  
pp. 202-209 ◽  
Author(s):  
Yves Martinet ◽  
William N. Rom ◽  
Gary R. Grotendorst ◽  
George R. Martin ◽  
Ronald G. Crystal
Keyword(s):  
Growth Factor ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Alveolar Macrophages ◽  
Platelet Derived Growth Factor ◽  
Spontaneous Release

scholarly journals Nintedanib (BIBF 1120) for IPF: a tomorrow therapy?

2012 ◽  
Vol 7 ◽  
Author(s):  
Sabina A. Antoniu
Keyword(s):  
Growth Factor ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Platelet Derived Growth Factor ◽  
Vascular Endothelial ◽  
Life Threatening ◽  
Endothelial Growth Factor ◽  
Potential Use ◽  
Existing Data ◽  
Bibf 1120

Idiopathic pulmonary fibrosis is a rare, life threatening disease characterized by an anarchic fibrogenesis, limited survival and few therapeutic options. Its pathogenesis is complex and involves the interaction among various pathways driven by proinflammatory/profibrogenetic mediators such as platelet -derived growth factor, vascular endothelial growth factor or basic fibroblast growth factor. Given their prominent pathogenic roles in this disease such growth factor might be suitable therapeutic targets.In fact, the existing preclinical and clinical data demonstrated that their therapeutic inhibition results in a delayed progression of the pulmonary fibrosis and in the improvement of the disease outcome. BIBF 1120 is a potent triple blocker of the receptors of these growth factors which is currently evaluated as a potential therapy in the idiopathic pulmonary fibrosis. This review discusses the existing data supporting its potential use in this disease.

scholarly journals Platelet-derived growth factor in idiopathic pulmonary fibrosis.

1990 ◽  
Vol 86 (4) ◽  
pp. 1055-1064 ◽  
Author(s):  
H N Antoniades ◽  
M A Bravo ◽  
R E Avila ◽  
T Galanopoulos ◽  
J Neville-Golden ◽  
...  
Keyword(s):  
Growth Factor ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Platelet Derived Growth Factor

Role of Bcl-xL in hepatocyte growth factor-elicited epithelial protection in idiopathic pulmonary fibrosis

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
S Skwarna ◽  
I Henneke ◽  
W Seeger ◽  
T Geiser ◽  
A Günther ◽  
...  
Keyword(s):  
Growth Factor ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Hepatocyte Growth Factor ◽  
Hepatocyte Growth

scholarly journals CD71− Alveolar Macrophages in Idiopathic Pulmonary Fibrosis: A Look beyond the Borders of the Disease

2019 ◽  
Vol 200 (11) ◽  
pp. 1444-1446
Author(s):  
Ermanno Puxeddu ◽  
Daniela Fraboni ◽  
Giuseppe Cillis ◽  
Francesco Cavalli ◽  
Francesco Buccisano ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Alveolar Macrophages
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